DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and Robo1

DIOPT Version :10

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:XP_017172382.1 Gene:Robo1 / 19876 MGIID:1274781 Length:1687 Species:Mus musculus


Alignment Length:1893 Identity:418/1893 - (22%)
Similarity:660/1893 - (34%) Gaps:507/1893 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   325 LCV----VNNSVGGESV-ETVLTVTA--PLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMK 382
            |||    |:..|.|.:| |...|||:  |.:|.:..||...|..|.     ...|.|..|..  .
Mouse    25 LCVFLSHVDLLVSGHAVIEMATTVTSVTPSAALVLFPTDPEDLERG-----NDNGTPAPTSD--N 82

  Fly   383 DGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPG 447
            |..::|::...||.|..                                ||.|.:...:..:..|
Mouse    83 DDNSLGYTGSRLRQEDF--------------------------------PPRIVEHPSDLIVSKG 115

  Fly   448 PSVFLKCVAGGNPTPEISWELDGKKI-ANNDRYQVGQYVTVNGDVVSYLNITSVHAN----DGGL 507
            ....|.|.|.|.|||.|.|...|::: .:.|..:..:.:..:|.:. :|.|  ||..    |.|:
Mouse   116 EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF-FLRI--VHGRKSRPDEGV 177

  Fly   508 YKCIAKSKVGVA-EHSAKLNVYGL-PYIRQMEKKAIVA-GETLIVTC-PVAGYPIDSIVWERDNR 568
            |.|:|::.:|.| .|:|.|.|..| ...||.....:|| ||..::.| |..|:|..:|.|::|..
Mouse   178 YICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 242

  Fly   569 ALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLI 633
            .|. ::.:::...|..::....|.||...|.||..|..|.......|:.|:..|..|.......:
Mouse   243 PLD-DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAV 306

  Fly   634 NMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGR 698
            .:.||.:..|: .:||....|.|..:        |...|:.|.....:.|  :.|...:....|.
Mouse   307 TVDDSAEFKCE-ARGDPVPTVRWRKD--------DGELPKSRYEIRDDHT--LKIRKVTAGDMGS 360

  Fly   699 DTCIASNKAGTTTYSVDLTVNV---PPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVG 760
            .||:|.|..|....|..|||.|   ||.::::|.|:..|.|.....:|:|.|.|:|.:.|::   
Mouse   361 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR--- 422

  Fly   761 DTPG------EYKDLKKSDNIRVEE-GTLHVDNIQKTNEGYYLCEAINGIGS-----GLSAVIMI 813
              .|      .|:..:.|....|.: |.|.:.|:|:::.|||:|:.:|..||     .|....:|
Mouse   423 --EGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 485

  Fly   814 SVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGV 878
            :.:.||...:...|||.......:|.|.|.|.....|||..:.:.:..::.     |.:.|.:||
Mouse   486 ADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVSTQDS-----RIKQLESGV 545

  Fly   879 MSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQE---------------VPEMPYALKVLD 928
               |.|:..:..|:..:||.|:...|....|..:.|||               :|..|...:|.|
Mouse   546 ---LQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD 607

  Fly   929 KSGRSVQLSWAQPYDGNSPLDRYIIE-FKR-SRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIR 991
            .|..:|.|||....:..:....|||| |.. |.:||......:   .|....::.|.|...|...
Mouse   608 VSKNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTAAENV---KTETFAIKGLKPNAIYLFL 669

  Fly   992 IVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEP-------------------VNQTTMRVTW 1037
            :.|.||.|.|..|:....:..::.|   |.:..|:.                   ::.:::.|.|
Mouse   670 VRAANAYGISDPSQISDPVKTQDVP---PTSQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHW 731

  Fly  1038 KPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNK 1102
            ....::::   |.||.:.|:.|.. |....|.:.|......::::.:.:||....|.:..:.|..
Mouse   732 TVDQQSQY---IQGYKILYRPSGA-SHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFN 792

  Fly  1103 IGAGPLSEEEKQFTAEGTPSQPPSDTACTTL--TSQTIRVGWVSPPLESANGVIKTYKVVYAPSD 1165
            ...|..||.:...|.|..||.||.....:..  ....|.|.|..||.::.||:::.|||      
Mouse   793 EFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKV------ 851

  Fly  1166 EWY--DETKRHYKKTASSDT---VLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEP-DVPEA 1224
             |.  :|||.|..||....|   |:..|.....|:::|.|:|..|.||:|.|...|.:. ..|.:
Mouse   852 -WCLGNETKYHINKTVDGSTFSVVIPSLVPGIRYSVEVAASTGAGPGVKSEPQFIQLDSHGNPVS 915

  Fly  1225 PTDVKALVMGNAAILVSWRPPAQPNGI------------ITQYTVYSKAEG-AETETKTQKVPHY 1276
            |.|..:|....:.::   |.||...||            |..|....|..| ..|....:|||  
Mouse   916 PEDQVSLAQQISDVV---RQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVP-- 975

  Fly  1277 QMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPC 1341
                           .|..|.:.|...|.::.|....|.              .....|.|..|.
Mouse   976 ---------------SFTFTPTVTYQRGGEAVSSGGRPG--------------LLNISEPATQPW 1011

  Fly  1342 LAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSIT----- 1401
            ||       .||...|                     .|..|.....|.|.|..:..::|     
Mouse  1012 LA-------DTWPNTG---------------------NNHNDCSINCCTAGNGNSDSNLTTYSRP 1048

  Fly  1402 ------------HKLIVLAPPQSP---HVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFG 1451
                        :|...|..|:|.   .|.||....:..|.. .|:..|     |..::...:..
Mouse  1049 ADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFN-SPNLKD-----GRFVNPSGQPT 1107

  Fly  1452 EWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVS 1516
            .:.|:::...:..:|:                 |.|||::|:      |..||...:||   ||:
Mouse  1108 PYATTQLIQANLSNNM-----------------NNGAGDSSE------KHWKPPGQQKP---EVA 1146

  Fly  1517 SNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHN 1581
                            |:.:.::|.        |:::.:.:.::.     :.|...||       
Mouse  1147 ----------------PIQYNIMEQ--------NKLNKDYRANDT-----IPPTIPYN------- 1175

  Fly  1582 SAGFTVAEYDFATLTVTGGTIAPLDDGS------GHGNVHTRIRLPAWMPE--------WLDLNF 1632
                  ..||    ..|||:....|.||      ||       :..|..|:        |.||  
Mouse  1176 ------QSYD----QNTGGSYNSSDRGSSTSGSQGH-------KKGARTPKAPKQGGMNWADL-- 1221

  Fly  1633 MVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMG---PGATLDKRRPDLRD 1694
            :.|..|                  .........:.::..|..|:|.|.   |.|.:..::.:|.:
Mouse  1222 LPPPPA------------------HPPPHSNSEEYNMSVDESYDQEMPCPVPPARMYLQQDELEE 1268

  Fly  1695 ELGYIAPPNRKLPPVPGS-------NYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVP 1752
            |.....|    .|||.|:       :|              |:.||  ....|:..|||:     
Mouse  1269 EEDERGP----TPPVRGAASSPAAVSY--------------SHQST--ATLTPSPQEELQ----- 1308

  Fly  1753 MHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLL----GFREEMDPTKAMNFQTFPHQNGH-AG 1812
                               |.::|  ||....|:.    ..|:.:.|.......:.||..|: :|
Mouse  1309 -------------------PMLQD--CPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISG 1352

  Fly  1813 PVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDP---------- 1867
            |:.....|..|       ........|..|....|:....|...  |||....|.          
Mouse  1353 PLVSDMDTDAP-------EEEEDEADMEVAKMQTRRLLLRGLEQ--TPASSVGDLESSVTGSMIN 1408

  Fly  1868 --ANCAEEDQYRR-YTRVNSQGGSLYSGPGPEYDDPANCAPE-----------EDQYGSQ--YGG 1916
              .:.:|||.... .:.|:|..||.::  ..::......|.|           :|..|.:  :..
Mouse  1409 GWGSASEEDNISSGRSSVSSSDGSFFT--DADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHAS 1471

  Fly  1917 PYGQPYDHYGSRGSMGRRSIGSAR-------NPG--------NGSPEPPPPPPRNHDMSNSSFND 1966
            ...:|.....:..:|....|..||       .||        :..|.||.|||    ...|....
Mouse  1472 QCPRPTSPVSTDSNMSAVVIQKARPAKKQKHQPGHLRREAYADDLPPPPVPPP----AIKSPTVQ 1532

  Fly  1967 SKESNEIS----------EAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQ 2021
            ||...|:.          ||..||....:|  |:.| ..:..|.|...::|    .|.:.|::.|
Mouse  1533 SKAQLEVRPVMVPKLASIEARTDRSSDRKG--GSYK-GREALDGRQVTDLR----TNPSDPREAQ 1590

  Fly  2022 LQQANGAG 2029
            .|..:|.|
Mouse  1591 EQPNDGKG 1598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547
Ig strand A 39..42 CDD:409547
Ig strand A' 48..52 CDD:409547
Ig strand B 55..64 CDD:409547
Ig strand C 70..76 CDD:409547
Ig strand C' 78..81 CDD:409547
Ig strand D 87..90 CDD:409547
Ig strand E 95..100 CDD:409547
Ig strand F 113..121 CDD:409547
Ig strand G 124..136 CDD:409547
IgI_2_Dscam 246..343 CDD:409545 8/22 (36%)
Ig strand A 247..250 CDD:409545
Ig strand A' 260..264 CDD:409545
Ig strand B 267..274 CDD:409545
Ig strand C 282..288 CDD:409545
Ig strand C' 294..297 CDD:409545
Ig strand D 303..307 CDD:409545
Ig strand E 309..315 CDD:409545
Ig strand F 322..330 CDD:409545 4/8 (50%)
Ig strand G 333..343 CDD:409545 3/10 (30%)
IgC2_3_Dscam 346..426 CDD:409549 14/79 (18%)
Ig strand A 347..352 CDD:409549 1/4 (25%)
Ig strand A' 355..359 CDD:409549 1/3 (33%)
Ig strand B 362..372 CDD:409549 1/9 (11%)
Ig strand C 377..383 CDD:409549 1/5 (20%)
Ig strand C' 384..387 CDD:409549 0/2 (0%)
Ig strand E 392..398 CDD:409549 2/5 (40%)
Ig strand F 405..413 CDD:409549 0/7 (0%)
Ig strand G 416..426 CDD:409549 0/9 (0%)
IgI_4_Dscam 432..527 CDD:409548 30/100 (30%)
Ig strand A 432..435 CDD:409548 2/2 (100%)
Ig strand A' 441..445 CDD:409548 0/3 (0%)
Ig strand B 448..457 CDD:409548 2/8 (25%)
Ig strand C 462..468 CDD:409548 3/5 (60%)
Ig strand C' 470..473 CDD:409548 1/2 (50%)
Ig strand D 478..486 CDD:409548 0/7 (0%)
Ig strand E 490..499 CDD:409548 2/8 (25%)
Ig strand F 506..514 CDD:409548 4/7 (57%)
Ig strand G 517..527 CDD:409548 5/10 (50%)
IgI_5_Dscam 531..618 CDD:409550 24/88 (27%)
Ig strand A 531..533 CDD:409550 0/1 (0%)
Ig strand A' 538..542 CDD:409550 0/3 (0%)
Ig strand B 545..552 CDD:409550 2/7 (29%)
Ig strand C 559..565 CDD:409550 2/5 (40%)
Ig strand C' 566..568 CDD:409550 1/1 (100%)
Ig strand D 575..579 CDD:409550 0/3 (0%)
Ig strand E 582..588 CDD:409550 1/5 (20%)
Ig strand F 596..604 CDD:409550 3/7 (43%)
Ig strand G 608..618 CDD:409550 1/9 (11%)
Ig 621..718 CDD:472250 22/96 (23%)
Ig strand B 639..643 CDD:409353 0/3 (0%)
Ig strand C 653..657 CDD:409353 1/3 (33%)
Ig strand E 684..688 CDD:409353 0/3 (0%)
Ig strand F 698..703 CDD:409353 2/4 (50%)
Ig strand G 711..714 CDD:409353 0/2 (0%)
IgI_7_Dscam 721..815 CDD:409546 29/105 (28%)
Ig strand A 721..725 CDD:409546 2/3 (67%)
Ig strand A' 730..734 CDD:409546 1/3 (33%)
Ig strand B 737..746 CDD:409546 1/8 (13%)
Ig strand C 752..758 CDD:409546 1/5 (20%)
Ig strand C' 764..767 CDD:409546 1/8 (13%)
Ig strand D 775..778 CDD:409546 0/2 (0%)
Ig strand E 780..786 CDD:409546 2/5 (40%)
Ig strand F 793..801 CDD:409546 4/7 (57%)
Ig strand G 806..815 CDD:409546 2/8 (25%)
Ig 818..916 CDD:472250 25/97 (26%)
Ig strand B 836..840 CDD:409353 1/3 (33%)
Ig strand C 849..853 CDD:409353 2/3 (67%)
Ig strand E 880..884 CDD:409353 1/3 (33%)
Ig strand F 894..899 CDD:409353 2/4 (50%)
FN3 <899..1212 CDD:442628 87/355 (25%)
Ig strand G 907..910 CDD:409353 0/2 (0%)
FN3 1222..1312 CDD:238020 22/102 (22%)
Ig <1339..1406 CDD:472250 13/83 (16%)
Ig strand C 1350..1354 CDD:409358 1/3 (33%)
Ig strand E 1372..1376 CDD:409358 0/3 (0%)
Ig strand F 1386..1391 CDD:409358 1/4 (25%)
Ig strand G 1399..1402 CDD:409358 1/19 (5%)
FN3 1409..1499 CDD:238020 16/92 (17%)
FN3 1504..1584 CDD:238020 11/79 (14%)
Dscam_C 1893..2008 CDD:463546 30/152 (20%)
Robo1XP_017172382.1 IgC_1_Robo 101..199 CDD:409490 29/100 (29%)
Ig strand A 101..105 CDD:409490 2/3 (67%)
Ig strand A' 108..113 CDD:409490 0/4 (0%)
Ig strand B 117..125 CDD:409490 2/7 (29%)
Ig strand C 131..136 CDD:409490 2/4 (50%)
Ig strand C' 139..141 CDD:409490 0/1 (0%)
Ig strand D 152..155 CDD:409490 0/2 (0%)
Ig strand E 158..164 CDD:409490 1/6 (17%)
Ig strand F 176..184 CDD:409490 4/7 (57%)
Ig strand G 187..199 CDD:409490 5/11 (45%)
IgI_2_Robo 206..291 CDD:409389 24/85 (28%)
Ig strand A 206..209 CDD:409389 2/2 (100%)
Ig strand A' 211..215 CDD:409389 0/3 (0%)
Ig strand B 219..226 CDD:409389 1/6 (17%)
Ig strand C 234..239 CDD:409389 2/4 (50%)
Ig strand C' 241..244 CDD:409389 0/2 (0%)
Ig strand D 250..254 CDD:409389 0/3 (0%)
Ig strand E 256..262 CDD:409389 0/5 (0%)
Ig strand F 269..277 CDD:409389 3/7 (43%)
Ig strand G 280..291 CDD:409389 2/10 (20%)
IgI_3_Robo 298..380 CDD:409390 21/92 (23%)
Ig strand A 298..301 CDD:409390 1/2 (50%)
Ig strand A' 303..307 CDD:409390 0/3 (0%)
Ig strand B 310..319 CDD:409390 3/9 (33%)
Ig strand C 325..330 CDD:409390 2/4 (50%)
Ig strand C' 333..336 CDD:409390 0/2 (0%)
Ig strand D 339..344 CDD:409390 1/4 (25%)
Ig strand E 345..352 CDD:409390 2/8 (25%)
Ig strand F 359..367 CDD:409390 4/7 (57%)
Ig strand G 370..380 CDD:409390 3/9 (33%)
IgI_4_Robo 388..485 CDD:409391 26/101 (26%)
Ig strand A 388..392 CDD:409391 0/3 (0%)
Ig strand A' 394..398 CDD:409391 1/3 (33%)
Ig strand B 404..412 CDD:409391 2/7 (29%)
Ig strand C 415..422 CDD:409391 2/6 (33%)
Ig strand C' 424..427 CDD:409391 1/2 (50%)
Ig strand D 440..445 CDD:409391 1/4 (25%)
Ig strand E 447..454 CDD:409391 2/6 (33%)
Ig strand F 460..469 CDD:409391 4/8 (50%)
FN3 461..897 CDD:442628 113/460 (25%)
Ig strand G 471..482 CDD:409391 3/10 (30%)
IgI_5_Robo 492..578 CDD:409544 22/93 (24%)
Ig strand A 492..495 CDD:409544 0/2 (0%)
Ig strand A' 499..502 CDD:409544 2/2 (100%)
Ig strand B 508..515 CDD:409544 2/6 (33%)
Ig strand C 521..526 CDD:409544 3/4 (75%)
Ig strand C' 528..530 CDD:409544 0/1 (0%)
Ig strand D 537..541 CDD:409544 1/3 (33%)
Ig strand E 544..549 CDD:409544 3/7 (43%)
Ig strand F 557..565 CDD:409544 3/7 (43%)
Ig strand G 568..578 CDD:409544 2/9 (22%)
FN3 597..683 CDD:238020 26/88 (30%)
Blue background indicates that the domain is not in the aligned region.

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