DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Ncam2

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:803 Identity:181/803 - (22%)
Similarity:324/803 - (40%) Gaps:179/803 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 SVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWM--KDGKAIGHSEPVLRIES 398
            |.:.:|.||..|| |::     :..|....|||...|.| :::.|.  :..|.|.....:|:.|.
  Rat    16 SGQALLQVTISLS-KVE-----LSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVMLQKEG 73

  Fly   399 VKK---------EDKGMYQCFVRNDQ-ESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLK 453
            |:.         ||.|:|:|...:.: ::.||:..|::   :.....|:....:..:.|....:.
  Rat    74 VRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI---YQKLTFREVLSPQEFKQGEDAEVV 135

  Fly   454 CVAGGNPTPEISWELDGKKIAN--NDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKV 516
            |....:|.|.:||....:::..  ::|:.    |..|.:    |.|.:::.:|.|:|:|..:.:.
  Rat   136 CRVSSSPAPAVSWLYHNEEVTTIPDNRFA----VLANNN----LQILNINKSDEGIYRCEGRVEA 192

  Fly   517 -GVAEHSAKLNVYGLPYIRQMEKKAIVA----GETLIVTCPVAGYPIDSIVWERDNRALPINRKQ 576
             |..:....:.:..:|....|.:|:..|    ||.:.:||..:|.|..:|.|             
  Rat   193 RGEIDFRDIIVIVNVPPAIVMPQKSFNATAERGEEMTLTCKASGSPDPAISW------------- 244

  Fly   577 KVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGS-LEVQVMVLPQIVPFAYEDLINMGDSID 640
              |.||.||.||                 |.|..:|| .|:.|           .::||      
  Rat   245 --FRNGKLIEEN-----------------EKYILKGSNTELTV-----------RNIIN------ 273

  Fly   641 LFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASN 705
                               :..|.|                                  .|.|:|
  Rat   274 -------------------KDGGSY----------------------------------VCKATN 285

  Fly   706 KAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAV-GDTPGEYKDL 769
            |||.......|.|.|.|. ||:..::..::.....:.|:|:|.|.|::|||:|: |.|   :.:.
  Rat   286 KAGEDQKQAFLQVFVQPH-ILQLKNETTSENGHVTLICEAEGEPVPEITWKRAIDGVT---FSEG 346

  Fly   770 KKSDNIRVE------EGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQ 828
            .||.:.|:|      ..:||:.:::.::.|.|.|||.:.|| |....:.:.::..|:|   :.||
  Rat   347 DKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIG-GHQRSMHLDIEYAPKF---VSNQ 407

  Fly   829 T---ARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERS 890
            |   :..|.|..:.|:.|...|..|.|....:.|..||    |...:..|.|....|.|..|..:
  Rat   408 TMYYSWEGNPINISCDVKANPPASIHWRREKLVLPAKN----TTHLKTHSVGRKMILEIAPTSDN 468

  Fly   891 DSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYD-GNSPLDRYIIE 954
            |...:.|.|||..|:......:.:.:||..|..:|:::.|..:.::|:.:|.. |..|:..|.::
  Rat   469 DFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIELSQTTAKISFNKPESHGGVPIHHYQVD 533

  Fly   955 FKR-SRASWSEIDRVIVPGHTTEAQV--QKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAP 1016
            .|. :..:|.     ||..|..:..|  ..|.|.|||.:|:.|.|..|....|: :.|.......
  Rat   534 VKEVTSETWK-----IVRSHGVQTTVVLSSLEPNTTYEVRVAAVNGKGQGDYSK-IEIFQTLPVR 592

  Fly  1017 SGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHN 1081
            ...|.:|..:|.:..:.:::  ...:.:....||.|.|.|:..:....::.:.:     :|.:.:
  Rat   593 EPSPPSIHGQPSSGKSFKIS--ITKQDDGGAPILEYIVKYRSKDKEDQWLEKKV-----QGNKDH 650

  Fly  1082 LELQNLRVYTQYSVVIQAFNKIG 1104
            :.|::|:....|.|.|.|.|::|
  Rat   651 IILEHLQWTMGYEVQITAANRLG 673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653 2/6 (33%)
Ig 269..340 CDD:143165 1/3 (33%)
IG_like 353..425 CDD:214653 19/83 (23%)
IGc2 361..413 CDD:197706 17/62 (27%)
I-set 433..527 CDD:254352 17/96 (18%)
IGc2 446..517 CDD:197706 15/73 (21%)
I-set 533..618 CDD:254352 23/89 (26%)
IGc2 544..607 CDD:197706 15/62 (24%)
Ig 641..714 CDD:143165 8/72 (11%)
IGc2 735..804 CDD:197706 22/75 (29%)
I-set 819..914 CDD:254352 27/97 (28%)
Ig 833..921 CDD:299845 24/87 (28%)
FN3 918..1011 CDD:238020 26/96 (27%)
FN3 1018..1116 CDD:238020 17/87 (20%)
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 26/101 (26%)
Ig strand B 38..42 CDD:409452 1/3 (33%)
Ig strand C 50..54 CDD:409452 0/3 (0%)
Ig strand E 76..80 CDD:409452 0/3 (0%)
Ig strand F 90..95 CDD:409452 2/4 (50%)
Ig strand G 104..107 CDD:409452 2/2 (100%)
IGc2 128..189 CDD:197706 15/68 (22%)
Ig strand B 130..139 CDD:409353 1/8 (13%)
Ig strand C 145..153 CDD:409353 2/7 (29%)
Ig strand C' 156..159 CDD:409353 0/2 (0%)
Ig strand D 162..167 CDD:409353 2/8 (25%)
Ig strand E 168..175 CDD:409353 3/10 (30%)
IgI_1_MuSK 209..298 CDD:409562 35/190 (18%)
Ig strand B 228..232 CDD:409562 0/3 (0%)
Ig strand C 241..245 CDD:409562 2/18 (11%)
Ig strand E 264..268 CDD:409562 1/3 (33%)
Ig strand F 278..283 CDD:409562 2/38 (5%)
Ig strand G 291..294 CDD:409562 0/2 (0%)
Ig 300..397 CDD:416386 29/101 (29%)
Ig strand A 300..305 CDD:409353 2/5 (40%)
Ig strand A' 309..313 CDD:409353 0/3 (0%)
Ig strand B 317..325 CDD:409353 1/7 (14%)
Ig strand C 331..337 CDD:409353 3/5 (60%)
Ig strand C' 340..343 CDD:409353 2/5 (40%)
Ig strand D 353..359 CDD:409353 2/5 (40%)
Ig strand E 362..368 CDD:409353 2/5 (40%)
Ig strand F 376..384 CDD:409353 5/7 (71%)
Ig strand G 387..397 CDD:409353 2/10 (20%)
Ig_3 401..479 CDD:404760 24/84 (29%)
Ig strand B 418..422 CDD:409353 0/3 (0%)
Ig strand C 431..435 CDD:409353 1/3 (33%)
Ig strand E 458..462 CDD:409353 1/3 (33%)
Ig strand F 472..477 CDD:409353 1/4 (25%)
Ig strand G 486..489 CDD:409353 0/2 (0%)
FN3 496..588 CDD:238020 26/97 (27%)
fn3 594..678 CDD:394996 17/87 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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