DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam1 and cntn3a.2

DIOPT Version :9

Sequence 1:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster
Sequence 2:	XP_001340839.5	Gene:	cntn3a.2 / 100000688	ZFINID:	ZDB-GENE-090312-57	Length:	1023	Species:	Danio rerio

Alignment Length:	1313	Identity:	292/1313 - (22%)
Similarity:	473/1313 - (36%)	Gaps:	395/1313 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFR 102
            ||.:..||::....|....|.:.|.|.|.|.|:..| ..:||.:......|:..|.|.||   .|
Zfish    28 GPKWRMEPSDLTVGSLEEEATLACDAKGIPAPQYRW-SLNGTLINLSTDSRRRLSGGNLV---IR 88

  Fly   103 AEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHY---EEDIHKAFVIR-GNSAILKCDIP 163
            :.|..|:  ..:|.|.|.|..|:|:||    ||.:...|   :.....|..:| |...:|.|..|
Zfish    89 SLDRAQD--GGIYQCTAFNPHGAILSR----RASLQFAYLNLKTQTRSAVSVREGQGVVLLCGTP 147

  Fly   164 SFVADFVNVISWHSDEKENFYPGTEYDG-KYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGET 227
            |:..|.  ..:|..:|...|   .:.|. :::...:|.|:|.:|.|.| ..:|.|...:|:|...
Zfish   148 SYAGDL--SFAWVFNEYPYF---VQQDNRRFVSQETGNLYIAKVEPSD-VGNYTCVVVNRITKGK 206

  Fly   228 RLSATKGRLVITEPV-GSVSPQLSGNGNQEHIT-LTRVPKMGSVTLMCPAQAYPVPFFRWYKFIE 290
            .||:....::.|:.| |...|::     :.|.: :....|...|||.|.|...|||...|
Zfish   207 VLSSPTPLVLRTDGVMGEYEPKI-----EVHFSDMVPAAKGSVVTLECFALGNPVPEITW----- 261

  Fly   291 GTTRKQAVVLNDRVKQVSGTLI--IKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDP 353
              .|..||....:||..:..::  |.....||:|.|.||..|.:|..:|:..|:..|
Zfish   262 --RRANAVPFPSKVKMKNSNVVLEIPSFQQEDAGGYECVAENKMGKNTVQGRLSFHA-------- 316

  Fly   354 PTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESA 418
                    :|               .|::..:.|     .|.||.
Zfish   317 --------KP---------------QWVQTMRDI-----ALSIEE-------------------- 333

  Fly   419 EASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQ 483
                                          .:|.:|.|.|.|.|..||..:|:.:|..||.|:
Zfish   334 ------------------------------RLFWECKANGKPKPSYSWLKNGELLAAEDRIQI-- 366

  Fly   484 YVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLP--YIRQMEKKAIVA--G 544
               .||    .|.|:||:.:|.|:|:|:|::|.|:....|:|.|...|  :.|...:..:.|  |
Zfish   367 ---ENG----ALTISSVNLSDAGMYQCVAENKHGIIYFGAELVVLASPPDFSRSPLRTLLKAKTG 424

  Fly   545 ETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYS 609
            .|:.:.|....:|....:|.:.|..:....:....|:|||.:.||.: .|...|.|:|:||.| :
Zfish   425 STVTMECKPQAFPSAITLWRKGNEVMQRTDRITFLPDGTLRLTNVTK-MDGGNYACLARNQFG-T 487

  Fly   610 ARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQM 674
            |..|..:.|....||.....:..|.:|:||.|.|||
Zfish   488 ASTSGRLLVTDPTQITQGPMDMEIIVGESIVLPCQI----------------------------- 523

  Fly   675 RTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDA 739
                           |..||                                  .|.:|:...:.
Zfish   524 ---------------SCDPA----------------------------------LDVSFSWAFNG 539

  Fly   740 KVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIG 804
            ::..|.|..      ::...|.|.|:                |.:.|||..:.|.|:|.....:.
Zfish   540 QLLSKLDQH------YEHVGGSTSGD----------------LMIRNIQLKHAGKYVCVVDTDVE 582

  Fly   805 SGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTI 869
            | |||..::.|:.||
Zfish   583 S-LSAAAILIVKGPP-------------------------------------------------- 596

  Fly   870 REEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSV 934
                                              |:.|   .:.|:|:.:            .:.
Zfish   597 ----------------------------------GAPD---GVTVEEITD------------STA 612

  Fly   935 QLSWAQPYDGNSPLDRYIIEFKRS-RASWSEIDRV--IVPGHTTEAQVQKLSPATTYNIRIVAEN 996
            ||||....|..||:..|||:.|.: ...|..::.|  ::.|:|..|.|..|:....:..|::|.|
Zfish   613 QLSWRPGQDNGSPITSYIIQAKTAFTVGWQAVNTVPEVIDGNTLTATVVDLNAWVEFEFRVLARN 677

  Fly   997 AIGTSQSSEAVTIITAEEA-PSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYK-LS 1059
            ::|..:.|.|......|:| |...|.::.....:::.:.:||:|.|....||:..||.:.:: |.
Zfish   678 SVGVGEPSPASLKTRTEDAVPDTAPTDVGGGGGSKSELVITWEPVPEDLQNGDGFGYIIAFRPLG 742

  Fly  1060 NTN-----------SSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEK 1113
            ..|           |.||:..               :::..::.:||.:.|:|..|.||.|....
Zfish   743 EVNWTHAVTSVPTQSRYVYRN---------------ESILPFSPFSVKVGAYNTKGQGPFSPVTI 792

  Fly  1114 QFTAEGTPSQPPSDTACTTLTSQTIRVGW--VSPPLESANGVIKTYKVVYAPSDEWYDETKRH-- 1174
            .|:||..||..|......::::..|.|.|  :|...|...|    |:|||     |.|:||..
Zfish   793 VFSAENEPSGVPDGVWARSISATEIEVSWHILSVSTERVLG----YEVVY-----WEDDTKPETM 848

  Fly  1175 --YKKTASSDTV-LHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVP-EAPTDVKALVMGN 1235
              .:.:|:.|.| :.||:.||.|.:.|.|....|.|..|..|:..|:...| :.|.:|:..::|
Zfish   849 GKVRVSANQDKVNISGLRGYTQYFLTVSAFNTAGTGPLSPTINVTTKKSPPGQPPLNVEWNLIG- 912

  Fly  1236 AAILVSWRP--PAQPNGIITQYTV-YSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTA 1297
            :.:.|.|.|  ..:....:|.|.| |.:....|..|.|..:...:::..|.:     .|...:.|
Zfish   913 SKLTVHWEPVISLEMESDVTGYQVSYRRNRHKEINTITTNLTSVELTLPADD-----DYVIQIRA 972

  Fly  1298 STTIGEGQQSKSI 1310
            .:..|||..::.|
Zfish   973 LSDGGEGMPTEPI 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	29/91 (32%)
		IG	57..133	CDD:214652	25/75 (33%)
		IG_like	267..343	CDD:214653	25/77 (32%)
		Ig	269..340	CDD:143165	24/72 (33%)
		IG_like	353..425	CDD:214653	6/71 (8%)
		IGc2	361..413	CDD:197706	6/51 (12%)
		I-set	433..527	CDD:254352	28/93 (30%)
		IGc2	446..517	CDD:197706	25/70 (36%)
		I-set	533..618	CDD:254352	23/86 (27%)
		IGc2	544..607	CDD:197706	18/62 (29%)
		Ig	641..714	CDD:143165	7/72 (10%)
		IGc2	735..804	CDD:197706	12/68 (18%)
		I-set	819..914	CDD:254352	3/94 (3%)
		Ig	833..921	CDD:299845	4/87 (5%)
		FN3	918..1011	CDD:238020	24/95 (25%)
		FN3	1018..1116	CDD:238020	22/109 (20%)
		FN3	1124..1217	CDD:238020	29/99 (29%)
		FN3	1222..1312	CDD:238020	21/93 (23%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
cntn3a.2	XP_001340839.5	Ig	28..119	CDD:299845	32/100 (32%)
		Ig	126..214	CDD:299845	24/93 (26%)
		Ig	227..315	CDD:299845	28/99 (28%)
		I-set	227..308	CDD:254352	26/92 (28%)
		I-set	318..403	CDD:254352	34/163 (21%)
		Ig	319..403	CDD:299845	33/147 (22%)
		IG_like	421..496	CDD:214653	22/76 (29%)
		Ig	424..496	CDD:299845	21/73 (29%)
		I-set	501..592	CDD:254352	31/191 (16%)
		Ig	515..596	CDD:299845	28/181 (15%)
		FN3	596..688	CDD:238020	28/190 (15%)
		FN3	701..793	CDD:238020	22/106 (21%)
		FN3	802..894	CDD:238020	29/100 (29%)
		FN3	902..987	CDD:238020	20/90 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100