Protein Alignment Incenp and SLI15

DIOPT Version :10

• Sequence 1: NP_523648.3
• Gene: Incenp / 35649
• FlyBaseID: FBgn0260991
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_009714.3
• Gene: SLI15 / 852453
• SGDID: S000000360
• Length: 698
• Species: Saccharomyces cerevisiae
• Alignment Length: 764
• Identity: 153/764 - (20%)
• Similarity: 267/764 - (34%)
• Gaps: 219/764 - (28%)

  Fly    53 KSQENSSVTPQQTKKR-----PKRL--TSLAEDQNEPEAPDATANNTSARQSTRVSNSQLLAIAE 110
            |..|.|.::|:.|..:     ||..  ..|:..||: .|.|.|....:...:.:....:.|...|
Yeast    65 KKMEESLISPENTHNKMDVEFPKMKGEYELSNSQND-AAKDVTKTPRNGLHNDKSITPKSLRRKE 128

  Fly   111 --------DEHNSTASLMPP-PPVPVSADTTLGSGRPQRAAKLKTEKLLKEPSLNRKMRRPSSEE 166
                    ..|::..|.:.| ..|.|.|:.   |.:....:..|.||:|:|.|       .:||.
Yeast   129 VTEGMNRFSIHDTNKSPVEPLNSVKVDANE---SEKSSPWSPYKVEKVLRESS-------KTSES 183

  Fly   167 LVKVKVESEQRVSQFNSFTSAQALE-ENKLAEPELEEPAAETAEQQKPPEEASVTEDVNTTKTLR 230
            .:..|        :|::.|.|...| ||   ||.|:......:.:.|||..:.:......:....
Yeast   184 PINTK--------RFDNQTWAAKEEMEN---EPILQALKKAESVKVKPPPNSGIARSQRRSNMFV 237

  Fly   231 VKVKREKLSTEAVPPLTNAVSTANVTTV----------SSVTTEAARPDDTVASNTTTSTEVSKK 285
            ....::.|..:.:||..::.|...|.||          |::.:.|.|..:.  |:|..||:.|..
Yeast   238 PLPNKDPLIIQHIPPTKSSGSIPKVRTVKESPIAFKKKSTINSPAIRAVEN--SDTAGSTKASSV 300

  Fly   286 VRK----KKKDVESHRPIKVER--------FSDLD-KSSP---VSSRTRKCSSDSRTVQERSIYK 334
            ..:    ..|..|:    |:.|        .|.:| ..||   ||.:.:..:|....:||
Yeast   301 FDRLSSIPTKSFEN----KISRGNVGHKYSSSSIDLTGSPMKKVSQKFKSINSTDTDMQE----- 356

  Fly   335 DALEDPPVAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSPIGPAGDATFEVHSNDKKQPLSK 399
                               |:.:..::.|      ....::||.|          .|.:|..:.:
Yeast   357 -------------------ALRDIFSVKN------KITKNNSPKG----------KNSRKSSIPR 386

  Fly   400 QDSLLTEDESVEEKLPTTKLLSSI----KAIKLPTRTHEL-FNPLLQSPVKMRVEAFENAANAQN 459
            .|       ....||.|.|.|:.|    |..|..:..|:. ..|...||.|:.|::...:...:|
Yeast   387 FD-------KTSLKLTTHKKLAIIAEQKKKSKHSSDVHKTGSRPHSISPTKISVDSSSPSKEVKN 444

  Fly   460 SMR-PKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTPTQTTSTLPLSSAQPKKGPASASKATSLL 523
            ..: |.||                         :..||              |...|.:|..:|.
Yeast   445 YYQSPVRG-------------------------YLRPT--------------KASISPNKNKNLT 470

  Fly   524 KTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAE----ERKKLREQK--HQQAAQQREAKER 582
            .:.|...|:    ...|||         ||...|:|:    |.:|.:..:  :.|.....||:..
Yeast   471 TSQTPHRLK----IKEKTL---------RKLSPNIADISKPESRKSKNYRLTNLQLLPPAEAERD 522

  Fly   583 ERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEE----------AEALKKAKFKEL 637
            :..::..|..:...:.|:|..|.::.|::.:..|::.:::|..          .|:|  |.|...
Yeast   523 DLKKKFDKRLSGIMRSQQEHHRRKQEKQKRMSHLEQDLKKQTSFSNDYKDIRLKESL--APFDNH 585

  Fly   638 EQQKLQQLTGAKPKKMLPP-------------PPKTKYTWEMLHE-DDSTDDEGKVTHKRPPAPT 688
            .:..:.:.|......:|..             .||.....:.|.| :..::||..||     ...
Yeast   586 VRDTINKNTAFSTDNILATINTVDHREIIGNVTPKIASVNDSLPEINTDSEDEASVT-----LAA 645

  Fly   689 WSRS-HVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLK 736
            |::| :::.:.|..|...|..|   |..:.|...|  :||||...::||
Yeast   646 WAKSPYLQEQLIRQQDINPQTI---FGPIPPLHTD--EIFPNPRLNRLK 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_523648.3	PTZ00266	<437..>633	CDD:173502	38/212 (18%)
		MAP7	558..>641	CDD:461709	17/98 (17%)
SLI15	NP_009714.3	INCENP_ARK-bind	632..680	CDD:461100	13/57 (23%)