DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam1 and let-805

DIOPT Version :10

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001022641.1 Gene:let-805 / 175384 WormBaseID:WBGene00002915 Length:4450 Species:Caenorhabditis elegans


Alignment Length:2220 Identity:440/2220 - (19%)
Similarity:706/2220 - (31%) Gaps:784/2220 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 RAEDYRQ---EVHAQVYACLARNQFGSIISRDVHV----RAVVSQHYEEDIH------------- 146
            |.||.|.   .:..|...||..|  |.|...:..|    |....|...|:|.             
 Worm  1406 RTEDIRPTDVSISWQAPPCLQTN--GEITEYEYEVTAGDRRQTVQKTTENIRGTRAKIENLQPQT 1468

  Fly   147 ------KAFVIRG------------NSAILKCDIPSFV------ADFVNVISWHSDEKENFYPGT 187
                  :|:..||            ::.......|.||      ||...:: |.|.     ||..
 Worm  1469 RYNVKVRAYTARGAGPWSTEVPFQTSAGQQNVQAPGFVKVLHTGADNAQLV-WQSP-----YPNP 1527

  Fly   188 EYDGKY--LVLPSG--------------------------------ELH---IREVGPEDGYKSY 215
            .|..||  ...|||                                .||   |..:.||..| .:
 Worm  1528 GYVDKYKCRYAPSGTQQYQERQFPAVSPCQQRQIERQNLPQSPPGSRLHCGRIENLRPEQTY-DF 1591

  Fly   216 QCRTKHRLTG--------ETRLSATKGRLVITEPVGSVSPQLSGNGNQEHIT------------- 259
            |.....:.:|        .|:::.:..:::..:.:|       |:.|..||.             
 Worm  1592 QVSAHVKDSGWGPYSPPERTKVTESAVQVLFVKKIG-------GSENSLHINWDVRPDDKNRVTA 1649

  Fly   260 --LTRVPKMGS----------------VTLMCPAQAYPVPFFRWYKFIEGTTRKQ------AVVL 300
              :|.||:.||                :..:.|...|.|.       :...|.|:      ||:.
 Worm  1650 FRITVVPQDGSQRSQTFNVDRATYQYRIDNLRPRTTYNVT-------VSAATHKEMCGGTAAVMT 1707

  Fly   301 NDRVKQVSGTLIIKDAVVEDSGKYLCVV----NNSVGGESVETVLTVTA--PLSAKIDP-PTQTV 358
            .|.....:  |.....|:.:....:.:.    |...||..||..|...|  ..:.:|.. |:|| 
 Worm  1708 TDAAALTA--LSTAPRVIAEEPTSITIEWESRNREAGGFIVEYRLEGGAWQQYARRIPAHPSQT- 1769

  Fly   359 DFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAE 423
                  .:|....|.|...|             ..||:..|.:::            |.:..|.|
 Worm  1770 ------TYTATVDGLPTNAV-------------VDLRVRVVSQQN------------EQSNPSPE 1803

  Fly   424 LKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDR------YQVG 482
            ::...:..||.            .|...::..|.......:||....|.....|:      |:||
 Worm  1804 VRARTKCSPPT------------SPPQGVRVDAPSTNEVRVSWARPAKNTWMCDQMNVEISYRVG 1856

  Fly   483 ----QYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNV---YGLP-YIRQMEKK 539
                :.:||.||...|  ......|...:.|..|.::||.::.|.:.::   .|.| .:|.:..|
 Worm  1857 NQPEKVLTVPGDQTEY--TFPAEPNQRWVVKLRATNQVGSSQWSPEQSITTRQGAPGSVRDLRVK 1919

  Fly   540 AIVAGET-------LIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQAT 597
            |:...|.       |:....:.||.|...:..|  .|.|               |...|:..:..
 Worm  1920 ALSPNEVHVQWLAPLVQRGTIVGYDISYRLKHR--LACP---------------EEEPRDVSRDF 1967

  Fly   598 YTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSA 662
            .|........|:..|       :||                                        
 Worm  1968 VTVYNHKDLDYTITG-------LLP---------------------------------------- 1985

  Fly   663 GDYGFDQVQPQMRTNRIS-EKTSMISI----PSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPP 722
              |...:|:.:.||..:. |:|..:|.    ||:.|.:.            .:||:::.:::.  
 Worm  1986 --YSLYEVRVRARTTELGPEETKEVSTEQQPPSSPPLNL------------ESTYALERSLSF-- 2034

  Fly   723 RWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNI 787
            :|  ||.|.:...|.....|.:..|    |..|.|.       .:.:..:.::||.     :|.:
 Worm  2035 QW--EPVDCSQRHGHVVNYEYEILG----QDDWAKL-------ERQIANTSDLRVT-----IDGL 2081

  Fly   788 QKTNEGYYLCEAINGIGSGLS----AVIMISVQAP----------------------------PE 820
            ....:.....:|.|.||.|.:    .|:....|||                            |.
 Worm  2082 TPYTKYVMRVKAYNSIGGGPNTENLVVMTAKAQAPLPPQDLVVAQEGTSFFMVSWLPPYPPYGPH 2146

  Fly   821 FTEKLRNQ--------TARRG-EPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILST 876
            ...|:|.|        ...:| :..:|||  .||.| ...:|...:....:...:...|.|..|.
 Worm  2147 DAYKIRYQQIPSDDWKEVEKGIKDPLLQC--PGESP-RFCYNATGLDSGQQFKIQVATRIEGGSY 2208

  Fly   877 GVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQP 941
            |..|||.|..|                          :|.:|:.|.|:.:::|:..|:.:.|..|
 Worm  2209 GPWSSLVIANT--------------------------LQVLPDAPRAIHLIEKTDHSLHIRWVPP 2247

  Fly   942 YDGNSPLDRYIIEFKRSRASWSEID---RVIVPGHTTEAQV-QKLSPATTYNIRIVAENAIGTSQ 1002
            .|...    |:.:::.|..|..:::   |..:..|.|...: ::|:|.|:|||.|.|    ||.|
 Worm  2248 IDPKG----YVTQYRVSIVSLDDVNDKKRTHIVNHPTLTYLFEELNPETSYNISISA----GTKQ 2304

  Fly  1003 --SSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPP-----RTEWN------GEILGYYV 1054
              ..|..|..|.:      |.||   ||..|...||   |.     ..:||      ..:.||.:
 Worm  2305 GFGREIWTRYTTD------PFNI---PVVGTMPTVT---PDGANALDVQWNAVLDPKNRVKGYII 2357

  Fly  1055 GYKLSNTNSSYVFETINFIT--EEGKE-HNLELQNLRVYTQYSV---VIQAFNKIGAGPLSEEEK 1113
            ..:.|:|.   |::.|..:|  :.||. :..:|..|...|.|.:   |:....::|..  |.|.:
 Worm  2358 EIRNSDTP---VWQEIGGVTNHDAGKSTYFKKLTGLDSDTLYFIRIKVVDQRQRVGVP--SPEAQ 2417

  Fly  1114 QFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKT 1178
            ..|....|..||::....:.::..:||.|.:|...|.......||:.|...    .|.::.....
 Worm  2418 ARTGCAAPLSPPTNLNLASPSNVQVRVSWQAPNQNSWKCSAIRYKLEYING----TEGRKQIDLP 2478

  Fly  1179 ASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWR 1243
            :||...|...|..|.:|:::......|....|..:...|....|.....:.|...|..:|:..|:
 Worm  2479 SSSIEHLFDSKSNTKWTVRIRTENDAGSSEWSKELSITTSEGAPGPVEGLTAKPTGPTSIVARWK 2543

  Fly  1244 PPAQPNGIITQYTVYSKAE-----GAETETKTQKVPHYQMSFEATE-LEKNKPYEFWVTASTTIG 1302
            ||..|||:||.||:..:.:     |..:.|..:|  |.:...|..| |..:..||..|.|.|: .
 Worm  2544 PPRDPNGVITGYTLTYQLKSIGECGPRSSTPIEK--HVKNEEETLEGLLPDSTYEIHVVAHTS-H 2605

  Fly  1303 EGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQ-----------PEITW--- 1353
            .|.|| |:|                  |.|.:|.|     ..|.||           .:|||   
 Worm  2606 AGPQS-SVV------------------TVTTEEAA-----PTGPPQNVRAGSVTSSRADITWTQP 2646

  Fly  1354 -------KIKGVEF---------------SANDRM---RVLP--DGSLLIKSVNRQDAGDYSCHA 1391
                   ||...|:               :..:|:   :::|  ...:.::::|::..|.:|   
 Worm  2647 ECEQRNGKITDYEYELWSMDTWADNSTGHNPTERLNLDQLIPYTQYQIRVRAINKEGDGPFS--- 2708

  Fly  1392 ENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHG----YTLHYKPEFGE 1452
                  :.:........||....:...||...|:.:...|    ..|.||    |.:.|.|. ||
 Worm  2709 ------EWVPFTTSATNPPAPSDLQEEATFPHAIEISWLP----PTPPHGNIDFYKVRYTPS-GE 2762

  Fly  1453 WETSEVSVDSQK-----HNIEGLLC--------GSRYQVYATGFNNIGA-GEASDILNTRTKGQK 1503
            ....|:.|::.:     .|.:..||        ...|.:..:.....|. .|.||.|.:||  |:
 Worm  2763 ANYREIRVETDRLECSDSNKKDRLCYRLSDLDPEQEYDIQVSAHTEGGGWSEWSDELTSRT--QQ 2825

  Fly  1504 PKLPEKPRFIEV---SSNSVSLHFKAWKDGGCPMSH------FVVESKKR-DQIEWNQISNNVK- 1557
            ..:|...|.:||   :|||:||   .|:  |.|...      :|:|.|.. |..||.:.:..|| 
 Worm  2826 QNIPVLERELEVTDKTSNSISL---KWE--GLPQDQATHVVGYVLEFKSEDDNAEWQEYNGVVKH 2885

  Fly  1558 ----PDNNYVVLDLEPATWY--NLRITAHN--------------SAG--------FTVAEYDFAT 1594
                .|....|..||.||.|  .||:...|              |.|        ..:...||.|
 Worm  2886 RKTSSDYKITVKQLETATLYFFRLRVVGKNDKRGQPGPETKETTSCGKPEAPPESLKLESLDFET 2950

  Fly  1595 LTVTGGTIAPLDDGSGHGNVHTRIRLPAWMP----EWL--DLNFMVPLIATVVVVAVGICVVCVA 1653
            |.:|                        |.|    .|.  ::.:::..:.|.             
 Worm  2951 LKIT------------------------WTPPEESTWRCDNVEYLIDFVNTT------------- 2978

  Fly  1654 LSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCD 1718
                    .||           |.|:...                 ||....:|..||:.::...
 Worm  2979 --------SRG-----------NWTVSTD-----------------APSELIVPTQPGTKWDVKI 3007

  Fly  1719 RIKRGRGGLRSNHSTWDPR------------------RNPNLYEELKAPPVPMHGNHYGHAHGNA 1765
            |.:......:...|.|..|                  :.|.  |.|....:|.....:.:     
 Worm  3008 RTQTVEDSGKPQASRWSDRVSITTQSLPGEIFVTVEPKGPR--EALVTWELPDKDQKWNY----- 3065

  Fly  1766 ECHYRHPGMEDEICPYATFHL--LGFREEM-----DPTKAMNFQ--TFPHQNGHAGPVPGHAGTM 1821
                   |::      .|:.|  ||...|:     :|...:|.|  ..|.:|...|.:   ....
 Worm  3066 -------GVD------ITYKLKQLGGCNEVQTGAKEPVTLLNVQEKQIPLENLQPGSL---YEVS 3114

  Fly  1822 LPPGHPGHVHSRSGSQSMPRANR-YQRKNS------QGGQSSIYTPAP---EYDDPANCAEED-- 1874
            :.|..|..:||   |...|:..| ::.||.      |..||::...:.   ::|.| .|.:::  
 Worm  3115 VTPRRPPSLHS---SIVTPKTVRTFRTKNDVPTGPPQNLQSTVRKDSELGFKWDAP-ECIQQNGN 3175

  Fly  1875 --QY--------------------RRYTRVNS-QGGSLY---------SGPGPEYDDPANCAPEE 1907
              ||                    |:.|.::. |.||||         .||||..|     :.|.
 Worm  3176 ITQYEFELVGLDEWNEGTREGVTPRQNTLIDQLQPGSLYRIKVRAYTAEGPGPWSD-----SLEI 3235

  Fly  1908 DQYGSQYGGP 1917
            ...||:.|.|
 Worm  3236 RTTGSELGPP 3245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547 12/40 (30%)
Ig strand A 39..42 CDD:409547
Ig strand A' 48..52 CDD:409547
Ig strand B 55..64 CDD:409547
Ig strand C 70..76 CDD:409547
Ig strand C' 78..81 CDD:409547
Ig strand D 87..90 CDD:409547
Ig strand E 95..100 CDD:409547
Ig strand F 113..121 CDD:409547 3/7 (43%)
Ig strand G 124..136 CDD:409547 4/15 (27%)
IgI_2_Dscam 246..343 CDD:409545 25/137 (18%)
Ig strand A 247..250 CDD:409545 0/2 (0%)
Ig strand A' 260..264 CDD:409545 1/3 (33%)
Ig strand B 267..274 CDD:409545 2/22 (9%)
Ig strand C 282..288 CDD:409545 0/5 (0%)
Ig strand C' 294..297 CDD:409545 1/8 (13%)
Ig strand D 303..307 CDD:409545 0/3 (0%)
Ig strand E 309..315 CDD:409545 1/5 (20%)
Ig strand F 322..330 CDD:409545 0/11 (0%)
Ig strand G 333..343 CDD:409545 5/9 (56%)
IgC2_3_Dscam 346..426 CDD:409549 14/80 (18%)
Ig strand A 347..352 CDD:409549 0/4 (0%)
Ig strand A' 355..359 CDD:409549 2/3 (67%)
Ig strand B 362..372 CDD:409549 1/9 (11%)
Ig strand C 377..383 CDD:409549 1/5 (20%)
Ig strand C' 384..387 CDD:409549 0/2 (0%)
Ig strand E 392..398 CDD:409549 2/5 (40%)
Ig strand F 405..413 CDD:409549 0/7 (0%)
Ig strand G 416..426 CDD:409549 3/9 (33%)
IgI_4_Dscam 432..527 CDD:409548 22/104 (21%)
Ig strand A 432..435 CDD:409548 2/2 (100%)
Ig strand A' 441..445 CDD:409548 0/3 (0%)
Ig strand B 448..457 CDD:409548 1/8 (13%)
Ig strand C 462..468 CDD:409548 2/5 (40%)
Ig strand C' 470..473 CDD:409548 1/2 (50%)
Ig strand D 478..486 CDD:409548 3/17 (18%)
Ig strand E 490..499 CDD:409548 2/8 (25%)
Ig strand F 506..514 CDD:409548 2/7 (29%)
Ig strand G 517..527 CDD:409548 2/9 (22%)
IgI_5_Dscam 531..618 CDD:409550 17/94 (18%)
Ig strand A 531..533 CDD:409550 1/2 (50%)
Ig strand A' 538..542 CDD:409550 2/3 (67%)
Ig strand B 545..552 CDD:409550 2/13 (15%)
Ig strand C 559..565 CDD:409550 0/5 (0%)
Ig strand C' 566..568 CDD:409550 0/1 (0%)
Ig strand D 575..579 CDD:409550 0/3 (0%)
Ig strand E 582..588 CDD:409550 0/5 (0%)
Ig strand F 596..604 CDD:409550 1/7 (14%)
Ig strand G 608..618 CDD:409550 2/9 (22%)
Ig 621..718 CDD:472250 14/101 (14%)
Ig strand B 639..643 CDD:409353 0/3 (0%)
Ig strand C 653..657 CDD:409353 0/3 (0%)
Ig strand E 684..688 CDD:409353 0/3 (0%)
Ig strand F 698..703 CDD:409353 0/4 (0%)
Ig strand G 711..714 CDD:409353 2/2 (100%)
IgI_7_Dscam 721..815 CDD:409546 19/97 (20%)
Ig strand A 721..725 CDD:409546 0/3 (0%)
Ig strand A' 730..734 CDD:409546 1/3 (33%)
Ig strand B 737..746 CDD:409546 1/8 (13%)
Ig strand C 752..758 CDD:409546 2/5 (40%)
Ig strand C' 764..767 CDD:409546 0/2 (0%)
Ig strand D 775..778 CDD:409546 1/2 (50%)
Ig strand E 780..786 CDD:409546 0/5 (0%)
Ig strand F 793..801 CDD:409546 1/7 (14%)
Ig strand G 806..815 CDD:409546 2/12 (17%)
Ig 818..916 CDD:472250 22/134 (16%)
Ig strand B 836..840 CDD:409353 1/3 (33%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 880..884 CDD:409353 3/3 (100%)
Ig strand F 894..899 CDD:409353 0/4 (0%)
FN3 <899..1212 CDD:442628 78/335 (23%)
Ig strand G 907..910 CDD:409353 0/2 (0%)
FN3 1222..1312 CDD:238020 30/95 (32%)
Ig <1339..1406 CDD:472250 14/107 (13%)
Ig strand C 1350..1354 CDD:409358 3/13 (23%)
Ig strand E 1372..1376 CDD:409358 0/3 (0%)
Ig strand F 1386..1391 CDD:409358 1/4 (25%)
Ig strand G 1399..1402 CDD:409358 0/2 (0%)
FN3 1409..1499 CDD:238020 25/107 (23%)
FN3 1504..1584 CDD:238020 31/110 (28%)
Dscam_C 1893..2008 CDD:463546 9/25 (36%)
let-805NP_001022641.1 FN3 <102..483 CDD:442628
FN3 438..530 CDD:238020
FN3 1007..1094 CDD:238020
FN3 1115..1195 CDD:238020
FN3 1205..1293 CDD:238020
FN3 <1260..>1543 CDD:442628 33/144 (23%)
FN3 1502..1613 CDD:238020 24/117 (21%)
fn3 1629..1696 CDD:394996 12/73 (16%)
FN3 1720..1808 CDD:238020 22/119 (18%)
FN3 1815..1905 CDD:238020 20/91 (22%)
FN3 <1864..>2119 CDD:442628 65/354 (18%)
FN3 2116..2219 CDD:238020 21/105 (20%)
fn3 2225..2309 CDD:394996 24/91 (26%)
FN3 2289..>2765 CDD:442628 126/541 (23%)
FN3 <2688..3031 CDD:442628 86/436 (20%)
FN3 3040..3129 CDD:238020 21/114 (18%)
FN3 3145..3237 CDD:238020 21/97 (22%)
FN3 3243..3350 CDD:238020 2/3 (67%)
fn3 3368..3436 CDD:394996
fn3 3460..3550 CDD:394996
FN3 3561..3644 CDD:214495
Blue background indicates that the domain is not in the aligned region.

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