DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and rig-6

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001022014.1	Gene:	rig-6 / 173828	WormBaseID:	WBGene00016354	Length:	1196	Species:	Caenorhabditis elegans

Alignment Length:	1350	Identity:	272/1350 - (20%)
Similarity:	445/1350 - (32%)	Gaps:	419/1350 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 ISRDVHVRAVVS----QHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVI-SWHSD--EKENFY 184
            |:.|..||.|::    :|.::..|     .....::...:...:.|.:::: :.|.:  .:..|:
Worm    32 IASDQCVRIVIAPANLKHSKKYCH-----HEGGELMDTSVTLLLEDVMDLLKNLHENGLSEPTFH 91

  Fly   185 PG--------TEYDGKYLVLPSGELHIREVGPEDGYK---SYQCRTKHRLTGETRLSATKGRLVI 238
            .|        || ||.|.::        .:.|...:.   |.....:..|..:.:|.
Worm    92 VGGMGQALNRTE-DGNYKII--------TINPSSHFPFICSLNKMARRSLLFQQKLL-------- 139

  Fly   239 TEPVGSVSPQLSGNGNQE---HITLTRVPKMGS--VTLMCPAQAYPVPFFRWYKFIEGTTRKQAV 298
              |||  :||:|..|..|   |      |:..:  :.|.|..|..|.|...|||       ....
Worm   140 --PVG--APQISLTGQSEIYFH------PRHDADYIALPCTVQGNPKPTVAWYK-------NDVE 187

  Fly   299 VLNDRVKQVS-----GTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTV 358
            ||:..:..||     |.|::..:.......:.|...||:|  .|.:...:..|  :.|||
Worm   188 VLSPSMSNVSYLLSGGNLLVPASSTLAYSSFHCTARNSLG--EVRSPPILLKP--SFIDP----- 243

  Fly   359 DFGRP------------AVFTCQYTGNPIK--TVSWM---KDGKAIGHSE-------PVLRIESV 399
              .||            |...|....:..|  |.||:   ...:.:..:|       ..|....|
Worm   244 --FRPHRLDVYSLATGGAKLDCDAPAHQPKSLTYSWLYGSSTDRILSQNERKFISLDGTLFFSYV 306

  Fly   400 KKEDKGMYQC--FVRNDQESAEA------SAELKLGGRFDPPVI----RQAFQEETMEPGPSVFL 452
            ..||:..|.|  .|.:.|.....      |:..||.....||.:    .|.|.|:. :.|.|::|
Worm   307 TAEDEDSYACSLSVYSTQSGHYGPFFRLISSTPKLVNSTFPPKLDSTQPQIFPEDP-KVGDSIYL 370

  Fly   453 KCVAGGNPTPEISW-ELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKV 516
            :|.|..:|.|:..| .:|||.|.  .|..:..|..|       |.|..|:..|.|.|||:|
Worm   371 ECFAYASPLPQYKWSRVDGKPIP--ARSHISNYGRV-------LKIEKVNYGDAGKYKCVA---- 422

  Fly   517 GVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPN 581
                    :|.:|
Worm   423 --------MNAFG---------------------------------------------------- 427

  Fly   582 GTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQ 646
                                       ||.|.:.|::...|.|:...::.|:....::...|.:.
Worm   428 ---------------------------SAAGEVHVKLRAPPSILQGLHDRLVPTESNVSFECLLS 465

  Fly   647 KGDRPIKVHWSFERSAGDYGFDQVQPQM-------RTNRISEKTSMISIPSASPAHTGRDTCIAS 704
            ..|....|.|          |...:|.:       :..|:....:::.:..|....:|...|:||
Worm   466 NADSYSSVEW----------FKDAKPIVPLLLPAEKRKRLKIDHNVLHLKFADETDSGVYQCVAS 520

  Fly   705 NKAGTTTYSVDLTVN-----VPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPG 764
            |..|:::.|..|||.     .||..:......||  ||...:.|..:..|:....|..|.|
Worm   521 NDVGSSSSSALLTVKDSAPVFPPNAMSRKVFAAF--GSTVSIPCIFEASPRFHGKWADAGG---- 579

  Fly   765 EYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQT 829
              ..|.:...||.|||.:.::.:...:.|.:.|.|.|.:|...:.|.:|.|..|...|..|..:|
Worm   580 --SKLPQKGRIRDEEGVISIEKVLHEDAGLFFCTAHNKLGKAHAQVQLIVVNKPSIKTNFLDEET 642

  Fly   830 ARRGEPAVLQCEAKGEKPIGIL-WNMNNMRL-----------DPKNDNRYTIREEILSTGVMSSL 882
            ........|.||...|.|..:. |.:|:...           :.|:.::....::.:...|..||
Worm   643 VNMSCEVELTCENSAECPEALFEWKINDRPAKEYPSLKSKVHEKKSGHKGRHLKQKVDLEVPKSL 707

  Fly   883 SIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEM--PYALKV--LDKSGRS---VQLSWAQ 940
            :..|    ....|.|  ::.:|.....:..     |::  |.||.|  :|:.|:.   .:|.|..
Worm   708 AGSR----QIGRFAC--SSLYGGSSEFVTK-----PQLPSPIALTVEQMDEDGKKKKMFRLRWRL 761

  Fly   941 P------YDGNSPLDRYIIEFK-RSRASWSEIDRVIVPGHTTEA-QVQKLSPATTYNIRI--VAE 995
            |      .|.:..::.|::|.: |....|...:|.:|.....:: .|:.|.|.|.|..|:  |..
Worm   762 PPQHRDTRDHSPKVEGYLVELRTRKNRKWRAAERQLVGNMEKDSITVENLLPNTEYQFRVRSVES 826

  Fly   996 NAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKP-PPRTEWNGEILGYYVGY--- 1056
            .||| ..|..:..:.||..|||....|:|...::..|:.|.|:| ....|.:|:.|.|.|.:
Worm   827 AAIG-EPSIPSDWVKTAPGAPSETIDNLKWRSLDSQTLLVEWQPIEIGQESSGDNLRYRVSWSEA 890

  Fly  1057 ----------KLSNT---------------------------------------NSSYVFETINF 1072
                      ||||.                                       |.|...:||.|
Worm   891 TVGKNATDDMKLSNQDDDFENHLDSDQPQAILKLNTTEGCRMVVLAVRPVNDQGNGSVGTDTIAF 955

  Fly  1073 ITEEGKEHNLELQNLRVY------------------TQYSVVIQAFNKIGA-------------- 1105
            :...|:...:.|.|::..                  |:::|.|...|..|:
Worm   956 LNSHGELKKVSLHNVKPINASHVNISWTWDNTSDCDTKHAVQITCINLSGSEISATVASDRIFWM 1020

  Fly  1106 -----------------------GPLSEEEKQFTAEGTPSQPP----------SDTACTTLTSQT 1137
                                   ||.|::.:..|.:..||:.|          .||..|.|...:
Worm  1021 LGGLEAETAYDCDLKAIDNHGSFGPASKKFRIHTKQHPPSETPLIGKLMMKQMKDTYTTILEWSS 1085

  Fly  1138 IRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSD-----TVLHGLKKYTNYTMQ 1197
            |.   :..|..:.||.  .||:....|:...:..:........||     ..|.|||....||::
Worm  1086 IE---LQKPNRTENGC--GYKIFIYISETATEAIELDMPLQRLSDRRNPSARLDGLKLMYMYTIK 1145

  Fly  1198 VLATTAGGDG----VRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWR 1243
            |.....||.|    .||:.:......|.....:||....:....:|:.||
Worm  1146 VAGYNPGGIGPISEPRSIRLGSPGTMDYTTGSSDVPIPSLLLLLLLLLWR 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	1/2 (50%)
		IG	57..133	CDD:214652	2/5 (40%)
		IG_like	267..343	CDD:214653	19/82 (23%)
		Ig	269..340	CDD:143165	19/75 (25%)
		IG_like	353..425	CDD:214653	19/103 (18%)
		IGc2	361..413	CDD:197706	16/77 (21%)
		I-set	433..527	CDD:254352	28/98 (29%)
		IGc2	446..517	CDD:197706	24/71 (34%)
		I-set	533..618	CDD:254352	4/84 (5%)
		IGc2	544..607	CDD:197706	0/62 (0%)
		Ig	641..714	CDD:143165	14/79 (18%)
		IGc2	735..804	CDD:197706	17/68 (25%)
		I-set	819..914	CDD:254352	18/106 (17%)
		Ig	833..921	CDD:299845	16/101 (16%)
		FN3	918..1011	CDD:238020	28/109 (26%)
		FN3	1018..1116	CDD:238020	31/205 (15%)
		FN3	1124..1217	CDD:238020	26/111 (23%)
		FN3	1222..1312	CDD:238020	4/21 (19%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
rig-6	NP_001022014.1	Ig	153..237	CDD:299845	22/98 (22%)
		Ig	240..335	CDD:299845	20/101 (20%)
		Ig	358..427	CDD:299845	27/90 (30%)
		IG_like	363..436	CDD:214653	29/172 (17%)
		I-set	441..534	CDD:254352	19/102 (19%)
		IGc2	456..524	CDD:197706	13/77 (17%)
		I-set	547..627	CDD:254352	21/87 (24%)
		Ig	552..627	CDD:299845	21/82 (26%)
		FN3	737..839	CDD:238020	27/102 (26%)
		fn3	970..1047	CDD:278470	7/76 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010