DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Lepr

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_036728.2	Gene:	Lepr / 24536	RGDID:	3001	Length:	1162	Species:	Rattus norvegicus

Alignment Length:	1033	Identity:	184/1033 - (17%)
Similarity:	337/1033 - (32%)	Gaps:	304/1033 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   746 DGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVE----EGTLHVDNIQKT-------NEGYYLCEA 799
            |.|..|        ...|.....||.:....||    ...::|..:.||       ||....|.|
  Rat    45 DSFLSP--------AGVPNNTSSLKGASEALVEAKFNSTGIYVSELSKTIFHCCFGNEQGQNCSA 101

  Fly   800 INGIGSGLSAVIMISVQAPPEFTEKLRN---QTARRGEPAVLQCEAKG---------EKPIGILW 852
            :.|...|.:   :.||..|..|.:...|   :...:|:..:..|..:.         :..:.:|:
  Rat   102 LTGNTEGKT---LASVVKPLVFRQLGVNWDIECWMKGDLTLFICHMEPLLKNPFKNYDSKVHLLY 163

  Fly   853 NM----NNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNA---FGSDDASI 910
            ::    :::.|.|..|:..|::...........:.:.|.:.:.:.|.....|:|   |.|...|:
  Rat   164 DLPEVIDDLPLPPLKDSFQTVQCNCSVQECECHVPVPRAKVNYALLMYLEITSAGVSFQSPLMSL 228

  Fly   911 NMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTT 975
            ..::...|:.|..|::......::::||........|| :|.:::..:.....|...::   ..|
  Rat   229 QPMLVVKPDPPLGLRMEVTDDGNLKISWDSQTKAPFPL-QYQVKYLENSTIVREAAEIV---SDT 289

  Fly   976 EAQVQKLSPATTYNIRIVAENAIGTSQSSE--AVTIITAEEAPSGKPQNI-------------KV 1025
            ...|..:.|.::|.:::.::...|:...|:  ...:.|.::.....|:.:             |.
  Rat   290 SLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSLPQLFTTQDVMYFPPKILTSVGSNASFCCIYKN 354

  Fly  1026 EPVNQT--TMRVTW-----KPPPRTEWN------GEILGYYVGYKLSNTNSSYVFETINFITEEG 1077
            |  |||  :.::.|     :..|.|::|      .::.  :...|.:.....:.::.:....|:.
  Rat   355 E--NQTISSKQIVWWMNLAEKIPETQYNTVSDHISKVT--FSNLKATRPRGKFTYDAVYCCNEQA 415

  Fly  1078 KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGW 1142
            ..|.        |.:..|:....|      :|.|...:..:.|....||  ...:|...|:::.:
  Rat   416 CHHR--------YAELYVIDVNIN------ISCETDGYLTKMTCRWSPS--TIQSLVGSTVQLRY 464

  Fly  1143 ------------VSPPLESANGVIKT---YKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYT 1192
                        :.|..|..|.|::|   |:.|:.|                        :...:
  Rat   465 HRRSLYCPDNPSIRPTSELKNCVLQTDGFYECVFQP------------------------IFLLS 505

  Fly  1193 NYTMQVLATTAGGDGVRSVPIHCQTEPDV--PEAPTDVKALVMGNAAIL-VSWRPPAQPNGIITQ 1254
            .|||.:....:.|.  ...|..|.....|  |..|::|||.:..|..:| |||..|..|...: |
  Rat   506 GYTMWIRINHSLGS--LDSPPTCVLPDSVVKPLPPSNVKAEITINTGLLKVSWEKPVFPENNL-Q 567

  Fly  1255 YTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKP-------YEFWVTASTTIGEGQQSKSIVA 1312
            :.:.....|.|.:.||.:|      |:|.....:.|       |...|......|.|..|
  Rat   568 FQIRYGLNGKEIQWKTHEV------FDAKSKSASLPVSDLCAVYVVQVRCRRLDGLGYWS----- 621

  Fly  1313 MPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIK 1377
              :...||          .|...|.|:|...     ||. |:|...:.:..:|     :.:||.|
  Rat   622 --NWSSPA----------YTLVMDVKVPMRG-----PEF-WRIMDGDITKKER-----NVTLLWK 663

  Fly  1378 SVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGY 1442
            .:.:.|:   .|.....:.|....|.
  Rat   664 PLMKNDS---LCSVRRYVVKHRTAHN--------------------------------------- 686

  Fly  1443 TLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLP 1507
                    |.|..   .|.:|. |:..|...|.:.|.....|:|||...:..|.......|....
  Rat   687 --------GTWSQ---DVGNQT-NLTFLWAESAHTVTVLAINSIGASLVNFNLTFSWPMSKVNAV 739

  Fly  1508 EKPRFIEVSSNSVSLHFKAW--KDGGCPMSHFVVESKK---RDQIEWNQISNNVKPDNNYVVLDL 1567
            :......:||:.|.|   :|  ......:.:.|:|.|.   .|.::|.:|.:||   |.|.:.|
  Rat   740 QSLSAYPLSSSCVIL---SWTLSPNDYSLLYLVIEWKNLNDDDGMKWLRIPSNV---NKYYIHD- 797

  Fly  1568 EPATWYNLRITAHNSAGFTVAEYDFATLTV--------------TGGTIAPLDDGSGHGNVHTRI 1618
                  |.         ..:.:|.|:...|              |...||...:.:|
  Rat   798 ------NF---------IPIEKYQFSLYPVFMEGVGKPKIINGFTKDDIAKQQNDAG-------- 839

  Fly  1619 RLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYN 1676
                       |..:||:|.:..|:.:|..::    |.:|       .|.:::|.|.|
  Rat   840 -----------LYVIVPIIISSCVLLLGTLLI----SHQR-------MKKLFWDDVPN 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	16/68 (24%)
		I-set	819..914	CDD:254352	16/113 (14%)
		Ig	833..921	CDD:299845	15/103 (15%)
		FN3	918..1011	CDD:238020	15/94 (16%)
		FN3	1018..1116	CDD:238020	18/123 (15%)
		FN3	1124..1217	CDD:238020	18/107 (17%)
		FN3	1222..1312	CDD:238020	26/97 (27%)
		Ig	1339..1406	CDD:299845	13/66 (20%)
		FN3	1409..1499	CDD:238020	13/89 (15%)
		FN3	1504..1584	CDD:238020	17/84 (20%)
		Dscam_C	1890..2008	CDD:289151
Lepr	NP_036728.2	ObR_Ig	126..231	CDD:408372	15/104 (14%)
		FN3	236..328	CDD:238020	15/95 (16%)
		Lep_receptor_Ig	327..418	CDD:399379	13/94 (14%)
		ObR_Ig	429..531	CDD:408372	22/135 (16%)
		Leptin-binding. /evidence=ECO:0000250\|UniProtKB:P48357	465..482		1/16 (6%)
		FN3	535..625	CDD:238020	26/103 (25%)
		WSXWS motif	620..624		1/10 (10%)
		FN3	738..818	CDD:214495	20/101 (20%)
		Box 1 motif	869..877		3/7 (43%)
		Required for JAK2 activation. /evidence=ECO:0000250\|UniProtKB:P48356	891..896
		Required for STAT3 phosphorylation. /evidence=ECO:0000250\|UniProtKB:P48356	896..904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910