DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and egl-15

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	140/776 - (18%)
Similarity:	262/776 - (33%)	Gaps:	245/776 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 GLYKCIAKSKVGVAEHSAKLNVYGLPYIRQM--EKKAIVAGETLIVTCPVAGYPIDSIV-WERDN 567
            ||...::.|..|:..|..:    .:|..:.:  |:..:..|:.:...|..|...|.:.| |.|::
Worm    12 GLLSTVSCSLQGLTSHYRE----NIPRFKHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRND 72

  Fly   568 RALPINR--KQKVFPNGT---LIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPF 627
            :.|..::  |.|:..:..   |.::|:: .|||..::|...|..|..:|   ...|.|:.....|
Worm    73 KLLKNDQIDKDKIRKDNNRMMLHLKNID-VSDQGLWSCRVHNAYGQISR---NFTVEVIDFCDYF 133

  Fly   628 AYEDLINMGDSIDLFC-----------------------------QIQKGDRPIKVHWSFERSAG 663
            .:.|:.::...::..|                             .|.:..:|:.:...|    |
Worm   134 LFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCF----G 194

  Fly   664 DY---------------GFDQVQPQMRTNRISEKTSMISIP----SASPAHTGRDTCIASNK--- 706
            |:               |..:..|.::  |:..|...:.:|    ..||:.:..:...|..|
Worm   195 DHCKEFDTTPVSDFGLPGKPEDDPLVK--RVVLKKDDVIVPVHDSEESPSESRTEFINADEKENK 257

  Fly   707 ----------------AGTTTYSVDLTVNVPPRW------ILEPTDKAFAQGSDAKVECKADGFP 749
                            ||.|  .:::|...||.:      :|.....|...|...|:.|:|.|:|
Worm   258 EDEEEDYSVSQPVAPDAGLT--ELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNCRAKGYP 320

  Fly   750 KPQVTWKKAVGDTPGEYKDLKKSD------NIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSG-- 806
            :||:.|.|       ..|.||||.      ..:....:|.|::....:.|.:.|||:|.:||.
Worm   321 EPQIIWYK-------NGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKK 378

  Fly   807 -LSAVIMISVQAPPEFTEK-LRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDN---- 865
             ...:|:..::.||..... |.||:....:.|...|:...:....|:|    :|::..|.:
Worm   379 YFHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSDLLPHIIW----VRINKINGSYSYY 439

  Fly   866 ---------RYT-----IREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQE 916
                     .||     .:..:...|..|:|:|......|..::.|::.|:.|...|:..:.|.|
Worm   440 NNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNE 504

  Fly   917 VPEMPYALKVLDKSGRSVQLSWAQPYDGNSP-LDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQ 980
            .    .|:.:|               .|:.| :||           |:..|.:.     |...:.
Worm   505 F----MAIHLL---------------TGDEPKIDR-----------WTTSDYIF-----TTILLF 534

  Fly   981 KLSPATTYNIRIVA-----------ENAIGTSQSSEAVTII---------TAEEAPSGKPQNIKV 1025
            .|..||.:.|..:.           ::.:|.....:.|.:.         .:::.||  |..|::
Worm   535 LLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPS--PYQIQI 597

  Fly  1026 EPVNQTTMRVTWKPPPRTEWNGEILGYY-------------------------------VGYKLS 1059
            .....|......|...|......:|..|                               ..||.:
Worm   598 IETPITKKEAARKQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKET 662

  Fly  1060 NTN-----------SSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFN-KIGAGPL 1108
            ..|           |::..|.|:.::        |::..:|..::..|::... ..|||||
Worm   663 ENNEIAVAVKKLKMSAHEKELIDLVS--------EMETFKVIGEHENVLRLIGCCTGAGPL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	5/20 (25%)
		IGc2	446..517	CDD:197706	3/10 (30%)
		I-set	533..618	CDD:254352	20/92 (22%)
		IGc2	544..607	CDD:197706	17/68 (25%)
		Ig	641..714	CDD:143165	18/139 (13%)
		IGc2	735..804	CDD:197706	22/74 (30%)
		I-set	819..914	CDD:254352	21/113 (19%)
		Ig	833..921	CDD:299845	19/105 (18%)
		FN3	918..1011	CDD:238020	15/113 (13%)
		FN3	1018..1116	CDD:238020	21/134 (16%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	21/88 (24%)
		Ig	47..126	CDD:299845	20/82 (24%)
		Ig	302..382	CDD:299845	25/86 (29%)
		IG_like	306..384	CDD:214653	24/84 (29%)
		IG_like	401..502	CDD:214653	19/104 (18%)
		Ig3_FGFR	407..503	CDD:143175	17/99 (17%)
		PKc_like	627..933	CDD:304357	14/97 (14%)
		Pkinase_Tyr	640..928	CDD:285015	14/84 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000