DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Incenp and Incenp

DIOPT Version :9

Sequence 1:	NP_001260762.1	Gene:	Incenp / 35649	FlyBaseID:	FBgn0260991	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_006231086.1	Gene:	Incenp / 293733	RGDID:	1305292	Length:	923	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	201/993 - (20%)
Similarity:	323/993 - (32%)	Gaps:	387/993 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RELEVLRKAHFEELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQN 80
            :|:|       ||.:.:|......|.|..|:              ||.|..:|.||..|..:|:|
  Rat    59 KEIE-------EEAERMFVREFNNEPELMPK--------------TPSQKNRRKKRRVSNIQDEN 102

  Fly    81 EPEAPDATANNTSARQS------TRVSNSQLLAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQ 139
            .    |......|.|:|      .|...|:|.|:.|:                       :|.|
  Rat   103 R----DPVRKRLSRRKSRSSQVGPRHRRSKLGAVVEE-----------------------NGSP- 139

  Fly   140 RAAKLKTEKLLKEPSLNRKMRRPSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPA 204
                           :.|::.|.::.........|....|..:|.|:...:...|.|..|:....
  Rat   140 ---------------VLRRITRAAAAAAAAAASTSASVASASSSPTTVSPIVLIKKAVVEVSTGE 189

  Fly   205 AETAEQQKPPEEASVTEDVNTTKTLRVKVKREKLSTEAVP-PLTNAVSTANVTTVSSVT---TEA 265
            ..:||.|                  .:|:| ..|...:|| |.|::||...:|:....|   :||
  Rat   190 QLSAELQ------------------LIKLK-GGLPQSSVPAPATSSVSQGTLTSEEEATPKKSEA 235

  Fly   266 ARPD---DTVASNTTTSTEVSKKVRKKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDSRTV 327
            .|.|   |:||.|:..:|..|.| .:...:..|...:|:.|.|...:.||.|:
  Rat   236 GRLDSATDSVAVNSLKATPQSPK-NRGVGEARSVSKLKIARASRGLQDSPGST------------ 287

  Fly   328 QERSIYKDALEDPPVAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSPIGPAGDATFEVHSND 392
                       |.|..|:.::.:.|..:..|              |:.:|:|........:.|.|
  Rat   288 -----------DSPWQERVLSPILPNNILST--------------TAKNPLGSIQSVQQSLISQD 327

  Fly   393 KKQPLSKQDSLLTEDESVEEKLPTTKLLSSIKAIKLPTRT-----HELFNPLLQSPVKMRV---- 448
            .:.||:|:..|:|:.|:...:  ::::..  ||.|.|..:     |.....||...|...|
  Rat   328 SQVPLAKKYCLVTQQENASRR--SSRIAK--KAGKEPEASARIICHSYLERLLNVEVPQNVGLEK 388

  Fly   449 ---------EAFENAANAQN--------------------------------------------- 459
                     ||.|....::|
  Rat   389 EPVEVAEPEEAVEEQEVSKNSGCSSKPHSATKMAISTPTSKPVATGQATAVEEQDAELDQTDGHR 453

  Fly   460 ----SMRPKRG-------------KDLQGTPGSNNTPKIGKLPAPTVGR--------------FF 493
                |:|.||.             :|.:..|..|.||. ...||..|.|              ..
  Rat   454 EPPQSVRRKRSYKQAMSELDEEHLEDEELQPPRNKTPS-PPCPASKVVRPLRTFLHTVQKNQMLM 517

  Fly   494 TPTQTTSTLPLSSAQPKKGPASASKATSLLKTATGTNLRSV-NSTSTKTLSRENSGDDFRKGL-- 555
            |||..:.:..:.|...:..|.......|.::... ..|.|: .....:.|.|:...:|.|:.|
  Rat   518 TPTLASRSSVMKSFIKRNTPLRVDPKCSFVEKER-QRLESLRRKEEAEQLRRQKVEEDKRRRLEE 581

  Fly   556 -------------------HNLAEERKKLREQK-------------------------------- 569
                               ..:.||:||..|||
  Rat   582 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEKAKKKAAAKKMEEM 646

  Fly   570 ------------------------HQQAAQQREAKERER-----AERMAKLAAERAKKQEER--- 602
                                    ||:..|:::.:|:||     |.|:|:...:..::::||
  Rat   647 EARRKQEEEARRLKWLQQEEEERRHQEMLQRKKEEEQERRKAAEARRLAEQREQERRREQERREQ 711

  Fly   603 ------KRIEERKRQELEELQRKMRQQEEAEALK-----------------------KAKFKELE 638
                  :|.:||:.||..|.:|:.:::.|.|.|:                       :.|.|:.|
  Rat   712 ERREQERREQERREQERREQERREQERREQERLRAKREMQEREKALRLQKERLQRELEEKKKKEE 776

  Fly   639 QQKL--QQLTGAKPKK-------------------------MLPPPPKTKYTWEM------LHED 670
            ||:|  |||...:.||                         |.|..||:.....|      |:.|
  Rat   777 QQRLAEQQLQEEQAKKAKEVAAGKALNMTVDVQSPVCTSYQMTPQGPKSFPKISMDDYGMDLNSD 841

  Fly   671 DSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQL 735
            ||||||   .|.|.|.|:|::.....:||..|.:.|.:|::.|.|:.|.  ||:.||........
  Rat   842 DSTDDE---AHPRKPIPSWAKGTQLSQAIVHQYYHPPNILELFGSILPL--DLEDIFKKRKTRYH 901

  Fly   736 KRNSSVLWSTPPRYSELP 753
            ||.||.:|::||..:.:|
  Rat   902 KRTSSAVWNSPPLKATIP 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_001260762.1	FAM199X	<505..591	CDD:292442	26/168 (15%)
		MAP7	558..>641	CDD:283355	32/175 (18%)
		GBP_C	<559..644	CDD:303769	34/179 (19%)
		coiled coil	631..642	CDD:293879	5/10 (50%)
Incenp	XP_006231086.1	INCENP_N	30..65	CDD:288989	2/5 (40%)
		PhaG_MnhG_YufB	<559..629	CDD:294390	21/152 (14%)
		INCENP_ARK-bind	843..894	CDD:281874

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11814
eggNOG	1	0.900	-	-		E1_KOG4456
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007007
OrthoInspector	1	1.000	-	-		oto95909
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13142
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.000