DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and dscamb

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	2123	Identity:	614/2123 - (28%)
Similarity:	951/2123 - (44%)	Gaps:	315/2123 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAED 105
            |:......:.||::|||.:.|.|:..|...:.|..:.|..:.||||:|.:..:|.|....|....
Zfish    26 FVNASLQEVVFSSTTGALVPCPAAAVPPATLRWYLATGEEIYDVPGIRHVHPNGTLQIYGFLPSS 90

  Fly   106 YRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFV 170
            :...::...|.|.|.|..|.|.|:|:|::||..:.|...:....|:|||:|:.||.||:.|.::|
Zfish    91 FSNLINDNTYYCTAENPSGKIRSQDLHIKAVFREPYTVRVADQRVMRGNTAVFKCIIPASVEEYV 155

  Fly   171 NVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGR 235
            :|:||..| ..:...|:    :||:..:|.|:|.:|..||....|:|.|:||.|||||.| ...|
Zfish   156 SVVSWEKD-TVSLVSGS----RYLITSTGALYILDVQSEDAVNIYRCTTRHRYTGETRQS-NSAR 214

  Fly   236 LVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYKF---IEGTTRKQA 297
            |:::|||.|....|.|...:|.:...|      |.|.|.|..:|.|.:||.:.   :|..:|..
Zfish   215 LLLSEPVDSAPVILDGFERKEVMVGHR------VELPCKASGHPPPRYRWLRDNSPLESDSRYH- 272

  Fly   298 VVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGR 362
                   :.||| |:|:.....|:|.|:|.|.||.|...|...|.|..||.|.:.|.......|.
Zfish   273 -------QSVSG-LLIEATRPSDAGSYVCEVWNSFGNAKVVGRLVVKQPLKAVVSPRKVRGSVGS 329

  Fly   363 PAVFTCQYTGNPIKTVSWMKDGKAI---------GHSEPVLRIESVKKEDKGMYQCFVRNDQESA 418
            .....|..||:....::|.::.:.|         |.:...|.:|.:.|.|.|.||||.||.:.|.
Zfish   330 QVSLFCSVTGSDEFDITWYRNAEKIYQGINVRITGINNENLVMEGMAKSDGGAYQCFARNGKMST 394

  Fly   419 EASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQ 483
            :...::.|  ....|.|..||.|:.:.|...:.|.|...|.|.|.::|.||...:..:..:::.:
Zfish   395 QDLVQVVL--EDGTPKILSAFSEKVVSPNEPISLVCHVKGTPLPTVTWTLDDDPVIKDSNHRMDR 457

  Fly   484 YVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLI 548
            .:|..|.|:||||::....:|||:|:|...:..|...:.|::||.|...||.|:....:||....
Zfish   458 IITTEGHVLSYLNVSHTQVSDGGVYRCTCNNSAGSVSYQARINVRGPASIRPMKNVTAIAGRDTY 522

  Fly   549 VTCPVAGYPIDSIVWERDNRALPINRKQKVFP-NGTLIIENVERNSDQATYTCVAKNQEGYSARG 612
            :.|.:.|||..||.|.:|:..||.|.:|:.|. ||||.:.||: |||:..|||............
Zfish   523 IHCRIIGYPYYSIKWYKDSNLLPFNHRQRAFENNGTLKLSNVQ-NSDEGEYTCYVLVDPEKQIHR 586

  Fly   613 SLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHW-----SFERSAGDYGFDQVQP 672
            |:.|.|.| |.::..:.....::|..:.:.|.:..||.|:.:.|     ....|.| ...|.:
Zfish   587 SVHVTVKV-PPLIQHSDSQSASIGQRVFIPCVVISGDLPMSITWHKDGRPINASLG-VTIDNI-- 647

  Fly   673 QMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGS 737
                    :.||.:.|.:.|..|.|..||||.|:|....:|:.|.|.|||.:.::|.|:....|.
Zfish   648 --------DFTSSLRISNLSEIHNGSYTCIARNEAAAVEHSIQLIVKVPPHFEVQPKDQDGIYGK 704

  Fly   738 DAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV---EEGTLHVDNIQKTNEGYYLCEA 799
            ...:.|.|.|.|.|.:.|..:.|....:::.:..:...||   |.|:|.:.::.:.:.|:|||:.
Zfish   705 SVTLNCSAKGNPIPTIVWNHSKGAGVPQFQPIALNSGSRVQLLENGSLLIKHVLEEDAGFYLCKV 769

  Fly   800 INGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKND 864
            .|.:|:.:|..:.::|:.|...|.......|.:|....:.|.|.|||||.:.|...:..::| :.
Zfish   770 SNDVGADISKSMYLTVKIPAMITSYPNTTRAEQGHMTEMSCTAHGEKPIKVRWEKESHIINP-DM 833

  Fly   865 NRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDK 929
            :||.:..:.:...|:|:|.|..|.|.||..|:|:|.|::|.|...|.:|||:.|:.| .:::.:.
Zfish   834 SRYVVTVKEVGDEVISTLQILHTVREDSGFFSCIAINSYGEDKGIIQLIVQDRPDPP-EVEIREV 897

  Fly   930 SGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASW--SEIDRVIVPGHTTEAQVQKLSPATTYNIRI 992
            ..|::.|.|...:|||||:..|.|.:|...|||  |::.:.:.| ...:|.:.:|.||:|||||:
Zfish   898 KDRTIALRWTMGFDGNSPITGYDINYKNKSASWASSQMTKDVSP-QLNQATIIELHPASTYNIRM 961

  Fly   993 VAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYK 1057
            .|:|.||.|:.|..:||.|.|..|.|.||::::|.::...::||||||.:...||.|..|.|.|:
Zfish   962 FAKNQIGESRPSNELTITTDEAPPDGAPQDVQLEAISSQGIKVTWKPPHKHLQNGLIRSYQVCYR 1026

  Fly  1058 LSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPS 1122
            ...|..|..:.||| :...|....|.|.||:.||||.|.:||.|:.|.||.|||....|.|..||
Zfish  1027 EFGTGGSPQYNTIN-VDTTGDIETLTLDNLKKYTQYEVRVQAANRAGMGPTSEEITITTLEDVPS 1090

  Fly  1123 QPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVY---APSDEWYDETKRHYKKTASSDTV 1184
            :||.:...|..|.:||.:.|.:.|.|:.||::..|:|::   .|..| ..|.:.  ..|......
Zfish  1091 RPPENVVTTATTPETISLSWSALPKEALNGMLLGYRVIFWANLPDGE-LGEIRN--ITTTKPSLE 1152

  Fly  1185 LHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPN 1249
            |..|:|||||::||||.|..||||||..|:.:|:.|||..|..|||....::.:.|||.||.:.|
Zfish  1153 LERLEKYTNYSIQVLAFTRAGDGVRSEQIYTRTKEDVPGPPAGVKAAASTSSVVFVSWLPPHKLN 1217

  Fly  1250 GIITQYTVYSKAEGAETETKTQKVPHYQMSFEA---------TELEKNKPYEFWVTASTTIGEGQ 1305
            |||.:|.|:.          :...|.....|||         |.|.:|..|..||.|.|..|.|.
Zfish  1218 GIIRKYIVFC----------SNPYPTVISEFEAAPDVYFRRLTNLNQNWQYSIWVVAVTAAGRGN 1272

  Fly  1306 QSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKG-----VEFSANDR 1365
            .|:.|...|..:.||:|.:|..|.|..:..|..:||.|||.|.|.|.| :||     ...|.:.|
Zfish  1273 TSEIITVEPQAKAPARILTFSGTVTTPWMRDIVLPCKAVGDPPPTIKW-LKGNNGTPAPVSIDGR 1336

  Fly  1366 MRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLK 1430
            .....:||.:|::|..:|:|.|.|.|.|:...|.|...|.|..||..|.:|::.|||.::|:...
Zfish  1337 RSAHNNGSFVIRTVKAEDSGYYRCVASNNWGSDEIMLNLQVQVPPDQPRLTVTKTTTTSITLFWI 1401

  Fly  1431 PHEGDTAPLHGYTLHYKPEFG-EWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDI 1494
            |.:...:.:.||.|.|..:.. ||.:..:|...:.:.:|.|.||:.|:...|..|.:|.|..|:|
Zfish  1402 PGDNGGSSIRGYILQYSEDNSEEWGSYSISPSERSYRLENLKCGTWYKFTLTAQNAVGPGRISEI 1466

  Fly  1495 LNTRTKGQKPKL-PEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKP 1558
            :..:|.|::|:. .:...|..::|..|.|:...|.:||||:..|.:|.:..|..:|..    ||.
Zfish  1467 IEAKTHGKEPQFAKDHELFSSINSTRVELNLIGWNNGGCPIDSFTLEYRPVDTTKWTM----VKR 1527

  Fly  1559 DN---NYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRL 1620
            |:   ::::.||:.||||.|::...||||.......||||.:.|.|||||
Zfish  1528 DSLTKSHILYDLQEATWYELQMRVGNSAGTAEKRVLFATLNMDGSTIAPL--------------- 1577

  Fly  1621 PAWMPEWLDL-------NFMVPLIATVVVVAVGIC---VVCVALSRRRADDMRGGQKD------- 1668
                |:.:|.       |..:.::.|::.:.|.||   :|.:.|.|||.:......:|
Zfish  1578 ----PKSVDPSQENRQGNEGLKMMVTIICILVAICMVFIVLLVLRRRRREQRLKRLRDAKSLAEM 1638

  Fly  1669 --------------------VYYDV---------------------------------------- 1673
                                ::.|:
Zfish  1639 LMSKNARTPDTVNKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDNDFGETSKQKSSTV 1703

  Fly  1674 ---VYNQTMG-------------PGATLDKRR-----PDLRDELGYIAPPNRKLPPVPGSNYNTC 1717
               |:.|::.             ||.....||     |..|.........||..|||......|.
Zfish  1704 THTVHYQSLSQATGPLVDVSDARPGTNPTARRTAKAGPATRSRYASQWTLNRPHPPVSSHTLTTD 1768

  Fly  1718 DRI--KRGRGGL----------------RSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGN 1764
            .|:  .|..|.:                |:..|........:.||||...
Zfish  1769 WRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARA--------------- 1818

  Fly  1765 AECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAG----TMLPPG 1825
                |.|..||::: .:|.|.:.........::.|...|..:.:......|..:|    |..||
Zfish  1819 ----YEHAKMEEQL-RHAKFTITECFISDTSSEQMTAGTNDYTDSLTSSTPSESGICRFTASPP- 1877

  Fly  1826 HPGHVHSRSGSQSMPRANR----------YQRKN---SQGGQSSIYTPAPEYDDPANCAEEDQYR 1877
            .|... ||..:.::|:|:|          |.|.:   ::|..||      ..:.......:.|..
Zfish  1878 KPQDA-SRVMNMAVPKAHRPAGELVHLPPYLRMDFLLNRGAASS------GREATGQTCMDPQKS 1935

  Fly  1878 RYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNP 1942
            |.|:                 .||..||.          |...|.....|.|...|.:: ....|
Zfish  1936 RITK-----------------RPALLAPT----------PSETPSSALSSSGPPSREAV-QQWQP 1972

  Fly  1943 GNGSPEPPPPPPRNHDMSNSS-FNDSKESNEISEAECDRDHGP 1984
            |..|..|...|   .|::.:: .:.|:||...|.....:.:.|
Zfish  1973 GTASTLPQREP---GDLAQAAKLSSSQESLLDSRGHLKQSNNP 2012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	26/88 (30%)
		IG	57..133	CDD:214652	22/75 (29%)
		IG_like	267..343	CDD:214653	25/78 (32%)
		Ig	269..340	CDD:143165	24/73 (33%)
		IG_like	353..425	CDD:214653	20/80 (25%)
		IGc2	361..413	CDD:197706	16/60 (27%)
		I-set	433..527	CDD:254352	28/93 (30%)
		IGc2	446..517	CDD:197706	21/70 (30%)
		I-set	533..618	CDD:254352	32/85 (38%)
		IGc2	544..607	CDD:197706	26/63 (41%)
		Ig	641..714	CDD:143165	20/77 (26%)
		IGc2	735..804	CDD:197706	18/71 (25%)
		I-set	819..914	CDD:254352	29/94 (31%)
		Ig	833..921	CDD:299845	31/87 (36%)
		FN3	918..1011	CDD:238020	35/94 (37%)
		FN3	1018..1116	CDD:238020	40/97 (41%)
		FN3	1124..1217	CDD:238020	36/95 (38%)
		FN3	1222..1312	CDD:238020	32/98 (33%)
		Ig	1339..1406	CDD:299845	26/71 (37%)
		FN3	1409..1499	CDD:238020	27/90 (30%)
		FN3	1504..1584	CDD:238020	26/83 (31%)
		Dscam_C	1890..2008	CDD:289151	20/96 (21%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352	25/70 (36%)
		I-set	225..310	CDD:254352	29/99 (29%)
		IGc2	239..300	CDD:197706	23/75 (31%)
		IG_like	320..400	CDD:214653	20/79 (25%)
		IGc2	328..391	CDD:197706	18/62 (29%)
		IG_like	417..501	CDD:214653	23/83 (28%)
		Ig	424..498	CDD:143165	21/73 (29%)
		IG_like	511..592	CDD:214653	29/81 (36%)
		IGc2	518..576	CDD:197706	26/58 (45%)
		I-set	595..685	CDD:254352	24/100 (24%)
		Ig	612..682	CDD:143165	21/80 (26%)
		I-set	689..785	CDD:254352	23/95 (24%)
		Ig7_DSCAM	706..785	CDD:143211	19/78 (24%)
		IG_like	795..883	CDD:214653	28/88 (32%)
		Ig	803..890	CDD:299845	31/87 (36%)
		FN3	887..980	CDD:238020	35/94 (37%)
		FN3	987..1084	CDD:238020	40/97 (41%)
		FN3	1092..1185	CDD:238020	36/95 (38%)
		FN3	1190..1279	CDD:238020	32/98 (33%)
		IGc2	1302..1367	CDD:197706	24/65 (37%)
		FN3	1398..1471	CDD:238020	19/72 (26%)
		FN3	1485..1557	CDD:238020	26/75 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4915
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	917	1.000	Inparanoid score	I353
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840