DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and Cntn4

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_446331.1	Gene:	Cntn4 / 116658	RGDID:	621361	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	1391	Identity:	280/1391 - (20%)
Similarity:	467/1391 - (33%)	Gaps:	459/1391 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RLKW-LMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTN---RIDFSNSTGAEIECKASGNP 67
            ||.| |::..:..|......||         .||||::||::   .:| |.....::.|:..|||
  Rat     2 RLPWELLVLQSFMLCLADDYTL---------HGPVFVQEPSHVMFPLD-SEEKKVKLSCEVKGNP 56

  Fly    68 MPEIIWIRSDGTAVGDVPGLRQISSDGKLVF-PPFRAEDYRQEVHAQVYACLARNQFGSIISRDV 131
            .|.|.| :.:||.|......|....:|.|:. .|.:.:|      :..|.|:|.|.||:|:||:.
  Rat    57 KPHIRW-KLNGTDVDIGMDFRYSVVEGSLLINNPNKTQD------SGTYQCIATNSFGTIVSREA 114

  Fly   132 HVRAVVSQHYEEDIHKAF-VIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLV 195
            .::....::::....... |.||...:|.|..|..
  Rat   115 KLQFAYLENFKTRTRSTVSVRRGQGMVLLCGPPPH------------------------------ 149

  Fly   196 LPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPQLSGNGNQEHITL 260
              ||||....:..|  :.|||...:.
  Rat   150 --SGELSYAWIFNE--HPSYQDNRRF--------------------------------------- 171

  Fly   261 TRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 325
                                                       |.|.:|.|.|......|.|.|.
  Rat   172 -------------------------------------------VSQETGNLYIAKVEKADVGNYT 193

  Fly   326 CVVNNSVGGESVETVLTVTAPLSAKID--------------PPTQTVDFGRPAVFTCQYTGNPIK 376
            |||.|:|   :...||....||..:.|              |.|...:.|......|...|||:.
  Rat   194 CVVTNTV---TSHQVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPAEKGSTVKLECFALGNPVP 255

  Fly   377 TVSWMK-DGKAIGH------SEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPV 434
            |:.|.: |||.|..      |..:|.|.:.::||.|.|:|...|.:....|..::..   :..|.
  Rat   256 TILWRRADGKPIARKARRHKSSGILEIPNFQQEDAGSYECVAENSRGKNIAKGQVTF---YAQPN 317

  Fly   435 IRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITS 499
            ..|...:..:....|||.:|.|.|.|.|...|..:|..:...:|.|:.|         ..||||.
  Rat   318 WVQIINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRERIQIEQ---------GTLNITI 373

  Fly   500 VHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWE 564
            |:.:|.|:|:|:|::|.||...||:|:|                         :|..|
  Rat   374 VNLSDAGMYQCVAENKHGVIYASAELSV-------------------------IAESP------- 406

  Fly   565 RDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAY 629

  Rat   407 ----------------------------------------------------------------- 406

  Fly   630 EDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPA 694
                                       .|.|:                 :.::.:::.:
  Rat   407 ---------------------------DFSRT-----------------LLKRVTLVKV------ 421

  Fly   695 HTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAV 759
                                                     |.:..:|||....|:|..||:|.
  Rat   422 -----------------------------------------GGEVVIECKPKASPRPVYTWRKG- 444

  Fly   760 GDTPGEYKDLKKSDNIRV-EEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMI-----SVQAP 818
                  .:.|::::.|.: |:|.|.:.|:.|::.|.|.|.|.|..|:..|...::     .|..|
  Rat   445 ------REILRENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVVVKDPTKVMVP 503

  Fly   819 PEFTEKLRNQTARRGEPAVLQCEAKGEKPIGIL--WNMNNMRLDPKNDNRYTIREEILSTGVMSS 881
            |.      :.....||..||.|:...:..:.|:  |..|...:|...|..:.  |.:........
  Rat   504 PS------SMDVTVGESIVLPCQVTHDHSLDIVFTWTFNGHLIDFDKDGDHF--ERVGGQDSAGD 560

  Fly   882 LSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNS 946
            |.|:..:...:..:.|:...:.....|:.::||:..|..|.|:.:.:.:..:.||||....|.:|
  Rat   561 LMIRNIQLKHAGKYVCMVQTSVDKLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHS 625

  Fly   947 PLDRYIIEFKRS-RASWSEIDRV--IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVT 1008
            |:..|:|:.:.. ...|..:..|  :|.|.|..|.|..|:|...|..|.||.|.||..:.|....
  Rat   626 PITMYVIQARTPFSVGWQAVSTVPELVDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSE 690

  Fly  1009 IITAEEA-PSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYK-----------LSNT 1061
            ....||| |...|.|:.....:::.:.:||:..|....||...||.|.::           |::.
  Rat   691 KRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPHGKMIWMLTVLASA 755

  Fly  1062 NSS-YVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPP 1125
            ::| |||..               :::|.::.:.|.:..||..|.||.|.....::||..|::||
  Rat   756 DASRYVFRN---------------ESVRPFSPFEVKVGVFNNKGEGPFSPTTLVYSAEEEPTKPP 805

  Fly  1126 SDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEW-YDETKRHYKKTAS----SDTVL 1185
            :.....:|::..|.|.|.| |:....|.|:.|:|.|     | :|:.:.:.:|..:    :.|.:
  Rat   806 ASIFARSLSATDIEVFWAS-PIGKNRGRIQGYEVKY-----WRHDDKEENARKIRTVGNQTSTKI 864

  Fly  1186 HGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNG 1250
            ..||....|.:.|.|..:.|.|..|..::..|....|..|.........::.|:::|.
  Rat   865 TNLKGNALYHLSVKAYNSAGTGPSSAAVNVTTRKPPPSQPPGNIIWNSSDSKIILNWD------- 922

  Fly  1251 IITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPS 1315
                   ..||...|:|.|..||                .|.:...:||::.|..::...:::|.
  Rat   923 -------QVKALDNESEVKGYKV----------------LYRWNRQSSTSVIETNKTSVELSLPF 964

  Fly  1316 DQ-VPAKIASFDDTFTATFKEDAKMP 1340
            |: ...:|..|.|....:..|..::|
  Rat   965 DEDYIIEIKPFSDGGDGSSSEQIRIP 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	31/95 (33%)
		IG	57..133	CDD:214652	24/76 (32%)
		IG_like	267..343	CDD:214653	15/75 (20%)
		Ig	269..340	CDD:143165	13/70 (19%)
		IG_like	353..425	CDD:214653	23/78 (29%)
		IGc2	361..413	CDD:197706	19/58 (33%)
		I-set	433..527	CDD:254352	31/93 (33%)
		IGc2	446..517	CDD:197706	24/70 (34%)
		I-set	533..618	CDD:254352	2/84 (2%)
		IGc2	544..607	CDD:197706	2/62 (3%)
		Ig	641..714	CDD:143165	2/72 (3%)
		IGc2	735..804	CDD:197706	21/69 (30%)
		I-set	819..914	CDD:254352	16/96 (17%)
		Ig	833..921	CDD:299845	18/89 (20%)
		FN3	918..1011	CDD:238020	29/95 (31%)
		FN3	1018..1116	CDD:238020	23/109 (21%)
		FN3	1124..1217	CDD:238020	25/97 (26%)
		FN3	1222..1312	CDD:238020	15/89 (17%)
		Ig	1339..1406	CDD:299845	1/2 (50%)
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Cntn4	NP_446331.1	Ig	25..114	CDD:299845	32/96 (33%)
		I-set	26..117	CDD:254352	31/98 (32%)
		Ig	120..213	CDD:299845	30/211 (14%)
		IG_like	130..204	CDD:214653	27/192 (14%)
		Ig	225..313	CDD:299845	23/90 (26%)
		IG_like	232..311	CDD:214653	23/78 (29%)
		I-set	316..401	CDD:254352	31/93 (33%)
		Ig	318..401	CDD:299845	30/91 (33%)
		IG_like	415..494	CDD:214653	23/132 (17%)
		Ig5_Contactin_like	422..494	CDD:143170	23/78 (29%)
		IG_like	504..593	CDD:214653	16/96 (17%)
		Ig6_Contactin-4	513..597	CDD:143261	16/85 (19%)
		FN3	597..690	CDD:238020	29/92 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		7/24 (29%)
		FN3	703..792	CDD:238020	23/103 (22%)
		FN3	804..896	CDD:238020	25/97 (26%)
		FN3	904..989	CDD:238020	20/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010