DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Lrit1

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_647547.2 Gene:Lrit1 / 246214 RGDID:628607 Length:623 Species:Rattus norvegicus


Alignment Length:458 Identity:83/458 - (18%)
Similarity:142/458 - (31%) Gaps:166/458 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   736 GSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLH--------------VDN 786
            ||...:.|.|.|.|.|:::|::|.|               |...||:|              :..
  Rat   268 GSTVLLRCGATGIPGPEMSWRRANG---------------RPLNGTVHQEVSSDGSSWTLLDLPV 317

  Fly   787 IQKTNEGYYLCEAINGIGSG--LSAVIMISVQAPPEFT----------------EKLRNQTARRG 833
            :...:.|.|:|:|.|.:|:.  |.::|:...|...|:|                ....|:...|.
  Rat   318 VSLFDSGDYICQAKNFLGASETLISLIV
TEPQTSTEYTGIPGALWARTGEGAEAAAYNNKLVARH 382

  Fly   834 EPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEI----LSTGVMSSLSIKRTERSDSAL 894
            .|.|.:..|...||                 :..:|:||:    ....|....|.:.:|..::  
  Rat   383 VPHVPEPVALATKP-----------------SVPSIKEELPLQNFQMDVPGEFSREPSEHQET-- 428

  Fly   895 FTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSR 959
                                    :|..:|||:..:..||.|.|..|..||:      ..|....
  Rat   429 ------------------------QMVRSLKVVGDTYHSVSLVWKAPQAGNT------TAFSVLY 463

  Fly   960 ASWSEID--RVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQN 1022
            |.:.:.|  |:.|....|...::.|:|.|.|...:.....:.|   .|...|.:.:|....:...
  Rat   464 AVFGQRDMRRMTVEAGKTSVTIEGLAPKTKYVACVCVRGLVPT---KEQCVIFSTDEVVDAEGTQ 525

  Fly  1023 IKVEPVNQTTMRVTWKPPP---------------RTEWNGEILGYYVGYKLSNTNSSYVFETINF 1072
            ..:..|..:...:...||.               |...:.|..|.||.           .|.:..
  Rat   526 RLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRAGGSAEASGAYVN-----------LERLGH 579

  Fly  1073 ITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQT 1137
             :|:|.|                      ::....|||.::..:|.            ::|.||.
  Rat   580 -SEDGSE----------------------ELSRSSLSEADRLLSAR------------SSLDSQV 609

  Fly  1138 IRV 1140
            :.|
  Rat   610 LGV 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706 19/81 (23%)
I-set 819..914 CDD:254352 15/114 (13%)
Ig 833..921 CDD:299845 11/91 (12%)
FN3 918..1011 CDD:238020 24/94 (26%)
FN3 1018..1116 CDD:238020 15/112 (13%)
FN3 1124..1217 CDD:238020 4/17 (24%)
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Lrit1NP_647547.2 LRRNT 23..61 CDD:214470
LRR 1 60..81
LRR_8 63..143 CDD:290566
leucine-rich repeat 64..84 CDD:275378
LRR 2 84..105
leucine-rich repeat 85..132 CDD:275378
LRR 3 108..128
LRR_8 131..>176 CDD:290566
LRR_4 131..172 CDD:289563
LRR 4 132..153
leucine-rich repeat 133..156 CDD:275378
LRR 5 156..177
leucine-rich repeat 157..180 CDD:275378
leucine-rich repeat 181..205 CDD:275378
TPKR_C2 201..>240 CDD:301599
Ig 257..345 CDD:299845 21/91 (23%)
IG_like 267..345 CDD:214653 21/91 (23%)
FN3 431..501 CDD:214495 20/75 (27%)
LRR 6 525..548 3/22 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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