DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and ptprub

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_009290693.1	Gene:	ptprub / 335096	ZFINID:	ZDB-GENE-030131-7036	Length:	1450	Species:	Danio rerio

Alignment Length:	1488	Identity:	277/1488 - (18%)
Similarity:	457/1488 - (30%)	Gaps:	543/1488 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRN 827
            |.||:.|.::...|  :|.:.||:|...|   |.|                  ...|.|: :|.:
Zfish   153 PNEYQILLEATVDR--KGYIAVDDILLLN---YPC------------------YKAPHFS-RLGD 193

  Fly   828 QTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIRE---EILSTGVMS--------- 880
            .....|:.|..||.|.|.               |....::.:..   |:.|.|.:.
Zfish   194 VEVNAGQNATFQCVAAGR---------------PSEAEKFLLERHNGEVSSGGSVKHLGRNRFAV 243

  Fly   881 SLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---VQLSWAQPY 942
            |..::..::.:..|:.||..::.||..::...::.:||..|.|...|.::|.:   :||: ....
Zfish   244 SFQLEDVQKPEQDLYRCVTQSSRGSGVSNFAELIVKVPPSPIAPPQLLRAGSTYLIIQLN-TNSI 307

  Fly   943 DGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAV 1007
            .|:.|:.|..||::.|.|.||||..|    :....::..|.|.|.|:|               :|
Zfish   308 LGDGPIIRREIEYRASLAPWSEILGV----NMVTYKLWHLDPDTEYHI---------------SV 353

  Fly  1008 TIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINF 1072
            .:....|..:|.|                  .||               .:|.|..:.....:..
Zfish   354 LLTRPGEGGTGPP------------------GPP---------------LISRTKCAEPMRALRG 385

  Fly  1073 ITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQT 1137
            :...      |:|:.::..|:.|  .|||.                         |.|.|.:
Zfish   386 LRAS------EIQSRQLTLQWEV--PAFNL-------------------------TRCHTYS--- 414

  Fly  1138 IRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYT------NYTM 1196
                           |...|:...|.....::.|.|...      .|.|...::|      .:|:
Zfish   415 ---------------VSLCYRYTTAGGGGGHNTTVRECL------AVEHNTSRFTLRDLPPFHTI 458

  Fly  1197 QV---LATTAGGDGVRSVPIHCQTEPDVPE--APTDVKALVMGNAAILVSWRPPAQPNGIITQYT 1256
            |:   ||.|.|....:.|..  |||.|:|.  ||..:....:.: .|.:.|..|.:|||:||||.
Zfish   459 QIRLALANTEGKKEGKEVMF--QTEEDIPGGIAPESLTFTPLED-MIFLKWEEPVEPNGLITQYE 520

  Fly  1257 V-YSKAEGAE----------TETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQ----Q 1306
            : |...|.::          |.:|.:...::..|    .|.....|...|.|.|..|.||    :
Zfish   521 ISYQSIESSDPGINVPGPRRTVSKLKNETYHMFS----NLHPGTTYLISVRARTAKGFGQTALTE 581

  Fly  1307 SKSIVAMPS---DQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRV 1368
            ..:.::.|:   ..:|:.::..:.|.|...:     |....|||..  |:::. ||..|..::
Zfish   582 ITTNISAPTFDYGDMPSPLSETESTITVLLR-----PAQGRGAPVS--TYQVV-VEEEAGRKV-- 636

  Fly  1369 LPDGSLLIKSVNRQDAGDYSC------HAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTV 1427
                        :::.|...|      |.|....  ...|......||.|    ||..|  ..||
Zfish   637 ------------KRELGIQDCFPIPTSHGEAQAR--GAPHYYTAELPPSS----LSEAT--PFTV 681

  Fly  1428 KLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEAS 1492
                  ||....:||          |.:   .:|.:|:          |.||....:|. .||..
Zfish   682 ------GDNHTYNGY----------WNS---PLDPRKN----------YLVYFQAMSNF-RGETR 716

  Fly  1493 DILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCP---------MSHFVVESKK-RDQI 1547
              :|.....:|....:..|.:||:..|..:....   |.|.         :...::..|| ||..
Zfish   717 --INCIRIARKAACKDHQRALEVTQRSEEMGLIL---GVCAGGLVVLILLLGAIIIIIKKGRDYY 776

  Fly  1548 EWNQISNNVKPDNNYVVLDLEPATW--------------YNLRITAHNSAGFTVAEYDFATLTVT 1598
            .::....  ||.|    ::..|.|:              :..:.|........::..|..|.:..
Zfish   777 SYSYYPR--KPGN----MNKTPITYRQEKSNMMGSMERSFTDQSTLQEDERMALSFMDTHTCSTR 835

  Fly  1599 GGTIAPLDDGSG-----------------H-GNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAV 1645
            ....:.:::.|.                 | |.:|..:|:       .||...:..:.|    |.
Zfish   836 SDPRSSMNESSSLLGGSPRRQCGRKGSPYHTGQLHPAVRV-------ADLLQHINQMKT----AE 889

  Fly  1646 GICVVCVALSRRRADDMRGGQKDVY------YDV--VYNQTMGPGATL---DKRRPDLRDELGYI 1699
            |.                 |.|..|      :|:  ..::|.|...||   |:.|..|...||
Zfish   890 GY-----------------GFKQEYESFFDGWDINKKKDKTKGRHDTLMGYDRHRVKLHPLLG-- 935

  Fly  1700 APPNRKLPPVPGSNY---NTCD-RIKRGRGGLRSNH--STWDPRR-------------------- 1738
                     .|.|:|   |..| ||.| .|..||||  :|..|::
Zfish   936 ---------DPNSDYINANYIDIRINR-EGYHRSNHFIATQGPKQETVYDFWRMVWQENCFSIVM 990

  Fly  1739 ------------------NPNLYEELKAPPVPMHG-----------NHYGHAHGNAECHYRHPGM 1774
                              ...:|.::|...:....           ...|::..:..|.:.....
Zfish   991 ITKLVEVGRVKCCKYWPDESEMYGDIKITLLKTETLAEYTVRTFALERRGYSAKHEVCQFHFTSW 1055

  Fly  1775 EDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPG----------- 1828
            .:...||....||.|...:..:..::          ||||..|..  :..|..|
Zfish  1056 PEHGVPYHATGLLAFIRRVKTSTPLD----------AGPVVVHCS--VGAGRTGCYIVLDVMLDM 1108

  Fly  1829 -------HVHSRSGSQSMPRANRYQRKNSQ------------GGQSSIYTPAPEYDDPANCAEED 1874
                   .:::...:....|.|..|.:...            .|:::|  |..|:        ..
Zfish  1109 AECEGVVDIYNCVKTLCSRRINMIQTEEQYIFIHDAILEACLCGETAI--PVNEF--------AL 1163

  Fly  1875 QYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSA 1939
            .|:...||:||..|  |....|:....:..|..|                      :...||...
Zfish  1164 AYKEMLRVDSQSNS--SQLREEFQTLNSVTPHLD----------------------VEECSIALL 1204

  Fly  1940 RNPGNGSPEPPPPPPRNHDMSNS----------SF---NDSKESNEISEAECDRDHGPRGNYGAV 1991
                          |||.:.:.|          :|   .:.:.:|.|:.|..|..|.|    .|.
Zfish  1205 --------------PRNREKNRSMDVLPPDRALAFLVTTEGESNNYINAALMDSFHRP----AAF 1251

  Fly  1992 KRSPQPKDQRTTEEMRKLIERNETGPKQL-QLQQANGA----------GFTAYDTMAV 2038
            ..:|.|....|::..|.:.:...|....| ||.|:|.|          |...|..|.|
Zfish  1252 IVTPHPLPGTTSDFWRLVFDYGCTSVVMLNQLNQSNSAWPCVQYWPEPGLQQYGPMQV 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	12/40 (30%)
		I-set	819..914	CDD:254352	19/106 (18%)
		Ig	833..921	CDD:299845	18/99 (18%)
		FN3	918..1011	CDD:238020	25/95 (26%)
		FN3	1018..1116	CDD:238020	13/97 (13%)
		FN3	1124..1217	CDD:238020	18/101 (18%)
		FN3	1222..1312	CDD:238020	26/106 (25%)
		Ig	1339..1406	CDD:299845	13/72 (18%)
		FN3	1409..1499	CDD:238020	22/89 (25%)
		FN3	1504..1584	CDD:238020	16/103 (16%)
		Dscam_C	1890..2008	CDD:289151	21/130 (16%)
ptprub	XP_009290693.1	MAM	26..184	CDD:279023	12/53 (23%)
		MAM	26..182	CDD:99706	11/33 (33%)
		IG_like	192..278	CDD:214653	16/100 (16%)
		FN3	282..353	CDD:214495	23/90 (26%)
		FN3	384..480	CDD:238020	25/154 (16%)
		FN3	489..584	CDD:238020	25/99 (25%)
		Y_phosphatase	912..1147	CDD:278528	43/258 (17%)
		PTPc	923..1147	CDD:238006	39/247 (16%)
		PTPc	1179..1442	CDD:214550	32/171 (19%)
		PTPc	1209..1442	CDD:238006	24/105 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000