DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Osmr

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001005384.1	Gene:	Osmr / 310132	RGDID:	1302983	Length:	962	Species:	Rattus norvegicus

Alignment Length:	1173	Identity:	202/1173 - (17%)
Similarity:	353/1173 - (30%)	Gaps:	498/1173 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 VDLTVNVPPRWIL-EPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV 777
            |:..|:|||..:| .|.|:...:||:..: |...|.....|:.|             .:.:.||.
  Rat   138 VNAQVSVPPDTLLIFPEDRLLEEGSNVTI-CLMIGQNLYNVSCK-------------LQEEPIRG 188

  Fly   778 EEGTLHVDNIQKTNEGYYL--------CEAINGIGSGLSAVIMIS--VQAPPEFTEKLRNQTARR 832
            |:...|:..| |.|...:|        |:|:||..:....|:.:|  ::.|..|:
  Rat   189 EQLDSHLSLI-KLNNVVFLNNAGTNINCKAMNGTKNTFGTVLFVSKVLEEPKNFS---------- 242

  Fly   833 GEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTC 897
                   ||.:..|.:..||       :|               |:.::||..:.
  Rat   243 -------CETRDFKTLNCLW-------EP---------------GIDTTLSWHKQ---------- 268

  Fly   898 VATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASW 962
                                              ||...:..:.:.|...:..:     |:..:|
  Rat   269 ----------------------------------RSQHYTLYESFSGRREVSNH-----RNSHTW 294

  Fly   963 SEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEP 1027
            .         .|.::|       .|||..:.|||.:  .:.|.:::...........|.::.::.
  Rat   295 Q---------ITEDSQ-------ETYNFTLTAENNL--RKRSVSISFNLTHRVHPKAPHDVTLKT 341

  Fly  1028 VNQTTMRVTWKPPPRTEW----------NGEILGYYVGYKLS-NTNSSYVFETINFITEEGKEHN 1081
            |..|...:|||.|.|.::          .||::.   .:.:| :|:::|:|
  Rat   342 VGATKAHMTWKVPSRGDYTLLCQVELQCEGEVIH---EHNVSVHTSANYLF-------------- 389

  Fly  1082 LELQNLRVYTQYSVVIQAFNKIGAGPLSE-EEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSP 1145
               .:|...|:|...::..:.......|: .:|:|.   ||...||:..
  Rat   390 ---SDLEPDTEYKACVRCASANHFWKWSDWMQKKFR---TPEAAPSEAL---------------- 432

  Fly  1146 PLESANGVIKTYKVVYAPSDEWYD---ETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG 1207
                               |.|.|   |..||
  Rat   433 -------------------DVWRDVRTENGRH--------------------------------- 445

  Fly  1208 VRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRP--PAQPNGIITQYTVYSKAEGAETETKT 1270
                                         .:.:.|:|  .:|.||.|..|.:..:.|...||::
  Rat   446 -----------------------------VVTLFWKPLLKSQANGKIISYNIVVENEANPTESE- 480

  Fly  1271 QKVPHYQMSFEATELEKN-----KPYEFWVTASTTIGEGQQSKSIVAMPS--DQVPAK-IASFDD 1327
                  |.|..|..|..|     .||:..::|:.:.|...:|..:::..|  ::|..| |....:
  Rat   481 ------QYSVRAPALGTNLSLDLHPYKIHISANNSAGASPESLVVLSSHSGHEEVHEKTIKGIKN 539

  Fly  1328 TFTATFKEDAKMP------------CLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVN 1380
            .|..:::     |            |......:.::.||..|...:           |.:|.|
  Rat   540 GFNISWE-----PVSGDAIGYVVDWCAHSQTQRCDLQWKNVGPNIT-----------STIITS-- 586

  Fly  1381 RQDAGDYSCHAENSIAKDSITHKLIV----------LAPPQSPHVTLSATTTDALTVKLKPHEGD 1435
              ||.:........|.:.|:...:.:          |||..:|.||:...|.::.::|.:.:..|
  Rat   587 --DAFEPGVRYNFRIFERSVEENVRLVEKQRGYTQELAPSVNPGVTIHNLTPNSFSLKWQDYASD 649

  Fly  1436 --TAPLHGYTLHYK-------PEFGEWETSEVSV---------DSQKHNIEGLLCGSRYQVYATG 1482
              :..:.||.::.|       |.:.....|:.||         :::...:|.|...|.|:...|.
  Rat   650 FQSGFIKGYLVYLKSKELQCNPNWERTVLSDKSVLCKYDVDDPETKTLTVENLRPESLYEFLVTP 714

  Fly  1483 FNNIGAGEASDILNTRTKGQKPKLPEK-------PRFIEVSSNSVSLHFKA-WKDGGC------P 1533
            :.:.|.|..    .|.||...|.:...       |..:.|..:.:..::|: |....|      |
  Rat   715 YTSAGQGPN----ETYTKVTTPDVRSHMLLQIILPMTLGVFLSIIVCYWKSQWVKEKCYPDIPNP 775

  Fly  1534 MSHFV---VESKKRDQIEWNQISNNVK---PDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDF 1592
            ....:   ::|||..     .:..|||   ||...|:                |.|
  Rat   776 YKSSILSLIKSKKNP-----HLIMNVKDCIPDVLEVI----------------NKA--------- 810

  Fly  1593 ATLTVTGGTIAPLDDGS-----GHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCV 1652
                          :||     |.|.:||.           |:....||:.|
  Rat   811 --------------EGSKTQCVGSGKLHTE-----------DVPTKPPLVPT------------- 837

  Fly  1653 ALSRRRADDMRGGQKDVYYD-VVYNQT--------MGPGATLDKRRPDLRDELGYIAPPNRKLPP 1708
                  ..|..|....|:.: ..|:|:        ..||..  |..|   .:||.:|||| ||..
  Rat   838 ------EKDSSGPMPFVFLENFTYDQSAFDSGSHGFIPGPL--KNTP---HQLGLLAPPN-KLQN 890

  Fly  1709 VPGSNY------------------NTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHG 1755
            |..::|                  .....|...:..|.:|                  ||:|:||
  Rat   891 VLENDYMKSLVESPTEETSLIYVSQLASPICGDKDSLVTN------------------PPMPVHG 937

  Fly  1756 NHY 1758
            :.|
  Rat   938 SEY 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	202/1173 (17%)
		IGc2	735..804	CDD:197706	18/76 (24%)
		I-set	819..914	CDD:254352	10/94 (11%)
		Ig	833..921	CDD:299845	9/87 (10%)
		FN3	918..1011	CDD:238020	14/92 (15%)
		FN3	1018..1116	CDD:238020	19/109 (17%)
		FN3	1124..1217	CDD:238020	8/95 (8%)
		FN3	1222..1312	CDD:238020	20/96 (21%)
		Ig	1339..1406	CDD:299845	12/78 (15%)
		FN3	1409..1499	CDD:238020	22/107 (21%)
		FN3	1504..1584	CDD:238020	17/99 (17%)
		Dscam_C	1890..2008	CDD:289151
Osmr	NP_001005384.1	FN3	231..>276	CDD:304408	14/127 (11%)
		fn3	333..414	CDD:278470	17/100 (17%)
		WSXWS motif. /evidence=ECO:0000250	413..417		1/3 (33%)
		FN3	440..519	CDD:238020	23/147 (16%)
		fn3	539..607	CDD:278470	13/87 (15%)
		FN3	623..731	CDD:238020	24/111 (22%)
		Box 1 motif. /evidence=ECO:0000250	768..776		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..840		8/51 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910