DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and igcm-2

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	201/907 - (22%)
Similarity:	328/907 - (36%)	Gaps:	229/907 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 FVRNDQESAEASAEL-KLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKI 473
            |:|...:..|..|.. |.|.....|.....|.||:.                  .:.|..||:.|
Worm    10 FIRRQTDDGEMKAYWGKAGAPITLPCSISLFNEESF------------------SLDWRKDGQLI 56

  Fly   474 ANNDRYQVGQYV-TVNGDVV--SYLNIT--SVHANDGGLYKCI--------AKSKVGVAEHSAKL 525
            .:....:.|... |:.|.:.  .:|.||  ||...|.|:|:||        .:.:.|:   ||||
Worm    57 LSAFGQEQGHVTPTLQGRLARDGFLGITIHSVTDGDAGVYQCIVTKFSKQPTRPEKGL---SAKL 118

  Fly   526 NVYGLPYIRQMEKKAIV---AGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIE 587
            .|...|.|....|.||:   .|..||..|...|.|...|.|.|:        :|.:..:..|.:.
Worm   119 VVNVPPVIISPSKNAIIHKKVGADLIFECKAEGAPSPEITWSRN--------EQIISTSPVLTLS 175

  Fly   588 NVERNSDQATYTCVAKNQEGYSARGSLEVQV--MVLPQIVPFAYEDLINMGDSIDLFCQIQKGDR 650
            |:| ..|:..|||:|.|.||.|. .|::|:.  ..:..::|.  ...:..|.::...|.......
Worm   176 NLE-EGDKGLYTCLAVNIEGNST-SSIDVRFTKATILDLIPL--NKTVIEGSNVFWHCHANAQAT 236

  Fly   651 PIKVHWSFERSAGDYGFDQVQPQMRTN---RISEKTSMISIPSASPAHTGRDTCIASNKAGTTTY 712
            .|...|.||:          :|...|:   |.:.::..:|:.....:.:|..||.|.|.||.||.
Worm   237 AISYSWLFEK----------KPIKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEAKNSAGETTS 291

  Fly   713 SVD-LTVNVPPRWILEPTD-----KAFAQGSDAKVECKADGFPKP-QVTWKKAVGDTPGEYKDLK 770
            |.. |.|..||    ||..     :..|.|.:..|.|.....|.| ..||.|     .|.|...:
Worm   292 STAYLHVFYPP----EPLSSHQPVQTVASGRNTTVSCDVIANPTPTSYTWSK-----NGHYLPTQ 347

  Fly   771 KSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQ-TARRGE 834
            .|.:|.:...       :..:.|.|.|:|.|..|.|......:.|..||.||....:: ..|.|:
Worm   348 ASSHIIISYA-------KPGDGGIYGCQADNIAGKGSIVETHLIVAEPPVFTVAPPSEIKVRLGD 405

  Fly   835 PAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVA 899
            ...:.|:..|:....:.|..:..|::                  .|:|:.|:.|..|...:.||.
Worm   406 QVSIPCQGFGDPMPIVYWIRDKKRIN------------------QSTLTFKKVEHLDHGAYECVV 452

  Fly   900 TNAFGSDDASINMIVQ-EVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRA--- 960
            .|:..:....:.::|: ..|:|..::|....:..|:::||...|:|.         |.::.|
Worm   453 ANSVETISTRVMLLVEITKPQMASSIKFTCLNSSSMRISWTPGYNGG---------FDQTFAVHA 508

  Fly   961 ------SWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGK 1019
                  .|:.|...:     .|..:..|.|..:|.:.|.:.||.|::.|:
Worm   509 QNDVTLQWTSIKTSL-----NETILDHLEPFVSYRVSIESVNAKGSTNST--------------- 553

  Fly  1020 PQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYK-----LSNTNSSYVFETINFITEEGKE 1079
                            |:.....|..:.....|:.||.     .:...|||..|:   .||..|.
Worm   554 ----------------TYNRRSCTSLHAPDKLYFCGYNELCWTAAEGASSYRIES---RTEPSKN 599

  Fly  1080 HNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQ--FTAEGT-PSQPPSDTACTTLTSQTIRVG 1141
                      :...:.|::.:.::|..  .:|.||  |....| ||.|||:      .|..:|.|
Worm   600 ----------FQPLAEVLETYYRLGKD--VDETKQTIFRVRSTRPSYPPSE------PSNALRYG 646

  Fly  1142 W---VSPP---LESANGVIKTYKV-VYAPSDEW---YDETKR-HYKKTASSDTVLHGLKKYTNYT 1195
            .   |..|   |.:..|::..:.. ::|    |   :::.|: ..:|:.|:.|.....:.|..:|
Worm   647 IADNVDLPIFMLAAVFGLLFCFACGLFA----WRCFHNKNKKSKRRKSRSNSTPSKTYQDYGRFT 707

  Fly  1196 MQVLATTAGGDGVRSVPIHCQT--EPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQY 1255
            .        |||..|.....:|  ||.:        .|:..:     .||.|.....:..:|
Worm   708 Y--------GDGSSSSQPGTETYYEPSL--------RLLDDH-----EWRGPRDLEPVAVRY 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	4/15 (27%)
		IGc2	361..413	CDD:197706	1/2 (50%)
		I-set	433..527	CDD:254352	26/106 (25%)
		IGc2	446..517	CDD:197706	17/83 (20%)
		I-set	533..618	CDD:254352	28/87 (32%)
		IGc2	544..607	CDD:197706	19/62 (31%)
		Ig	641..714	CDD:143165	18/75 (24%)
		IGc2	735..804	CDD:197706	17/69 (25%)
		I-set	819..914	CDD:254352	17/95 (18%)
		Ig	833..921	CDD:299845	15/88 (17%)
		FN3	918..1011	CDD:238020	21/101 (21%)
		FN3	1018..1116	CDD:238020	17/104 (16%)
		FN3	1124..1217	CDD:238020	22/103 (21%)
		FN3	1222..1312	CDD:238020	5/34 (15%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	23/95 (24%)
		Ig	124..200	CDD:386229	27/85 (32%)
		IG_like	214..298	CDD:214653	22/95 (23%)
		Ig_3	309..371	CDD:372822	17/73 (23%)
		Ig	389..467	CDD:386229	17/95 (18%)
		FN3	476..548	CDD:238020	17/85 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810