DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and dig-1

DIOPT Version :10

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001366805.1 Gene:dig-1 / 175951 WormBaseID:WBGene00000998 Length:13084 Species:Caenorhabditis elegans


Alignment Length:2371 Identity:475/2371 - (20%)
Similarity:760/2371 - (32%) Gaps:837/2371 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 CGSQTLAANPPDADQKGPVFLKEP-TNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVP 85
            ||.:...:.||         :..| ..:...|.::|.|| |..|.:.:         .|:..||.
 Worm    86 CGMEEEVSAPP---------IPPPDEGKCIISKASGREI-CYPSYSQL---------DTSCTDVT 131

  Fly    86 GLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHY-EEDIH--- 146
            |.   ||:| ||.||.       ..||.|.|.       :.:..| ::|.::.|:| ::..|   
 Worm   132 GQ---SSNG-LVVPPV-------VPHATVRAM-------AFVPPD-NLRRLIIQYYRQQGKHQPK 177

  Fly   147 ------KAFVIRGNSAILKCDIPSFVADFVNVI-----SW------------------------- 175
                  |:|:.    ....||....:.|.|:.:     .|                         
 Worm   178 NATFSPKSFLF----VKYHCDYGYEMVDEVDTMFCQDKKWVMTPPMCRGQGLCAADNGGCSHTCI 238

  Fly   176 -HSDEK-ENFYP---GTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKG- 234
             ::||| |...|   ..:.|.|..:.|.         |:...:|....|.:.:| ||:.:.:.| 
 Worm   239 SYNDEKIECKCPRGMTLDVDEKTCIKPI---------PKSLCRSLSGCTCNGIT-ETQFACSCGD 293

  Fly   235 -----RLVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTR 294
                 .|:...|...:.||    |..|      |...|::.:.|.:.|||.|...|:|       
 Worm   294 NKQKCLLIAGPPRIYIEPQ----GPYE------VAPGGNINISCTSVAYPFPDIYWFK------- 341

  Fly   295 KQAVVLNDRVK---------QVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAP---- 346
                  |.:|.         :.|..||||:  :..:.::.||.:|..|..:....:.||.|    
 Worm   342 ------NQKVNTDGPDQNTLRASQILIIKE--IYRNEEFTCVSDNIHGSANRTVSIVVTGPGSAP 398

  Fly   347 -----------LSAKIDPPTQTVDFGRP-AVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESV 399
                       |:.:.:||:   ...|| ..:|..||.||.:.|   |:.|.:...||...:...
 Worm   399 HLKSASAGRTSLTVRWEPPS---IINRPITTYTLYYTNNPQQPV---KNWKKLEVKEPTREVAIP 457

  Fly   400 KKEDKGMYQCFVR-NDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGG--NPT 461
            .......|...|| ||          .||    |..:....|.:|::|....::..|.|.  ...
 Worm   458 DLRPDTAYYIRVRAND----------PLG----PGKLGNQVQIKTLKPAVRPYVNIVEGDEIRVP 508

  Fly   462 PEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLN 526
            |..::|:|                         .|:|...                         
 Worm   509 PMTAFEID-------------------------CNVTRAD------------------------- 523

  Fly   527 VYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKV----FPNGTLIIE 587
                                          |:..:||....|  |:|:..|.    ..||.::  
 Worm   524 ------------------------------PVPVLVWLHKGR--PLNKGSKTQHIKMKNGGVL-- 554

  Fly   588 NVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFC---QIQKGD 649
                  :...::|||:|:.|.|.:   ::.|.|.....|......|: ||.:.|..   ||..| 
 Worm   555 ------ESTQFSCVAENEAGKSTK---KINVTVTGPSAPERIRYQID-GDKVTLQWEPPQITNG- 608

  Fly   650 RPIKVHWSFERSAGDYGFDQVQ------PQMRTN---RISEKTSMISIPSASPAHTGRDTCIASN 705
             |:..:..|.........||.:      |..||.   |::|||....:            .:..|
 Worm   609 -PMAGYDVFYTEDPSLPRDQWKVHHIDDPNARTTTVLRLNEKTPYTFV------------IVGRN 660

  Fly   706 KAGTTTYSVDLTVNV-----PPRWILEPTDKAFAQGSDAK--VECKADGFPKPQVTWKKAVGDTP 763
            :.|....|...|...     ||...|||:::...:.|:.:  :||.|.|.|||::.|        
 Worm   661 RLGPGLPSAPFTATTWLAAKPPVVQLEPSEEMTKEPSNDEMIIECGAQGVPKPKIIW-------- 717

  Fly   764 GEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQ 828
                         :..|||    |:...|.:.:.:.                 .|.:..::.|  
 Worm   718 -------------LWSGTL----IEDGKEEFRVYDT-----------------TPTDAQDRTR-- 746

  Fly   829 TARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSA 893
                                                               |.|..:.|.||..|
 Worm   747 ---------------------------------------------------SKLIAQSTTRSGVA 760

  Fly   894 LFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSV-----------QLSWAQPYDGNSP 947
              ||.|.|:.|||:       ::||     :|:|......:           .::|..|...|..
 Worm   761 --TCQAVNSEGSDE-------KKVP-----VKILGPGSAPLGITPTPMHTGFDVAWKPPKVTNGR 811

  Fly   948 LDRYIIEF-KRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIIT 1011
            :..|::.: |...|..|:.:...||..|....|......|.|.:::.|....|....|||..:.|
 Worm   812 ITDYVVYYSKDPDAPLSDWESKTVPADTRNLTVNVDDEDTPYVVKVQARTDDGPGIISEAYEVTT 876

  Fly  1012 AEEA-----------PSGKPQNIK--VEPVNQTTMR--VTWKPPPRTEWNGEILGYYVGYKLSNT 1061
            ..:.           ||..|...:  |||......|  ...:|.|                    
 Worm   877 GRKQVPLSVRLEIADPSVDPSTGETIVEPTQPIHFRCVADGRPMP-------------------- 921

  Fly  1062 NSSYVFETINFITEEGKE------HNLELQ-----NLRVY----TQYSVVIQAFNKIGAGPLSEE 1111
            :.||.:..|| .:|.|.|      |:.:.|     :::||    |:..::.||.|..|    :.:
 Worm   922 SVSYSWLPIN-ASESGDEPVPIPIHSDDSQPHHYNSIQVYSTTATKRILLCQARNPDG----TVD 981

  Fly  1112 EKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYA-----PSDEW---- 1167
            ::.......|...|.:..........:.:.| .|| :..||.|.:|.|...     |.|:|    
 Worm   982 DRHVFIVNKPGSAPQNPEVIVDPDNRVTITW-QPP-KYPNGEITSYNVYITGDPSLPVDQWQVFP 1044

  Fly  1168 YDETKRHYKKTASSDTVLH--GLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVP-EAPTDVK 1229
            .|:       ......||.  .|:..|.|.:::.|....|:|:.:.|.|..|....| :|||||.
 Worm  1045 VDD-------VTDPKLVLQRGALQPETPYFVKIAAVNPHGEGIHTDPKHFDTVSGAPIDAPTDVL 1102

  Fly  1230 ALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKT-QKV--------PHYQMSFEATEL 1285
            ..|..:..:.::|.||.||.|.|..||||...|..:::.|| |::        .|.:::....:.
 Worm  1103 PSVSIDNTVNITWSPPTQPLGPIKSYTVYFAPEYDDSDFKTWQRISVDAPDGADHGEVTLPKEQF 1167

  Fly  1286 EKNKPYEFWVTASTTIGEGQQSKSI-VAMPSDQVPAKIA--SFDDTFTATFKEDAKMPCLAVGAP 1347
            ..|.||:..::|:..:.||..|..: ....|.::|..|.  ..:.|:|......|.:.|.|.|.|
 Worm  1168 NPNTPYKIRISATNDLSEGPASDPVRFETGSGEIPPTITLDPSNSTYTVEPLGAATITCTATGVP 1232

  Fly  1348 QPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQS 1412
            ||::.| ||....:.:.....|.|   |:|..:.      :|.|||:..|......:.|..|..:
 Worm  1233 QPKVHW-IKANGETVDSATLQLYD---LVKDTSA------TCVAENNAGKTQEAVSIQVTGPGTA 1287

  Fly  1413 PH-VTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGE-------WETSEVSVDSQKHNIEG 1469
            |: :.|.......:.|:....:.....:..|.:|| .|..|       |:...::.|...|.:..
 Worm  1288 PNEIVLLPMPNQEINVEWTSPDEVNGQITNYIIHY-GEISEDGSEPATWDQVTIARDDVNHKLAN 1351

  Fly  1470 LLCGSRYQVYATGFNNIGAG--EASDILNTRTKGQKPKLPEKPR-----FIEV-SSNSVSLHFKA 1526
            |.....|.:.....::.|.|  .|..::.|        ||..|:     .|:| .:|||::.|..
 Worm  1352 LEPKKTYAIRVQAVSDRGPGVISAPQVIKT--------LPLAPQAITNPIIQVHPNNSVTIEFTP 1408

  Fly  1527 WKD---GGCPMSHFVV----ESKKRDQIEWNQI---SNNVKPDNNYVVLDLE---PATWYNLRIT 1578
            ..|   .|..:..||:    :.:..|:..|.::   ..:...|...|.:|.|   |.|.||.||.
 Worm  1409 PDDPENPGKKVKDFVIQYTTDEEPDDESVWKELKFTDPDDTDDTTIVSIDGENFNPDTKYNTRII 1473

  Fly  1579 AHNSAGFTVAEYDFATLTVTG-GTIAPLDDGSGHGNVHTR---IRLPAW-------------MPE 1626
            |.   |...::.:..||..|| |.|||.....   ||.|.   ||:||.             .|:
 Worm  1474 AR---GEIDSQPNEPTLFATGDGVIAPSQPSF---NVDTEDGVIRVPAGTDYTIKCVSEGYPAPD 1532

  Fly  1627 --WLDLNFMV----PLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGAT- 1684
              |:|.:...    ||: .::.:...:...|:|       :.|||.|:....:.   ..|||.. 
 Worm  1533 VRWVDSHGNQLSDGPLL-RIIDIRKTLNAKCLA-------ENRGGLKETDLTIF---VAGPGTAP 1586

  Fly  1685 ------------------------------------LDKRRPDLRDELGYI-------------- 1699
                                                ||.:.||  .:||.:              
 Worm  1587 ENIQLTANKPTTISVQYEVPSIPNGNISKYIIYYTPLDDQDPD--HQLGQVQTKPISDWQNVHDM 1649

  Fly  1700 -----APPNRKLP----------------------PVPGSNYNTCDRIKRGRGGLRSNHSTWDPR 1737
                 .|  ||:.                      |.|.||..|...:.|.|.|           
 Worm  1650 NDGVEGP--RKVDIKDFVSTDTAYAVVVQAINDDGPGPYSNQYTIRTMSRAREG----------- 1701

  Fly  1738 RNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICP--YATFHLLGFR--EE------ 1792
                       |||.:.....|..  :|...::.| :..::.|  |..:::.|.:  ||      
 Worm  1702 -----------PPVELRVEPDGQR--SAVAQWKEP-VTSDVPPIGYEIYYVRGDKSVEEDDSAGL 1752

  Fly  1793 --------MDPTKAMN--------------------------------FQTFPHQN--------G 1809
                    .||||..:                                .:|.|..|        |
 Worm  1753 NDWIKISIDDPTKLTHKIQNLLLPDTDYVFKMRAIYPDGPSVFSEPCIMKTLPDGNAPYIQISTG 1817

  Fly  1810 HAGPVPGHAGTMLPPGHPGHVHSRSGSQSMP-----RANRYQ----RKNSQG--GQSSIYTPAPE 1863
            ..| |.|.....:.||....:...:....:|     :|..|:    |.::.|  .|.|:......
 Worm  1818 DNG-VEGSTTIQILPGSQMTIACNATGIPLPQVKWIKAGNYEIDPSRVDADGNHAQFSLQVANIT 1881

  Fly  1864 YDDPANCAEEDQ--YRRYT-RVN-----------------SQGGSL---YSGPGPEYDDPANCAP 1905
            .|...||..::.  :..:| .||                 |.||.:   ::...|||..|.|   
 Worm  1882 EDTTFNCVAQNPLGHANWTINVNLIEGLEPNWRDDFVTSKSDGGQIVLVFNDELPEYLKPPN--- 1943

  Fly  1906 EEDQYGSQYGGPYGQPYDHYGSRGSMG----RRSIGSAR----------NPGNGSPEP------P 1950
               ::..||.....||.|.:.|..|.|    |..:.:..          ||..|...|      |
 Worm  1944 ---EWTIQYTDDAEQPKDQWESIPSGGAPLTRVEVPNMNPGTFYYLVVDNPEKGIQTPTLVVMTP 2005

  Fly  1951 PPP------PRNHDMSNSSFNDSKESNEISE 1975
            .||      ..|.|.....|..:..|..|.|
 Worm  2006 KPPSDIRFGKNNDDEQIVDFKPAVASEPIKE 2036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547 24/98 (24%)
Ig strand A 39..42 CDD:409547 0/2 (0%)
Ig strand A' 48..52 CDD:409547 0/3 (0%)
Ig strand B 55..64 CDD:409547 4/8 (50%)
Ig strand C 70..76 CDD:409547 0/5 (0%)
Ig strand C' 78..81 CDD:409547 1/2 (50%)
Ig strand D 87..90 CDD:409547 0/2 (0%)
Ig strand E 95..100 CDD:409547 2/4 (50%)
Ig strand F 113..121 CDD:409547 2/7 (29%)
Ig strand G 124..136 CDD:409547 2/11 (18%)
IgI_2_Dscam 246..343 CDD:409545 24/105 (23%)
Ig strand A 247..250 CDD:409545 2/2 (100%)
Ig strand A' 260..264 CDD:409545 0/3 (0%)
Ig strand B 267..274 CDD:409545 1/6 (17%)
Ig strand C 282..288 CDD:409545 1/5 (20%)
Ig strand C' 294..297 CDD:409545 0/2 (0%)
Ig strand D 303..307 CDD:409545 1/12 (8%)
Ig strand E 309..315 CDD:409545 3/5 (60%)
Ig strand F 322..330 CDD:409545 2/7 (29%)
Ig strand G 333..343 CDD:409545 1/9 (11%)
IgC2_3_Dscam 346..426 CDD:409549 21/96 (22%)
Ig strand A 347..352 CDD:409549 1/4 (25%)
Ig strand A' 355..359 CDD:409549 0/3 (0%)
Ig strand B 362..372 CDD:409549 4/10 (40%)
Ig strand C 377..383 CDD:409549 1/5 (20%)
Ig strand C' 384..387 CDD:409549 1/2 (50%)
Ig strand E 392..398 CDD:409549 1/5 (20%)
Ig strand F 405..413 CDD:409549 3/8 (38%)
Ig strand G 416..426 CDD:409549 0/9 (0%)
IgI_4_Dscam 432..527 CDD:409548 11/96 (11%)
Ig strand A 432..435 CDD:409548 1/2 (50%)
Ig strand A' 441..445 CDD:409548 1/3 (33%)
Ig strand B 448..457 CDD:409548 1/8 (13%)
Ig strand C 462..468 CDD:409548 1/5 (20%)
Ig strand C' 470..473 CDD:409548 0/2 (0%)
Ig strand D 478..486 CDD:409548 0/7 (0%)
Ig strand E 490..499 CDD:409548 1/8 (13%)
Ig strand F 506..514 CDD:409548 0/7 (0%)
Ig strand G 517..527 CDD:409548 0/9 (0%)
IgI_5_Dscam 531..618 CDD:409550 15/90 (17%)
Ig strand A 531..533 CDD:409550 0/1 (0%)
Ig strand A' 538..542 CDD:409550 0/3 (0%)
Ig strand B 545..552 CDD:409550 0/6 (0%)
Ig strand C 559..565 CDD:409550 2/5 (40%)
Ig strand C' 566..568 CDD:409550 0/1 (0%)
Ig strand D 575..579 CDD:409550 1/7 (14%)
Ig strand E 582..588 CDD:409550 1/5 (20%)
Ig strand F 596..604 CDD:409550 3/7 (43%)
Ig strand G 608..618 CDD:409550 1/9 (11%)
Ig 621..718 CDD:472250 22/108 (20%)
Ig strand B 639..643 CDD:409353 1/3 (33%)
Ig strand C 653..657 CDD:409353 0/3 (0%)
Ig strand E 684..688 CDD:409353 0/3 (0%)
Ig strand F 698..703 CDD:409353 0/4 (0%)
Ig strand G 711..714 CDD:409353 0/2 (0%)
IgI_7_Dscam 721..815 CDD:409546 19/95 (20%)
Ig strand A 721..725 CDD:409546 2/3 (67%)
Ig strand A' 730..734 CDD:409546 0/3 (0%)
Ig strand B 737..746 CDD:409546 3/10 (30%)
Ig strand C 752..758 CDD:409546 1/5 (20%)
Ig strand C' 764..767 CDD:409546 0/2 (0%)
Ig strand D 775..778 CDD:409546 0/2 (0%)
Ig strand E 780..786 CDD:409546 3/5 (60%)
Ig strand F 793..801 CDD:409546 0/7 (0%)
Ig strand G 806..815 CDD:409546 0/8 (0%)
Ig 818..916 CDD:472250 15/97 (15%)
Ig strand B 836..840 CDD:409353 0/3 (0%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 880..884 CDD:409353 2/3 (67%)
Ig strand F 894..899 CDD:409353 2/4 (50%)
FN3 <899..1212 CDD:442628 75/365 (21%)
Ig strand G 907..910 CDD:409353 0/2 (0%)
FN3 1222..1312 CDD:238020 30/100 (30%)
Ig <1339..1406 CDD:472250 18/66 (27%)
Ig strand C 1350..1354 CDD:409358 0/3 (0%)
Ig strand E 1372..1376 CDD:409358 0/3 (0%)
Ig strand F 1386..1391 CDD:409358 1/4 (25%)
Ig strand G 1399..1402 CDD:409358 0/2 (0%)
FN3 1409..1499 CDD:238020 18/99 (18%)
FN3 1504..1584 CDD:238020 26/98 (27%)
Dscam_C 1893..2008 CDD:463546 27/109 (25%)
dig-1NP_001366805.1 FXa_inhibition 226..262 CDD:464251 7/35 (20%)
ig 311..389 CDD:395002 24/102 (24%)
Ig strand B 323..327 CDD:409353 0/3 (0%)
Ig strand C 336..340 CDD:409353 0/3 (0%)
Ig strand E 359..363 CDD:409353 1/3 (33%)
Ig strand F 371..376 CDD:409353 1/4 (25%)
Ig strand G 384..387 CDD:409353 0/2 (0%)
FN3 394..478 CDD:214495 23/103 (22%)
Ig 497..578 CDD:472250 23/173 (13%)
Ig strand C 527..531 CDD:409353 1/3 (33%)
Ig strand F 558..563 CDD:409353 1/4 (25%)
Ig strand G 571..574 CDD:409353 0/5 (0%)
FN3 581..675 CDD:238020 23/108 (21%)
Ig_3 681..766 CDD:464046 30/181 (17%)
FN3 784..876 CDD:238020 18/91 (20%)
FN3 993..1089 CDD:238020 23/104 (22%)
FN3 1096..1196 CDD:238020 29/99 (29%)
IG_like 1212..1281 CDD:214653 21/78 (27%)
Ig strand B 1222..1226 CDD:409353 1/3 (33%)
Ig strand C 1235..1239 CDD:409353 1/4 (25%)
Ig strand E 1249..1253 CDD:409353 0/3 (0%)
Ig strand G 1274..1277 CDD:409353 0/2 (0%)
FN3 1287..1381 CDD:238020 16/94 (17%)
FN3 1585..1694 CDD:238020 14/112 (13%)
FN3 1701..1803 CDD:238020 16/126 (13%)
ig 1824..1903 CDD:395002 13/78 (17%)
Ig strand B 1835..1839 CDD:409353 0/3 (0%)
Ig strand C 1848..1852 CDD:409353 0/3 (0%)
Ig strand E 1870..1877 CDD:409353 2/6 (33%)
Ig strand F 1885..1890 CDD:409353 2/4 (50%)
FN3 2005..2097 CDD:238020 9/32 (28%)
RhsA 5199..>5943 CDD:442442
VWA 6583..>6690 CDD:459670
RhsA 11138..>11861 CDD:442442
VWA 12151..12302 CDD:214621
vWFA_subfamily_ECM 12363..12522 CDD:238727
VWA 12596..12762 CDD:459670
EGF_CA 12972..13013 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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