DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Igsf10

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:XP_038958192.1 Gene:Igsf10 / 310448 RGDID:735030 Length:2647 Species:Rattus norvegicus


Alignment Length:1386 Identity:283/1386 - (20%)
Similarity:464/1386 - (33%) Gaps:448/1386 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 VISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGY--KSYQCRTKHRLTGETRLSATKG 234
            :|:..:|...|.:|.|......:..|..........||..|  |||         .||   ..||
  Rat  1560 IITGTTDSPSNLFPSTSVPALRVDKPQNSKWKPSPWPEHKYQLKSY---------SET---IEKG 1612

  Fly   235 RLVITEPVGSVSPQLS---------------------------GNGNQEHITLTRVPKM------ 266
            :    .|..|:||.||                           .|...:|:....:||.      
  Rat  1613 K----RPAVSMSPHLSLPEASTHASHWNTQKHAEKSVFDKKPAQNPTSKHLPYVSLPKTLLKKPR 1673

  Fly   267 --------------GSVTLMCPAQAYPVPFFRW------YKFIEGTTRKQAVVLNDRVKQVSGTL 311
                          ..|.|.|.|...|:|...|      .:..:||.:.:..||      .:|||
  Rat  1674 IIGGKAASFTVPANSDVFLPCEAVGDPLPIIHWTRVSSGLEISQGTQKSRFHVL------PNGTL 1732

  Fly   312 IIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQ--TVDFGRPAVFTCQYTGNP 374
            .|:...::|.|:|||..:|.:|.:.:...|:|.:..:..:|...:  ||..|......|:..|.|
  Rat  1733 SIQRVSIQDRGQYLCSASNPLGVDHLHVSLSVVSYPARILDRHVKEITVHSGSTVELKCRVEGMP 1797

  Fly   375 IKTVSWMKDGKAIGHS------------EPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLG 427
            ..||||:...:.:...            :..|.|.::...|:|.|:|...|  .|.:.|..:|:.
  Rat  1798 RPTVSWILANQTVVSETAKGSRKVWVTPDGTLIIYNLSLYDRGFYKCVASN--PSGQDSLLVKIQ 1860

  Fly   428 GRFDPPVI----RQAFQEETMEPGPSVFLKCVAGGNPTPEISWEL-DGKKI----ANNDRYQVGQ 483
            ....||||    |||.....   |.|:.|.|.|.|.|.|.:.|.| ||.::    ..:.|:    
  Rat  1861 VITAPPVIIEQKRQAIVGVL---GGSLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRF---- 1918

  Fly   484 YVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNV---YGLPYIRQMEKK--AIVA 543
            ::..||.    |.|.|:..:..|.|:|||.|..|.......|.|   ..:|.|....:|  .:..
  Rat  1919 FLYPNGT----LYIRSIAPSVRGTYECIATSSSGSERRVVILTVEEGETIPRIETASQKWTEVNL 1979

  Fly   544 GETLIVTCPVAGYPIDSIVWERDNRAL-----PINRKQKVFPNGTLIIENVERNSDQATYTCVAK 603
            ||.|::.|...|.|...|:|...::|:     .:..:..|:|||:|::.:| ...|...|.|||:
  Rat  1980 GEKLLLNCSATGDPKPRIIWRLPSKAVIDQWHRMGSRIHVYPNGSLVVGSV-TEKDAGDYLCVAR 2043

  Fly   604 NQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFD 668
            |:.|                      :||:.|                                 
  Rat  2044 NKMG----------------------DDLVLM--------------------------------- 2053

  Fly   669 QVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAF 733
            .|:.::...:|.:|                                            :...|..
  Rat  2054 HVRLRLTPAKIEQK--------------------------------------------QYFKKQV 2074

  Fly   734 AQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDN--------IRVEEGTLHVDNIQKT 790
            ..|.|.:|:|||.|.|.|:|:|....|..   ..::.::|:        .....|||:.:|:...
  Rat  2075 LHGKDFQVDCKASGSPVPEVSWSLPDGTV---LNNVAQADDSGYRTKRYTLFHNGTLYFNNVGMA 2136

  Fly   791 NEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLR-NQTARRGEPAVLQCEAKGEKPIGILWNM 854
            .||.|:|.|.|.:|.....|.:..:.|.|...:..: ....|.|:.|||.||..||....:.|.:
  Rat  2137 EEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQSYKTTMRLRAGDTAVLDCEVTGEPKPNVFWLL 2201

  Fly   855 NNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPE 919
            .:..:...:::|:|....       .:|||.:.:..||..:.|||.|..|.|..:..:.:...|.
  Rat  2202 PSNNVISFSNDRFTFHAN-------RTLSIHKVKPLDSGDYVCVAQNPSGDDTKTYKLDIVSKPP 2259

  Fly   920 M---PYALKVLDKSGR----------------SVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEI 965
            :   .||.|.:.|:..                |.|::|..|  ||..|.   ..:..||.:    
  Rat  2260 LINGLYANKTVIKATAIRHSKKYFDCRADGIPSSQVTWIMP--GNIFLP---APYFGSRVT---- 2315

  Fly   966 DRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEE---------------- 1014
               :.|..|.|.:..:||.:..:       ..:..|:..|:|.::..|.                
  Rat  2316 ---VHPNGTLEMRNIRLSDSADF-------TCVVRSEGGESVLVVQLEVLEMLRRPTFRNPFNEK 2370

  Fly  1015 --APSGKPQNIKVEPVNQTTMRVTWKPPPRTEW-----NGEIL----GYYVGYKLSNTNSSYVFE 1068
              |.:|||..:...........:||..|..|::     |...|    |..:.||.:...|     
  Rat  2371 VIAQAGKPVALNCSVDGNPPPEITWILPDGTQFANRPHNSPYLMAGNGSLILYKATRNKS----- 2430

  Fly  1069 TINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTL 1133
                    || :....:|...|.:..::::    ||..|:....:....:....:|.| ..|.:.
  Rat  2431 --------GK-YRCAARNKVGYIEKLILLE----IGQKPVILTYEPGMVKSVSGEPLS-LHCVSD 2481

  Fly  1134 TSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQV 1198
            ......|.|.:|    ...||...:|     |..|               :||     .|.|:.:
  Rat  2482 GIPKPNVKWTTP----GGHVIDRPQV-----DGKY---------------ILH-----ENGTLVI 2517

  Fly  1199 LATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEG 1263
            .||||...|    ...|:.:..|.:|...|..:|:.....::::.|                   
  Rat  2518 KATTAHDQG----NYICRAQNSVGQAVISVSVMVVAYPPRIINYLP------------------- 2559

  Fly  1264 AETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDT 1328
                              ...|.:.             ||..|                      
  Rat  2560 ------------------RNMLRRT-------------GEAMQ---------------------- 2571

  Fly  1329 FTATFKEDAKMPCLAVGAPQPEITWKI-------KGVEFSANDRMRVLPDGSLLIKSVNRQDAGD 1386
                      :.|:|:|.|:|::||:.       |......:....:.|.|:|:|:::...|:|.
  Rat  2572 ----------LHCVALGIPKPKVTWETPRHSLLSKATARKPHRSEMLHPQGTLVIQNLQTSDSGV 2626

  Fly  1387 YSCHAENSIAKDSITHKLIVL 1407
            |.|.|:|.:..|..|..:.||
  Rat  2627 YKCRAQNLLGTDYATTYIQVL 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653 23/81 (28%)
Ig 269..340 CDD:143165 22/76 (29%)
IG_like 353..425 CDD:214653 19/85 (22%)
IGc2 361..413 CDD:197706 14/63 (22%)
I-set 433..527 CDD:254352 32/102 (31%)
IGc2 446..517 CDD:197706 24/75 (32%)
I-set 533..618 CDD:254352 24/91 (26%)
IGc2 544..607 CDD:197706 21/67 (31%)
Ig 641..714 CDD:143165 3/72 (4%)
IGc2 735..804 CDD:197706 23/76 (30%)
I-set 819..914 CDD:254352 24/95 (25%)
Ig 833..921 CDD:299845 23/90 (26%)
FN3 918..1011 CDD:238020 22/111 (20%)
FN3 1018..1116 CDD:238020 20/106 (19%)
FN3 1124..1217 CDD:238020 21/92 (23%)
FN3 1222..1312 CDD:238020 8/89 (9%)
Ig 1339..1406 CDD:299845 20/73 (27%)
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Igsf10XP_038958192.1 LRRNT 78..110 CDD:214470
leucine-rich repeat 89..108 CDD:275380
leucine-rich repeat 109..132 CDD:275380
LRR_8 131..191 CDD:404697
leucine-rich repeat 133..156 CDD:275380
leucine-rich repeat 157..180 CDD:275380
LRR_8 180..245 CDD:404697
leucine-rich repeat 181..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..260 CDD:275380
PCC 242..>323 CDD:188093
LRRCT 269..>293 CDD:214507
Ig 532..605 CDD:416386
Ig strand A' 534..537 CDD:409353
Ig strand B 543..550 CDD:409353
Ig strand C 556..562 CDD:409353
Ig strand C' 564..566 CDD:409353
Ig strand D 577..581 CDD:409353
Ig strand E 584..589 CDD:409353
Ig strand F 597..605 CDD:409353
IG 632..712 CDD:214652
Herpes_BLLF1 <1189..1500 CDD:282904
Ig 1690..1763 CDD:416386 22/78 (28%)
Ig strand B 1690..1694 CDD:409353 2/3 (67%)
Ig strand C 1703..1707 CDD:409353 0/3 (0%)
Ig strand E 1730..1734 CDD:409353 3/3 (100%)
Ig strand F 1744..1749 CDD:409353 3/4 (75%)
Ig strand G 1758..1761 CDD:409353 0/2 (0%)
Ig 1768..1861 CDD:416386 21/94 (22%)
Ig strand A 1768..1771 CDD:409353 0/2 (0%)
Ig strand A' 1776..1780 CDD:409353 0/3 (0%)
Ig strand B 1786..1795 CDD:409353 1/8 (13%)
Ig strand C 1800..1805 CDD:409353 4/4 (100%)
Ig strand C' 1808..1810 CDD:409353 0/1 (0%)
Ig strand D 1819..1822 CDD:409353 0/2 (0%)
Ig strand E 1827..1834 CDD:409353 2/6 (33%)
Ig strand F 1840..1848 CDD:409353 3/7 (43%)
Ig strand G 1851..1861 CDD:409353 2/9 (22%)
Ig_3 1865..1944 CDD:404760 29/89 (33%)
Ig strand A 1866..1869 CDD:409353 2/2 (100%)
Ig strand A' 1875..1878 CDD:409353 1/2 (50%)
Ig strand B 1884..1891 CDD:409353 2/6 (33%)
Ig strand C 1897..1903 CDD:409353 1/5 (20%)
Ig strand C' 1909..1911 CDD:409353 0/1 (0%)
Ig strand D 1917..1922 CDD:409353 1/8 (13%)
Ig strand E 1924..1928 CDD:409353 2/7 (29%)
Ig strand F 1937..1945 CDD:409353 5/7 (71%)
Ig strand G 1948..1958 CDD:409353 2/9 (22%)
Ig_3 1965..2044 CDD:404760 23/79 (29%)
putative Ig strand B 1980..1990 CDD:409353 4/9 (44%)
putative Ig strand C 1996..2002 CDD:409353 2/5 (40%)
putative Ig strand D 2018..2021 CDD:409353 1/2 (50%)
putative Ig strand E 2023..2029 CDD:409353 2/5 (40%)
putative Ig strand F 2036..2044 CDD:409353 4/7 (57%)
IG_like 2077..2160 CDD:214653 25/85 (29%)
Ig strand B 2078..2085 CDD:409353 2/6 (33%)
Ig strand C 2093..2097 CDD:409353 1/3 (33%)
Ig strand D 2122..2125 CDD:409353 0/2 (0%)
Ig strand E 2126..2131 CDD:409353 3/4 (75%)
Ig strand F 2139..2147 CDD:409353 4/7 (57%)
Ig strand G 2153..2160 CDD:409353 1/6 (17%)
IG 2178..2252 CDD:214652 23/80 (29%)
IG_like 2283..2354 CDD:214653 17/89 (19%)
Ig strand C 2294..2298 CDD:409353 1/3 (33%)
Ig strand E 2320..2324 CDD:409353 1/3 (33%)
Ig strand F 2334..2339 CDD:409353 0/11 (0%)
Ig_3 2360..2439 CDD:404760 16/92 (17%)
Ig strand B 2379..2383 CDD:409353 0/3 (0%)
Ig strand C 2392..2396 CDD:409353 1/3 (33%)
Ig strand E 2418..2422 CDD:409353 1/3 (33%)
Ig strand F 2432..2437 CDD:409353 1/5 (20%)
Ig_3 2455..2534 CDD:404760 22/112 (20%)
Ig_3 2551..2633 CDD:404760 22/163 (13%)
Ig strand A 2552..2555 CDD:409353 0/2 (0%)
Ig strand A' 2561..2564 CDD:409353 0/2 (0%)
Ig strand B 2570..2577 CDD:409353 2/38 (5%)
Ig strand C 2583..2591 CDD:409353 2/7 (29%)
Ig strand C' 2596..2598 CDD:409353 1/1 (100%)
Ig strand D 2604..2610 CDD:409353 0/5 (0%)
Ig strand E 2612..2616 CDD:409353 2/3 (67%)
Ig strand F 2625..2633 CDD:409353 4/7 (57%)
Ig strand G 2636..2646 CDD:409353 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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