DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Incenp and incenp

DIOPT Version :9

Sequence 1:	NP_001260762.1	Gene:	Incenp / 35649	FlyBaseID:	FBgn0260991	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_012816427.1	Gene:	incenp / 496453	XenbaseID:	XB-GENE-990398	Length:	900	Species:	Xenopus tropicalis

Alignment Length:	929	Identity:	202/929 - (21%)
Similarity:	330/929 - (35%)	Gaps:	290/929 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANN 91
            ||...:|......|.|..|:              ||.|.::|.|| ||:..|:|.    |.:...
Frog    38 EEARKMFSSDFNAEPELMPK--------------TPSQKRRRKKR-TSIVPDENR----DPSGRR 83

  Fly    92 TSARQST-RVSNS-QLLAIAEDEHNSTASLMPPPPVP-----------VSADTTLGSGRPQRAAK 143
            .|.|:|: ..||| :.|:|......:..|:...|..|           :...:.:....|:..::
Frog    84 ISRRRSSANWSNSVRRLSIRNQNKTNEDSMQEEPAQPKRMTRARAQASIMCPSVVEMALPESPSQ 148

  Fly   144 LKTEKLLKEPSLNRKMRRPSSEELV-KVKVESEQR------------------------------ 177
            |..:.:  :.:::.:.||.:.::|| ....|||.:
Frog   149 LYQKNV--QVTISEQDRRSAEQKLVGSATEESEMKTDVLPVPKIAKDTISEIVNTVVPPPVPETP 211

  Fly   178 ---VSQFNSFTSAQALEENKLAEPELEEPAAE----TAEQQKPPEEASVTEDVNTT--------- 226
               |:..|...:|..|   |:|.......|||    |.|..:|..|.:..:.:|.|
Frog   212 AVPVTPENKSRAAAKL---KIAGSSTPIEAAEMVDLTCESPRPANELANEQPLNLTNQSVTPTGS 273

  Fly   227 KTLRVKVKREKLSTEAVPPLTNAVSTANVTTVS----SVTTEAARPDDTVASNTTTSTEVSKKVR 287
            |:.|..|:|   |...|.|.:...|.|:..:::    |:|.||.|            ..:.:.:.
Frog   274 KSDRRSVRR---SLVVVKPSSRRSSLASQFSLASKRESMTREAVR------------KSIRQSIA 323

  Fly   288 KKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDSRTVQERSIYKDALEDPP---VAEQSVAA 349
            |||..:|               :|..||: |.|.|....:.:....|...|..|   |:|::...
Frog   324 KKKAAME---------------TSSASSQ-RSCQSSIEIIDDEITIKIRPETAPSESVSEEAHTI 372

  Fly   350 VAP-----AAVNETVAISNATLVLGPAPTSDSP------------IGPAGDATFEVHSNDKKQPL 397
            .:|     :...:.:||||       .|.|:.|            ..|..:.|.:. .|.:::..
Frog   373 ESPRRSLRSRTFKKIAISN-------LPDSEEPQRRVTRQMVAMDAEPTPETTDDA-QNIRRKSY 429

  Fly   398 SKQDSLLTEDE--SVEEKLPTTKLLSS-----IKAIKLPTRTHELF-----NPLL---------- 440
            .:....|::||  |..|:.|..|...|     .|.:|.|.......     |.||
Frog   430 KRAVDELSDDERPSEGERSPPRKKTPSPPCPPSKIVKPPPHMKSFLHTVQKNQLLMMTPGSIGKN 494

  Fly   441 ---------QSPVKMRVEAFENAANAQNSMRPKRGKDLQGTPGSNNTPKI--GK------LPAPT 488
                     .:|:||..:..|......:::|.|...:||      ...||  ||      |....
Frog   495 IMMKSFIKRNTPLKMDPKTEEKERQRLDALRKKEEAELQ------RKQKIEEGKKRKQEELKLRR 553

  Fly   489 VGRFFTPTQTTSTLPLSSAQPKK---------------------GPASASKATSLLKTATGTNLR 532
            ..|.....|....:.....:.||                     ....|.|..:..|.......|
Frog   554 EERLRKVLQARERVEQLEEEKKKKIEQKFAQIDEKSEKVREDRMAEEKAKKKITAKKQEEVECRR 618

  Fly   533 SVNSTSTKTLSRENSGDDFR-------KGLHNLAEERKKLREQKHQQAAQQREAKERERAERMAK 590
            .....:.|..:::...::.|       |......|.:||:.|.|  :.|:||:|::....:|..:
Frog   619 RQEEEARKLKAKQMEEEERRHQDLLQKKREEEELERQKKIAEAK--RLAEQRQAEQERERQREQQ 681

  Fly   591 LAAERAKKQEERKRIEERKRQELE-ELQR----KMRQQEEAEALKKAKFKE-LEQQKLQQLTGAK 649
            |.||:.:.:.||:|||..|..:|: ||:|    |.:|:.|||..||.:.:| |||::|::|...:
Frog   682 LLAEKERLRAERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERLERLHKEQ 746

  Fly   650 PKKMLPPPPKTK-------------------------YTWEM--------------------LHE 669
            ..|.|....:.|                         .::||                    |:.
Frog   747 EAKRLQEEQQRKAKEQAAAASAPVMNVTVDMQNSPACESYEMTPKSYKAPSVKVNEENYGMDLNS 811

  Fly   670 DDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDI------IDSFFSVAPTTPDLKQIFP 728
            |||||||   :..|.|.|.|:..::..:||..|.:.|.|:      |||        |.|:::|.
Frog   812 DDSTDDE---SQPRKPIPAWASGNLLAQAIRQQYYKPMDVDRMYGTIDS--------PKLEELFY 865

  Fly   729 NIDPSQLKRNSSVLWSTPP 747
            ...|...||.||.:|.:||
Frog   866 KSKPRYYKRTSSAVWHSPP 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_001260762.1	FAM199X	<505..591	CDD:292442	19/113 (17%)
		MAP7	558..>641	CDD:283355	34/88 (39%)
		GBP_C	<559..644	CDD:303769	35/90 (39%)
		coiled coil	631..642	CDD:293879	5/11 (45%)
incenp	XP_012816427.1	INCENP_N	6..38	CDD:403416	202/929 (22%)
		PTZ00121	<512..762	CDD:173412	60/257 (23%)
		INCENP_ARK-bind	810..864	CDD:397846	21/64 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007007
OrthoInspector	1	1.000	-	-		oto102647
Panther	1	1.100	-	-	LDO	PTHR13142
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5096
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.130