DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and CG44153

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001097136.2	Gene:	CG44153 / 34341	FlyBaseID:	FBgn0265002	Length:	1946	Species:	Drosophila melanogaster

Alignment Length:	1651	Identity:	285/1651 - (17%)
Similarity:	483/1651 - (29%)	Gaps:	562/1651 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WLMLFAAVALIACGSQTLAANPPDADQK---------GPVFLKEPTNRIDFSNSTGAEIECKASG 65
            ||:.....|::.  .||    |||||||         .|...:...|....:...|.|   .|:|
  Fly    11 WLLTLLLPAVLP--HQT----PPDADQKFSLPAVPLPPPPPFQPGKNHFALNAFAGGE---HAAG 66

  Fly    66 NPMPEIIWIRSDGTAVGDVPGLRQI--SSDGKLVFPPF--------------RAEDYRQEVHAQV 114
            .        .|..:.....||...:  :..|.:..|.|              .|.|...:..|.|
  Fly    67 G--------HSHSSYSSSSPGCGGMLKARHGNIQTPNFPHRFATPIECVWIIDASDMPPQGQANV 123

  Fly   115 YACLARNQFGSIISRDVHVRAVVSQHYEEDI----HKAFVIRGNSAILKCDIPSFVADFVNVISW 175
            ...:...|. .::|   .::.....:|.:|.    |:.|.:              ..|.|..::|
  Fly   124 SIVVYLTQL-YVLS---GLKFTEYMYYSDDFKVPAHRVFTL--------------TEDDVTQVTW 170

  Fly   176 ---HSDEKENFYPGTEYDGKYLVLPSGELHI------REVGPEDGYKSYQCRT-KHRLTGETRLS 230
               ||...|..:.....||.:|......|.:      .||  ::..|:.||.| :.|..|:...|
  Fly   171 VKFHSQYLEIRFTMATLDGTHLRALDRLLDVYGFNITYEV--QNEVKTTQCNTLQCRFLGDCYAS 233

  Fly   231 ATKGRLVITEPVGSVS----PQLSGN-------------------GNQEHI-------------- 258
                     |...|..    |..||:                   |..:||
  Fly   234 ---------EDYSSYGCSCFPGFSGSDCGHGPLCKDLHTNVCQNGGTCKHIGDAAITCHCPKGFK 289

  Fly   259 -TLTRVPKMGSVTLMC------------------------PAQAYPVP----------------- 281
             |...:|::...|..|                        |.|:|...
  Fly   290 GTRCEIPEINETTQGCTSNSSSIECHQACDFDNFGRSISPPGQSYSASKGNRNAARSGKTRYEVT 354

  Fly   282 ------FFRWYKF-----IEGTTRKQ--AVVLNDRVKQVSGTLI--------------------- 312
                  ...:|:.     :.|...:|  .|:.|..:.::|...:
  Fly   355 MRLGANLTGYYRHADREQLSGVMERQLGRVLRNFNITKISDLELISNSTDRLDITFHFFGVKGDS 419

  Fly   313 --IKDAV---VEDS--GKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQY 370
              |:||:   ||..  |.:..|.|.....|:....|     |...::.|...|......:.:|..
  Fly   420 QRIRDAITRMVERGRIGNFTLVANFHHFDENPPLGL-----LELTVNQPQSGVREASEFIISCTA 479

  Fly   371 TGNPIKTVSWMKDGKAIGHSE-------------------PVLRIESVKKEDKGMYQCFVRN--D 414
            .|:......|.|||..:..|:                   .:|.:....:.|:|:|.|.|.:  .
  Fly   480 QGSSRMQFQWFKDGAVVNASKSTREIWTTVLPPETKDVYTAILGVTKASRIDEGVYSCKVTDWGV 544

  Fly   415 QESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPE------ISWELDGKKI 473
            ::.......:|     .||.:|......|::.|.|:.::|::.||...:      .||..:|...
  Fly   545 EQCRSLHIHIK-----SPPRLRVDPASVTLQRGDSLRVRCLSPGNDDIKRYAQLGYSWTRNGVLF 604

  Fly   474 ANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEK 538
            .::....:.:.:..:|.::...||     .....|.|:..:.|.....|..:||        :|:
  Fly   605 QSDAATAMWEDLYPDGSILKINNI-----QKSAEYACLVSNSVRPVSRSVYINV--------IER 656

  Fly   539 KAI----------------VAGETLIVTCPVAGYP--IDSIVWERDNRALPINRKQKVFPNGT-- 583
            .|:                ..|..:|..|| .|:.  :..|..:||.     .....:.|:.:
  Fly   657 NAVHVCPAESTYGVHWPTSAPGSPIITDCP-RGFEGHLKRICEQRDT-----GNSTWLLPDFSGC 715

  Fly   584 -----LIIEN---------VERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLIN 634
                 |:|.|         .:.||......|.         ..:|:.:...||....|    ||:
  Fly   716 VRDELLLIYNRFLALSAGFQQTNSSNILKACF---------EFTLQRRHSFLPGEASF----LID 767

  Fly   635 MGDSIDLFCQIQKGDRPIKVHWSFERSAG--------DYGFDQVQ---PQMRTNRISEKTSMISI 688
            |...:|.:.|: ||.:       .||...        |......|   .|.:..::.:.|...::
  Fly   768 MLHELDTYLQL-KGTQ-------LEREMAAEIILRILDKVMQNAQSLNSQQQIKKLQQLTQSAAL 824

  Fly   689 PSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAK------VECKADG 747
                    .|:|..||..|.:|:.|....          |.|.: .:|.|..      .|..|..
  Fly   825 --------NRETIAASQLATSTSGSSQPL----------PGDSS-TRGDDGSGSGVTAGEMSAAP 870

  Fly   748 FPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIM 812
            ....|.|.....|..||     ..|..:.|:|.||.:|.:....                  :.|
  Fly   871 AGSLQATRAGGAGGGPG-----GASSILTVDEDTLSLDRLNSLR------------------IYM 912

  Fly   813 ISVQAPP---------EFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPK------ 862
            .||:..|         .|:::|.........  :|...|.......::...|.....||
  Fly   913 TSVKTLPFNLRIYGEDLFSDQLYMDIGLSSR--LLHIMANSTIFASVISYKNLKSFLPKTYYTRG 975

  Fly   863 ---NDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYAL 924
               .|:.|.:...|:.|.:..|.......|....|       .|.:....|....:.||:....:
  Fly   976 SDPRDSDYVLASRIIQTWLFQSNRSNDNFREPLDL-------PFEAGHVEIIFQHESVPKKGDWV 1033

  Fly   925 KVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVP-GHTTEAQVQKLSP-ATT 987
            .|   .|...:.|:...:..:..:.::::         :.|.|.|.| ..|....:.|..| ||.
  Fly  1034 AV---CGHDYKASFDSTWRSDLCITKHLM---------ANITRCICPLSGTYVVMLTKRQPNATP 1086

  Fly   988 YN-----IRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPV--NQTTMRVTWKPPPRTEW 1045
            :|     |.::|..|....|...|:.|:.               |:  |:.......|.......
  Fly  1087 HNAPRRPIFVIASCACCLLQCGSALLILV---------------PIWCNRKCAVTFLKMQFCVST 1136

  Fly  1046 NGEILGYYVGYK----------LSNTNSSYVFETINFI--------------------------- 1073
            :..:|.|.:|:.          :|::.:|.:...|:.:
  Fly  1137 SSVMLIYLLGFMKMLPVSWHGIISSSLASLLLLGISTLIAIALAIHTELMPKKYLQIGSKPATPT 1201

  Fly  1074 ---------------TEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQ 1123
                           .:..:|.:.||.:|...||    |:|.:.:||...|......|:...|.|
  Fly  1202 KRRLRREQERERERERDRDRERDRELDSLSNITQ----IRAQSPLGATTASTTITTTTSSSNPGQ 1262

  Fly  1124 ---PPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYD---------ETKRHYK 1176
               |||.||.   ....|.:.|:.|.|.:....:....:...|...|.:         |......
  Fly  1263 RRPPPSSTAG---MRGAIGISWLLPLLFAVAAPLICSIIGQWPRHWWLEVLWTGSASPEAGAGKD 1324

  Fly  1177 KTASSDT----VLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQT------------EPDVPEAP 1225
            :...||:    ..|.|....|..::..|..  |:|..|.|....:            :.||..:.
  Fly  1325 EAGDSDSGAFYSAHSLLNGDNLLLESEAVM--GNGTSSPPTETSSASSSSSSTGRAVDDDVATST 1387

  Fly  1226 TDVKAL-VMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNK 1289
            :.:.:: ...|:....||      :||    |.:|.:....:.|.|....
  Fly  1388 SSITSIGSASNSGFSASW------SGI----TSFSTSTSTTSSTSTSVAA--------------- 1427

  Fly  1290 PYEFWVTASTTIGEGQQSKSIVAMPS 1315
                 :.|..|.|.|..|    |.||
  Fly  1428 -----LAAPLTSGPGDSS----ATPS 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	18/107 (17%)
		IG	57..133	CDD:214652	15/91 (16%)
		IG_like	267..343	CDD:214653	21/157 (13%)
		Ig	269..340	CDD:143165	20/152 (13%)
		IG_like	353..425	CDD:214653	15/92 (16%)
		IGc2	361..413	CDD:197706	13/70 (19%)
		I-set	433..527	CDD:254352	18/99 (18%)
		IGc2	446..517	CDD:197706	13/76 (17%)
		I-set	533..618	CDD:254352	18/118 (15%)
		IGc2	544..607	CDD:197706	15/80 (19%)
		Ig	641..714	CDD:143165	15/83 (18%)
		IGc2	735..804	CDD:197706	15/74 (20%)
		I-set	819..914	CDD:254352	17/112 (15%)
		Ig	833..921	CDD:299845	16/96 (17%)
		FN3	918..1011	CDD:238020	20/99 (20%)
		FN3	1018..1116	CDD:238020	20/151 (13%)
		FN3	1124..1217	CDD:238020	22/105 (21%)
		FN3	1222..1312	CDD:238020	14/90 (16%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
CG44153	NP_001097136.2	EGF_CA	<264..294	CDD:238011	4/29 (14%)
		IG_like	467..554	CDD:214653	14/86 (16%)
		Ig	474..551	CDD:143165	13/76 (17%)
		IG_like	564..653	CDD:214653	16/93 (17%)
		Ig	572..642	CDD:299845	13/74 (18%)
		HRM	661..718	CDD:280888	9/62 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100