DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_038937320.1	Gene:	Kirrel3 / 315546	RGDID:	1311382	Length:	869	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	165/717 - (23%)
Similarity:	259/717 - (36%)	Gaps:	167/717 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 QEETMEPGPSVFLKCVAGGNPTPE----ISWELDGKKI-ANNDRYQVGQYVTVNGDVVS---YLN 496
            |::.:..|..|.|.|.     .||    :.|..||..: ...|.....||:.| |:.:|   :|.
  Rat    55 QDQVVVSGQPVTLLCA-----IPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV-GNHLSGEHHLK 113

  Fly   497 ITSVHANDGGLYKCIAKSKVGVAEHSAKLNV---------YGLPYIRQMEKKAIVAGETLIVTCP 552
            |......|..:|:|.| .:..:....|:|.|         .|.|.|      ::.||:.|.:||.
  Rat   114 ILRAELQDDAVYECQA-IQAAIRSRPARLTVLVPPDDPIILGGPVI------SLRAGDPLNLTCH 171

  Fly   553 V-AGYPIDSIVWERDNRA----------LPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQE 606
            . ...|..||:|.|....          |...:::.:.  .||.|...:..:.| :..|.|.|:
  Rat   172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV--STLFISPGDVENGQ-SIVCRATNK- 232

  Fly   607 GYSARGSLEVQVMV---LPQIVPFAYEDLINMGDSIDLF-CQIQKGDRPIKVHWS---------- 657
              :..|..|..|.:   .|.:|..:.|....:.|:|..| |..:......:..|:
  Rat   233 --AIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEAS 295

  Fly   658 --FERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNV 720
              ..|:..||.:           .||..|                |..:|..|:|..|..:.|..
  Rat   296 GELYRTTVDYTY-----------FSEPVS----------------CEVTNALGSTNLSRTVDVYF 333

  Fly   721 PPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVD 785
            .||...||.......||||...|...|.|...:.|.|            :.|..:...|.||.:.
  Rat   334 GPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMK------------RGSGVVLSNEKTLTLK 386

  Fly   786 NIQKTNEGYYLCEA-INGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIG 849
            ::::.:.|.|:|.| :..:|:| ...:.::|..|| .....:.|.|..||...::|..:...|..
  Rat   387 SVRQEDAGKYVCRAVVPRVGAG-EREVTLTVNGPP-IISSTQTQHALHGEKGQIKCFIRSTPPPD 449

  Fly   850 -ILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSD-SALFTCVATNAFGSDDASINM 912
             |.|:.....|:.....|||:.......||:|:|:|....|:| ..::.|.|.|:||||...|.:
  Rat   450 RIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514

  Fly   913 IVQ----------EVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDR 967
            ..|          |...:|.|:.:....|..|..         ..|...|:.|..:|:..|...|
  Rat   515 KEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAF---------LVLMATIVAFCCARSQRSTGGR 570

  Fly   968 VIVPGHTTEAQVQKLSPATTYNIR--IVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQ 1030
            ..:.|..||.:.:...|... |::  :.|:|.|       .|.|:..|.| ||:      |..:.
  Rat   571 PGISGRGTEQKARLRLPRRA-NLKGVVSAKNDI-------RVEIVHKEPA-SGR------EAEDH 620

  Fly  1031 TTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQ--Y 1093
            ||::.....      .||.            ....|.:.:..:.||.|    |.|||:..|.  |
  Rat   621 TTIKQLMMD------RGEF------------QQDSVLKQLEVLKEEEK----EFQNLKDPTNGYY 663

  Fly  1094 SV 1095
            ||
  Rat   664 SV 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	24/94 (26%)
		IGc2	446..517	CDD:197706	21/78 (27%)
		I-set	533..618	CDD:254352	21/95 (22%)
		IGc2	544..607	CDD:197706	17/73 (23%)
		Ig	641..714	CDD:143165	13/85 (15%)
		IGc2	735..804	CDD:197706	17/69 (25%)
		I-set	819..914	CDD:254352	28/96 (29%)
		Ig	833..921	CDD:299845	27/99 (27%)
		FN3	918..1011	CDD:238020	20/94 (21%)
		FN3	1018..1116	CDD:238020	18/80 (23%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Kirrel3	XP_038937320.1	IG_like	54..143	CDD:214653	24/94 (26%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	3/11 (27%)
		Ig strand C	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	1/2 (50%)
		Ig strand D	97..101	CDD:409353	2/3 (67%)
		Ig strand E	104..116	CDD:409353	3/11 (27%)
		Ig strand G	132..143	CDD:409353	2/10 (20%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	24/108 (22%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	2/3 (67%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	1/2 (50%)
		Ig	<267..334	CDD:416386	15/93 (16%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	2/16 (13%)
		Ig strand G	321..334	CDD:409353	4/12 (33%)
		Ig	335..416	CDD:416386	23/93 (25%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	4/9 (44%)
		Ig strand C	365..371	CDD:409353	2/17 (12%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	29/97 (30%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	2/3 (67%)
		Ig strand F	496..501	CDD:409479	1/4 (25%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10917
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900