DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and SDK1

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:2399 Identity:478/2399 - (19%)
Similarity:783/2399 - (32%) Gaps:819/2399 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEP--------TNRIDFSNSTGAEIE 60
            |..|..|.:|...:.|:...:|         |...|.|..||        .||:        .:.
Human    78 PGRRGWWALLALQLHLLRALAQ---------DDVAPYFKTEPGLPQIHLEGNRL--------VLT 125

  Fly    61 CKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGS 125
            |.|.|:...|..|:|.|..       |...||:.|.:.|..      |::.|..|.|:.||:.|:
Human   126 CLAEGSWPLEFKWMRDDSE-------LTTYSSEYKYIIPSL------QKLDAGFYRCVVRNRMGA 177

  Fly   126 IISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYD 190
            ::.|...|:......:.:...:..|.:|.:|||                       |..|.|.| 
Human   178 LLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAIL-----------------------NLLPITSY- 218

  Fly   191 GKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSAT-KGRLVI----TEPVGSVSPQLS 250
                             |......:  |..|::....|::.| :.:|||    |...|:...|..
Human   219 -----------------PRPQVTWF--REGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAV 264

  Fly   251 GNGNQE-------HITLTR---------------------VPKMGSVTLMCPAQAYPVPFFRWYK 287
            ...|.|       |:::.|                     |......||.|.|.|.||      :
Human   265 NEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPV------E 323

  Fly   288 FIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVE-----TVLTVTAP- 346
            .:..|.::..|.:...:......|.|.:....|:|.|:|  ..::.|.:.|     ..|.:..| 
Human   324 DLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVC--EAALPGSAFEPARATAFLFIIEPP 386

  Fly   347 ---------LSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGH---------SEPV 393
                     :||:::   :|||.|      ||..|.|:.|:.|.||..:|..         :...
Human   387 YFTAEPESRISAEVE---ETVDIG------CQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG 442

  Fly   394 LRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGG 458
            |||:.::.||.|::|||..|  |..|......|......||..|...:.|:..|.:..|:|...|
Human   443 LRIQKLRPEDSGIFQCFASN--EGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSG 505

  Fly   459 NPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSA 523
            .|.|.|:|:.:...:|:.. .::.:::.:..   ..|.|..|...|.|.|.|.|.:..|....||
Human   506 APKPAITWKRENHILASGS-VRIPRFMLLES---GGLQIAPVFIQDAGNYTCYAANTEGSLNASA 566

  Fly   524 KLNVYG-LPYIRQMEKKAIVAGETLIVTCPVAGYPIDSI--VWERDNRALPINRKQKVF--PNGT 583
            .|.|:. ...:...|...::.|.|..:.|.....|..|:  ||::||.||..:...::.  .:|:
Human   567 TLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGS 631

  Fly   584 LIIENVERNSDQATYTCVAKNQEGYSAR-GSLEV-------------------QVMVLPQIVPFA 628
            |:|... .:.|...|:|...::.|..:| ..|||                   ..:||..:.||.
Human   632 LLISQT-WSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFD 695

  Fly   629 YEDLINMGDSIDLF--CQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSA 691
                   |:|..|:  .::.:.:.|.|||.|           .|.|:|         :.:::...
Human   696 -------GNSPILYYIVELSENNSPWKVHLS-----------NVGPEM---------TGVTVSGL 733

  Fly   692 SPAHTGRDTCIASNKAGTTTYSVDLT--------VNVPPRWILEP--TDKAFAQGSDAKVECKAD 746
            :||.|.:....|.|:.|...||.:.:        .:.||:.|:..  |:::.........|.:.:
Human   734 TPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHN 798

  Fly   747 GFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYL-------------CE 798
            |..:..:...:..| .||||:.                .||......|.|             ..
Human   799 GVLRGYILRYRLAG-LPGEYQQ----------------RNITSPEVNYCLVTDLIIWTQYEIQVA 846

  Fly   799 AINGIGSGL--SAVIMISVQ----APPE------------------------------------- 820
            |.||.|.|:  .||...::|    |||:                                     
Human   847 AYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWP 911

  Fly   821 ---------------------------------FTEKLRNQTARRGEPAVLQ------------- 839
                                             ||..|...|...|.|:..|             
Human   912 ADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVG 976

  Fly   840 -----------CEAKGEKPI---GIL------WNMNNMRLDPKNDNRYTIREEILSTG---VMSS 881
                       .:...::|:   ||:      |.:..     :||:|.|  ..:.||.   .:..
Human   977 HLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG-----RNDSRLT--HTLNSTTHEYKIQG 1034

  Fly   882 LSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNS 946
            ||...|...|.|..|.|.|....|...| :.:..::|..|..|.:.:.|.||..|.:...|||.:
Human  1035 LSSLTTYTIDVAAVTAVGTGLVTSSTIS-SGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKT 1098

  Fly   947 PLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQ-----KLSPATTYNIRIVAENAIGTSQSSEA 1006
            .:.|:|:| .:..|...|.:.|.:.....|...|     .|:|.|.|..|:...|.:|.|..|.:
Human  1099 SISRWIVE-GQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPS 1162

  Fly  1007 VTII-TAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNG--EILGYYVGYKLSNTNSSYVFE 1068
            ..:| |.:..|...|.::.|...::|::|:.|.|.|.:::||  |.:||.:.|..|:..||.|.:
Human  1163 SRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQ 1227

  Fly  1069 TINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTL 1133
            .::    :..|....::.|..:.:|.:.:||||.:||||.||..:..|.|..||..|.:.:...:
Human  1228 VVS----DRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAV 1288

  Fly  1134 TSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHY--KKTASSDTVLHGLKKYTNYTM 1196
            :|..|.:.|.|.|.:..||:|..||:::...|  .|...|.:  :...:...:|.||:|:..|.:
Human  1289 SSTQILLTWTSVPEQDQNGLILGYKILFRAKD--LDPEPRSHIVRGNHTQSALLAGLRKFVLYEL 1351

  Fly  1197 QVLATTAGGDGVRSVPIHCQ-TEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTV-YS 1259
            ||||.|..|:||.|.|:..: |:.|.|..|..:....:...::.:.|:||.:|||||..|.: |.
Human  1352 QVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416

  Fly  1260 KAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIAS 1324
            .|..:.....|.:|......|.||:|.....|.|.::|.|..|.|:                  .
Human  1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE------------------P 1463

  Fly  1325 FDDTFTATFKEDAKMPCLAVGAPQPEIT--------------------------------WKIKG 1357
            .:.|...|.|.:...|...:..||.|:|                                |:...
Human  1464 LEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528

  Fly  1358 VEFSAN------DRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQS---- 1412
            ...|..      ||:|......|.:|:.|.....|:|...|.......:..:     ||.|    
Human  1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE-----PPGSVSAT 1588

  Fly  1413 PHVTLS-------------------------------ATTTDALTVK------------------ 1428
            ||.|.|                               .:.|:|.|:|                  
Human  1589 PHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653

  Fly  1429 -------------LKPHE-------------------------GDTAP----------------- 1438
                         ||.:.                         |:.||                 
Human  1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718

  Fly  1439 ---------------LHGYTLHYKPEFGEWETSEVSVDSQKH--------------NIEGLLCGS 1474
                           :.||.::|      ||     .|||..              .::.|...:
Human  1719 EVTWDPPPPESQNGNIQGYKIYY------WE-----ADSQNETEKMKVLFLPEPVVRLKNLTSHT 1772

  Fly  1475 RYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSL----------------- 1522
            :|.|..:.||..|.|..||....||....|..|....|.|::|.::::                 
Human  1773 KYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRV 1837

  Fly  1523 ---------------------HFKAW--------------------------------------- 1527
                                 :::.|                                       
Human  1838 VYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGS 1902

  Fly  1528 -----------------------KDGGCPMSHFVVESKKRDQIEWNQISNNV-KPDNNYVV-LD- 1566
                                   ..|..|.:.:|:|::..|:..|:....:: :...:|.: || 
Human  1903 PGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDK 1967

  Fly  1567 LEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLN 1631
            |.....|..|:.|.|.||:  .|....:..|:....||                  :..||..| 
Human  1968 LRQGVTYEFRVVAVNEAGY--GEPSNPSTAVSAQVEAP------------------FYEEWWFL- 2011

  Fly  1632 FMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDEL 1696
            .::.|.:.:|::.|...:|....:::..:...|  |.:       .||....|||          
Human  2012 LVMALSSLIVILLVVFALVLHGQNKKYKNCSTG--KGI-------STMEESVTLD---------- 2057

  Fly  1697 GYIAPPNRKLPPVPGSNYNTCDRIKRGRGG-----LRSNH----STWDPRRNPNLYEELKAPPVP 1752
                                       .||     |.|.|    ||:..:..      .::||.|
Human  2058 ---------------------------NGGFAALELSSRHLNVKSTFSKKNG------TRSPPRP 2089

  Fly  1753 MHGN-HYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPG 1816
            ..|. ||.               :::||......:|.....:....|...::....:.:...:|.
Human  2090 SPGGLHYS---------------DEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPK 2139

  Fly  1817 HAGTMLPPGHPGHVHS--RSGSQSMPRANRYQR-KNSQGG---------QSS--IYTPA 1861
            |:........|.:.:|  |......|..:||:. ..|:.|         ||:  :||||
Human  2140 HSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPA 2198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 25/99 (25%)
IG 57..133 CDD:214652 20/75 (27%)
IG_like 267..343 CDD:214653 18/80 (23%)
Ig 269..340 CDD:143165 17/75 (23%)
IG_like 353..425 CDD:214653 25/80 (31%)
IGc2 361..413 CDD:197706 19/60 (32%)
I-set 433..527 CDD:254352 25/93 (27%)
IGc2 446..517 CDD:197706 17/70 (24%)
I-set 533..618 CDD:254352 23/108 (21%)
IGc2 544..607 CDD:197706 17/66 (26%)
Ig 641..714 CDD:143165 16/74 (22%)
IGc2 735..804 CDD:197706 14/81 (17%)
I-set 819..914 CDD:254352 28/200 (14%)
Ig 833..921 CDD:299845 24/123 (20%)
FN3 918..1011 CDD:238020 28/98 (29%)
FN3 1018..1116 CDD:238020 30/99 (30%)
FN3 1124..1217 CDD:238020 29/95 (31%)
FN3 1222..1312 CDD:238020 25/90 (28%)
Ig 1339..1406 CDD:299845 16/104 (15%)
FN3 1409..1499 CDD:238020 33/226 (15%)
FN3 1504..1584 CDD:238020 20/182 (11%)
Dscam_C 1890..2008 CDD:289151
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352 27/104 (26%)
Ig 122..176 CDD:143165 18/74 (24%)
Ig 219..265 CDD:299845 11/47 (23%)
IGc2 312..364 CDD:197706 15/59 (25%)
I-set 386..475 CDD:254352 28/99 (28%)
Ig 404..472 CDD:143165 24/75 (32%)
I-set 480..570 CDD:254352 25/93 (27%)
Ig 494..570 CDD:299845 21/79 (27%)
I-set 575..664 CDD:254352 21/89 (24%)
Ig 580..664 CDD:299845 21/84 (25%)
FN3 668..759 CDD:238020 23/117 (20%)
fn3 771..857 CDD:278470 20/102 (20%)
FN3 872..967 CDD:238020 9/94 (10%)
FN3 972..1054 CDD:238020 17/88 (19%)
FN3 1070..1166 CDD:238020 27/96 (28%)
FN3 1176..1271 CDD:238020 30/98 (31%)
fn3 1279..1365 CDD:278470 27/87 (31%)
FN3 1378..1471 CDD:238020 26/110 (24%)
FN3 1477..1572 CDD:238020 16/94 (17%)
FN3 1580..1694 CDD:238020 13/118 (11%)
FN3 1704..1797 CDD:238020 17/103 (17%)
FN3 1802..1883 CDD:238020 6/80 (8%)
FN3 1903..1996 CDD:238020 17/94 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098 8/43 (19%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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