DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam1 and Palld

DIOPT Version :9

Sequence 1:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster
Sequence 2:XP_038950842.1 Gene:Palld / 100360205 RGDID:2322545 Length:1409 Species:Rattus norvegicus


Alignment Length:1019 Identity:195/1019 - (19%)
Similarity:309/1019 - (30%) Gaps:416/1019 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 PDADQKG---PVFLKEPTNRIDFSNSTGAE-----IECKASGNPMPEIIWIRSDGTAVGDVPGLR 88
            ||....|   |||.||      ..|:..:|     :||:..|.|..::.|.| .|:.:.|.|..|
  Rat   439 PDGTTMGCLLPVFTKE------LQNTAASEGQVVVLECRVRGAPPLQVQWFR-QGSEIQDSPDFR 496

  Fly    89 QISSDGKLVFPPFR------AEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVV---------- 137
            .:....:....|..      ||.:.::  |.::.|.|||.:||:.|.   .:.||          
  Rat   497 ILQKKPRSTAEPEEICTLVIAESFPED--AGIFTCSARNDYGSVTST---AQLVVTSANTENCSY 556

  Fly   138 -------SQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNV-----------ISWHSDEKE--N 182
                   |.|::.......::...|..|....||.:.. ||.           :.::|.|:|  .
  Rat   557 DSMGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQ-VNTPNLGFNMAALQMQFNSAERETNG 620

  Fly   183 FYP---------GTEYDGKYLVLPSGELHIREVGPE-------DGYKSYQCRTKHRLTGETRL-- 229
            .:|         |..|..|....|:..|...:..|.       |..|..|.:.:.||..|...  
  Rat   621 VHPSHGVNGLINGKAYGNKSPPTPAALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWP 685

  Fly   230 ---------SATKGRL-----------------------VITEPVG-----SVSPQLSGNGN--- 254
                     |::.|..                       |.:||:.     |.:.|.||:.|   
  Rat   686 PAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASRSTAMQSSGSFNYAR 750

  Fly   255 -QEHI------------TLTRVPKMGSV------------------------------------- 269
             ::.|            |.|..|...|:                                     
  Rat   751 PKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVEPEAMWGPSSPSPPPPP 815

  Fly   270 -TLMCPAQAYPVP-FFRW-----------------YKFIEGTT---------------------- 293
             .:..|:.|:||| .|..                 .:|..|.|                      
  Rat   816 PPVFSPSTAFPVPDVFPLPPPPPPLPSSTSHCASPARFSPGQTPAAFLSALLPSQPPPVAVNALG 880

  Fly   294 --------------RKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL----CVVNN---------- 330
                          .:.|.:.:|  :::.||   ||||::|..:.|    .::||          
  Rat   881 LPKGVTPAGFPKKASRTARIASD--EEIQGT---KDAVIQDLERKLRFKEDLLNNGQPRLTYEER 940

  Fly   331 ---------------------------------SVGG----------ESVETVLTVTAPLSAKID 352
                                             ||||          .|.|..|........:..
  Rat   941 MARRLLGADSANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCEQRLISEIEYRLERS 1005

  Fly   353 PPTQTVD---------------------------FGRPAVFTCQYTGNPIKTVSWMKDGKAIGHS 390
            |..:|.|                           .|.|..|||:..|:|...:.|.||||.|...
  Rat  1006 PVEETGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFTCRVAGSPKPKIYWFKDGKQISPK 1070

  Fly   391 EPVLRIE------------SVKKEDKGMYQCFVRNDQESAEASAELKLGG--------------- 428
            .....|:            :...:|.|.|.....|.|.....:..|.:..               
  Rat  1071 SDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRVSCTGRLMVQAVNQRGRSPRSPPGHP 1135

  Fly   429 ---------------------RFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKK 472
                                 ||..|...||..:.|::.|....:.|...|.|||::||:||||.
  Rat  1136 HARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKP 1200

  Fly   473 IANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNV-----YGLP- 531
            |..:..:::  .|..||  |..|.|..|.:.|.|:|.|||.::.|....:.:|.|     :..| 
  Rat  1201 IRPDSAHKM--LVRENG--VHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPV 1261

  Fly   532 YIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALP-----INRKQKVFPNGTLIIENVER 591
            :|.:::...:..|..:.:.|.|:|.|...|.|:::|.:|.     ::..|.......|:|:...:
  Rat  1262 FIEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATK 1326

  Fly   592 NSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQ---KGDRPIK 653
             .|...||..|||:.|                        :::....:|::.|..   :..:|.|
  Rat  1327 -EDAGWYTVSAKNEAG------------------------IVSCTARLDVYTQWHQQPQTTKPKK 1366

  Fly   654 VHWSFERSA--GDYGFDQVQPQMRTNRISEKTSMISIPSASPAH 695
            |..|..|.|  .|.|.| ::...:             |.|||:|
  Rat  1367 VRPSASRYAALSDQGLD-IKAAFQ-------------PEASPSH 1396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam1NP_001246162.1 Ig 38..130 CDD:299845 29/105 (28%)
IG 57..133 CDD:214652 22/86 (26%)
IG_like 267..343 CDD:214653 29/224 (13%)
Ig 269..340 CDD:143165 27/219 (12%)
IG_like 353..425 CDD:214653 22/110 (20%)
IGc2 361..413 CDD:197706 17/63 (27%)
I-set 433..527 CDD:254352 32/93 (34%)
IGc2 446..517 CDD:197706 26/70 (37%)
I-set 533..618 CDD:254352 20/89 (22%)
IGc2 544..607 CDD:197706 18/67 (27%)
Ig 641..714 CDD:143165 15/60 (25%)
IGc2 735..804 CDD:197706
I-set 819..914 CDD:254352
Ig 833..921 CDD:299845
FN3 918..1011 CDD:238020
FN3 1018..1116 CDD:238020
FN3 1124..1217 CDD:238020
FN3 1222..1312 CDD:238020
Ig 1339..1406 CDD:299845
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1890..2008 CDD:289151
PalldXP_038950842.1 IgI_2_Titin_Z1z2-like 278..369 CDD:409564
Ig strand B 296..300 CDD:409564
Ig strand C 309..313 CDD:409564
Ig strand E 335..339 CDD:409564
Ig strand F 349..354 CDD:409564
Ig strand G 362..365 CDD:409564
I-set 449..546 CDD:400151 28/108 (26%)
Ig strand A' 454..458 CDD:409353 1/9 (11%)
Ig strand B 466..474 CDD:409353 2/7 (29%)
Ig strand C 479..484 CDD:409353 1/4 (25%)
Ig strand C' 487..489 CDD:409353 0/1 (0%)
Ig strand D 495..500 CDD:409353 1/4 (25%)
Ig strand E 511..516 CDD:409353 0/4 (0%)
Ig strand F 525..533 CDD:409353 2/7 (29%)
Ig strand G 536..546 CDD:409353 3/12 (25%)
IgI_1_Palladin_C 1027..1118 CDD:409474 20/90 (22%)
Ig strand B 1044..1048 CDD:409474 1/3 (33%)
Ig strand C 1057..1061 CDD:409474 0/3 (0%)
Ig strand E 1084..1088 CDD:409474 0/3 (0%)
Ig strand F 1098..1103 CDD:409474 1/4 (25%)
Ig strand G 1111..1114 CDD:409474 0/2 (0%)
Ig 1161..1251 CDD:416386 32/93 (34%)
Ig strand A 1161..1164 CDD:409353 1/2 (50%)
Ig strand A' 1167..1172 CDD:409353 0/4 (0%)
Ig strand B 1177..1184 CDD:409353 1/6 (17%)
Ig strand C 1191..1197 CDD:409353 2/5 (40%)
Ig strand C' 1198..1201 CDD:409353 2/2 (100%)
Ig strand D 1207..1213 CDD:409353 1/7 (14%)
Ig strand E 1216..1226 CDD:409353 4/9 (44%)
Ig strand F 1230..1238 CDD:409353 5/7 (71%)
Ig strand G 1240..1251 CDD:409353 2/10 (20%)
IgI_Myotilin_C 1260..1351 CDD:409473 21/115 (18%)
Ig strand B 1277..1281 CDD:409473 0/3 (0%)
Ig strand C 1290..1294 CDD:409473 1/3 (33%)
Ig strand E 1317..1321 CDD:409473 1/3 (33%)
Ig strand F 1331..1336 CDD:409473 2/4 (50%)
Ig strand G 1344..1347 CDD:409473 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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