DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Incenp and INCENP

DIOPT Version :9

Sequence 1:	NP_001260762.1	Gene:	Incenp / 35649	FlyBaseID:	FBgn0260991	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_011543297.1	Gene:	INCENP / 3619	HGNCID:	6058	Length:	933	Species:	Homo sapiens

Alignment Length:	928	Identity:	201/928 - (21%)
Similarity:	339/928 - (36%)	Gaps:	257/928 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANN 91
            ||.:.:|......|.|..|:              ||.|..:|.||..|..:|:|.    |.....
Human    39 EEAERMFTREFSKEPELMPK--------------TPSQKNRRKKRRISYVQDENR----DPIRRR 85

  Fly    92 TSAR--QSTRVSNSQL--------LAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQRAAKLKT 146
            .|.|  :|:::|:.:|        ||....|:.|....:.......:| .|:....|........
Human    86 LSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAA-ATMALAAPSSPTPESP 149

  Fly   147 EKLLKEPSLNRKMRR--PSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAE 209
            ..|.|:|..|....:  |..|..:..:..:||.|:|.        :....|.......||:.||
Human   150 TMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQL--------MSTEPLPRTLSPTPASATA- 205

  Fly   210 QQKPPEEASVTEDVNTTKTLRVKVKREKL---------STEAVP--PLTNAVSTANVTTVSSVTT 263
               |..:...|.|..:|.      |:.|.         |..|.|  |....|.|....:...:..
Human   206 ---PTSQGIPTSDEESTP------KKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQ 261

  Fly   264 EAARPDDTVA-------------------SNTTTSTEVSKKVRKKKKDVESHRP-IKVERFSDLD 308
            .:..|.|:.|                   |..|.|...|:.||.......|..| :..:::|.:.
Human   262 VSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVA 326

  Fly   309 KSSPV----SSRTRKCSSDSRTVQERSIYKDALE----------------DPPVAEQSVAAVAPA 353
            |...|    |.|..|.:::......|.|....||                :||...:.|||..|.
Human   327 KQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPE 391

  Fly   354 AV----------NETVAISNATLVLGPAPTSDSPIGP-AGDATFEVHSND----------KKQPL 397
            ..          |:| .|:|:|  ..|.|.:.||..| ||....:....|          :|:..
Human   392 VPENNGNNSWPHNDT-EIANST--PNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSY 453

  Fly   398 SKQDSLLTEDESVE-EKL--PTTKLLSS----IKAIKLPTRT--HEL-FNPLLQSPV-------- 444
            .:..|.|.|::.:| |:|  |.:|..||    .|.:: |.||  |.: .|.:|.:|.
Human   454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVR-PLRTFLHTVQRNQMLMTPTSAPRSVMK 517

  Fly   445 ---------------------KMRVEAFENAANAQNSMRPKRGKD-------------------L 469
                                 :.|:|.......|:...|.|..:|                   |
Human   518 SFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL 582

  Fly   470 QGTPGSNNTPKIGKLPAPTVGRFFT----PTQTTSTLPLSSAQPKKGPASASKATSL----LKTA 526
            |   ......::.:.....:.:.|.    .|:......|:..:.|| .|:|.|...:    .:..
Human   583 Q---ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-KAAAKKMEEVEARRKQEE 643

  Fly   527 TGTNLRSVNSTSTK-----------TLSRENSGDDFRKGLH--NLAEERKKLR--EQKHQQAAQQ 576
            ....||.:.....:           ...:|...:..||...  .|||:|::.|  :::.:|..::
Human   644 EARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 708

  Fly   577 REAKERERAERMAKLAAERAKKQEER----KRIEERK---RQELEELQRKM---RQQEEAEALKK 631
            :|.:|:||.|:..:||.:..::::||    :.::||:   |.:.|:|||::   :::||.:.|.:
Human   709 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 773

  Fly   632 AKFKELEQQKLQQLTGAKP------KKMLPPPPKTK-------YTWEM----------------- 666
            .:.:|.:::|.::..||..      ...:||.|:.:       .:::|
Human   774 RQLQEEQEKKAKEAAGASKALNVTVDVQVPPGPQWRGSQSPACTSYQMTPQGHRAPPKINPDNYG 838

  Fly   667 --LHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPN 729
              |:.|||||||   .|.|.|.|||:|.....:||..|.:.|.::::.|.::.|.  ||:.||..
Human   839 MDLNSDDSTDDE---AHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPL--DLEDIFKK 898

  Fly   730 IDPSQLKRNSSVLWSTPP 747
            ..|...||.||.:|::||
Human   899 SKPRYHKRTSSAVWNSPP 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_001260762.1	FAM199X	<505..591	CDD:292442	21/104 (20%)
		MAP7	558..>641	CDD:283355	26/94 (28%)
		GBP_C	<559..644	CDD:303769	26/96 (27%)
		coiled coil	631..642	CDD:293879	1/10 (10%)
INCENP	XP_011543297.1	INCENP_N	6..41	CDD:288989	1/1 (100%)
INCENP	XP_011543297.1	INCENP_ARK-bind	846..897	CDD:281874	21/55 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12092
eggNOG	1	0.900	-	-		E1_KOG4456
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007007
OrthoInspector	1	1.000	-	-		oto88775
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13142
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5096
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.030