DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	1055	Identity:	234/1055 - (22%)
Similarity:	369/1055 - (34%)	Gaps:	292/1055 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 GESVETVLTVTAPLSAKIDPPTQTVD---FGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLR 395
            ||||.....|..|::.:  ||...|:   ||.|.....::...| ..|.....|:|..|.:..||
Human    38 GESVVLRCDVIHPVTGQ--PPPYVVEWFKFGVPIPIFIKFGYYP-PHVDPEYAGRASLHDKASLR 99

  Fly   396 IESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFD--------------PPVIRQAFQE--ETM 444
            :|.|:.||:|.|:|.|            |.|..::|              ||...:...:  |..
Human   100 LEQVRSEDQGWYECKV------------LMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152

  Fly   445 EPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYK 509
            | |.|:.:.|.|.|||.|.::|..:|..:..:.:|||..         ..|.:|||...|.|.|.
Human   153 E-GGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSD---------GSLTVTSVSREDRGAYT 207

  Fly   510 CIAKSKVGVAEHSAKLNVYGLPYI-RQMEKKAIVAGETLIVTCPVAGYPID---SIVWERDNRAL 570
            |.|.|..|.|.|:..|.|.|.|:| ...|...:...:..::||....||.:   :..|:.:|...
Human   208 CRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYF 272

  Fly   571 --PINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGS--LEVQ----VMVLPQI--V 625
              .:..:.::..:|||||..| :..|...||||..|..|.|...|  |.||    |:.:|.:  |
Human   273 QNDLKLRVRILIDGTLIIFRV-KPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYV 336

  Fly   626 PFAYEDLINMGDSIDLFCQI-----------QKGDRPIKVH----WSFERSAGDYGFDQVQPQMR 675
            |......|.        |.:           .|..||::|.    |:......
Human   337 PVGIHGYIR--------CPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS------------ 381

  Fly   676 TNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVD--LTVNVPPRW-ILEPTDKAFAQGS 737
                      |.|..|:....|..||:..|..||...|..  |.:..||.: :|...:.....|.
Human   382 ----------IRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGR 436

  Fly   738 DAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAING 802
            :..:.|.|.|.|.|.:||:| ||..       .:|.:..:..|:|....:.|.:.|.:.|.|.|.
Human   437 ELLIPCAAAGDPFPVITWRK-VGKP-------SRSKHSALPSGSLQFRALSKEDHGEWECVATNV 493

  Fly   803 IGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRY 867
            :.|..::..:..:...|                     .|.|...:.:.....|:..:|..|..|
Human   494 VTSITASTHLTVIGTSP---------------------HAPGSVRVQVSMTTANVSWEPGYDGGY 537

  Fly   868 TIREEILSTGVM------------------SSLSIKRTERSDSALFTCVATNAFG----SDDASI 910
               |:..|..:.                  |.|.:...|...:..|:.:|.|..|    |:..::
Human   538 ---EQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTV 599

  Fly   911 NMIVQEV--PE-----MPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRV 968
            |.:...:  ||     .|....:.:::.:.|.|||..|.:.:.|:||||:|| |....|..:|..
Human   600 NTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEF-RVAERWELLDDG 663

  Fly   969 IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTM 1033
            | ||...|...:.||..|.|..|::|                        ..|::..||.|
Human   664 I-PGTEGEFFAKDLSQDTWYEFRVLA------------------------VMQDLISEPSN---- 699

  Fly  1034 RVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQ 1098
                                    ::..:|:.:|...: :||:|....: |..:.....:.....
Human   700 ------------------------IAGVSSTDIFPQPD-LTEDGLARPV-LAGIVATICFLAAAI 738

  Fly  1099 AFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAP 1163
            .|:.:.|..::::.|: ..:.....|.|.|.|.......:..|.|||         ::.:.:.||
Human   739 LFSTLAACFVNKQRKR-KLKRKKDPPLSITHCRKSLESPLSSGKVSP---------ESIRTLRAP 793

  Fly  1164 SDEWYDE----TKRHYKKTASSDTVLH-------GLKKYT--------NYTMQVLATTAGGDGVR 1209
            |:...|:    .||....|...:..|:       ..|||:        ..|..:...:.|.|| |
Human   794 SESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDG-R 857

  Fly  1210 SVPIHCQTEPDV-----------------------------PEAPTDVKALVMGNAAILVSWR-- 1243
            .|....:.||.:                             |..||.|.||......:..|..
Human   858 FVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESY 922

  Fly  1244 --PPA-----QPNGI 1251
              |||     ||.|:
Human   923 LPPPAYSPRFQPRGL 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	4/8 (50%)
		Ig	269..340	CDD:143165	4/5 (80%)
		IG_like	353..425	CDD:214653	21/74 (28%)
		IGc2	361..413	CDD:197706	17/51 (33%)
		I-set	433..527	CDD:254352	30/95 (32%)
		IGc2	446..517	CDD:197706	23/70 (33%)
		I-set	533..618	CDD:254352	26/96 (27%)
		IGc2	544..607	CDD:197706	18/67 (27%)
		Ig	641..714	CDD:143165	15/87 (17%)
		IGc2	735..804	CDD:197706	19/68 (28%)
		I-set	819..914	CDD:254352	18/116 (16%)
		Ig	833..921	CDD:299845	19/116 (16%)
		FN3	918..1011	CDD:238020	28/97 (29%)
		FN3	1018..1116	CDD:238020	13/97 (13%)
		FN3	1124..1217	CDD:238020	25/111 (23%)
		FN3	1222..1312	CDD:238020	13/39 (33%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	26/79 (33%)
		Ig	41..115	CDD:143165	23/76 (30%)
		I-set	139..225	CDD:254352	30/95 (32%)
		IGc2	153..210	CDD:197706	22/66 (33%)
		I-set	229..321	CDD:254352	25/92 (27%)
		Ig	235..321	CDD:299845	23/86 (27%)
		IG_like	331..414	CDD:214653	20/112 (18%)
		Ig	<353..414	CDD:299845	15/82 (18%)
		IG_like	426..505	CDD:214653	20/86 (23%)
		Ig	442..505	CDD:299845	19/70 (27%)
		FN3	510..601	CDD:238020	17/114 (15%)
		FN3	617..699	CDD:238020	29/107 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		15/67 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810