Protein Alignment Br140 and NTO1

DIOPT Version :9

• Sequence 1: NP_001286155.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_015356.1
• Gene: NTO1 / 856143
• SGDID: S000006235
• Length: 748
• Species: Saccharomyces cerevisiae
• Alignment Length: 635
• Identity: 170/635 - (26%)
• Similarity: 295/635 - (46%)
• Gaps: 120/635 - (18%)

  Fly   191 EIPDYRVSDAPPRPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTME 255
            |.|:..:|.:....:..:..|..:|  ::.:.:||:||:|..:|.::|   :|...:.:..:..|
Yeast   154 EAPNITISTSTKSAIQKFASISPNL--VNFKPQYDMDEQDELYLHYLN---KRYFKDQMSHEIFE 213

  Fly   256 LLMDRLEK-----ESHFQAAAN-----------------GTPTGVEVDDDAVCCICLDGECQNTN 298
            :||..||.     |.|..:..:                 |:..|..:..|..|.:||..:..|.|
Yeast   214 ILMTTLETEWFHIEKHIPSTNSLIARHNILRDCKNYELYGSDDGTGLSMDQACAVCLGTDSDNLN 278

  Fly   299 VILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVC 363
            .|:|||.|::||||:|||:.:||||:||||||:.|.:....|::||:..|||||||.|.|.|.:|
Yeast   279 TIVFCDGCDIAVHQECYGIIFIPEGKWLCRRCMISKNNFATCLMCPSHTGAFKQTDTGSWVHNIC 343

  Fly   364 ALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAG 428
            |||:||:.|:|..::|||:.::.:..:||:|.||:||:| :||||||.:.:|:.|:|||||::||
Yeast   344 ALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCYICKKK-MGACIQCFQRNCFTAYHVTCARRAG 407

  Fly   429 LYMTMDTVKDGHNDSSMHVQKF---AYCHAHTPAD------------------AKLKMNVPDFED 472
            |||:..........|:...||:   ::||.|.|..                  :.|:...|...:
Yeast   408 LYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGINKARKYFSLLSTLQTETPQHNE 472

  Fly   473 TRHKM-KEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNG 536
            ...:. .:..|.:.|..:..||.  |.:..:.:|::.....:.........|..||::||....|
Yeast   473 ANDRTNSKFNKTIWKTPNQTPVA--PHVFAEILQKVVDFFGLANPPAGAFDICKYWSMKRELTGG 535

  Fly   537 VPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRK-------- 593
            .||.          ...:.|.: ||....::..::.:.....:||.|.:.|..||:|
Yeast   536 TPLT----------ACFENNSL-GSLTEEQVQTRIDFANDQLEDLYRLKELTTLVKKRTQASNSL 589

  Fly   594 -REKLKVAFVRISEEVVMLQLNPLEAALN--------------KLLDALEA-----RDSMQIFRE 638
             |.:.||..:..|.:..:|::|.|:..:.              |||..||.     .|::|||:|
Yeast   590 SRSRKKVFDIVKSPQKYLLKINVLDIFIKSEQFKALERLVTEPKLLVILEKCKHCDFDTVQIFKE 654

  Fly   639 PVDTSEVPDYTDIVK----QPMDLGTMRAKLKECQYNSLEQLE-ADFDLMIQNCLAYNNKDTVFY 698
                 |:..:.::::    ....|.|:.:|.||...|.:..:| .|...::       ::|.:..
Yeast   655 -----EIMHFFEVLETLPGASRILQTVSSKAKEQVTNLIGLIEHVDIKKLL-------SRDFIIN 707

  Fly   699 RAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLL 748
            ...|..|..:.|:.      ::.:||      ...:.:.|...:.|:|:|
Yeast   708 DDKIEERPWSGPVI------MEEEGL------SDAEELSAGEHRMLKLIL 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	17/76 (22%)
		PHD_BRPF	283..336	CDD:277047	29/52 (56%)
		ePHD_BRPF	340..456	CDD:277140	55/118 (47%)
		Bromo_brd1_like	615..712	CDD:99944	24/120 (20%)
		BR140_related	1303..1414	CDD:99900
NTO1	NP_015356.1	COG5141	18..748	CDD:227470	170/635 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I1058
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3175
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	1	1.000	-	-		oto99897
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
TreeFam	0	0.000	Not matched by this tool.
	10	9.790