DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and csf3r

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	NP_001106848.1	Gene:	csf3r / 100134935	ZFINID:	ZDB-GENE-080104-4	Length:	810	Species:	Danio rerio

Alignment Length:	939	Identity:	185/939 - (19%)
Similarity:	320/939 - (34%)	Gaps:	262/939 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 YTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSA 662
            |..|.....|.|:.|::.....|:....|      :::..||:..|.:.|| :...|.|..:
Zfish    13 YIYVVIKVTGASSCGNVYTPAPVVLAGSP------VSVSCSIEEDCPLTKG-KVFYVQWRID--- 67

  Fly   663 GDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILE 727
                 .||.|:..|.:.|..|..:.||                :...|:.|:...|.|
Zfish    68 -----GQVVPRTYTYQESNMTYSVLIP----------------RLQDTSASILCLVCV------- 104

  Fly   728 PTDKAFAQGSDAKVECKADGFPKPQ-VTWKKAVGDTPG---EYKDLKKSDNIRVEEGTLHV--DN 786
            ..|.....|    ||.|....|.|| ::....:...|.   ::..:::..|:.:.. ||||  ..
Zfish   105 QEDCQIVDG----VEVKTGNPPVPQNLSCALTLVKMPSLRCDWNPVQEIKNLPINY-TLHVFRAK 164

  Fly   787 IQKT-----NEGYYLCEAINGIGSGLSAVIMISVQA----------PPEFTEKLRNQTARRGEPA 836
            .||.     .:.:|:   :.....|..:.:.|||.|          |.:.|..   .|.:...|:
Zfish   165 SQKVYAVPPGQHFYV---VPRDAYGYFSELEISVTAANVLGNTTSDPLKLTPL---NTVKFDPPS 223

  Fly   837 VLQCEAKGEKPIGILWNMN------------NMRL-----DPKNDNRYTIREEILSTGVMSSLSI 884
            :.:.||.....:...|:::            .:||     .|..|..||.|:..|:...:.|| :
Zfish   224 ITRIEAHKYGCLKYSWSLSETQKWLQLTFIVQLRLKTVSNQPNKDLVYTSRQLQLNPIEVCSL-L 287

  Fly   885 KRTERSDSALFTCVATNAFGS-DDASINMIVQEVP--EMPYALKVLDKSGRSVQLSW--AQPYDG 944
            ..|:...:......||:.:.. .|......:.:.|  .:...|||   :.::.||.|  :|.:..
Zfish   288 HWTDYRSTVRVKYYATSEWSEWSDPKTATTLNKAPAGRLDTWLKV---NNQTAQLYWKPSQQFRA 349

  Fly   945 NSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTY----------NIRIVAENAIG 999
            |.....|.::.|.::      .|:.|   |||          ||          .|.:.|.|.:|
Zfish   350 NGQNLSYSVDSKDTK------KRLCV---TTE----------TYCFFSLTKWDKKIFLRARNEVG 395

  Fly  1000 TSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSS 1064
            .|..:| |.:............|..|.|.:.|::.|.||.|                ..||. :|
Zfish   396 FSDHNE-VPVAVHRNKGLEPVSNFSVHPQSNTSLHVIWKSP----------------AFSNV-TS 442

  Fly  1065 YVFE----------TINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAG-PLSEEEKQFTAE 1118
            ||.|          .::|......:.|..|..|.....|.:.|......|.| |::  ...:::|
Zfish   443 YVLEWRSLCGTTAAPLSFTLIHKNKSNTTLTGLEPSKPYEISIYPRYVKGIGRPVT--VLAYSSE 505

  Fly  1119 GTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDT 1183
            ..||..| :.....::...::..|...|||..||:|:.|:..:     |:::.:.....|..:..
Zfish   506 TAPSDAP-ELNYEEISRSHLKFHWGQIPLEKRNGIIQGYRFYF-----WHNKNEIKEIMTTETSV 564

  Fly  1184 VLHGLKKYTNYTMQVLATTAGG--------------DGVRSVPIHCQTEPDVPEAPTDVKALVMG 1234
            .:..|:.:|.|...:...|.||              ||:..|         :...|..:.|.::
Zfish   565 EVKDLQPHTKYHALLSICTKGGCVNGSFSTLTTERLDGIEMV---------IFVIPACIGASLL- 619

  Fly  1235 NAAILV-------------SWRP--PAQPNGIITQYTVYSKAEG--AETETK------------- 1269
             ..|:|             .| |  |...|..|.::|.....:|  |..|.|
Zfish   620 -VIIIVFTCFGKQERVKMCLW-PIIPDPANSSIKRWTTTDSLQGLPAFKEDKDPVLVYLSHLSLL 682

  Fly  1270 --TQKVPHYQMSFEATELEKNK-PYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTF-- 1329
              |:|.|     |::..:::|: |.:..:.|.|      ||..: .:..:.||.....|...:
Zfish   683 DMTEKEP-----FKSGYVKENQWPDDLNIHADT------QSCDL-ELERESVPYATVLFSTPYQI 735

  Fly  1330 -----TATFKEDAKMPCLA---VGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGD 1386
                 .|..:.::..|.||   .|:|.|.               ...:|.|. .:.::||..|..
Zfish   736 NSSNPPAYVRSESTQPLLAGDEPGSPPPP---------------YENVPRGG-AVSALNRFSAFS 784

  Fly  1387 YSCHAENSIAKDSITHKLIVLAPPQSPHV 1415
            .|..:|.|   |.:..:..:|...:..|:
Zfish   785 QSTQSEES---DELWEEFPMLRSLEVNHI 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352	5/19 (26%)
		IGc2	544..607	CDD:197706	2/8 (25%)
		Ig	641..714	CDD:143165	14/72 (19%)
		IGc2	735..804	CDD:197706	16/79 (20%)
		I-set	819..914	CDD:254352	20/112 (18%)
		Ig	833..921	CDD:299845	19/107 (18%)
		FN3	918..1011	CDD:238020	25/106 (24%)
		FN3	1018..1116	CDD:238020	23/108 (21%)
		FN3	1124..1217	CDD:238020	20/106 (19%)
		FN3	1222..1312	CDD:238020	24/122 (20%)
		Ig	1339..1406	CDD:299845	15/69 (22%)
		FN3	1409..1499	CDD:238020	1/7 (14%)
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
csf3r	NP_001106848.1	Lep_receptor_Ig	25..102	CDD:283889	20/107 (19%)
		FN3	414..494	CDD:214495	21/96 (22%)
		FN3	508..597	CDD:238020	19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910