DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Sdk1

DIOPT Version :10

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_808547.3 Gene:Sdk1 / 330222 MGIID:2444413 Length:2193 Species:Mus musculus


Alignment Length:2383 Identity:480/2383 - (20%)
Similarity:802/2383 - (33%) Gaps:801/2383 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 WLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEP--------TNRIDFSNSTGAEIECKASGN 66
            |.:|...:.|:...:|         |...|.|..||        .||:        .:.|.|.|:
Mouse    66 WALLLLQLHLLRALAQ---------DDVAPYFKTEPGLPQIHLEGNRL--------VLTCLAEGS 113

  Fly    67 PMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDV 131
            ...|..|||:|..       |...||:.|.:.|..      |::.|..|.|:.||:.|:::.|..
Mouse   114 WPLEFKWIRNDSE-------LTTYSSEYKYIIPSL------QKLDAGFYRCVVRNRMGALLQRKS 165

  Fly   132 HVRAVVSQHYEEDIHKAFVIRGNSAIL------KCDIPSFVADFVNVISWHSDEKENFYPGTE-- 188
            .::.....::.:...:..|.:|::|:|      .|..|.        ::|.. |.....|.:.  
Mouse   166 EIQVAYMGNFMDTDQRKTVSQGHAALLNLLPIVSCPQPQ--------VTWFR-EGHKIIPSSRIA 221

  Fly   189 --YDGKYLVL-----PSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATK--GRLVITEPVGS 244
              .:.:.::|     .:|..:::.|..::|        :::.:....||..:  |......|:..
Mouse   222 ITLENQLVILATTASDAGAYYVQAVNEKNG--------ENKTSPFIHLSVARDTGTHEAMAPIIV 278

  Fly   245 VSPQLSGNGNQEHITLTRVPKMGS--VTLMCPAQAYPVP--FFRWYKFIEGTTRKQAVVLNDRVK 305
            |:|     ||:..:.       ||  .||.|.|.|.||.  ...|        ::..|.|...:.
Mouse   279 VAP-----GNRSVVA-------GSSETTLECIANARPVEELSVHW--------KRNGVRLTSGLH 323

  Fly   306 QVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAK-----IDPP----------- 354
            .....|.|.:....|:|.|:|  ..::.|.:.|       |..|:     |:||           
Mouse   324 SYGRRLTITNPTSADTGMYVC--EATLRGSTFE-------PARARAFLSIIEPPYFTAEPESRIL 379

  Fly   355 ---TQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPV---------LRIESVKKEDKGMY 407
               .:|:|      ..|:..|.|:.|:.|.||...:...:..         |.|:.:..||.|::
Mouse   380 GEVEETMD------IPCRAMGVPLPTLQWYKDAVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGIF 438

  Fly   408 QCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKK 472
            |||..|  |..|......|......|...|...:.|:..|.:..|:|...|.|.|.|:|: .|..
Mouse   439 QCFASN--EGGEVQTHTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKPAITWK-RGNH 500

  Fly   473 IANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYG-LPYIRQM 536
            |..:...::.:::.:..   ..|.|..|...|.|.|.|.|.:.......||.|.|:. ...:...
Mouse   501 ILASGSVRIPRFMLLES---GGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVHPP 562

  Fly   537 EKKAIVAGETLIVTCPVAGYPIDSI--VWERDNRALPINRKQKVF--PNGTLIIENVERNSDQAT 597
            |.:.::.|.|..:.|.....|..|:  ||::||..:..:...::.  .:|:|:|... .:.|...
Mouse   563 EDRVVIKGTTATLCCGATHDPRTSLRYVWKKDNVVITASSSSRIVVEKDGSLVISQT-WSGDIGD 626

  Fly   598 YTCVAKNQEGYSARGSLEVQVMVLPQ---------------------IVPFAYEDLINMGDSIDL 641
            |||...::.|..:| :..::|:.||.                     :.||.       |:|..|
Mouse   627 YTCEIISEGGSDSR-TARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFD-------GNSPVL 683

  Fly   642 F--CQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIAS 704
            :  .|:.:.:.|.|||.|           .|.|:|         :.:::...:||.|.:....|.
Mouse   684 YYIVQVSENNSPWKVHLS-----------NVGPEM---------TGVTVSGLTPARTYQFRVCAV 728

  Fly   705 NKAGTTTYSVDLT--------VNVPPRWILEP--TDKAFAQGSDAKVECKADGFPKPQVTWKKAV 759
            |:.|...||.:.:        .:.||:.|:..  |:::.........|.:.:|..:..:...:..
Mouse   729 NQVGKGQYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLA 793

  Fly   760 GDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYL-------------CEAINGIGSGL--SA 809
            | .|||::.                .||......|.|             ..|.||.|.|:  .|
Mouse   794 G-LPGEHQQ----------------RNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRA 841

  Fly   810 VIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWN------MNNMRLDPK------ 862
            |...::|..|         ||   .|..:|.||.....:..|||      :|.:....|      
Mouse   842 VTEYTLQGVP---------TA---PPQNVQAEAVNSTTVHFLWNPPPQQFINGINQGYKLLAWPA 894

  Fly   863 ------------------------NDNRYTIR--------------------------------- 870
                                    |..::|..                                 
Mouse   895 DAPETVTVVTIAPDFHGIHHGYITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGH 959

  Fly   871 ---EEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDA----SINMIVQEV----------- 917
               .|||.|.:..|.. :..||:...:...::...:|.:|:    ::|..:.|.           
Mouse   960 LSFTEILDTSLKVSWQ-EPLERNGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTTY 1023

  Fly   918 -------------------------PEMPYA---LKVLDKSGRSVQLSWAQPYDGNSPLDRYIIE 954
                                     |::|.|   |.:.:.|.||..|.:...|||.:.:.|:|:|
Mouse  1024 TIDVAALTAAGVGVTTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVE 1088

  Fly   955 FKRSRASWSEIDRVIVPGHTTEAQVQ-----KLSPATTYNIRIVAENAIGTSQSSEAVTII-TAE 1013
             .:..|...|.:.|.:.....|...|     .|:|.|.|..|:...|.:|.|..|::..:| |.:
Mouse  1089 -GQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQ 1152

  Fly  1014 EAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNG--EILGYYVGYKLSNTNSSYVFETINFITEE 1076
            ..|...|.::.|...::|::|:.|.|.|.:::||  |.:||.|.|..|:..||.:.:.::    :
Mouse  1153 APPDVAPTSLTVRTASETSLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPSSALAQVVS----D 1213

  Fly  1077 GKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVG 1141
            ..|..|.::.|..:|:|.:.:||||.|||||.||..:..|.|..||..|.:.:...::|..|.:.
Mouse  1214 RLERELTIEELEEWTEYELRMQAFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLT 1278

  Fly  1142 WVSPPLESANGVIKTYKVVYAPSDEWYDETKRHY--KKTASSDTVLHGLKKYTNYTMQVLATTAG 1204
            |.|.|.:..||:|..|||:|...|  .|...|.:  :...:...:|.||:|:..|.:||||.|..
Mouse  1279 WASVPEQDQNGLILGYKVLYCAKD--LDPEPRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRI 1341

  Fly  1205 GDGVRSVPIHCQ-TEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTV-YSKAEGAETE 1267
            |:||.|.|:..: |:.|.|..|..:....:...|:.:.|:||.:|||:|..|.: |..|.|:...
Mouse  1342 GNGVPSSPLILERTKDDTPGPPVRLVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHT 1406

  Fly  1268 TKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTAT 1332
            ..|.:|......|.||||.....|.|.::|.|..|.|:                  ..:.|...|
Mouse  1407 FTTVEVGATVRQFTATELAPESAYIFRLSAKTRQGWGE------------------PLEATVITT 1453

  Fly  1333 FKEDAKMPCLAVGAPQPEIT-------W------------------KIKGVEFS----------- 1361
            .|.:...|...:..||.|:|       |                  ::.|.|:.           
Mouse  1454 EKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTVQVRELPGGEWQTYSSSISHEAT 1518

  Fly  1362 --ANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSAT--TT 1422
              |.:|:|......|.:|:.|  |.||....||.    :::|....|   |..|..::|||  ||
Mouse  1519 ACAVERLRPFTSYKLRLKATN--DIGDSDFSAET----EAVTTLQDV---PGEPPGSVSATPHTT 1574

  Fly  1423 DALTVKLKP--HEGDTAPLHGYTLHYK---------PE--------------------------- 1449
            .::.::.:|  .|.....|.||.::|:         ||                           
Mouse  1575 SSVLIQWQPPRDESLNGLLQGYRIYYRELESETGMSPEPKTLKSPSALRAELTAQSSFKTVNSSS 1639

  Fly  1450 -------------------------FGEWETS---EVSV-------------------------- 1460
                                     .||...|   ||.|                          
Mouse  1640 SLTTYELTHLKKYRRYEVIMTAYNIIGESPASVPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW 1704

  Fly  1461 -----DSQKHNIEG-------------------------------LLCGSRYQVYATGFNNIGAG 1489
                 :||..||:|                               |...::|.:..:.||..|.|
Mouse  1705 DPPPPESQNGNIQGYKVYYWEADSRNETEKMKVLFLPEPVVKIKDLTSHTKYLISISAFNAAGDG 1769

  Fly  1490 EASDILNTRTKGQKPKLPEKPRFIEVSSNS----------------------------------- 1519
            ..||....||....|..|....|.|::|.:                                   
Mouse  1770 PKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNVSWGEPSAANGILQGYRVVYEPLAPVQGVSKVV 1834

  Fly  1520 --------------------VSLHFKA-------------------------------------- 1526
                                |:..|:.                                      
Mouse  1835 TVDVKGNWQRWLKVRDLTKGVTYFFRVQARTIAYGPELQANVTAGPAEGSPGSPRNVLVTKSASE 1899

  Fly  1527 ----WKDGGC---PMSHFVVESKKRDQIEWNQISNNV-KPDNNYVV-LD-LEPATWYNLRITAHN 1581
                |.:|..   |.:.:|:|::..|:..|:..:.:: :...:|.| || |.....|..|:.|.|
Mouse  1900 LTLQWTEGNAGTTPTTGYVIEARPSDEGLWDMFAKDIPRSATSYTVDLDKLRQGVTYEFRVVAVN 1964

  Fly  1582 SAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVG 1646
            .|||  .|....::.|:....||                  :..||..| .::.|.:.::::.|.
Mouse  1965 KAGF--GEPSRPSIAVSAQAEAP------------------FYEEWWFL-LVMALSSLLLILLVV 2008

  Fly  1647 ICVVCVALSRRRADDMRG-GQKDVYYDVVYNQTMGPGATLDKRRPDLRDEL----GYIAPPNRKL 1706
            ..:|....|::......| |..::...|..:........|:.|..:::...    |..:||.   
Mouse  2009 FVLVLHGQSKKYKSCSTGKGISNMEETVTLDNGGFAALELNSRHLNVKSTFSKKNGTRSPPR--- 2070

  Fly  1707 PPVPG----SNYNTCDRI------------KRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHG 1755
             |.||    |:.:.|::.            ::...|..|..|..|       |||    .:|.|.
Mouse  2071 -PSPGGLHYSDEDICNKYNGAVLTESVNLKEKSVDGSESEASDSD-------YEE----ALPKHS 2123

  Fly  1756 --NHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHA 1818
              |||                                 ..|||...:::..|             
Mouse  2124 FVNHY---------------------------------MSDPTYYNSWKRRP------------- 2142

  Fly  1819 GTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPA 1861
                |...|....:.:|:::.|..:......|.||   :||||
Mouse  2143 ----PAAAPHRYEAVAGAEAGPHLHTVITTQSAGG---VYTPA 2178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547 27/105 (26%)
Ig strand A 39..42 CDD:409547 1/2 (50%)
Ig strand A' 48..52 CDD:409547 1/3 (33%)
Ig strand B 55..64 CDD:409547 1/8 (13%)
Ig strand C 70..76 CDD:409547 3/5 (60%)
Ig strand C' 78..81 CDD:409547 0/2 (0%)
Ig strand D 87..90 CDD:409547 1/2 (50%)
Ig strand E 95..100 CDD:409547 1/4 (25%)
Ig strand F 113..121 CDD:409547 2/7 (29%)
Ig strand G 124..136 CDD:409547 2/11 (18%)
IgI_2_Dscam 246..343 CDD:409545 23/100 (23%)
Ig strand A 247..250 CDD:409545 1/2 (50%)
Ig strand A' 260..264 CDD:409545 0/3 (0%)
Ig strand B 267..274 CDD:409545 4/8 (50%)
Ig strand C 282..288 CDD:409545 1/5 (20%)
Ig strand C' 294..297 CDD:409545 0/2 (0%)
Ig strand D 303..307 CDD:409545 0/3 (0%)
Ig strand E 309..315 CDD:409545 2/5 (40%)
Ig strand F 322..330 CDD:409545 3/7 (43%)
Ig strand G 333..343 CDD:409545 2/9 (22%)
IgC2_3_Dscam 346..426 CDD:409549 25/107 (23%)
Ig strand A 347..352 CDD:409549 1/9 (11%)
Ig strand A' 355..359 CDD:409549 1/3 (33%)
Ig strand B 362..372 CDD:409549 1/9 (11%)
Ig strand C 377..383 CDD:409549 2/5 (40%)
Ig strand C' 384..387 CDD:409549 0/2 (0%)
Ig strand E 392..398 CDD:409549 2/14 (14%)
Ig strand F 405..413 CDD:409549 4/7 (57%)
Ig strand G 416..426 CDD:409549 2/9 (22%)
IgI_4_Dscam 432..527 CDD:409548 24/94 (26%)
Ig strand A 432..435 CDD:409548 1/2 (50%)
Ig strand A' 441..445 CDD:409548 1/3 (33%)
Ig strand B 448..457 CDD:409548 2/8 (25%)
Ig strand C 462..468 CDD:409548 3/5 (60%)
Ig strand C' 470..473 CDD:409548 1/2 (50%)
Ig strand D 478..486 CDD:409548 0/7 (0%)
Ig strand E 490..499 CDD:409548 2/8 (25%)
Ig strand F 506..514 CDD:409548 4/7 (57%)
Ig strand G 517..527 CDD:409548 3/9 (33%)
IgI_5_Dscam 531..618 CDD:409550 19/90 (21%)
Ig strand A 531..533 CDD:409550 0/1 (0%)
Ig strand A' 538..542 CDD:409550 0/3 (0%)
Ig strand B 545..552 CDD:409550 1/6 (17%)
Ig strand C 559..565 CDD:409550 3/7 (43%)
Ig strand C' 566..568 CDD:409550 1/1 (100%)
Ig strand D 575..579 CDD:409550 0/3 (0%)
Ig strand E 582..588 CDD:409550 3/5 (60%)
Ig strand F 596..604 CDD:409550 3/7 (43%)
Ig strand G 608..618 CDD:409550 1/9 (11%)
Ig 621..718 CDD:472250 24/127 (19%)
Ig strand B 639..643 CDD:409353 1/5 (20%)
Ig strand C 653..657 CDD:409353 3/3 (100%)
Ig strand E 684..688 CDD:409353 0/3 (0%)
Ig strand F 698..703 CDD:409353 0/4 (0%)
Ig strand G 711..714 CDD:409353 1/2 (50%)
IgI_7_Dscam 721..815 CDD:409546 21/110 (19%)
Ig strand A 721..725 CDD:409546 2/3 (67%)
Ig strand A' 730..734 CDD:409546 0/3 (0%)
Ig strand B 737..746 CDD:409546 1/8 (13%)
Ig strand C 752..758 CDD:409546 0/5 (0%)
Ig strand C' 764..767 CDD:409546 2/2 (100%)
Ig strand D 775..778 CDD:409546 0/2 (0%)
Ig strand E 780..786 CDD:409546 0/5 (0%)
Ig strand F 793..801 CDD:409546 3/20 (15%)
Ig strand G 806..815 CDD:409546 3/10 (30%)
Ig 818..916 CDD:472250 24/173 (14%)
Ig strand B 836..840 CDD:409353 0/3 (0%)
Ig strand C 849..853 CDD:409353 1/3 (33%)
Ig strand E 880..884 CDD:409353 1/3 (33%)
Ig strand F 894..899 CDD:409353 0/4 (0%)
FN3 <899..1212 CDD:442628 102/365 (28%)
Ig strand G 907..910 CDD:409353 1/6 (17%)
FN3 1222..1312 CDD:238020 27/90 (30%)
Ig <1339..1406 CDD:472250 20/104 (19%)
Ig strand C 1350..1354 CDD:409358 3/28 (11%)
Ig strand E 1372..1376 CDD:409358 1/3 (33%)
Ig strand F 1386..1391 CDD:409358 1/4 (25%)
Ig strand G 1399..1402 CDD:409358 0/2 (0%)
FN3 1409..1499 CDD:238020 34/219 (16%)
FN3 1504..1584 CDD:238020 23/182 (13%)
Dscam_C 1893..2008 CDD:463546
Sdk1NP_808547.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56
Ig_3 86..155 CDD:464046 23/89 (26%)
Ig 180..248 CDD:472250 12/76 (16%)
Ig strand B 190..194 CDD:409353 2/3 (67%)
Ig strand C 204..208 CDD:409353 0/11 (0%)
Ig strand E 227..230 CDD:409353 0/2 (0%)
Ig strand F 240..245 CDD:409353 0/4 (0%)
Ig_3 275..347 CDD:464046 23/93 (25%)
Ig 368..457 CDD:472250 22/96 (23%)
Ig strand B 386..390 CDD:409353 1/9 (11%)
Ig strand C 399..403 CDD:409353 1/3 (33%)
Ig strand E 423..427 CDD:409353 1/3 (33%)
Ig strand F 437..442 CDD:409353 2/4 (50%)
Ig strand G 450..453 CDD:409353 0/2 (0%)
I-set 462..552 CDD:400151 24/93 (26%)
Ig strand B 479..483 CDD:409353 1/3 (33%)
Ig strand C 492..496 CDD:409353 1/3 (33%)
Ig strand E 518..522 CDD:409353 1/3 (33%)
Ig strand F 532..537 CDD:409353 2/4 (50%)
Ig strand G 545..548 CDD:409353 0/2 (0%)
FN3 <554..943 CDD:442628 80/446 (18%)
fn3 652..737 CDD:394996 20/111 (18%)
fn3 753..839 CDD:394996 19/102 (19%)
FN3 954..1036 CDD:238020 11/82 (13%)
FN3 1022..>1415 CDD:442628 117/399 (29%)
FN3 1360..1453 CDD:238020 28/110 (25%)
FN3 <1501..1923 CDD:442628 63/430 (15%)
FN3 1885..1978 CDD:238020 20/94 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2057..2080 6/26 (23%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2187..2193
Blue background indicates that the domain is not in the aligned region.

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