DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and DSCAM

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	2041	Identity:	610/2041 - (29%)
Similarity:	954/2041 - (46%)	Gaps:	178/2041 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAED 105
            |:......:.|:::||..:.|.|:|.|...:.|..:.|..:.||||:|.:..:|.|...||....
Human    26 FVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSS 90

  Fly   106 YRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFV 170
            :...:|...|.|.|.|..|.|.|:|||::||:.:.|...:.....:|||.|:.||.|||.|..::
Human    91 FSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYI 155

  Fly   171 NVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGR 235
            .|:||..| ..:...|:    ::|:..:|.|:|::|..|||..:|:|.|:||.|||||.| ...|
Human   156 TVVSWEKD-TVSLVSGS----RFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQS-NSAR 214

  Fly   236 LVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTRKQAVVL 300
            |.:::|..|....|.|..:::.:...|      |.|.|.|..:|.|.:||.|      ....:.|
Human   215 LFVSDPANSAPSILDGFDHRKAMAGQR------VELPCKALGHPEPDYRWLK------DNMPLEL 267

  Fly   301 NDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAV 365
            :.|.::....|:|::....|||.|:|.|:|..|...|...|.|..||.|.|.|.......|....
Human   268 SGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVS 332

  Fly   366 FTCQYTGNPIKTVSWMKDGKAIGHSEPV---------LRIESVKKEDKGMYQCFVRNDQESAEAS 421
            .:|..||...:.:||.::|:.:...:.|         |.::.:.|.|.|.||||||.|:.||:..
Human   333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY 397

  Fly   422 AELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVT 486
            .::.|  ....|.|..||.|:.:.|...|.|.|...|.|.|.|:|.||...|.....:::.|.:|
Human   398 VQVVL--EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460

  Fly   487 VNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTC 551
            ..|:|||||||:|....|||:|:|.|.:..||..:.|::||.|...||.|:....:||....:.|
Human   461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHC 525

  Fly   552 PVAGYPIDSIVWERDNRALPINRKQKVFP-NGTLIIENVERNSDQATYTCVAKNQEGYSARGSLE 615
            .|.|||..||.|.:::..||.|.:|..|. ||||.:.:|::..|:..|||....|...|...|:.
Human   526 RVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590

  Fly   616 VQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERS--AGDYG--FDQVQPQMRT 676
            |.|.|.|.|.||.: ...::|..:.:.|.:..||.||.:.|..:..  .|..|  .|.:
Human   591 VTVKVPPFIQPFEF-PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI------ 648

  Fly   677 NRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKV 741
                :.||.:.|.:.|..|.|..||||.|:|....:...|.|.|||:::::|.|:....|....:
Human   649 ----DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVIL 709

  Fly   742 ECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV-EEGTLHVDNIQKTNEGYYLCEAINGIGS 805
            .|.|:|:|.|.:.||.:.|....:::.:..:..|:| ..|:|.:.::.:.:.|||||:..|.:|:
Human   710 NCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774

  Fly   806 GLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIR 870
            .:|..:.::|:.|...|.......|.:|:...:.|.|.|||||.:.|...:..::|:. .||.:.
Human   775 DVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEM-ARYLVS 838

  Fly   871 EEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQ 935
            .:.:...|:|:|.|..|.|.||..|:|.|.|::|.|...|.:.|||.|:.| .:::.|...|::.
Human   839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTIT 902

  Fly   936 LSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRV-IVPGHTTEAQVQKLSPATTYNIRIVAENAIG 999
            |.|...:|||||:..|.||.|....||....|. .|......|.:..:.|::||:||:.|:|.||
Human   903 LRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIG 967

  Fly  1000 TSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSS 1064
            .|:.|..:||...|.||.|.||.:.:||::..::|||||.|.:...||.|.||.:||:..:|..:
Human   968 KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGN 1032

  Fly  1065 YVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTA 1129
            :.|..|: :...|......|.||..:|||.:|:||.|:.|.||.|:|....|.|..||.||.:..
Human  1033 FQFNIIS-VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ 1096

  Fly  1130 CTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPS--DEWYDETKRHYKKTASSDTVLHGLKKYT 1192
            ....:.::|.:.|.:...|:.||:::.::|:|..:  |....|.|.  ..|......|.||:|||
Human  1097 AIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKN--ITTTQPSLELDGLEKYT 1159

  Fly  1193 NYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTV 1257
            ||::||||.|..||||||..|..:|:.|||..|..|||.....:.:.|||.||.:.||||.:|||
Human  1160 NYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224

  Fly  1258 YSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKI 1322
            :.........::.:..|. ..|:....|.:|:.|..||.|.|:.|.|..|:.|...|..:.||:|
Human  1225 FCSHPYPTVISEFEASPD-SFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI 1288

  Fly  1323 ASFDDTFTATFKEDAKMPCLAVGAPQPEITW--KIKGVE--FSANDRMRVLPDGSLLIKSVNRQD 1383
            .:|..|.|..:.:|..:||.|||.|.|.:.|  ...|..  .:.:.|..:..:||.:|::|..:|
Human  1289 LTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED 1353

  Fly  1384 AGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKP 1448
            :|.|||.|.|:...|.|...|.|..||..|.:|:|.||:.::|:...|.:...:.:.||.|.|..
Human  1354 SGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSE 1418

  Fly  1449 EFGE-WETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKL-PEKPR 1511
            :..| |.:..:|...:.:.:|.|.||:.|:...|..|.:|.|..|:|:..:|.|::|:. .|:..
Human  1419 DNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQEL 1483

  Fly  1512 FIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLR 1576
            |..:::..|.|:...|.|||||::.|.:|.:......|. .:.......:|::.||:.||||.|:
Human  1484 FASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWT-TAQRTSLSKSYILYDLQEATWYELQ 1547

  Fly  1577 ITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVV 1641
            :...||||....:.:||||...|.||.||            |:......|.|..|..:.::.|:.
Human  1548 MRVCNSAGCAEKQANFATLNYDGSTIPPL------------IKSVVQNEEGLTTNEGLKMLVTIS 1600

  Fly  1642 VVAVGICVVCVAL---SRRRADDMRGGQKDV--YYDVVYNQTMGPGATLDKRRPDLRDELGYIAP 1701
            .:.||:.::.|.|   .|||.:......:|.  ..:::.::......||.|::..||   .:|..
Human  1601 CILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLR---MHIDI 1662

  Fly  1702 PNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPR-----RNPNLYEELKAPPVPM-HGNHYGH 1760
            |..:|            .|:.     |....|.|.|     .:.:..|..|...:.: |..||
Human  1663 PRAQL------------LIEE-----RDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHY-- 1708

  Fly  1761 AHGNAECHYRHPGMEDEICPYATFHLLGF---REEMDPTKAMNFQTFP-HQNGHAG------PVP 1815
                            :....||..|:..   |...:||...|.:..| .:|.:|.      |.|
Human  1709 ----------------QSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHP 1757

  Fly  1816 ---GHAGT---MLP-PGHPGHVHSRSGSQSMPRANRYQRKNSQ----GGQSSIYTPAPEYDDPAN 1869
               .|..|   .|| |...|.|...|.|.|:..:....|..|.    ...||.|.......:.|.
Human  1758 TISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAK 1822

  Fly  1870 CAEEDQYRRYTRV-----NSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRG 1929
            ..|:.::.::|..     ::....|.:|.. ||.|....:...:....::.....:|.|    .|
Human  1823 MEEQLRHAKFTITECFISDTSSEQLTAGTN-EYTDSLTSSTPSESGICRFTASPPKPQD----GG 1882

  Fly  1930 SMGRRSIGSARNPGNGSPEPP------------PPPPRNHDMSNSSFNDSKESN----------- 1971
            .:...::..|..||:....||            |...|:..:..:.....|...
Human  1883 RVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIP 1947

  Fly  1972 -EISEAECDRDHGPRGNYGAVKRSPQ 1996
             |.:.:......|.....|||...||
Human  1948 MEAASSASSTREGQSWQPGAVATLPQ 1973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	27/88 (31%)
		IG	57..133	CDD:214652	25/75 (33%)
		IG_like	267..343	CDD:214653	23/75 (31%)
		Ig	269..340	CDD:143165	22/70 (31%)
		IG_like	353..425	CDD:214653	22/80 (28%)
		IGc2	361..413	CDD:197706	17/60 (28%)
		I-set	433..527	CDD:254352	37/93 (40%)
		IGc2	446..517	CDD:197706	29/70 (41%)
		I-set	533..618	CDD:254352	31/85 (36%)
		IGc2	544..607	CDD:197706	24/63 (38%)
		Ig	641..714	CDD:143165	21/76 (28%)
		IGc2	735..804	CDD:197706	19/69 (28%)
		I-set	819..914	CDD:254352	29/94 (31%)
		Ig	833..921	CDD:299845	31/87 (36%)
		FN3	918..1011	CDD:238020	33/93 (35%)
		FN3	1018..1116	CDD:238020	37/97 (38%)
		FN3	1124..1217	CDD:238020	33/94 (35%)
		FN3	1222..1312	CDD:238020	30/89 (34%)
		Ig	1339..1406	CDD:299845	24/70 (34%)
		FN3	1409..1499	CDD:238020	27/90 (30%)
		FN3	1504..1584	CDD:238020	24/80 (30%)
		Dscam_C	1890..2008	CDD:289151	22/131 (17%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273	22/67 (33%)
		I-set	235..310	CDD:254352	24/86 (28%)
		I-set	315..385	CDD:333254	16/69 (23%)
		Ig_3	407..488	CDD:316449	34/80 (43%)
		IGc2	518..575	CDD:197706	21/56 (38%)
		I-set	596..686	CDD:333254	27/100 (27%)
		Ig_DSCAM	707..784	CDD:143211	20/76 (26%)
		Ig	802..889	CDD:325142	31/87 (36%)
		FN3	885..978	CDD:238020	32/93 (34%)
		FN3	986..1083	CDD:238020	37/97 (38%)
		FN3	1091..1184	CDD:238020	33/94 (35%)
		FN3	1189..1278	CDD:238020	30/89 (34%)
		Ig	1303..1369	CDD:319273	21/65 (32%)
		FN3	1380..1470	CDD:238020	26/89 (29%)
		FN3	1486..1555	CDD:238020	21/69 (30%)
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012		75/400 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810		23/91 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883		3/31 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4888
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	968	1.000	Inparanoid score	I322
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8541
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840