DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and PTPRT

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_024307588.1	Gene:	PTPRT / 11122	HGNCID:	9682	Length:	1535	Species:	Homo sapiens

Alignment Length:	1482	Identity:	257/1482 - (17%)
Similarity:	430/1482 - (29%)	Gaps:	609/1482 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 VECKADGFPKPQVTWKKAVGDT--------------PGEYKDLKKSDNIRVEEGTLHVDNIQKTN 791
            |..|.:|.|:....|..:...|              |..|:.:.:|.:::...|.:.||.::
Human   122 VYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVR--- 183

  Fly   792 EGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNN 856
                              |:....:..|.|. :|:|.....|:.|..||.|.|:      |:.::
Human   184 ------------------VLAHPCRKAPHFL-RLQNVEVNVGQNATFQCIAGGK------WSQHD 223

  Fly   857 -MRLDPKN--DNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVP 918
             :.|...|  |....:...:......:::|:..|.:...:.:.||..:..||..::...::.:.|
Human   224 KLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEP 288

  Fly   919 EMPYALKVLDKSGRSVQLSWAQP----YDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQV 979
            ..|.|...|...|.:  ..|.:|    ..|:.|:....:|::.:..:|:|...|..|.:    ::
Human   289 PTPIAPPELLAVGAT--YLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY----KL 347

  Fly   980 QKLSPATTYNIRIV----AENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPP 1040
            ..|.|...|.||::    .|.  ||......:|..|....|...|||:::..:....:.:.|:|
Human   348 WHLDPDVEYEIRVLLTRPGEG--GTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP- 409

  Fly  1041 PRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGA 1105
                         .||.::..:|                     .||.|..||     .||
Human   410 -------------FGYAVTRCHS---------------------YNLTVQYQY-----VFN---- 431

  Fly  1106 GPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDE 1170
                  ::|:.||                                       :|:         :
Human   432 ------QQQYEAE---------------------------------------EVI---------Q 442

  Fly  1171 TKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMG- 1234
            |..||        .|.||:.:....:::|.:...| .:.|..:..|||.|||.| ..::::..|
Human   443 TSSHY--------TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGA-VPLESIQGGP 497

  Fly  1235 -NAAILVSWRPPAQPNGIITQYTVYSKAEGA---ETETKTQKVPHYQMSFEA----TELEKNKPY 1291
             ...|.:.|:||.:.||:||.|.:..||.|:   ..:..:|:...:::..|.    ..|.....|
Human   498 FEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTY 562

  Fly  1292 EFWVTASTTIGEGQQSKSIVA-------MPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQP 1349
            .|.:.|||..|.|....:.:|       ||.......:...|.|.|...|     |..:.|||..
Human   563 SFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLK-----PAQSRGAPVS 622

  Fly  1350 EITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHA-----ENSIAKDSITHKLIVLAP 1409
            .....:|      .:|::         ||  |:.|....|.:     .|:.:.||:.:....|.|
Human   623 VYQLVVK------EERLQ---------KS--RRAADIIECFSVPVSYRNASSLDSLHYFAAELKP 670

  Fly  1410 PQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGS 1474
            ...|       .|...||      ||....:||          |......:.|
Human   671 ANLP-------VTQPFTV------GDNKTYNGY----------WNPPLSPLKS------------ 700

  Fly  1475 RYQVYATGFNNIGAGEASDILNTRTK---GQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSH 1536
             |.:|....:........:.:...||   |.....|..|..:..:             |....:.
Human   701 -YSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTT-------------GASTQNS 751

  Fly  1537 FVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGT 1601
            ..||.:|       |:.|.||                                        ..|.
Human   752 NTVEPEK-------QVDNTVK----------------------------------------MAGV 769

  Fly  1602 IAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVV-----AVGICVVCVALSRRRADD 1661
            ||.|                        |.|::.|:..::.:     |...... :.|::::.:.
Human   770 IAGL------------------------LMFIIILLGVMLTIKRRRNAYSYSYY-LKLAKKQKET 809

  Fly  1662 MRGGQKDVYYDVVYNQTMGPGATLDKRRPDL---RDELGY-----------------IAPPNRKL 1706
            ..|.|::          |||.|:.||....|   |::.|:                 ::.|...:
Human   810 QSGAQRE----------MGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTI 864

  Fly  1707 PPVPGSNYNTCD-------------------------RIKRGRG-GLRSNH--------STW--- 1734
            ...|   |.|||                         ::|||:| |.:..:        ::|
Human   865 QTHP---YRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTA 926

  Fly  1735 --DPRRNPNLYEELKAPPVPMHGNHYGHAHGN-AECHYRHPGMEDEICPYATFHLLGFREEMDPT 1796
              |..||.|.|                   || ..|..|.|..               |.:|..|
Human   927 KEDENRNKNRY-------------------GNIISCRGRSPAK---------------RADMRKT 957

  Fly  1797 KAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPA 1861
            ..::                                :..|...|.|...||:          |.|
Human   958 PQLD--------------------------------KEMSSVFPEAPLIQRR----------TLA 980

  Fly  1862 PEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYG 1926
            ..:||            ::||.     |....|.         |..|...:.|...|.:|..:..
Human   981 ATWDD------------HSRVR-----LLVLDGD---------PHSDYINANYIDGYHRPRHYIA 1019

  Fly  1927 SRGSM-------------------------------------GRRSIGSARNPGNGS-----PEP 1949
            ::|.|                                     |..::|.|.:||...     |:
Human  1020 TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGMVKCVRYWPD- 1083

  Fly  1950 PPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMR------- 2007
                      ....:.|.|.:  :.|.|      |...|.....:.|.|......|:|
Human  1084 ----------DTEVYGDIKVT--LIETE------PLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1130

  Fly  2008 -------------------KLIERNETGPKQLQLQQANGAG----FTAYDTM 2036
                               |.:...|.||  :.:..:.|||    |.|.|||
Human  1131 PDHGVPCYATGLLGFVRQVKFLNPPEAGP--IVVHCSAGAGRTGCFIAIDTM 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	12/76 (16%)
		I-set	819..914	CDD:254352	20/97 (21%)
		Ig	833..921	CDD:299845	17/90 (19%)
		FN3	918..1011	CDD:238020	23/100 (23%)
		FN3	1018..1116	CDD:238020	16/97 (16%)
		FN3	1124..1217	CDD:238020	10/92 (11%)
		FN3	1222..1312	CDD:238020	25/98 (26%)
		Ig	1339..1406	CDD:299845	14/71 (20%)
		FN3	1409..1499	CDD:238020	13/89 (15%)
		FN3	1504..1584	CDD:238020	10/79 (13%)
		Dscam_C	1890..2008	CDD:289151	24/185 (13%)
PTPRT	XP_024307588.1	MAM	29..189	CDD:214533	13/87 (15%)
		fn3	294..360	CDD:306538	15/71 (21%)
		FN3	390..480	CDD:238020	28/196 (14%)
		fn3	502..577	CDD:306538	22/74 (30%)
		PTPc	985..1222	CDD:238006	40/243 (16%)
		PTPc	1284..1504	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910