DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and him-4

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	2323	Identity:	459/2323 - (19%)
Similarity:	774/2323 - (33%)	Gaps:	725/2323 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LAANPPDADQKG---------------------PVFLKEPTNRIDFSNSTGAEIECKASGNPMPE 70
            :.|.|.|||...                     |....:..:..:....|..||.|:..|.|.||
Worm  3002 MQATPEDADSYSCIAVNDAGGAEAVFQVTVNTPPKIFGDSFSTTEIVADTTLEIPCRTEGIPPPE 3066

  Fly    71 IIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHV-- 133
            |.|. .||..:.::||:.....|..|     |.::.:.....: |.|:|.|:.|. ..:|.:|
Worm  3067 ISWF-LDGKPILEMPGVTYKQGDLSL-----RIDNIKPNQEGR-YTCVAENKAGR-AEQDTYVEI 3123

  Fly   134 ----RAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVN---VISWHSDEKENFYPGTEYDG 191
                |.|::.....      |:.|....::|::      |.|   |::|..|       |..|..
Worm  3124 SEPPRVVMASEVMR------VVEGRQTTIRCEV------FGNPEPVVNWLKD-------GEPYTS 3169

  Fly   192 KYLVLPS--GELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGNGN 254
            ..|...:  ..||:||....|| .:|.|...:: .||:: :.|...:::...:......|.|
Worm  3170 DLLQFSTKLSYLHLRETTLADG-GTYTCIATNK-AGESQ-TTTDVEVLVPPRIEDEERVLQG--- 3228

  Fly   255 QEHITLTRVPKMGSVTLM-CPAQAYPVPFFRWYKFIEGTTRKQAVVLNDR-VKQVSGTLIIKDAV 317
                      |.|:..:: |.....|||:..|.:             |.: ::|.:..|.|::|.
Worm  3229 ----------KEGNTYMVHCQVTGRPVPYVTWKR-------------NGKEIEQFNPVLHIRNAT 3270

  Fly   318 VEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMK 382
            ..|.|||.|:.:|..|....:.::.|....:.:....|..:..|..|...|:..|:|..|:||:|
Worm  3271 RADEGKYSCIASNEAGTAVADFLIDVFTKPTFETHETTFNIVEGESAKIECKIDGHPKPTISWLK 3335

  Fly   383 DGKAIGHSEPV-------LRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQ 440
            .|:.......:       |.|...::.|.|:|.|...|....:|..        |...|..:.:.
Worm  3336 GGRPFNMDNIILSPRGDTLMILKAQRFDGGLYTCVATNSYGDSEQD--------FKVNVYTKPYI 3392

  Fly   441 EETMEPGP------SVFLKCVAGGNPTPEISWELDGKKIANNDRYQV----------------GQ 483
            :||::..|      .:.|||...|||||.::|:.....:.|:.|:.:                ||
Worm  3393 DETIDQTPKAVAGGEIILKCPVLGNPTPTVTWKRGDDAVPNDSRHTIVNNYDLKINSVTTEDAGQ 3457

  Fly   484 Y--VTVN-------------------------------GDVV----------------------- 492
            |  :.||                               .|.:
Worm  3458 YSCIAVNEAGNLTTHYAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPLPSISWFRGDKPV 3522

  Fly   493 ------------SYLNITSVHANDGGLYKCIAKSKVGVAEHSA-----------KLNVYGLPYIR 534
                        |::.|.....:|||.|.|.|.::.|.::...           |.|:.|.|.
Worm  3523 YLYDRYSISPDGSHITINKAKLSDGGKYICRASNEAGTSDIDLILKILVPPKIDKSNIIGNPL-- 3585

  Fly   535 QMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFP--NGTLIIENVERNSDQAT 597
                 |||| .|:.:.||::|.|...::|.::...:.:...:.:..  |.|..||||: .:||..
Worm  3586 -----AIVA-RTIYLECPISGIPQPDVIWTKNGMDINMTDSRVILAQNNETFGIENVQ-VTDQGR 3643

  Fly   598 YTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINM-GDSIDLFCQIQK----GDRPIKVHWS 657
            |||.|.|:.| .|.....:.|:..|:......:..|.. ||:|.|.|.|:.    .|:.:.|.|:
Worm  3644 YTCTATNRGG-KASHDFSLDVLSPPEFDIHGTQPTIKREGDTITLTCPIKLAEDIADQVMDVSWT 3707

  Fly   658 FE----------------------------RSAG---------------------------DYGF 667
            .:                            .:||                           |...
Worm  3708 KDSRALDGDLTDNVDISDDGRKLTISQASLENAGLYTCIALNRAGEASLEFKVEILSPPVIDISR 3772

  Fly   668 DQVQPQMRTN--------------------------------RISEKTSMISIPSASPAHTGRDT 700
            :.||||:..|                                ||.|:..::.|......|.|:.:
Worm  3773 NDVQPQVAVNQPTIMRCAVTGHPFPSIKWLKNGKEVTDDENIRIVEQGQVLQILRTDSDHAGKWS 3837

  Fly   701 CIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKA---VGDT 762
            |:|.|.||.....:.|.|..||...::..:...|.|....:.|.|.|.|.||:.|.|.   :.|:
Worm  3838 CVAENDAGVKELEMVLDVFTPPVVSVKSDNPIKALGETITLFCNASGNPYPQLKWAKGGSLIFDS 3902

  Fly   763 PGEYKDLKKSDNIRV--EEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKL 825
            |         |..|:  :...|.:.:::||:.|.|.|:|:|..|:. .|.:.:.|..|||.....
Worm  3903 P---------DGARISLKGARLDIPHLKKTDVGDYTCQALNAAGTS-EASVSVDVLVPPEINRDG 3957

  Fly   826 RNQTARRGEPA----VLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKR 886
            .:.:.|.  ||    .|||.|:|:....:.|.:|...|...... .|:..:      .:.:.|..
Worm  3958 IDMSPRL--PAQQSLTLQCLAQGKPVPQMRWTLNGTALTHSTPG-ITVASD------STFIQINN 4013

  Fly   887 TERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRY 951
            ...||..::||.|.|..|||:...|:.|.:.|       |:...|..      |..:|...:...
Worm  4014 VSLSDKGVYTCYAENVAGSDNLMYNVDVVQAP-------VISNGGTK------QVIEGELAVIEC 4065

  Fly   952 IIE-FKRSRASWSEIDRVIVPG-----HTTEAQVQKLSPATTYNIRIV---AENAIGTSQSSEAV 1007
            ::| :...:.||......:..|     :.|:.::..:..|.:.:..|.   |.|..|::|.:..:
Worm  4066 LVEGYPAPQVSWLRNGNRVETGVQGVRYVTDGRMLTIIEARSLDSGIYLCSATNEAGSAQQAYTL 4130

  Fly  1008 TIITAEEAPSGKPQNIKVEPVNQTTM--RVTWKPPPRTEW--NG-EILGYYVGYKLSNTNSSYVF 1067
            .::.:.:..:..|..:.....::.::  .|...|.|...|  || :|.....|:.:....:.::
Worm  4131 EVLVSPKIITSTPGVLTPSSGSKFSLPCAVRGYPDPIISWTLNGNDIKDGENGHTIGADGTLHI- 4194

  Fly  1068 ETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTA--------------E 1118
                   |:.:|.:|      :|.     ..|.|..||..|....:...|              |
Worm  4195 -------EKAEERHL------IYE-----CTAKNDAGADTLEFPVQTIVAPKISTSGNRYINGSE 4241

  Fly  1119 GTPSQPPSDTACTTLTSQTIRVGWV--SPPLESANGVI--KTYKVVYAPSDEWYDETKRHYKKTA 1179
            ||.:....:     :.|::....|.  ..||..:|.:|  :.||::...|....|:.:  |..||
Worm  4242 GTETVIKCE-----IESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGE--YSCTA 4299

  Fly  1180 SSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSW-R 1243
            ::                     ..|:..:...::....|.:.|.|   :..|:.....:..| .
Worm  4300 AN---------------------KAGNATQKTNLNVGVAPKIMERP---RTQVVHKGDQVTLWCE 4340

  Fly  1244 PPAQPNGIITQY---TVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPY----EFWVTASTTI 1301
            ....|...||.|   .:.:.....||.|..:|    .:.|.:....:...|    |.|| |||.
Worm  4341 ASGVPQPAITWYKDNELLTNTGVDETATTKKK----SVIFSSISPSQAGVYTCKAENWV-ASTE- 4399

  Fly  1302 GEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITW-KIKGVEFSANDR 1365
               :....||.:|.:.||.::     ..:...::...:.|.|.|.|:|.|:| :...:....|::
Worm  4400 ---EDIDLIVMIPPEVVPERM-----NVSTNPRQTVFLSCNATGIPEPVISWMRDSNIAIQNNEK 4456

  Fly  1366 MRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAP--------------------- 1409
            .::| ..:|.|::|...|.|.|.|.|::...:...|.||||..|
Worm  4457 YQIL-GTTLAIRNVLPDDDGFYHCIAKSDAGQKIATRKLIVNKPSDRPAPIWVECDEKGKPKKTE 4520

  Fly  1410 -------------------------------------PQSPHVTL----------SATTTDAL-- 1425
                                                 |:|....|          ...||.|:
Worm  4521 YMIDRGDTPDDNPQLLPWKDVEDSSLNGSIAYRCMPGPRSSRTVLLHAAPQFIVKPKNTTAAIGA 4585

  Fly  1426 TVKLK------PHEGDTAPLHG----------------YTLHYKPEFGEWE------------TS 1456
            .|:|:      ||...|....|                .||:...:.||:.            ::
Worm  4586 IVELRCSAAGPPHPTITWAKDGKLIEDSKFEIAYSHLKVTLNSTSDSGEYTCMAQNSVGSSTVSA 4650

  Fly  1457 EVSVD----------SQKHNIEGLLCGSRYQVYATG------------------FNNIGAGEASD 1493
            .::||          |.:.|:..:.|..|.|.|:.|                  |.|.|:....|
Worm  4651 FINVDNNILPTPKPSSNQKNVAVITCYERNQAYSRGLTWEYNGVPMPKNLAGIHFMNNGSLVILD 4715

  Fly  1494 I--------------LNTRTKGQKPKL-------PEKPRFIEVSSN---SVSLHFKAWKDGGCPM 1534
            .              :..|.:...|.|       ||.....:|..|   ||.|..:...|   |:
Worm  4716 TSSLKEGDLELYTCKVRNRRRHSIPHLTSAFEGVPEVKTIDKVEVNNGDSVVLDCEVTSD---PL 4777

  Fly  1535 SHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAG-------FTVAEYDF 1592
            :..||.: |.||...:..:..|.|:|:.|:|::|.......:..|.||.|       ..|.|.||
Worm  4778 TTHVVWT-KNDQKMLDDDAIYVLPNNSLVLLNVEKYDEGVYKCVASNSIGKAFDDTQLNVYEGDF 4841

  Fly  1593 ATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFM-------------VPLIATVVVVA 1644
            ..||...|:...:||.|..|....|   .|:..|..|.:..             .||..|::.
Worm  4842 LPLTGFEGSGINIDDSSNAGGSSRR---EAYKKENEDASTTTITTTSPTTTTTETPLTTTIIP-- 4901

  Fly  1645 VGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGA--TLDKRRPDLRDELGYI-------A 1700
               .::.:...:...||...|..:       :...||..  :|.:..|.|..|:..:       .
Worm  4902 ---ALITLPAKQYPTDDYHEGSAN-------DDGFGPTTQDSLFEFNPPLHPEISVVNTDCAGTI 4956

  Fly  1701 PPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPN--LYEELKA----PPVPMHGNHYG 1759
            ..|.......|..:|.  :|..|     .||.......||:  :.|:|..    .|......:|
Worm  4957 NENGDCVDKDGKTHNL--KILTG-----ENHCPEGFAMNPHTRICEDLDECAFYQPCDFECINY- 5013

  Fly  1760 HAHGNAECHYRHPGMEDEICPY------------------------ATFHLLGFREEMDPTKAMN 1800
              .|..:|:          ||.                        |.|:.||..|.:|.....|
Worm  5014 --DGGFQCN----------CPLGYELAEEGCRDVNECESVRCEDGKACFNQLGGYECIDDPCPAN 5066

  Fly  1801 FQTFPH-------QNGHAGPVPGHAGTMLPPGHP-GHV-----HSRSG 1835
            :.....       :|..:.|:..|. ..:|.|.| .|:     :.:||
Worm  5067 YSLVDDRYCEPECENCTSTPIQVHM-LAIPSGLPISHIATLTAYDKSG 5113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	23/112 (21%)
		IG	57..133	CDD:214652	22/75 (29%)
		IG_like	267..343	CDD:214653	18/77 (23%)
		Ig	269..340	CDD:143165	17/72 (24%)
		IG_like	353..425	CDD:214653	19/78 (24%)
		IGc2	361..413	CDD:197706	16/58 (28%)
		I-set	433..527	CDD:254352	31/194 (16%)
		IGc2	446..517	CDD:197706	26/160 (16%)
		I-set	533..618	CDD:254352	25/86 (29%)
		IGc2	544..607	CDD:197706	19/64 (30%)
		Ig	641..714	CDD:143165	25/163 (15%)
		IGc2	735..804	CDD:197706	21/73 (29%)
		I-set	819..914	CDD:254352	25/98 (26%)
		Ig	833..921	CDD:299845	24/91 (26%)
		FN3	918..1011	CDD:238020	16/101 (16%)
		FN3	1018..1116	CDD:238020	18/102 (18%)
		FN3	1124..1217	CDD:238020	14/96 (15%)
		FN3	1222..1312	CDD:238020	21/97 (22%)
		Ig	1339..1406	CDD:299845	20/67 (30%)
		FN3	1409..1499	CDD:238020	30/235 (13%)
		FN3	1504..1584	CDD:238020	25/89 (28%)
		Dscam_C	1890..2008	CDD:289151
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652
		Ig	628..694	CDD:319273
		I-set	702..789	CDD:369462
		I-set	793..881	CDD:369462
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229
		IGc2	1563..1628	CDD:197706
		Ig	1651..1732	CDD:386229
		Ig	1755..1818	CDD:319273
		Ig	1839..1912	CDD:386229
		Ig	1930..2002	CDD:386229
		IG_like	2014..2095	CDD:214653
		Ig	2094..2182	CDD:386229
		Ig	2190..2283	CDD:386229
		I-set	2296..2380	CDD:369462
		Ig	2384..2471	CDD:386229
		IGc2	2492..2556	CDD:197706
		Ig	2580..2654	CDD:386229
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653	5/28 (18%)
		I-set	3046..3116	CDD:369462	22/77 (29%)
		I-set	3127..3213	CDD:369462	24/107 (22%)
		Ig	3217..3292	CDD:386229	21/100 (21%)
		I-set	3300..3386	CDD:369462	20/93 (22%)
		I-set	3396..3472	CDD:369462	17/75 (23%)
		I-set	3481..3569	CDD:369462	10/87 (11%)
		I-set	3591..3663	CDD:369462	21/73 (29%)
		Ig	3667..3762	CDD:386229	13/94 (14%)
		Ig	3775..3848	CDD:386229	16/72 (22%)
		Ig	3859..3947	CDD:386229	25/97 (26%)
		IGc2	3968..4031	CDD:197706	16/69 (23%)
		Ig_3	4045..4119	CDD:372822	13/86 (15%)
		Ig_3	4136..4210	CDD:372822	14/92 (15%)
		Ig	<4262..4314	CDD:386229	12/74 (16%)
		Ig	4318..4406	CDD:386229	21/99 (21%)
		IG_like	4418..4496	CDD:214653	20/78 (26%)
		I-set	4570..4654	CDD:369462	13/83 (16%)
		I-set	4752..4836	CDD:369462	22/87 (25%)
		EGF_CA	4996..5027	CDD:238011	7/43 (16%)
		EGF_CA	5034..5076	CDD:214542	7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910