Protein Alignment Incenp and INCENP

DIOPT Version :10

• Sequence 1: NP_523648.3
• Gene: Incenp / 35649
• FlyBaseID: FBgn0260991
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_011543297.1
• Gene: INCENP / 3619
• HGNCID: 6058
• Length: 933
• Species: Homo sapiens
• Alignment Length: 928
• Identity: 201/928 - (21%)
• Similarity: 339/928 - (36%)
• Gaps: 257/928 - (27%)

  Fly    27 EELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANN 91
            ||.:.:|......|.|..|:              ||.|..:|.||..|..:|:|.    |.....
Human    39 EEAERMFTREFSKEPELMPK--------------TPSQKNRRKKRRISYVQDENR----DPIRRR 85

  Fly    92 TSAR--QSTRVSNSQL--------LAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQRAAKLKT 146
            .|.|  :|:::|:.:|        ||....|:.|....:.......:| .|:....|........
Human    86 LSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAA-ATMALAAPSSPTPESP 149

  Fly   147 EKLLKEPSLNRKMRR--PSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAE 209
            ..|.|:|..|....:  |..|..:..:..:||.|:|.        :....|.......||:.||
Human   150 TMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQL--------MSTEPLPRTLSPTPASATA- 205

  Fly   210 QQKPPEEASVTEDVNTTKTLRVKVKREKL---------STEAVP--PLTNAVSTANVTTVSSVTT 263
               |..:...|.|..:|.      |:.|.         |..|.|  |....|.|....:...:..
Human   206 ---PTSQGIPTSDEESTP------KKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQ 261

  Fly   264 EAARPDDTVA-------------------SNTTTSTEVSKKVRKKKKDVESHRP-IKVERFSDLD 308
            .:..|.|:.|                   |..|.|...|:.||.......|..| :..:::|.:.
Human   262 VSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVA 326

  Fly   309 KSSPV----SSRTRKCSSDSRTVQERSIYKDALE----------------DPPVAEQSVAAVAPA 353
            |...|    |.|..|.:::......|.|....||                :||...:.|||..|.
Human   327 KQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPE 391

  Fly   354 AV----------NETVAISNATLVLGPAPTSDSPIGP-AGDATFEVHSND----------KKQPL 397
            ..          |:| .|:|:|  ..|.|.:.||..| ||....:....|          :|:..
Human   392 VPENNGNNSWPHNDT-EIANST--PNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSY 453

  Fly   398 SKQDSLLTEDESVE-EKL--PTTKLLSS----IKAIKLPTRT--HEL-FNPLLQSPV-------- 444
            .:..|.|.|::.:| |:|  |.:|..||    .|.:: |.||  |.: .|.:|.:|.
Human   454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVR-PLRTFLHTVQRNQMLMTPTSAPRSVMK 517

  Fly   445 ---------------------KMRVEAFENAANAQNSMRPKRGKD-------------------L 469
                                 :.|:|.......|:...|.|..:|                   |
Human   518 SFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL 582

  Fly   470 QGTPGSNNTPKIGKLPAPTVGRFFT----PTQTTSTLPLSSAQPKKGPASASKATSL----LKTA 526
            |   ......::.:.....:.:.|.    .|:......|:..:.|| .|:|.|...:    .:..
Human   583 Q---ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-KAAAKKMEEVEARRKQEE 643

  Fly   527 TGTNLRSVNSTSTK-----------TLSRENSGDDFRKGLH--NLAEERKKLR--EQKHQQAAQQ 576
            ....||.:.....:           ...:|...:..||...  .|||:|::.|  :::.:|..::
Human   644 EARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 708

  Fly   577 REAKERERAERMAKLAAERAKKQEER----KRIEERK---RQELEELQRKM---RQQEEAEALKK 631
            :|.:|:||.|:..:||.:..::::||    :.::||:   |.:.|:|||::   :::||.:.|.:
Human   709 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 773

  Fly   632 AKFKELEQQKLQQLTGAKP------KKMLPPPPKTK-------YTWEM----------------- 666
            .:.:|.:::|.::..||..      ...:||.|:.:       .:::|
Human   774 RQLQEEQEKKAKEAAGASKALNVTVDVQVPPGPQWRGSQSPACTSYQMTPQGHRAPPKINPDNYG 838

  Fly   667 --LHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPN 729
              |:.|||||||   .|.|.|.|||:|.....:||..|.:.|.::::.|.::.|.  ||:.||..
Human   839 MDLNSDDSTDDE---AHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPL--DLEDIFKK 898

  Fly   730 IDPSQLKRNSSVLWSTPP 747
            ..|...||.||.:|::||
Human   899 SKPRYHKRTSSAVWNSPP 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_523648.3	PTZ00266	<437..>633	CDD:173502	49/276 (18%)
		MAP7	558..>641	CDD:461709	26/94 (28%)
INCENP	XP_011543297.1	INCENP_N	6..41	CDD:463484	1/1 (100%)
		PRK12323	<141..>287	CDD:481241	31/163 (19%)
		Herpes_BLLF1	<142..513	CDD:282904	86/392 (22%)
		Smc	536..>794	CDD:440809	50/261 (19%)
		INCENP_ARK-bind	842..896	CDD:461100	22/58 (38%)