DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Br140 and JADE1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_024309986.1	Gene:	JADE1 / 79960	HGNCID:	30027	Length:	857	Species:	Homo sapiens

Alignment Length:	919	Identity:	246/919 - (26%)
Similarity:	382/919 - (41%)	Gaps:	213/919 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SSASAGGGSAS---GVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAAL 159
            |..|...||.|   ..::|......|...:.:.:.:..|..| ....:.:.|:..|..||.:..
Human    25 SEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTD-LITAMKLHDSYQLNPDEYYVL- 87

  Fly   160 VARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSL---- 215
                    ||        ||.:     |||||:          ....|:|:|.....||||
Human    88 --------AD--------PWRQEWEKGVQVPVS----------PGTIPQPVARVVSEEKSLMFIR 126

  Fly   216 ------------EEL---------DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMD 259
                        .||         |....||:::.|:||||..|||.:.:|:..:...|||.:::
Human   127 PKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLE 191

  Fly   260 RLEKE-----SHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPY 319
            ..|:.     :|......|  .|:|.|:|.||.:|...:.::.|.::|||.||:.|||.|||:..
Human   192 EFEQRCYDNMNHAIETEEG--LGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILK 254

  Fly   320 IPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDS 383
            :|||.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||...:...:|||..
Human   255 VPEGSWLCRTCALGVQP--KCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITK 317

  Fly   384 IETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQ 448
            :..||.:||.|.|.:|.|| .||.|||...:|..|||||||...||  .|.|:. ..||   .|:
Human   318 VSHIPSSRWALVCSLCNEK-FGASIQCSVKNCRTAFHVTCAFDRGL--EMKTIL-AEND---EVK 375

  Fly   449 KFAYCHAHT----PAD-----AKLKMNVPD---------FEDTRHKMKEARKALAKKRSTAPVVL 495
            ..:||..|:    |.:     |..:...|:         |.......:||.:...:|:....:
Human   376 FKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQL-- 438

  Fly   496 IPTIPPDRVQEIATMVTMQR----KKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN 556
                 .|.......::.:.|    .:|.:|.:..||.|||......||:...:.:.:|  :.:|
Human   439 -----EDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDN--LAKR- 495

  Fly   557 GIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLE---- 617
                  :...|:|:|:.:..|||||||.|.|..:|.:|||:|.:..::.|::..|....||
Human   496 ------EQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERV 554

  Fly   618 ---------AALNKLL---------DALEARD---SMQIFREPVDTSEV-----PDYTD------ 650
                     ::|..:|         ||.:..|   ....||:.:.||.|     |...|
Human   555 SGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSP 619

  Fly   651 ------IVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMI---QNCLAY----NNKDTVFYRAGI 702
                  ::|||...|.....:....:..||:..|:..|:.   :|.:..    ..:|..|:...|
Human   620 GSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLI 684

  Fly   703 R--MRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPAS-EGIVQKL---L 761
            :  ::|::   |.|..|.|:...:   ||| |:|:..|.....:.  .:||.: :.||.|.   |
Human   685 KGDLKDKS---FKQSHKPLRSTDV---SQR-HLDNTRAATSPGVG--QSAPGTRKEIVPKCNGSL 740

  Fly   762 ILADKSQ-VLKNPTYRTKKIKQ---IRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSP 822
            |..:.:| .:|.||.....:|.   .|:.....|:...:|...|.| .|::.....    ||..|
Human   741 IKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACH-QHSDYPYLG----LGRVP 800

  Fly   823 SKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPV 887
            :|:|.:.:..|...:.  |:..|.|..||:.::                   |..|.::.||:
Human   801 AKERAKSKLKSDNEND--GYVPDVEMSDSESEA-------------------SEKKCIHTSST-- 842

  Fly   888 GINRRTAIL 896
             |:|||.|:
Human   843 -ISRRTDII 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	25/96 (26%)
		PHD_BRPF	283..336	CDD:277047	24/52 (46%)
		ePHD_BRPF	340..456	CDD:277140	55/116 (47%)
		Bromo_brd1_like	615..712	CDD:99944	27/147 (18%)
		BR140_related	1303..1414	CDD:99900
JADE1	XP_024309986.1	EPL1	114..>544	CDD:331339	145/456 (32%)
JADE1	XP_024309986.1	ePHD_JADE1	270..387	CDD:277174	56/125 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840