DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Lifr

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001345522.1	Gene:	Lifr / 16880	MGIID:	96788	Length:	1092	Species:	Mus musculus

Alignment Length:	1112	Identity:	219/1112 - (19%)
Similarity:	363/1112 - (32%)	Gaps:	318/1112 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 GYSARGSL-EVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQV 670
            |:.::.:| |..|.::|:.     .:::::  |.|.|..      .:.:.|:      |.|....
Mouse   115 GFQSKFTLNEKDVSLIPET-----PEILDL--SADFFTS------SLLLKWN------DRGSALP 160

  Fly   671 QPQMRTNRI----SEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDL-----TVNVPPRWIL 726
            .|...|..|    :.:|..:::...:...:|:||....|      ::.||     |.:|..||.:
Mouse   161 HPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWN------WTSDLPLQCATHSVSIRWHI 219

  Fly   727 E------------------------------PTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGD 761
            :                              |.||....||:..:.|.:     |.......:|:
Mouse   220 DSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMS-----PTKVLSGQIGN 279

  Fly   762 TPGEYKDLKKSDNIRVEEGTLHVDNI-----QKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEF 821
            |      |:...::..:...:|:.||     ..||..:...:.:.|        .::....||:.
Mouse   280 T------LRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYG--------TVVFAGYPPDV 330

  Fly   822 TEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMR--LDPKNDNRYTIREEILS--------- 875
            .:|             |.||....|.|...||...:.  :.|:| ..||:.|.|..
Mouse   331 PQK-------------LSCETHDLKEIICSWNPGRITGLVGPRN-TEYTLFESISGKSAVFHRIE 381

  Fly   876 --TGVMSSLSIKRTERSDSALFTCVATNAFGSDDAS--INMIVQEVPEMPYALKVLDKSGRSVQL 936
              |.....|.::.....:...||....|..|...::  ||:..:..|..|.:|||.|.:...|..
Mouse   382 GLTNETYRLGVQMHPGQEIHNFTLTGRNPLGQAQSAVVINVTERVAPHDPTSLKVKDINSTVVTF 446

  Fly   937 SWAQPYDGNSPLDRYIIEFKRSRA-SWSEIDRVIVPG---HTTEAQVQKLSPATTYNIRIVAENA 997
            ||..|  ||......:.:.:..:| |..|:....:.|   .|....|.||:|.|.|..|:...:.
Mouse   447 SWYLP--GNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSSK 509

  Fly   998 I--GTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSN 1060
            .  ..|:.|:....:|.|..||..|...:....:...:.|.|||.|..|.||:||.|.|...| |
Mouse   510 TFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKILSYNVSCSL-N 573

  Fly  1061 TNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSE------EEKQFTAEG 1119
            ..:..|.|..:      .:|..|:|..:  ..|.:.:.|.|..|:.|.|:      .....|.|.
Mouse   574 EETQSVLEIFD------PQHRAEIQLSK--NDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQ 630

  Fly  1120 ----------TPSQPPSDTA------CTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWY 1168
                      |....|:.|.      |.:..|:...:.|...|..|...||:        ||::.
Mouse   631 AVGLGNRIFLTWRHDPNMTCDYVIKWCNSSRSEPCLLDWRKVPSNSTETVIE--------SDQFQ 687

  Fly  1169 DETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVP-EAPT----DV 1228
            ...:.::        .|:|.   ||...|:|.:..|           ..|...| .||.    |.
Mouse   688 PGVRYNF--------YLYGC---TNQGYQLLRSIIG-----------YVEELAPIVAPNFTVEDT 730

  Fly  1229 KALVMGNAAILVSWR--PPAQPNGIITQYTVYSKAEGAETETKTQKV-PHY------------QM 1278
            .|     .:|||.|.  |..:..|.:..|..|.: :|.....||:.: ||:            |.
Mouse   731 SA-----DSILVKWDDIPVEELRGFLRGYLFYFQ-KGERDTPKTRSLEPHHSDIKLKNITDISQK 789

  Fly  1279 SFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQV--------PAKIASFDDTFTA---- 1331
            :....:|:....|...:.|.|..|.|.:....|....:.|        |..:|......|:
Mouse   790 TLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCY 854

  Fly  1332 --------TFKEDAKMPCLAVGAPQPEITWKIKGVEFSAN------------------DRMRVLP 1370
                    ||..|         .|.||   ..|.::|..:                  :.:.||.
Mouse   855 RKREWIKETFYPD---------IPNPE---NCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLE 907

  Fly  1371 DGSLLIKSVNRQDAGDYSCHAENSIAKDSI---THKLIVLAPP------QSPHVTLSATTTDALT 1426
            ..|::.|.   :|....|..||....:..:   .|.::...||      .:|........:..:.
Mouse   908 SRSIVPKI---EDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVY 969

  Fly  1427 VKLK---------PHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATG 1482
            :.::         ..|.|..|:  ....|||:. ....|....|:...:.||...|.|.|.....
Mouse   970 IDVQSMYQPQAKAEEEQDVDPV--VVAGYKPQM-RLPISPAVEDTAAEDEEGKTAGYRPQANVNT 1031

  Fly  1483 FNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMS----HFVVESKK 1543
            :|.:.                   |:.||..:.::..||.        |.|.|    .|::..|.
Mouse  1032 WNLVS-------------------PDSPRSTDSNNEVVSF--------GSPCSINSRQFLIPPKD 1069

  Fly  1544 RDQIEWN 1550
            .|..:.|
Mouse  1070 EDSPKSN 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352	3/11 (27%)
		IGc2	544..607	CDD:197706	219/1112 (20%)
		Ig	641..714	CDD:143165	12/76 (16%)
		IGc2	735..804	CDD:197706	13/73 (18%)
		I-set	819..914	CDD:254352	23/109 (21%)
		Ig	833..921	CDD:299845	22/102 (22%)
		FN3	918..1011	CDD:238020	26/98 (27%)
		FN3	1018..1116	CDD:238020	26/103 (25%)
		FN3	1124..1217	CDD:238020	18/98 (18%)
		FN3	1222..1312	CDD:238020	25/109 (23%)
		Ig	1339..1406	CDD:299845	14/87 (16%)
		FN3	1409..1499	CDD:238020	17/104 (16%)
		FN3	1504..1584	CDD:238020	12/51 (24%)
		Dscam_C	1890..2008	CDD:289151
Lifr	NP_001345522.1	LIFR_N	50..124	CDD:375634	2/8 (25%)
		LIFR_D2	126..239	CDD:375455	22/137 (16%)
		FN3	428..525	CDD:238020	26/98 (27%)
		WSXWS motif	514..518		1/3 (33%)
		FN3	547..613	CDD:389787	23/74 (31%)
		FN3	724..816	CDD:238020	21/97 (22%)
		Box 1 motif	864..872		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1009..1092		19/95 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910