DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	632	Identity:	119/632 - (18%)
Similarity:	199/632 - (31%)	Gaps:	227/632 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 VAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPI-----NRKQK 577
            ::|.|| |.:.||..:|::.    :.|..| ||.|.|..        ||...|.:     ||...
Mouse    95 LSELSA-LMLRGLRRLRELR----LPGNRL-VTFPWAAL--------RDTPQLQLLDLQANRLST 145

  Fly   578 VFPNGTLIIENVERNSDQATYTCVAKNQ---------------------EGYSARGSLEVQVMVL 621
            :.|.....:||:       |:..::.||                     .|:.||..|.:|..
Mouse   146 LPPEAAHFLENL-------TFLDLSNNQLMRLPEELLDVWAHLKTGPFLSGHHARLILGLQDN-- 201

  Fly   622 PQIVPFAYEDLINMGD----SIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQ------PQMRT 676
            |.:......||:::.|    |..:|.:       .::..:..||.....|.|::      |::|
Mouse   202 PWVCDCRLYDLVHLLDGWVSSNLIFIE-------ARLRCASPRSLAGVAFSQLELRKCQSPELR- 258

  Fly   677 NRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKV 741
                                          .|.|:             |:.|.      ||...:
Mouse   259 ------------------------------PGVTS-------------IISPL------GSTVLL 274

  Fly   742 ECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLH--------------VDNIQKTNE 792
            .|.|.|.|.|:::|::|.|               |...||:|              :..:...:.
Mouse   275 RCGATGIPGPEMSWRRANG---------------RPLNGTVHQEVSSDGSSWTLLDLPVVSLFDS 324

  Fly   793 GYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNM 857
            |.|:|:|.|.:|:. ..:|.:.|..|       :..|...|.|.||.... ||......:|
Mouse   325 GDYICQAKNFLGAS-ETLISLIVTEP-------QTSTGYSGIPGVLWART-GEGAEAAAYN---- 376

  Fly   858 RLDPKNDNRYTIR------EEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQE 916
                   |:...|      |.:......|..|||                    ::.::.....:
Mouse   377 -------NKLVARHVPHMPEHVALATKPSMPSIK--------------------EELALQNFQMD 414

  Fly   917 VP-------------EMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRV 968
            ||             :|..:|||:..:..||.|.|..|..||:.....:......|    ::.|:
Mouse   415 VPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGHR----DMRRM 475

  Fly   969 IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTM 1033
            .|....|...::.|:|.|.|...:.....:.|   .|...|.:.:|....:.....:..|..:..
Mouse   476 TVEPGKTSVTIEGLAPKTKYVACVCVRGLVPT---KEQCVIFSTDEVVDAEGTQRLINMVVISVA 537

  Fly  1034 RVTWKPPP---------------RTEWNGEILGYYVGY-KLSNTNSS 1064
            .:...||.               ||..:.|..|.||.. :|.::..|
Mouse   538 AIIALPPTLLVCCGALRRRCHKCRTGGSAEASGAYVNLERLGHSEDS 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	4/8 (50%)
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352	22/110 (20%)
		IGc2	544..607	CDD:197706	17/88 (19%)
		Ig	641..714	CDD:143165	9/78 (12%)
		IGc2	735..804	CDD:197706	19/82 (23%)
		I-set	819..914	CDD:254352	15/100 (15%)
		Ig	833..921	CDD:299845	16/106 (15%)
		FN3	918..1011	CDD:238020	23/105 (22%)
		FN3	1018..1116	CDD:238020	11/63 (17%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566	17/61 (28%)
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105		4/10 (40%)
		leucine-rich repeat	85..132	CDD:275378	15/50 (30%)
		LRR 3	108..129		7/33 (21%)
		LRR_8	131..>176	CDD:290566	9/51 (18%)
		LRR_4	131..172	CDD:289563	9/47 (19%)
		LRR 4	132..153		4/20 (20%)
		leucine-rich repeat	133..156	CDD:275378	4/22 (18%)
		LRR 5	156..177		4/27 (15%)
		leucine-rich repeat	157..180	CDD:275378	3/29 (10%)
		leucine-rich repeat	181..205	CDD:275378	6/25 (24%)
		TPKR_C2	201..>241	CDD:301599	8/48 (17%)
		Ig	258..346	CDD:299845	26/153 (17%)
		IG_like	268..346	CDD:214653	21/99 (21%)
		FN3	432..502	CDD:214495	18/73 (25%)
		LRR 6	526..549		3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900