DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Igsf10

DIOPT Version :10

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:XP_038958192.1 Gene:Igsf10 / 310448 RGDID:735030 Length:2647 Species:Rattus norvegicus


Alignment Length:1386 Identity:283/1386 - (20%)
Similarity:464/1386 - (33%) Gaps:448/1386 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 VISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGY--KSYQCRTKHRLTGETRLSATKG 234
            :|:..:|...|.:|.|......:..|..........||..|  |||         .||   ..||
  Rat  1560 IITGTTDSPSNLFPSTSVPALRVDKPQNSKWKPSPWPEHKYQLKSY---------SET---IEKG 1612

  Fly   235 RLVITEPVGSVSPQLS---------------------------GNGNQEHITLTRVPKM------ 266
            :    .|..|:||.||                           .|...:|:....:||.      
  Rat  1613 K----RPAVSMSPHLSLPEASTHASHWNTQKHAEKSVFDKKPAQNPTSKHLPYVSLPKTLLKKPR 1673

  Fly   267 --------------GSVTLMCPAQAYPVPFFRW------YKFIEGTTRKQAVVLNDRVKQVSGTL 311
                          ..|.|.|.|...|:|...|      .:..:||.:.:..||      .:|||
  Rat  1674 IIGGKAASFTVPANSDVFLPCEAVGDPLPIIHWTRVSSGLEISQGTQKSRFHVL------PNGTL 1732

  Fly   312 IIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQ--TVDFGRPAVFTCQYTGNP 374
            .|:...::|.|:|||..:|.:|.:.:...|:|.:..:..:|...:  ||..|......|:..|.|
  Rat  1733 SIQRVSIQDRGQYLCSASNPLGVDHLHVSLSVVSYPARILDRHVKEITVHSGSTVELKCRVEGMP 1797

  Fly   375 IKTVSWMKDGKAIGHS------------EPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLG 427
            ..||||:...:.:...            :..|.|.::...|:|.|:|...|  .|.:.|..:|:.
  Rat  1798 RPTVSWILANQTVVSETAKGSRKVWVTPDGTLIIYNLSLYDRGFYKCVASN--PSGQDSLLVKIQ 1860

  Fly   428 GRFDPPVI----RQAFQEETMEPGPSVFLKCVAGGNPTPEISWEL-DGKKI----ANNDRYQVGQ 483
            ....||||    |||.....   |.|:.|.|.|.|.|.|.:.|.| ||.::    ..:.|:    
  Rat  1861 VITAPPVIIEQKRQAIVGVL---GGSLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRF---- 1918

  Fly   484 YVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNV---YGLPYIRQMEKK--AIVA 543
            ::..||.    |.|.|:..:..|.|:|||.|..|.......|.|   ..:|.|....:|  .:..
  Rat  1919 FLYPNGT----LYIRSIAPSVRGTYECIATSSSGSERRVVILTVEEGETIPRIETASQKWTEVNL 1979

  Fly   544 GETLIVTCPVAGYPIDSIVWERDNRAL-----PINRKQKVFPNGTLIIENVERNSDQATYTCVAK 603
            ||.|::.|...|.|...|:|...::|:     .:..:..|:|||:|::.:| ...|...|.|||:
  Rat  1980 GEKLLLNCSATGDPKPRIIWRLPSKAVIDQWHRMGSRIHVYPNGSLVVGSV-TEKDAGDYLCVAR 2043

  Fly   604 NQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFD 668
            |:.|                      :||:.|                                 
  Rat  2044 NKMG----------------------DDLVLM--------------------------------- 2053

  Fly   669 QVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAF 733
            .|:.::...:|.:|                                            :...|..
  Rat  2054 HVRLRLTPAKIEQK--------------------------------------------QYFKKQV 2074

  Fly   734 AQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDN--------IRVEEGTLHVDNIQKT 790
            ..|.|.:|:|||.|.|.|:|:|....|..   ..::.::|:        .....|||:.:|:...
  Rat  2075 LHGKDFQVDCKASGSPVPEVSWSLPDGTV---LNNVAQADDSGYRTKRYTLFHNGTLYFNNVGMA 2136

  Fly   791 NEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLR-NQTARRGEPAVLQCEAKGEKPIGILWNM 854
            .||.|:|.|.|.:|.....|.:..:.|.|...:..: ....|.|:.|||.||..||....:.|.:
  Rat  2137 EEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQSYKTTMRLRAGDTAVLDCEVTGEPKPNVFWLL 2201

  Fly   855 NNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPE 919
            .:..:...:::|:|....       .:|||.:.:..||..:.|||.|..|.|..:..:.:...|.
  Rat  2202 PSNNVISFSNDRFTFHAN-------RTLSIHKVKPLDSGDYVCVAQNPSGDDTKTYKLDIVSKPP 2259

  Fly   920 M---PYALKVLDKSGR----------------SVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEI 965
            :   .||.|.:.|:..                |.|::|..|  ||..|.   ..:..||.:    
  Rat  2260 LINGLYANKTVIKATAIRHSKKYFDCRADGIPSSQVTWIMP--GNIFLP---APYFGSRVT---- 2315

  Fly   966 DRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEE---------------- 1014
               :.|..|.|.:..:||.:..:       ..:..|:..|:|.::..|.                
  Rat  2316 ---VHPNGTLEMRNIRLSDSADF-------TCVVRSEGGESVLVVQLEVLEMLRRPTFRNPFNEK 2370

  Fly  1015 --APSGKPQNIKVEPVNQTTMRVTWKPPPRTEW-----NGEIL----GYYVGYKLSNTNSSYVFE 1068
              |.:|||..:...........:||..|..|::     |...|    |..:.||.:...|     
  Rat  2371 VIAQAGKPVALNCSVDGNPPPEITWILPDGTQFANRPHNSPYLMAGNGSLILYKATRNKS----- 2430

  Fly  1069 TINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTL 1133
                    || :....:|...|.:..::::    ||..|:....:....:....:|.| ..|.:.
  Rat  2431 --------GK-YRCAARNKVGYIEKLILLE----IGQKPVILTYEPGMVKSVSGEPLS-LHCVSD 2481

  Fly  1134 TSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQV 1198
            ......|.|.:|    ...||...:|     |..|               :||     .|.|:.:
  Rat  2482 GIPKPNVKWTTP----GGHVIDRPQV-----DGKY---------------ILH-----ENGTLVI 2517

  Fly  1199 LATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEG 1263
            .||||...|    ...|:.:..|.:|...|..:|:.....::::.|                   
  Rat  2518 KATTAHDQG----NYICRAQNSVGQAVISVSVMVVAYPPRIINYLP------------------- 2559

  Fly  1264 AETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDT 1328
                              ...|.:.             ||..|                      
  Rat  2560 ------------------RNMLRRT-------------GEAMQ---------------------- 2571

  Fly  1329 FTATFKEDAKMPCLAVGAPQPEITWKI-------KGVEFSANDRMRVLPDGSLLIKSVNRQDAGD 1386
                      :.|:|:|.|:|::||:.       |......:....:.|.|:|:|:::...|:|.
  Rat  2572 ----------LHCVALGIPKPKVTWETPRHSLLSKATARKPHRSEMLHPQGTLVIQNLQTSDSGV 2626

  Fly  1387 YSCHAENSIAKDSITHKLIVL 1407
            |.|.|:|.:..|..|..:.||
  Rat  2627 YKCRAQNLLGTDYATTYIQVL 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547
Ig strand A 39..42 CDD:409547
Ig strand A' 48..52 CDD:409547
Ig strand B 55..64 CDD:409547
Ig strand C 70..76 CDD:409547
Ig strand C' 78..81 CDD:409547
Ig strand D 87..90 CDD:409547
Ig strand E 95..100 CDD:409547
Ig strand F 113..121 CDD:409547
Ig strand G 124..136 CDD:409547
IgI_2_Dscam 246..343 CDD:409545 31/149 (21%)
Ig strand A 247..250 CDD:409545 1/2 (50%)
Ig strand A' 260..264 CDD:409545 0/3 (0%)
Ig strand B 267..274 CDD:409545 2/6 (33%)
Ig strand C 282..288 CDD:409545 1/11 (9%)
Ig strand C' 294..297 CDD:409545 0/2 (0%)
Ig strand D 303..307 CDD:409545 0/3 (0%)
Ig strand E 309..315 CDD:409545 4/5 (80%)
Ig strand F 322..330 CDD:409545 4/7 (57%)
Ig strand G 333..343 CDD:409545 2/9 (22%)
IgC2_3_Dscam 346..426 CDD:409549 20/93 (22%)
Ig strand A 347..352 CDD:409549 0/4 (0%)
Ig strand A' 355..359 CDD:409549 1/5 (20%)
Ig strand B 362..372 CDD:409549 1/9 (11%)
Ig strand C 377..383 CDD:409549 4/5 (80%)
Ig strand C' 384..387 CDD:409549 0/2 (0%)
Ig strand E 392..398 CDD:409549 2/5 (40%)
Ig strand F 405..413 CDD:409549 3/7 (43%)
Ig strand G 416..426 CDD:409549 2/9 (22%)
IgI_4_Dscam 432..527 CDD:409548 33/103 (32%)
Ig strand A 432..435 CDD:409548 2/2 (100%)
Ig strand A' 441..445 CDD:409548 0/3 (0%)
Ig strand B 448..457 CDD:409548 3/8 (38%)
Ig strand C 462..468 CDD:409548 2/5 (40%)
Ig strand C' 470..473 CDD:409548 1/2 (50%)
Ig strand D 478..486 CDD:409548 1/7 (14%)
Ig strand E 490..499 CDD:409548 2/8 (25%)
Ig strand F 506..514 CDD:409548 5/7 (71%)
Ig strand G 517..527 CDD:409548 2/9 (22%)
IgI_5_Dscam 531..618 CDD:409550 25/93 (27%)
Ig strand A 531..533 CDD:409550 1/1 (100%)
Ig strand A' 538..542 CDD:409550 1/5 (20%)
Ig strand B 545..552 CDD:409550 2/6 (33%)
Ig strand C 559..565 CDD:409550 2/5 (40%)
Ig strand C' 566..568 CDD:409550 0/1 (0%)
Ig strand D 575..579 CDD:409550 0/3 (0%)
Ig strand E 582..588 CDD:409550 2/5 (40%)
Ig strand F 596..604 CDD:409550 4/7 (57%)
Ig strand G 608..618 CDD:409550 0/9 (0%)
Ig 621..718 CDD:472250 6/96 (6%)
Ig strand B 639..643 CDD:409353 0/3 (0%)
Ig strand C 653..657 CDD:409353 0/3 (0%)
Ig strand E 684..688 CDD:409353 0/3 (0%)
Ig strand F 698..703 CDD:409353 0/4 (0%)
Ig strand G 711..714 CDD:409353 0/2 (0%)
IgI_7_Dscam 721..815 CDD:409546 26/101 (26%)
Ig strand A 721..725 CDD:409546 0/3 (0%)
Ig strand A' 730..734 CDD:409546 1/3 (33%)
Ig strand B 737..746 CDD:409546 4/8 (50%)
Ig strand C 752..758 CDD:409546 2/5 (40%)
Ig strand C' 764..767 CDD:409546 0/2 (0%)
Ig strand D 775..778 CDD:409546 0/2 (0%)
Ig strand E 780..786 CDD:409546 3/5 (60%)
Ig strand F 793..801 CDD:409546 4/7 (57%)
Ig strand G 806..815 CDD:409546 1/8 (13%)
Ig 818..916 CDD:472250 24/98 (24%)
Ig strand B 836..840 CDD:409353 3/3 (100%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 880..884 CDD:409353 1/3 (33%)
Ig strand F 894..899 CDD:409353 1/4 (25%)
FN3 <899..1212 CDD:442628 68/358 (19%)
Ig strand G 907..910 CDD:409353 0/2 (0%)
FN3 1222..1312 CDD:238020 8/89 (9%)
Ig <1339..1406 CDD:472250 20/73 (27%)
Ig strand C 1350..1354 CDD:409358 1/3 (33%)
Ig strand E 1372..1376 CDD:409358 2/3 (67%)
Ig strand F 1386..1391 CDD:409358 2/4 (50%)
Ig strand G 1399..1402 CDD:409358 0/2 (0%)
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1893..2008 CDD:463546
Igsf10XP_038958192.1 LRRNT 78..110 CDD:214470
leucine-rich repeat 89..108 CDD:275380
LRR <98..>282 CDD:443914
leucine-rich repeat 109..132 CDD:275380
leucine-rich repeat 133..156 CDD:275380
leucine-rich repeat 157..180 CDD:275380
leucine-rich repeat 181..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..260 CDD:275380
Ig 532..605 CDD:472250
Ig strand B 543..547 CDD:409353
Ig strand C 556..561 CDD:409353
Ig strand E 584..588 CDD:409353
Ig strand F 598..603 CDD:409353
IG_like 632..712 CDD:214653
Ig strand B 641..645 CDD:409570
Ig strand C 654..658 CDD:409570
Ig strand E 678..682 CDD:409570
Ig strand F 692..697 CDD:409570
Ig strand G 705..708 CDD:409570
DUF5585 <1022..1351 CDD:465521
Herpes_BLLF1 <1189..1500 CDD:282904
Ig 1690..1763 CDD:472250 22/78 (28%)
Ig strand B 1690..1694 CDD:409353 2/3 (67%)
Ig strand C 1703..1707 CDD:409353 0/3 (0%)
Ig strand E 1730..1734 CDD:409353 3/3 (100%)
Ig strand F 1744..1749 CDD:409353 3/4 (75%)
Ig strand G 1758..1761 CDD:409353 0/2 (0%)
Ig 1768..1861 CDD:472250 21/94 (22%)
Ig strand B 1787..1791 CDD:409353 0/3 (0%)
Ig strand C 1800..1804 CDD:409353 3/3 (100%)
Ig strand E 1827..1831 CDD:409353 1/3 (33%)
Ig strand F 1841..1846 CDD:409353 2/4 (50%)
Ig strand G 1854..1857 CDD:409353 1/2 (50%)
Ig 1866..1958 CDD:472250 32/102 (31%)
Ig strand B 1884..1888 CDD:409570 1/3 (33%)
Ig strand C 1897..1902 CDD:409570 1/4 (25%)
Ig strand E 1924..1928 CDD:409570 2/7 (29%)
Ig strand F 1938..1943 CDD:409570 2/4 (50%)
Ig strand G 1951..1954 CDD:409570 0/2 (0%)
Ig_3 1965..2044 CDD:464046 23/79 (29%)
IG_like 2077..2160 CDD:214653 25/85 (29%)
Ig strand B 2080..2084 CDD:409353 1/3 (33%)
Ig strand C 2093..2097 CDD:409353 1/3 (33%)
Ig strand E 2126..2130 CDD:409353 3/3 (100%)
Ig strand F 2140..2145 CDD:409353 2/4 (50%)
Ig strand G 2153..2156 CDD:409353 0/2 (0%)
IG_like 2178..2252 CDD:214653 23/80 (29%)
Ig strand B 2183..2187 CDD:409353 3/3 (100%)
Ig strand C 2196..2200 CDD:409353 0/3 (0%)
Ig strand E 2220..2224 CDD:409353 1/3 (33%)
Ig strand F 2234..2239 CDD:409353 1/4 (25%)
Ig strand G 2247..2250 CDD:409353 0/2 (0%)
IG_like 2283..2354 CDD:214653 17/89 (19%)
Ig strand C 2294..2298 CDD:409353 1/3 (33%)
Ig strand E 2320..2324 CDD:409353 1/3 (33%)
Ig strand F 2334..2339 CDD:409353 0/11 (0%)
Ig_3 2360..2439 CDD:464046 16/92 (17%)
Ig_3 2455..2534 CDD:464046 22/112 (20%)
Ig_3 2551..2633 CDD:464046 22/163 (13%)
Blue background indicates that the domain is not in the aligned region.

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