DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Ptprk

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_006512669.1	Gene:	Ptprk / 19272	MGIID:	103310	Length:	1485	Species:	Mus musculus

Alignment Length:	1308	Identity:	240/1308 - (18%)
Similarity:	404/1308 - (30%)	Gaps:	478/1308 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRN 827
            |.||:.:.:::......|.:.:|:||..:   |.|:                  ..|.|. :|.:
Mouse   160 PNEYQVIFEAEVSGGRSGYIAIDDIQVLS---YPCD------------------KSPHFL-RLGD 202

  Fly   828 QTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIRE--EILSTGVMSSLSIKRTERS 890
            .....|:.|..||.|.|...:     .|.:.|..:|.....:.:  .|......:|..::...::
Mouse   203 VEVNAGQNATFQCIATGRDAV-----HNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKT 262

  Fly   891 DSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---VQLSWAQPYDGNSPLDRYI 952
            |..|:.||..:..||..::...::...|..|.|...|...|.:   :||: |....|:.|:....
Mouse   263 DQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLN-ANSIIGDGPIILKE 326

  Fly   953 IEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV----AENAIGTSQSSEAVTIITAE 1013
            :|::.:..||:|...|..|.:    ::..|.|.|.|.||::    .|.  ||......:...|..
Mouse   327 VEYRMTSGSWTETHAVNAPTY----KLWHLDPDTEYEIRVLLTRPGEG--GTGLPGPPLITRTKC 385

  Fly  1014 EAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGK 1078
            ..|...|:.:|:..:....:.|.|          |.|||       |....:.|
Mouse   386 AEPMRTPKTLKIAEIQARRIAVDW----------ESLGY-------NITRCHTF----------- 422

  Fly  1079 EHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWV 1143
                   |:.:...|   .:..|:..|..|..:.|
Mouse   423 -------NVTICYHY---FRGHNESRADCLDMDPK------------------------------ 447

  Fly  1144 SPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGV 1208
                              ||         :|         |::.|..|||.:::::.|...|...
Mouse   448 ------------------AP---------QH---------VVNHLPPYTNVSLKMILTNPEGRKE 476

  Fly  1209 RSVPIHCQTEPDVPEAPTDVKALVMGNA---AILVSWRPPAQPNGIITQYTV-YSK--------- 1260
            ....| .||:.||| .|..||:| .|.:   .|.::|:.|.:||||||||.| ||.
Mouse   477 SEETI-IQTDEDVP-GPVPVKSL-QGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVP 538

  Fly  1261 -AEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQS----KSIVAMPS----D 1316
             |...:|.:......|:..    ..|.....|:|::.|||..|.|..:    .:.::.||    :
Mouse   539 VAGPPQTVSNLWNSTHHVF----MHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYE 599

  Fly  1317 QVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVN- 1380
            .|.|.:.....|.|...:     |..|.|||            .||.         .::::.::
Mouse   600 GVDASLNETATTITVLLR-----PAQAKGAP------------ISAY---------QIVVEQLHP 638

  Fly  1381 ---RQDAGDYSCHA-----ENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVK------LKP 1431
               :::||...|:.     :|:::..:..:....|.|...|. ....|..|..|.|      |.|
Mouse   639 HRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPE-PAPFTVGDNRTYKGFWNPPLAP 702

  Fly  1432 HEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILN 1496
            .:|                                         |.:|....:::.....:..:.
Mouse   703 RKG-----------------------------------------YNIYFQAMSSVEKETKTQCVR 726

  Fly  1497 TRTKGQKPKLPE--------KPRFIEVSSNS----------------VSLHFKAWKDGGC----- 1532
            ..||....:.||        ..|.::::..|                |...:..|:...|
Mouse   727 IATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKRYICWRRHICIRNIR 791

  Fly  1533 ----PMSHFVVESKKRDQIEWN---QISNNVKP-DNNY--------------VVLD--------- 1566
                ..|:::..:|||.....|   ::::.|.. |.:|              ..:|
Mouse   792 RSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLP 856

  Fly  1567 ---------LEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPA 1622
                     |.|.|..|...||.:|....|..|      :..||.:|...    |.:|..||:..
Mouse   857 NDPLVPTAVLVPITDENHSATAESSRLLDVPRY------LCEGTESPYQT----GQLHPAIRVAD 911

  Fly  1623 WMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDK 1687
            .:..   :|.|                        :..|..|.:::  |:..:.   |..|:.|.
Mouse   912 LLQH---INLM------------------------KTSDSYGFKEE--YESFFE---GQSASWDV 944

  Fly  1688 RRPD---LRDELGYIAPPNRK---LPPV---PGSNYNTCDRIKRGRGGLRSNH-STW---DPRRN 1739
            .:.|   .::..|.|...:..   |.||   |.|:|            :.:|: ..|   |..:.
Mouse   945 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY------------INANYIDIWLYRDGYQR 997

  Fly  1740 PNLYEELKAPPVPMHGNHYGHAH-------------------GNAECHYRHPGMEDEICPYATFH 1785
            |:.|   .|...|:|...|....                   |..:|:...|   |:...|..|.
Mouse   998 PSHY---IATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFK 1056

  Fly  1786 LLGFREEMDPTKAMNFQTFP---------------HQNG---HAGPVPGHAGTML---------- 1822
            :...  ||:|......:||.               |..|   |.  ||.||..:|
Mouse  1057 VTCV--EMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHG--VPYHATGLLSFIRRVKLSN 1117

  Fly  1823 -PPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPA---------NCAEEDQYR 1877
             |...|..||..:|:                |::..|.......|.|         ||.:..:.|
Mouse  1118 PPSAGPIVVHCSAGA----------------GRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR 1166

  Fly  1878 RYTRVNSQ 1885
            |...|.::
Mouse  1167 RINMVQTE 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	9/40 (23%)
		I-set	819..914	CDD:254352	20/96 (21%)
		Ig	833..921	CDD:299845	18/89 (20%)
		FN3	918..1011	CDD:238020	25/99 (25%)
		FN3	1018..1116	CDD:238020	16/97 (16%)
		FN3	1124..1217	CDD:238020	11/92 (12%)
		FN3	1222..1312	CDD:238020	31/107 (29%)
		Ig	1339..1406	CDD:299845	11/75 (15%)
		FN3	1409..1499	CDD:238020	11/95 (12%)
		FN3	1504..1584	CDD:238020	23/148 (16%)
		Dscam_C	1890..2008	CDD:289151
Ptprk	XP_006512669.1	MAM	31..191	CDD:214533	8/33 (24%)
		IG	201..287	CDD:214652	17/90 (19%)
		fn3	296..370	CDD:365830	19/78 (24%)
		fn3	487..580	CDD:365830	32/98 (33%)
		PTP_DSP_cys	911..1189	CDD:391942	59/334 (18%)
		R-PTPc-K-2	1275..1480	CDD:350484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000