DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and unc-89

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:NP_001020985.1 Gene:unc-89 / 171990 WormBaseID:WBGene00006820 Length:8081 Species:Caenorhabditis elegans


Alignment Length:1825 Identity:396/1825 - (21%)
Similarity:644/1825 - (35%) Gaps:517/1825 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ERLKWLMLFAAVALIACGSQTLAAN---------PPDADQKGPVFLKEPTN-RIDFSNSTG-AEI 59
            |.::||   ....:|:.|:..:...         .|.||      ||:... .::..|.:| |:.
 Worm  4808 EDVRWL---RDANVISAGANAIIEKIDDTTYRLIIPSAD------LKDAGEYTVEVINESGKAKS 4863

  Fly    60 ECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQV-----YACLA 119
            :.|...:..|||            |.||..|.      .|....:.::.||.|.|     |    
 Worm  4864 DAKGEVDEKPEI------------VRGLENIE------IPEGDDDVFKVEVSAPVRQVKWY---- 4906

  Fly   120 RNQFGSIISRDVHVRA--VVSQHYEEDIHKA--------FVIRGNSA---------------ILK 159
            :|.  ..|..:.|:.|  :..:.||..|::|        .|:..|:|               :||
 Worm  4907 KND--QEIKPNSHLEAKKIGPKKYELAINRAQLDDGADYKVVLSNAAGDCDSSAALTVVKPNVLK 4969

  Fly   160 ---------------CDIPSFVADFVNVISWHSDEKENFYPGTEYDG-KYLVLP-SGE--LHIRE 205
                           .::...|.....||.|:.:.:| ..|  :.|| |:...| |||  |.|..
 Worm  4970 IVDGLKDVDVEEPQPVELKVKVEGIPKVIKWYKNGQE-LKP--DADGFKFEEKPESGEFSLTIPS 5031

  Fly   206 VGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGNGNQEHITLTRVPKMGSVT 270
            ....|| .:|:.     :.|..:.....|.:|..:...|..| .||......:..|.|.:...:|
 Worm  5032 SKKSDG-GAYRV-----VLGNDKGEVYSGSVVHVKSAKSSEP-TSGANFLSPLKDTEVEEGDMLT 5089

  Fly   271 LMCPAQAYPVPFFRWYKFIEGTTRKQAVVL--NDRVK-----QVSGTLIIKDAVVEDSGKYLCVV 328
            |.|.....|.|...|        .|..|||  :||:.     ..:.||.|:.|...|.|:|....
 Worm  5090 LQCTIAGEPFPEVIW--------EKDGVVLQKDDRITMRVALDGTATLRIRSAKKSDIGQYRVTA 5146

  Fly   329 NNSVGGESVETVLTVT----APLSAKIDPPTQTVDF--GRPAVFTCQYTGNPIKTVSWMKDGKAI 387
            .|..|..:.:..:|||    .|...|...|.:|...  |....|..:..|.|..|:.|..:|..|
 Worm  5147 KNEAGSATSDCKVTVTEQGEQPSKPKFVIPLKTGAALPGDKKEFNVKVRGLPKPTLQWFLNGIPI 5211

  Fly   388 GHSEPV-----------LRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFD---------P 432
            ...:.:           |.|..|::||.|..:|..:|:..:.|...|.:.|...|         |
 Worm  5212 KFDDRITLDDMADGNYCLTIRDVREEDFGTLKCIAKNENGTDETVCEFQQGAGHDDGSRDDLRYP 5276

  Fly   433 PVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNI 497
            |.......:..:..|..:|::|....|||.|:.|..|||||.:....::..  ||:|  ...:.|
 Worm  5277 PRFNVPLWDRRIPVGDPMFIECHVDANPTAEVEWFKDGKKIEHTAHTEIRN--TVDG--ACRIKI 5337

  Fly   498 TSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQ-------------MEKKAIVAGETLIV 549
            .....:|.|:|.|:|.:::|.||..|...|..|.::.:             :|.|.:..|:.:.:
 Worm  5338 IPFEESDIGVYMCVAVNELGQAETQATYQVEILEHVEEEKRREYAPKINPPLEDKTVNGGQPIRL 5402

  Fly   550 TCPVAGYPIDSIVWERDNRALPINRKQKVF----PNGTLIIE-NVERNSDQATYTCVAKNQEGYS 609
            :|.|...|..|:||.:|  .||:....:..    .:||..:. |.....|...|.|||.|..| :
 Worm  5403 SCKVDAIPRASVVWYKD--GLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNAHG-T 5464

  Fly   610 ARGSLEVQVMVLPQIV------PFAYEDLINM----GDSIDLFCQIQKGDRPIKVHWSFERSAGD 664
            ...|..|.|.|..|.|      ||..:.|:::    |||..|.|.: .||...::.|        
 Worm  5465 INTSCSVNVKVPKQEVKKEGEEPFFTKGLVDLWADRGDSFTLKCAV-TGDPFPEIKW-------- 5520

  Fly   665 YGFDQV---QPQMRTNRISEKTSMISIPSASPAHTGRDTCIASN---KAGT-TTYSVDLTV---- 718
            |...|:   .|:.......:.:..:::..::.:..|...|.|.|   ||.| .|..|.:.:    
 Worm  5521 YRNGQLLRNGPRTVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQMALGKTE 5585

  Fly   719 ------NVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVG----DTPGEYKD--LKK 771
                  ..||::|||.:|.:.:.|:...:|||..|.|.|.|.|.|..|    |:..|:.:  .|.
 Worm  5586 KPKMDEGKPPKFILELSDMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKG 5650

  Fly   772 SDNIRVEEGTLHVDNIQKTNEGYYLCEAIN---------------GIGSGLSAVIMISVQAPPEF 821
            ...:|::..|:|       :||.|.|.|.|               |:|||     :::...||.|
 Worm  5651 VYQLRIKNATVH-------DEGTYRCVATNENGSATTKSFVRMDDGLGSG-----VVTASQPPRF 5703

  Fly   822 TEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEI-LSTGVMSSLSIK 885
            |.|:.:.....|:|..|:|:........::|..:...:.|.:      |.:| ||...:::|.|.
 Worm  5704 TLKMGDVRTTEGQPLKLECKVDASPLPEMVWYKDGAIVTPSD------RIQISLSPDGVATLLIP 5762

  Fly   886 RTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGN----- 945
            .....|..::..:|||..|:........|:::|....|.:..|:          ..:|.|     
 Worm  5763 SCVYDDDGIYRVIATNPSGTAQDKGTATVKKLPRDSGARRSADR----------DVFDANKAPKL 5817

  Fly   946 -SPLDRYIIEFKRS---RASWS--------------------EIDRVIVPGHTTEAQVQKLSPAT 986
             .||:...|..|:|   |..:|                    .:..:..|....|..|...:...
 Worm  5818 MEPLENIRIPEKQSFRLRCKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQD 5882

  Fly   987 TYNIRIVAENAIGTSQSSEAVTIITAEEAP--------SGK------PQNI-KVEPVNQTTMRVT 1036
            ....|.||||..|::::|..|.:|..:..|        .||      |..| :.:|.:..|....
 Worm  5883 AGGYRCVAENTYGSARTSCDVNVIRGDRKPRDIDSSIREGKAPGFTTPLTIRRAKPGDSVTFECL 5947

  Fly  1037 --WKPPPRTEWNGEILGYYVGYKL-----SNTNSSYVFETINFITE------EGKEHNLELQNLR 1088
              ..|.|..:|..:.|..:...|:     ::.....:...:.|::|      ...||.      .
 Worm  5948 PFGNPFPSIKWLKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRCVATNEHG------T 6006

  Fly  1089 VYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTT-----LTSQTIRVGWVSPPLE 1148
            ..|:..:||:....||:.||.|      ..|.|.:      |..     |.:.:|..|.|...:.
 Worm  6007 ASTKAELVIEGDRTIGSRPLPE------VNGEPEE------CKPRIRRGLYNMSIHEGNVVEMIV 6059

  Fly  1149 SANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPI 1213
            .|.|       :..|:.:||.:.:                        :::     |||      
 Worm  6060 CATG-------IPTPTVKWYKDGQ------------------------EIV-----GDG------ 6082

  Fly  1214 HCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQM 1278
                 ||             |...|....|      ||                       |:.:
 Worm  6083 -----PD-------------GKRVIFTDER------GI-----------------------HHLV 6100

  Fly  1279 SFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDD----TFTATFKEDAK- 1338
            ...|:..::.   |:.:.|:..:|..:...|:..:.    |..||..|:    .|...|....| 
 Worm  6101 IVNASPDDEG---EYSLEATNKLGSAKTEGSLNIIR----PRHIADADERGGMPFPPGFVRQLKN 6158

  Fly  1339 ------MP----CLAVGAPQPEITWKIKGVEFSANDRMRVLPDG----SLLIKSVNRQDAGDYSC 1389
                  ||    ||.||.|.||:.|...|.:.....|:::...|    :|:|.....:|||:|..
 Worm  6159 KHVFNHMPTIFDCLVVGHPAPEVEWFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLEDAGEYVA 6223

  Fly  1390 HAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWE 1454
            .|:||..                     ||:::..|.|        |.|.               
 Worm  6224 TAKNSHG---------------------SASSSAVLDV--------TVPF--------------- 6244

  Fly  1455 TSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFI-EVSSN 1518
                 :||.|.|  |.:..:.|.....||..         |||   ...|..|::..|| ||:.:
 Worm  6245 -----LDSIKFN--GEIDVTPYLTEEYGFKK---------LNT---ASLPTPPDRGPFIKEVTGH 6290

  Fly  1519 SVSLHFKAWKDG--GCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHN 1581
            .::|.:...|..  ..|...:|:|.::..:.:|:.:..|: |:....|.:||....|..|:.|.|
 Worm  6291 YLTLSWIPTKRAPPRYPQVTYVIEIRELPEKQWSLLEYNI-PEPVCKVRNLELGKSYQFRVRAEN 6354

  Fly  1582 SAGFT 1586
            ..|.:
 Worm  6355 IYGIS 6359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 21/98 (21%)
IG 57..133 CDD:214652 17/80 (21%)
IG_like 267..343 CDD:214653 21/82 (26%)
Ig 269..340 CDD:143165 21/77 (27%)
IG_like 353..425 CDD:214653 20/84 (24%)
IGc2 361..413 CDD:197706 15/62 (24%)
I-set 433..527 CDD:254352 27/93 (29%)
IGc2 446..517 CDD:197706 22/70 (31%)
I-set 533..618 CDD:254352 24/102 (24%)
IGc2 544..607 CDD:197706 19/67 (28%)
Ig 641..714 CDD:143165 16/79 (20%)
IGc2 735..804 CDD:197706 24/89 (27%)
I-set 819..914 CDD:254352 21/95 (22%)
Ig 833..921 CDD:299845 19/88 (22%)
FN3 918..1011 CDD:238020 23/121 (19%)
FN3 1018..1116 CDD:238020 23/117 (20%)
FN3 1124..1217 CDD:238020 13/97 (13%)
FN3 1222..1312 CDD:238020 11/89 (12%)
Ig 1339..1406 CDD:299845 22/74 (30%)
FN3 1409..1499 CDD:238020 17/89 (19%)
FN3 1504..1584 CDD:238020 21/82 (26%)
Dscam_C 1890..2008 CDD:289151
unc-89NP_001020985.1 SH3 65..124 CDD:302595
RhoGEF 153..328 CDD:238091
PH_unc89 341..455 CDD:270134
Ig 568..634 CDD:143165
I-set <570..638 CDD:254352
I-set 648..737 CDD:254352
Ig 661..728 CDD:299845
I-set 748..837 CDD:254352
IGc2 761..827 CDD:197706
I-set 844..935 CDD:254352
I-set 946..1034 CDD:254352
Ig 954..1034 CDD:299845
I-set 1044..1133 CDD:254352
Ig <1060..1132 CDD:299845
I-set 1140..1237 CDD:254352
Ig 1146..1237 CDD:299845
RCSD 1384..1491 CDD:282963
RCSD 1481..1590 CDD:282963
RCSD 1576..1678 CDD:282963
RCSD 1735..1819 CDD:282963
RCSD 1789..>1860 CDD:282963
I-set 1982..2068 CDD:254352
Ig 2009..2069 CDD:299845
Ig_TrkABC_d4 2075..2164 CDD:143173
I-set 2081..2164 CDD:254352
I-set 2171..2262 CDD:254352
Ig <2198..2262 CDD:299845
I-set 2269..2360 CDD:254352
Ig 2270..2360 CDD:299845
I-set 2367..2456 CDD:254352
IGc2 2380..2446 CDD:197706
I-set 2463..2554 CDD:254352
Ig 2490..2554 CDD:299845
I-set 2563..2652 CDD:254352
Ig 2579..2647 CDD:143165
I-set 2659..2747 CDD:254352
Ig 2667..2747 CDD:299845
I-set 2754..2843 CDD:254352
Ig 2777..2841 CDD:143165
I-set 2887..2981 CDD:254352
Ig 2904..2978 CDD:143165
I-set 2994..3082 CDD:254352
IGc2 3009..3072 CDD:197706
I-set 3087..3183 CDD:254352
Ig 3101..3179 CDD:299845
I-set 3189..3279 CDD:254352
Ig 3206..3276 CDD:299845
I-set 3286..3377 CDD:254352
Ig 3303..3374 CDD:143165
I-set 3384..3472 CDD:254352
Ig 3402..3472 CDD:143165
I-set 3482..3573 CDD:254352
Ig 3501..3570 CDD:143165
I-set 3580..3671 CDD:254352
IGc2 3593..3661 CDD:197706
I-set 3686..3776 CDD:254352
IGc2 3699..3766 CDD:197706
I-set 3817..3902 CDD:254352
Ig 3834..3899 CDD:143165
I-set 3920..4010 CDD:254352
Ig 3921..4010 CDD:299845
I-set 4018..4107 CDD:254352
Ig 4046..4107 CDD:299845
Ig 4108..4201 CDD:299845
I-set 4114..4202 CDD:254352
I-set 4212..4298 CDD:254352
IGc2 4226..4288 CDD:197706
I-set 4302..4388 CDD:254352
Ig 4319..4384 CDD:143165
I-set 4400..4486 CDD:254352
Ig 4417..4482 CDD:143165
I-set 4493..4581 CDD:254352
Ig 4518..>4566 CDD:299845
I-set 4588..4679 CDD:254352
Ig 4599..4679 CDD:299845
I-set 4685..4772 CDD:254352
Ig <4713..4772 CDD:299845
I-set 4781..4869 CDD:254352 14/69 (20%)
Ig 4790..4869 CDD:299845 14/69 (20%)
I-set 4873..4962 CDD:254352 24/112 (21%)
Ig 4891..4960 CDD:299845 16/74 (22%)
I-set 4969..5059 CDD:254352 22/98 (22%)
Ig 4985..5051 CDD:143165 19/74 (26%)
I-set 5073..5161 CDD:254352 23/95 (24%)
Ig 5094..5161 CDD:299845 18/74 (24%)
I-set 5171..5260 CDD:254352 21/88 (24%)
Ig 5189..5255 CDD:143165 15/65 (23%)
I-set 5277..5367 CDD:254352 27/93 (29%)
IGc2 5291..5357 CDD:197706 22/69 (32%)
I-set 5383..5473 CDD:254352 24/92 (26%)
IGc2 5397..5463 CDD:197706 19/67 (28%)
I-set 5487..5577 CDD:254352 22/98 (22%)
IGc2 5501..5567 CDD:197706 15/74 (20%)
I-set 5595..5684 CDD:254352 28/95 (29%)
Ig 5614..5681 CDD:143165 22/73 (30%)
I-set 5701..5791 CDD:254352 21/95 (22%)
IGc2 5714..5781 CDD:197706 16/72 (22%)
I-set 5815..5905 CDD:254352 18/89 (20%)
IGc2 5828..5895 CDD:197706 12/66 (18%)
I-set 5925..6015 CDD:254352 14/95 (15%)
Ig 5939..6015 CDD:299845 11/81 (14%)
I-set 6038..6131 CDD:254352 25/184 (14%)
Ig 6058..6126 CDD:143165 20/159 (13%)
I-set 6150..6240 CDD:254352 27/110 (25%)
Ig 6168..6237 CDD:143165 22/89 (25%)
FN3 6275..6358 CDD:214495 21/83 (25%)
IG_like 6413..6501 CDD:214653
Ig 6427..6499 CDD:143165
I-set 6507..6597 CDD:254352
Ig 6529..6594 CDD:143165
PK_Unc-89_rpt1 6620..6878 CDD:271011
S_TKc 6640..6878 CDD:214567
I-set 7528..7616 CDD:254352
Ig 7546..7616 CDD:299845
FN3 7621..7716 CDD:238020
STKc_Unc-89_rpt2 7781..8035 CDD:271014
S_TKc 7793..8035 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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