DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Kirrel

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus

Alignment Length:	915	Identity:	195/915 - (21%)
Similarity:	303/915 - (33%)	Gaps:	262/915 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 DPPTQTVDFGRPAVFTC---QYTGNPIKTVSWMKDGKAIGHSE-----PVLRIESVKKEDKGMYQ 408
            :|..|||..|:.||..|   .|:|    .|.|.|||.|:|..:     |..|:  |...|.|.|.
Mouse    58 EPADQTVVAGQRAVLPCVLLNYSG----IVQWTKDGLALGMGQGLKAWPRYRV--VGSADAGQYN 116

  Fly   409 CFVRNDQESAEAS-----AELKLGGR------FDPPVIRQAFQEETMEPGPSVFLK--------C 454
            ..:.:.:.|.:||     .|..|..|      ..||      :|..::.||.:.|:        |
Mouse   117 LEITDAELSDDASYECQATEAALRSRRAKLTVLIPP------EETRIDGGPVILLQAGTPYNLTC 175

  Fly   455 VA-GGNPTPEISWELDGKK----IANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKS 514
            .| ...|...|.|..||.:    :.:.:..:.|:..|    .:|.|.|.....:.|.::.|.:.:
Mouse   176 RAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRET----TISQLLIEPTDLDIGRVFTCRSMN 236

  Fly   515 KV--GVAEHSAKLNVYGLPYIR-QMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQ 576
            :.  ...|.|.:|:|:..|.:. .:|.:.::.||.:|.||
Mouse   237 EAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTC------------------------- 276

  Fly   577 KVFPNGTLIIENVERNSDQATYTCVAKNQE--GYS-ARGSLEVQVMVLPQIVPFAYEDLINMGDS 638
                              |||     .|.|  ||. |:|.             |..||
Mouse   277 ------------------QAT-----ANPEILGYRWAKGG-------------FLIED------- 298

  Fly   639 IDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIA 703
                           .|.|...:..||.|           .:|..|                |..
Mouse   299 ---------------AHESRYETNVDYSF-----------FTEPVS----------------CEV 321

  Fly   704 SNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGD----TPG 764
            .||.|:|..|..:.|:..||.::.|.......|||..:.|...|.|...:||.|...:    .||
Mouse   322 YNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRLPG 386

  Fly   765 EYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQT 829
            ...:...|..:......|.:.::.:.:.|.|.|.||..........:.:.|..||..:.: ..|.
Mouse   387 SPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSE-AVQF 450

  Fly   830 ARRGEPAVLQC-EAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSD-S 892
            |.||:...::| ......|..|.|......|:.....|||:......:||:|:|:|.....:| .
Mouse   451 AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQ 515

  Fly   893 ALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKR 957
            ..:.|.|.|:||...|.|.:..:||..:.........:|..|..|:|.         .....::|
Mouse   516 THYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFAA---------LVFFLYRR 571

  Fly   958 SRASWSE------------IDRVIVPGHT-TEAQVQKLSPATTYNIRIVA--ENAIGTSQSSEAV 1007
            .:.|..:            ::|..:..|: .|.....:|.||.....|.:  ::.:...|.....
Mouse   572 RKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDLRCD 636

  Fly  1008 TIITAEE----APSGKPQNIKV---EPVNQTTMRVTWKPPPRTEWNG---EILGYYVGYKLSNTN 1062
            ||.|.||    .|:....|::.   .|.::..:...::.|..|.::|   ..|.:..||...||.
Mouse   637 TIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTY 701

  Fly  1063 SSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQP--P 1125
            |                                         ..|.|:    :..|.|||.|  |
Mouse   702 S-----------------------------------------RAPASD----YGTEPTPSGPSAP 721

  Fly  1126 SDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVY--APSD-------EWYDETKRHYKKTASS 1181
            ..|..|:..|......:.|.|...|.| ..||::.|  ||..       |.||...::...|..|
Mouse   722 GGTDTTSQLSYENYEKFNSHPFPGAAG-YPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFS 785

  Fly  1182 DTVLH 1186
            .|..|
Mouse   786 YTSQH 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	27/84 (32%)
		IGc2	361..413	CDD:197706	19/59 (32%)
		I-set	433..527	CDD:254352	22/108 (20%)
		IGc2	446..517	CDD:197706	17/85 (20%)
		I-set	533..618	CDD:254352	15/88 (17%)
		IGc2	544..607	CDD:197706	10/64 (16%)
		Ig	641..714	CDD:143165	12/72 (17%)
		IGc2	735..804	CDD:197706	18/72 (25%)
		I-set	819..914	CDD:254352	26/96 (27%)
		Ig	833..921	CDD:299845	24/89 (27%)
		FN3	918..1011	CDD:238020	16/107 (15%)
		FN3	1018..1116	CDD:238020	13/103 (13%)
		FN3	1124..1217	CDD:238020	21/74 (28%)
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	29/95 (31%)
		Ig2_KIRREL3-like	170..251	CDD:143236	17/84 (20%)
		Ig	255..336	CDD:386229	32/190 (17%)
		Ig_3	340..421	CDD:372822	19/80 (24%)
		Ig5_KIRREL3	439..536	CDD:143306	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11159
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900