DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Kirrel2

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:856 Identity:198/856 - (23%)
Similarity:309/856 - (36%) Gaps:248/856 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 MLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRS 76
            ||.:|:.:..|..:..|.:.|.       ||::|.:.:...... |.:.| |.|.....:.|.: 
Mouse     1 MLASALLVFLCCFKGHAGSSPH-------FLQQPEDMVVLLGEE-ARLPC-ALGAYRGLVQWTK- 55

  Fly    77 DGTAVG---DVPGLRQI-----SSDGK--LVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDV 131
            ||.|:|   |:||..:.     |:.|:  |...|...||...      |.|.| :|.| :.||..
Mouse    56 DGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEAS------YECQA-SQAG-LRSRPA 112

  Fly   132 HVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVL 196
            .:..:|.....:      |:.|.|..|...:|.                 |....:..|.:    
Mouse   113 QLHVMVPPEAPQ------VLGGPSVSLVAGVPG-----------------NLTCRSRGDSR---- 150

  Fly   197 PSGE-LHIREVGPEDGYKSYQCRTKHRLTGE-------TRLSATKGRLVITEPVGSVSPQLSGNG 253
            |:.| |..|:....||...:|...|.:.||.       |..|...|..:|........|    .|
Mouse   151 PAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQALP----TG 211

  Fly   254 NQEHITLT-RVPKM-------------GSVTLMCPAQAY-PVPFFRWYKFIEGTTRKQAVVLNDR 303
            ....:||: :.|.|             ..||.:|.|.|. ||..:||.|       ..:.||..|
Mouse   212 RDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAK-------GGSPVLGAR 269

  Fly   304 VKQVSGTLIIKDAVVEDSGKYL-----CVVNNSVGGESVETVLTVT-AP-LSAKIDPPTQTVDFG 361
            ..::.   ::.||.      :|     |.|:|:||..:..|.|.|. .| |.||  |.:.:||.|
Mouse   270 GPRLE---VVADAT------FLTEPVSCEVSNAVGSANRSTALEVLYGPILQAK--PKSVSVDVG 323

  Fly   362 RPAVFTCQYTGNPIKTVSWMK-DGKAIGHSEPVLRIESVKKEDKGMYQCFV---RNDQESAEASA 422
            :.|.|:|.:.|||:..::|.: .|..:..|.|.||:.||..||.|.|.|..   |......:|.|
Mouse   324 KDASFSCVWRGNPLPRITWTRMGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGLGGGKAQA 388

  Fly   423 ELKLGGRFDPPVIRQAFQEETMEPGPSVF-----LKCVAGGNPTPEI---SWELDGKKIANNDRY 479
            .|.:..   |||:      ..::|.|:..     |:||...:|.|:.   ||:....:..:..|:
Mouse   389 RLTVNA---PPVV------TALQPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRF 444

  Fly   480 QVGQYVT--VNG----DVVSYLNITSVHAND---GGLYKCIAKSKVG---VAEHSAKLNVYGLPY 532
            .|..:..  |.|    .::|.|:|:....:|   |  :.|.|::::|   |..|..:.::  ||.
Mouse   445 LVEAFPAPEVEGGQGPGLISVLHISGTQESDFTTG--FNCSARNRLGEGRVQIHLGRRDL--LPT 505

  Fly   533 IRQMEKKAIVAGETLIVTCPVAGYPIDSIV---WERDNRALPINRKQKVFPNGTLIIENVERNSD 594
            :|.:...|..|...|:|        |..:|   |.                :|:|        |.
Mouse   506 VRIVAGAASAATSLLMV--------ITGVVLCCWR----------------HGSL--------SK 538

  Fly   595 QATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDL--INMGDSIDLFCQIQKGDRPIKVHWS 657
            |.....:..:.||.|:||         |:....:.||.  |...|..||..:             
Mouse   539 QKNLVRIPGSSEGSSSRG---------PEEETGSSEDRGPIVHTDHSDLVLE------------- 581

  Fly   658 FERSAGDYGFDQVQPQMRTNRISEKTSM-------ISIPSASPAHTGRDTCIASNKAGTTTY--- 712
             |:.|.:.. |......|...:|...|:       :.:|..||.          ...||.||   
Mouse   582 -EKEALETK-DPTNGYYRVRGVSVSLSLGEAPGGGLFLPPPSPI----------GLPGTPTYYDF 634

  Fly   713 --SVDLTVNVPP--------RWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYK 767
              .:||   |||        .::..|..:||..      ..|...|..|::    :.|..|..|.
Mouse   635 KPHLDL---VPPCRLYRARAGYLTTPHPRAFTS------YMKPTSFGPPEL----SSGTPPFPYA 686

  Fly   768 DLKKSDNIRVE 778
            .|....:.|::
Mouse   687 TLSPPSHQRLQ 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 27/101 (27%)
IG 57..133 CDD:214652 25/85 (29%)
IG_like 267..343 CDD:214653 23/81 (28%)
Ig 269..340 CDD:143165 21/76 (28%)
IG_like 353..425 CDD:214653 26/75 (35%)
IGc2 361..413 CDD:197706 20/55 (36%)
I-set 433..527 CDD:254352 25/113 (22%)
IGc2 446..517 CDD:197706 20/87 (23%)
I-set 533..618 CDD:254352 17/87 (20%)
IGc2 544..607 CDD:197706 9/65 (14%)
Ig 641..714 CDD:143165 14/84 (17%)
IGc2 735..804 CDD:197706 8/44 (18%)
I-set 819..914 CDD:254352
Ig 833..921 CDD:299845
FN3 918..1011 CDD:238020
FN3 1018..1116 CDD:238020
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
Kirrel2NP_766486.1 IG 27..116 CDD:214652 26/99 (26%)
Ig 122..220 CDD:416386 25/128 (20%)
Ig strand A 123..126 CDD:409353 0/8 (0%)
Ig strand A' 129..133 CDD:409353 1/3 (33%)
Ig strand B 140..147 CDD:409353 1/6 (17%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 2/4 (50%)
Ig strand C' 161..163 CDD:409353 0/1 (0%)
Ig strand D 166..173 CDD:409353 2/6 (33%)
Ig strand E 180..188 CDD:409353 1/7 (14%)
Ig strand F 197..205 CDD:409353 1/7 (14%)
Ig strand G 211..217 CDD:409353 1/5 (20%)
Ig_3 223..292 CDD:404760 20/84 (24%)
Ig strand B 241..245 CDD:409353 2/3 (67%)
Ig strand C 255..259 CDD:409353 1/3 (33%)
Ig strand E 272..275 CDD:409353 0/5 (0%)
Ig strand F 281..290 CDD:409353 2/8 (25%)
Ig strand G 298..301 CDD:409353 0/2 (0%)
Ig 315..392 CDD:416386 27/76 (36%)
Ig strand A' 316..321 CDD:409353 0/4 (0%)
Ig strand B 324..333 CDD:409353 3/8 (38%)
Ig strand C 339..343 CDD:409353 0/3 (0%)
Ig strand C' 346..348 CDD:409353 0/1 (0%)
Ig strand D 351..354 CDD:409353 0/2 (0%)
Ig strand E 355..360 CDD:409353 3/4 (75%)
Ig strand F 368..376 CDD:409353 3/7 (43%)
Ig strand G 382..392 CDD:409353 3/9 (33%)
Ig 394..498 CDD:416386 26/114 (23%)
Ig strand A 395..399 CDD:409353 3/9 (33%)
Ig strand A' 401..404 CDD:409353 0/2 (0%)
Ig strand B 412..419 CDD:409353 3/6 (50%)
Ig strand C 426..431 CDD:409353 0/4 (0%)
Ig strand C' 433..436 CDD:409353 0/2 (0%)
Ig strand D 444..451 CDD:409353 1/6 (17%)
Ig strand E 461..468 CDD:409353 2/6 (33%)
Ig strand F 479..486 CDD:409353 3/8 (38%)
Ig strand G 489..496 CDD:409353 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11159
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.900

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