DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Ptprm

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001344554.1	Gene:	Ptprm / 19274	MGIID:	102694	Length:	1486	Species:	Mus musculus

Alignment Length:	1071	Identity:	210/1071 - (19%)
Similarity:	351/1071 - (32%)	Gaps:	334/1071 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 DRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSAS-------------------PA 694
            |.|.......:....|:.::||      |.:::.||...:||.|                   |.
Mouse    30 DEPYSTCGYSQADEDDFNWEQV------NTLTKPTSDPWMPSGSFMLVNTSGKPEGQRAHLLLPQ 88

  Fly   695 HTGRDT-CI-----ASNKAGTTTYSVDLTVNV------PPRWIL--EPTDKAFAQGSDAKVECKA 745
            ....|| ||     .|:|:......:::.|.|      .|.|.:  :||.
Mouse    89 LKENDTHCIDFHYFVSSKSNAAPGLLNVYVKVNNGPLGNPIWNISGDPTR--------------- 138

  Fly   746 DGFPKPQVTWKKA--VGDT--PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSG 806
                    ||.:|  ...|  |..|:.:              .:.:...::||...:.:..:|..
Mouse   139 --------TWHRAELAISTFWPNFYQVI--------------FEVVTSGHQGYLAIDEVKVLGHP 181

  Fly   807 LSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIG-ILWNMN-NMRLDPKNDNRYTI 869
            .:..        |.|. :::|.....|:.|..||.|.|....| .||... ::|..|..:.:.|
Mouse   182 CTRT--------PHFL-RIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVT- 236

  Fly   870 REEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS- 933
                .|...::|.::..|.:.|:..:.|:.....|...::...:|.:.|.:|.|...|...|.:
Mouse   237 ----SSRRFIASFNVVNTTKRDAGKYRCMICTEGGVGISNYAELVVKEPPVPIAPPQLASVGATY 297

  Fly   934 --VQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV--- 993
              :||: |...:|:.|:....:|:..:..||:  ||  .|..:|..::..|.|.|.|.|.::
Mouse   298 LWIQLN-ANSINGDGPIVAREVEYCTASGSWN--DR--QPVDSTSYKIGHLDPDTEYEISVLLTR 357

  Fly   994 -AENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYV--- 1054
             .|.  ||.....|:...|....|...|:.::|..|....:.:.|:|          .||.|
Mouse   358 PGEG--GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP----------FGYNVTRC 410

  Fly  1055 ---------GYKLSNTNSSYVFETINFITEEG-KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLS 1109
                     ||::.  ....|.|.:::.|:.. .:|.  :.||..||..||.:...|..|... |
Mouse   411 HSYNLTVHYGYQVG--GQEQVREEVSWDTDNSHPQHT--ITNLSPYTNVSVKLILMNPEGRKE-S 470

  Fly  1110 EEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYA------PSDEWY 1168
            :|....|.|..|...|:::...:...:.|.:.|..|  ....|||..|::.|.      |..:..
Mouse   471 QELTVQTDEDLPGAVPTESIQGSAFEEKIFLQWREP--TQTYGVITLYEITYKAVSSFDPEIDLS 533

  Fly  1169 DETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG------------VRSVPIHCQTEPDV 1221
            :::.|..|....:..:..||...|.|:..:.|:||.|.|            ..|:|.:   |.:.
Mouse   534 NQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAY---EFET 595

  Fly  1222 PEAPTDVKALVMGNAAILVSWRPPAQPNGI-ITQYTVYSKAEGAETETKTQK------VP-HYQ- 1277
            |...||....||         ..|||..|. ::.|.:..:.|......||.:      || |:|
Mouse   596 PLNQTDNTVTVM---------LKPAQSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQN 651

  Fly  1278 -----------MSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTA 1331
                       ..|.|..|:..:|:        |||:.:........|  .:|.|  |:...:.|
Mouse   652 ASILNSQYYFAAEFPADSLQAAQPF--------TIGDNKTYNGYWNTP--LLPHK--SYRIYYQA 704

  Fly  1332 TFKE--DAKMPCLAV----------------------------GA------PQPE----ITWKIK 1356
            ..:.  :.|:.|:.|                            ||      |:||    .|.||.
Mouse   705 ASRANGETKIDCVRVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAVTPKPVPEPEKQTDHTVKIA 769

  Fly  1357 GV------------------------------EFSANDRMRVL---PDGSLLIKSVNRQDA---- 1384
            ||                              ..|....|.|:   .|.|...:..|..:|
Mouse   770 GVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFM 834

  Fly  1385 GDYSCHAENSIAKDSITHKLIVLAP--PQS--------------PHVTLSATTTDALTVKLKPHE 1433
            |.::.:..:..:..|.|.|...|:.  |.|              .|...|.|::.|.....|..|
Mouse   835 GTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDETHTMASDTSSLAQPHTYKKRE 899

  Fly  1434 GDTAPLHGYTLH----------------------YKPEF--------GEWETSEVSVDSQKHNIE 1468
            ....|.....||                      :|.|:        ..|::::...:..|:...
Mouse   900 AADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYG 964

  Fly  1469 GLLCGSRYQV---YATGFNNIGAGEASDILN 1496
            .::.....:|   ...|.||      ||.:|
Mouse   965 NIIAYDHSRVRLQMLEGDNN------SDYIN 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	18/89 (20%)
		IGc2	735..804	CDD:197706	8/72 (11%)
		I-set	819..914	CDD:254352	21/96 (22%)
		Ig	833..921	CDD:299845	20/89 (22%)
		FN3	918..1011	CDD:238020	26/99 (26%)
		FN3	1018..1116	CDD:238020	24/110 (22%)
		FN3	1124..1217	CDD:238020	23/110 (21%)
		FN3	1222..1312	CDD:238020	24/109 (22%)
		Ig	1339..1406	CDD:299845	23/141 (16%)
		FN3	1409..1499	CDD:238020	22/137 (16%)
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Ptprm	NP_001344554.1	MAM	22..182	CDD:214533	33/194 (17%)
		ig	192..274	CDD:278476	19/86 (22%)
		FN3	282..361	CDD:214495	21/83 (25%)
		FN3	383..467	CDD:214495	21/97 (22%)
		fn3	499..574	CDD:306538	20/76 (26%)
		PTPc	933..1187	CDD:214550	11/63 (17%)
		PTPc	1249..1481	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000