DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and ncam1a

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	986	Identity:	216/986 - (21%)
Similarity:	370/986 - (37%)	Gaps:	216/986 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 GPSVFLKCVAGGNPTPEISW-ELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKC 510
            |.|.|..|...|: ..||.| ..:|:|:... |..:.  ::...:..|.|.|.:.:.:..|:|||
Zfish    34 GESKFFLCEVVGD-AKEIDWFAPNGEKLLPG-RPDIS--ISKTDESSSTLTIYNANVDHAGMYKC 94

  Fly   511 IAKSKVGVAEHSA--------KLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWE-RD 566
            :|||  |..|...        ||.....|..::..:     |:...:.|.|...|..:|:|. :.
Zfish    95 VAKS--GEKESQGTIIVKIFQKLTFQYAPSPQEFNE-----GDDADIICDVISSPPPTIIWRYKK 152

  Fly   567 NRALP-INRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEG-YSARGSLEVQVM-----VLPQI 624
            .|..| .:.:.||..|..|.|..::: :|:..|||     || ..|||.::::|:     |||.|
Zfish   153 MRIQPETDVRLKVLSNNHLQIRGIKK-TDEGDYTC-----EGRIMARGEIDLRVIKVIVNVLPSI 211

  Fly   625 VPFAYEDL---INMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMI 686
             ...|.:|   .::..::.|.|.......| .|.|:       .|..:::...:.: ::|..|.:
Zfish   212 -RTRYTELNATADINQAVTLACHADGYPEP-TVKWA-------RGNTELESDEKYS-LNEDGSEL 266

  Fly   687 SIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKP 751
            :|...:....|...|||.||||..:..|.|.|.|.|:........|........:.|:|.|.|.|
Zfish   267 TIKDVNKLDEGDYKCIARNKAGERSEEVTLNVFVQPKITFLENQTASELEEQITLTCEATGDPTP 331

  Fly   752 QVTW----------KKAVGDTPGEYKDLKKSDNIRVEE--GTLHVDNIQKTNEGYYLCEAINGIG 804
            .:.|          ::|....|.::|.|..:..:|.:.  .:|.:..:|.|:.|.|||.|.|.||
Zfish   332 NIIWSFGRRVFTENEQASWTRPEKHKSLDGNVVVRSDARVSSLTLKYVQFTDAGQYLCTARNSIG 396

  Fly   805 SGLSAVIMISVQAPPEFTEKLRNQTA---RRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNR 866
            ..:.::.:....||     |::...|   ..|.||.:.|||.......:||..:..:|...|
Zfish   397 QDIQSMYLEVRYAP-----KIQGPQAVFTWEGNPANITCEALAHPGASVLWFRDGQQLPSAN--- 453

  Fly   867 YTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSG 931
             |...:|.:|..:|.|.:....::|...:.|.|||..|::.....::..:||..| :::.::...
Zfish   454 -TTNVKIYNTPTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSAP-SIERVEPYS 516

  Fly   932 RSVQLSWAQP-YDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAE 995
            .:..:.:.:| ..|..|:.:|..|::.:...|::.:..:..| .....:..|.|.|||.::|.|.
Zfish   517 STAMIEFEEPASSGGVPVLKYKAEWRIAGQDWTDREYELEDG-LNLITIVGLKPETTYEVKISAI 580

  Fly   996 NAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSN 1060
            |..|..:||              .|::.|.:||     |:.::..|.|
Zfish   581 NGKGEGESS--------------APESFKTQPV-----RLPFRMSPET----------------- 609

  Fly  1061 TNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPP 1125
                                                          |.|........:|.|: ||
Zfish   610 ----------------------------------------------PTSIPPTTADIKGEPN-PP 627

  Fly  1126 SDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSD--EWYDETKRHYKKTASSDTVLHGL 1188
            ...|....|...::|.::..  :.....||.|.|.|...:  :|..|.:   ...||...||.||
Zfish   628 KLEAKPQSTGNEMKVHFIKQ--DDGGSPIKHYLVRYRAKNRQDWKPEIR---MPDASDYIVLRGL 687

  Fly  1189 KKYTNYTMQVLATTAGGDGVRSVP--IHCQTEPD---VPEAPT---------------------- 1226
            ...|.|.:.|:|....|   ||.|  :..:|.|:   :||..:
Zfish   688 DWNTEYEVYVIAENQRG---RSEPGTLSFRTLPEPTAIPETSSGLGTGAIVGILIVVFILLLFGV 749

  Fly  1227 DVKALVMGNAAILV--------SWRPPAQPNGIITQYTVYSKAEG----AETETKTQKVPHYQMS 1279
            ||....:....:|:        ...|.|:...|......::|.|.    .|..|:.::.|::: .
Zfish   750 DVTCYFLNKCGLLMCIAVNFCGKSGPSAKSKDIEEGKAAFTKDESKEPIVEVRTEEERTPNHE-G 813

  Fly  1280 FEATELEKNKPY---EFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPC 1341
            ...||..:..|.   |.....:.|:.:...|.:..:.|..:.||     .|:.|.|...|.| |.
Zfish   814 GGPTEPNETTPLTDPEHAADTTATVVDLLPSVTTNSDPGTESPA-----SDSTTLTTSTDPK-PT 872

  Fly  1342 LAVGAPQPEIT 1352
            .....|:|.:|
Zfish   873 PQSSTPKPSVT 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	25/88 (28%)
		IGc2	446..517	CDD:197706	21/70 (30%)
		I-set	533..618	CDD:254352	22/87 (25%)
		IGc2	544..607	CDD:197706	17/64 (27%)
		Ig	641..714	CDD:143165	17/72 (24%)
		IGc2	735..804	CDD:197706	20/80 (25%)
		I-set	819..914	CDD:254352	23/97 (24%)
		Ig	833..921	CDD:299845	23/87 (26%)
		FN3	918..1011	CDD:238020	20/93 (22%)
		FN3	1018..1116	CDD:238020	9/97 (9%)
		FN3	1124..1217	CDD:238020	26/96 (27%)
		FN3	1222..1312	CDD:238020	19/126 (15%)
		Ig	1339..1406	CDD:299845	4/14 (29%)
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	23/83 (28%)
		I-set	21..111	CDD:254352	23/82 (28%)
		IG_like	121..200	CDD:214653	23/89 (26%)
		IGc2	128..189	CDD:197706	18/71 (25%)
		Ig	208..301	CDD:299845	25/102 (25%)
		IG_like	219..298	CDD:214653	19/87 (22%)
		Ig	300..406	CDD:299845	25/105 (24%)
		IG_like	308..406	CDD:214653	23/97 (24%)
		ig	413..498	CDD:278476	22/88 (25%)
		IG_like	415..498	CDD:214653	22/86 (26%)
		fn3	505..589	CDD:278470	17/85 (20%)
		FN3	624..715	CDD:238020	27/99 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900