DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Incenp and icp-1

DIOPT Version :9

Sequence 1:	NP_001260762.1	Gene:	Incenp / 35649	FlyBaseID:	FBgn0260991	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_490956.1	Gene:	icp-1 / 171788	WormBaseID:	WBGene00002047	Length:	622	Species:	Caenorhabditis elegans

Alignment Length:	698	Identity:	150/698 - (21%)
Similarity:	263/698 - (37%)	Gaps:	196/698 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 PSLNRKMRRPSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAEQQKPPEEA 217
            |...|.:.|..:|..:|:          |:|.....::.: :::|...:..|...|:..|  ..:
Worm     2 PPKKRAVSRKPAEPTIKL----------FSSIPKISSIFD-EVSEAHDDAAAKVFADLYK--RMS 53

  Fly   218 SVTEDVNTTKTLRVKVKREKLSTEAVPPLTNAV---STANVTTVSSVTTEAARPDDTVASNTTTS 279
            |:||::.|          .:.|.|   .|.|||   ...:...|..::.:.|:|
Worm    54 SITEELAT----------PQFSAE---QLLNAVLKPGRIDAEFVELISRQKAKP----------- 94

  Fly   280 TEVSKKVRKKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDS-----------RTVQERSIY 333
            .:.|....:...|:|:.   :||    .|::.|::.|....::|.           :.:|:.||.
Worm    95 AQPSSSSHRGDDDMETD---EVE----TDQAGPITPRAGSVATDGDFEEDILPVTLKRMQQMSIS 152

  Fly   334 KDALE---------------DPP------VAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSP 377
            |...|               :||      ...:::.:..|..:..|.  ..|.:|    |.:...
Worm   153 KKKTEGSISRNAAYSGTPRRNPPREAHNQATPRNIFSSTPGRMAGTP--GRAAVV----PRTPHR 211

  Fly   378 IGPAGDATFEVHSN------------DKKQPLSKQD--------SLLTEDESV-EEKLPTTK--- 418
            :.|..||..:.::.            :||:..:::|        ....|.|.| :|||...|
Worm   212 VIPFNDAEKDPNARMKHADELRMKELEKKREKARKDEEKRNAVMERRKEQERVRQEKLDQLKQKE 276

  Fly   419 -----LLSSIKAIKLPTRTHELFNPLLQSPVKMRVEAFENAANAQNSMRPKRG-------KDLQG 471
                 |.....:.|.|||..     |:|.....:..:.:....|:::..|.||       :.|.|
Worm   277 ERNANLAKLHNSAKSPTRAR-----LMQDHAPNKAASRKIFPTAESTSTPGRGPAKKGKVEILIG 336

  Fly   472 TPGSNNTPKIGKLPAPTVGRFFTPTQ-----------------TTSTLPLSSAQP-----KKGPA 514
            :.|....|    :..|||.  .:|::                 ..||.|....:|     |:...
Worm   337 SDGQKTAP----VAQPTVE--LSPSRELQRNGSRQVKMEPMSCDDSTPPARQHKPKAKATKRSAH 395

  Fly   515 SASKATSLLKTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAEERKKLREQKHQQAAQQREA 579
            :||.:||.::.|..  |.::.......|.:|       :.|..|||:.::.||||..:...::|.
Worm   396 AASSSTSNVEAAAA--LAALQEQQRIQLEQE-------QYLLQLAEDERRKREQKEMKEKAEKER 451

  Fly   580 KERERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEEAEALKKAKFKELEQQKLQQ 644
            :.|.|.|:...||.:|    ||:.::|:::.:|..|||..:.:..|         |:..|:.|::
Worm   452 QLRAREEQEHFLAVQR----EEQAQLEKQREREEAELQATLARCAE---------KQARQEALRK 503

  Fly   645 LTGAKPKKMLPP-----PPKTKYTWEMLHEDDSTDDEGKVTHKRPPAPTWS-----RSHVRGEAI 699
            .......:|.||     ..|..|....|:.||.||.|   ...|...|.|:     |.:||..||
Worm   504 TPPPAAYEMTPPRTYQNNSKNDYGLNDLNSDDETDQE---DDPRKDVPAWAEFAVVRENVRRHAI 565

  Fly   700 AMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLKRNSSVLWSTPP 747
                :.|.|:...|.|:.  .|:||:||.:....: ||.||.:|...|
Worm   566 ----NPPFDVAQFFGSIG--KPNLKEIFSDAVKVK-KRGSSAVWKKSP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Incenp	NP_001260762.1	FAM199X	<505..591	CDD:292442	22/90 (24%)
		MAP7	558..>641	CDD:283355	24/82 (29%)
		GBP_C	<559..644	CDD:303769	24/84 (29%)
		coiled coil	631..642	CDD:293879	2/10 (20%)
icp-1	NP_490956.1	PTZ00121	<216..540	CDD:173412	80/356 (22%)
icp-1	NP_490956.1	INCENP_ARK-bind	532..587	CDD:367736	20/63 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4456
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13142
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5096
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030