Protein Alignment Br140 and GIS1

DIOPT Version :9

• Sequence 1: NP_001286155.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_010381.1
• Gene: GIS1 / 851670
• SGDID: S000002503
• Length: 894
• Species: Saccharomyces cerevisiae
• Alignment Length: 561
• Identity: 110/561 - (19%)
• Similarity: 187/561 - (33%)
• Gaps: 169/561 - (30%)

  Fly   820 GSPSKKRTRKRFNSSGVDMELGHDDDDEEE-----DSDEDSMGEDTVSKDLLNSTQTPPCSPIKS 879
            |..:||..||    ||....|.:|.::.|:     |:|.|...:.....:|||.:.    ..:::
Yeast   323 GCGNKKEERK----SGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSS----QELQN 379

  Fly   880 LNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGS-------SSS 937
            |.::.:|:..|    |.:.|...::|:.     |||....|..:.:..|.|...|       ..|
Yeast   380 LEDNKNPLFSN----INMNRPQSSSLRS-----TTPNGVNQFLNMNQTTISRISSPLLSRMMDLS 435

  Fly   938 VTTAATAASSGAGTLNHVLS------SAPPTASSF---ALTQNNSSGGGALASGTG----IGGSS 989
            .....|....|:.....||:      :.|..:|:|   :||..||......|:.|.    ..||.
Yeast   436 NIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQ 500

  Fly   990 SAGTAAAASL-TSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQAL 1053
            :.....|..: ||.|.::|:.:|:.                    ::|.:...|.|...||..::
Yeast   501 NHNNVNANGINTSAAASINNNISST--------------------NNSANNSSSNNNVSTVPSSM 545

  Fly  1054 PMPETLPFERIPDSFRVYRANNQRDV-SDSDD----------APSQSSSPCSSCSDFSMSGSCSD 1107
            ....||              |....: .|:||          |.|.::||..:....|
Yeast   546 MHSSTL--------------NGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLS------- 589

  Fly  1108 FDSDEASEGDADGDPDRDGGRSRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGS 1172
                         .|....|                      |.|.      ||||..::|..||
Yeast   590 -------------SPMNPNG----------------------HTSY------NGNMMNNNSGNGS 613

  Fly  1173 GGSSSEDDEL---EERPLSARQNKPMKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSST 1234
            .||:|..:.:   .....||..|..:.     :|.||.....::|.....:....|.|:..:.||
Yeast   614 NGSNSYSNGVTTAAATTTSAPHNLSIV-----SPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPST 673

  Fly  1235 ATPPPLRRAGKLR---SATPNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNN-H 1295
            :..|.|:|...:.   |...:.||:.:.:...|:.....:..:.::..:.:|..:...:..|| :
Yeast   674 SNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNIN 738

  Fly  1296 SHGQKPALEPLQLVWAKCRGYPWYPALILDPKTPKGFVYNG 1336
            .....|:..||.                   |.||  :.||
Yeast   739 PLDAGPSFSPLH-------------------KKPK--ILNG 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484
		PHD_BRPF	283..336	CDD:277047
		ePHD_BRPF	340..456	CDD:277140
		Bromo_brd1_like	615..712	CDD:99944
		BR140_related	1303..1414	CDD:99900	7/34 (21%)
GIS1	NP_010381.1	JmjN	11..52	CDD:128818
		JmjC	191..307	CDD:202224
		zf-C2H2_4	828..851	CDD:290605
		C2H2 Zn finger	830..851	CDD:275368
		zf-H2C2_2	842..868	CDD:290200
		C2H2 Zn finger	859..876	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900