DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	802	Identity:	179/802 - (22%)
Similarity:	322/802 - (40%)	Gaps:	177/802 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 SVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWM--KDGKAIGHSEPVLRIES 398
            |.:.:|.||..|| |::     :..|....|||...|.| :::.|.  :..|.|.....:|:.|.
Mouse    16 SGQALLQVTISLS-KVE-----LSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVMLQKEG 73

  Fly   399 VKK---------EDKGMYQCFVRNDQ-ESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLK 453
            |:.         ||.|:|:|...:.: ::.||:..|::   :.....|:....:..:.|....:.
Mouse    74 VRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI---YQKLTFREVVSPQEFKQGEDAEVV 135

  Fly   454 CVAGGNPTPEISWELDGKKIAN--NDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKV 516
            |....:|.|.:||....:::..  ::|:.    |..|.:    |.|.:::.:|.|:|:|..:.:.
Mouse   136 CRVSSSPAPAVSWLYHNEEVTTIPDNRFA----VLANNN----LQILNINKSDEGIYRCEGRVEA 192

  Fly   517 -GVAEHSAKLNVYGLPYIRQMEKKAIVA----GETLIVTCPVAGYPIDSIVWERDNRALPINRKQ 576
             |..:....:.:..:|....|.:|:..|    ||.:.:||..:|.|..:|.|
Mouse   193 RGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKASGSPDPTISW------------- 244

  Fly   577 KVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGS-LEVQVMVLPQIVPFAYEDLINMGDSID 640
              |.||.||.||                 |.|..:|| .|:.|           .::||
Mouse   245 --FRNGKLIEEN-----------------EKYILKGSNTELTV-----------RNIIN------ 273

  Fly   641 LFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASN 705
                               :..|.|                                  .|.|:|
Mouse   274 -------------------KDGGSY----------------------------------VCKATN 285

  Fly   706 KAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLK 770
            |||.......|.|.|.|. ||:..::..::.....:.|:|:|.|.|::|||:|:...  .:.:..
Mouse   286 KAGEDQKQAFLQVFVQPH-ILQLKNETTSENGHVTLVCEAEGEPVPEITWKRAIDGV--MFSEGD 347

  Fly   771 KSDNIRVE------EGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQT 829
            ||.:.|:|      ..:||:.:::.::.|.|.|||.:.|| |....:.:.::..|:|   :.|||
Mouse   348 KSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIG-GHQRSMHLDIEYAPKF---VSNQT 408

  Fly   830 ---ARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSD 891
               :..|.|..:.|:.....|..|.|....:.|..||    |...:..|.|....|.|..|..:|
Mouse   409 MYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKN----TTHLKTHSVGRKMILEIAPTSDND 469

  Fly   892 SALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYD-GNSPLDRYIIEF 955
            ...:.|.|||..|:......:.:.:||..|:.:|:::.|..:.::|:.:|.. |..|:..|.::.
Mouse   470 FGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDV 534

  Fly   956 KR-SRASWSEIDRVIVPGHTTEAQV--QKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPS 1017
            |. :..:|.     ||..|..:..|  ..|.|.|||.||:.|.|..|....|: :.|........
Mouse   535 KEVASETWK-----IVRSHGVQTMVVLSSLEPNTTYEIRVAAVNGKGQGDYSK-IEIFQTLPVRE 593

  Fly  1018 GKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNL 1082
            ..|.:|..:|.:..:.:::  ...:.:....||.|.|.|:..:....::.:.:     :|.:.::
Mouse   594 PSPPSIHGQPSSGKSFKIS--ITKQDDGGAPILEYIVKYRSKDKEDQWLEKKV-----QGNKDHI 651

  Fly  1083 ELQNLRVYTQYSVVIQAFNKIG 1104
            .|::|:....|.|.|.|.|::|
Mouse   652 ILEHLQWTMGYEVQITAANRLG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	2/6 (33%)
		Ig	269..340	CDD:143165	1/3 (33%)
		IG_like	353..425	CDD:214653	19/83 (23%)
		IGc2	361..413	CDD:197706	17/62 (27%)
		I-set	433..527	CDD:254352	17/96 (18%)
		IGc2	446..517	CDD:197706	15/73 (21%)
		I-set	533..618	CDD:254352	23/89 (26%)
		IGc2	544..607	CDD:197706	15/62 (24%)
		Ig	641..714	CDD:143165	8/72 (11%)
		IGc2	735..804	CDD:197706	20/74 (27%)
		I-set	819..914	CDD:254352	26/97 (27%)
		Ig	833..921	CDD:299845	23/87 (26%)
		FN3	918..1011	CDD:238020	27/96 (28%)
		FN3	1018..1116	CDD:238020	17/87 (20%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	26/100 (26%)
		I-set	22..111	CDD:254352	25/95 (26%)
		I-set	117..193	CDD:254352	16/83 (19%)
		IGc2	128..189	CDD:197706	15/68 (22%)
		Ig	208..301	CDD:299845	37/194 (19%)
		I-set	215..298	CDD:254352	34/184 (18%)
		Ig	300..397	CDD:299845	27/100 (27%)
		IG_like	308..395	CDD:214653	23/89 (26%)
		IG_like	413..491	CDD:214653	21/81 (26%)
		IGc2	414..482	CDD:197706	20/71 (28%)
		FN3	496..588	CDD:238020	27/97 (28%)
		fn3	594..678	CDD:278470	17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900