DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Br140 and BRPF1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_024309509.1	Gene:	BRPF1 / 7862	HGNCID:	14255	Length:	1254	Species:	Homo sapiens

Alignment Length:	1525	Identity:	561/1525 - (36%)
Similarity:	746/1525 - (48%)	Gaps:	390/1525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLDFDAVEYCKGVKTQQSQPPFACPVRGCDRSYKTIMGLQYHLMKYDHDNPQPLTPVLTPSRKK 65
            ||:|||...:|..::.  ::||:.|||..|.:.||:..|::|||..||||||.|  |..||.||.
Human     1 MGVDFDVKTFCHNLRA--TKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPP--PQQTPLRKH 61

  Fly    66 ARSRSGGHHSTPRPHKDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYNEEEAT 130
            .:.   |..|.| .:|..|:|           |..|...|             ..::||.:.:..
Human    62 KKK---GRQSRP-ANKQSPSP-----------SEVSQSPG-------------REVMSYAQAQRM 98

  Fly   131 VTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPPLEENAPWARVQVPVA-------- 187
            |..:|.|:..|:.|.|.|.:|.::|.|.         .:||  |..:.....:.|.|
Human    99 VEVDLHGRVHRISIFDNLDVVSEDEEAP---------EEAP--ENGSNKENTETPAATPKSGKHK 152

  Fly   188 -------------------RVAEIPD--YR-----VSDAPPRPLAYYRFIEKSLEELDGEVEYDV 226
                               ...::|:  ||     ..||||||.:|||:||||.||||.|||||:
Human   153 NKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDM 217

  Fly   227 DEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLD 291
            ||||..||:.|||.|:..|::.:..:..|.|||||||||:|::...|.|..: ||:|||||||.|
Human   218 DEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNAL-VDEDAVCCICND 281

  Fly   292 GECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG 356
            |||||:|||||||||||||||:||||||||||||||||||||||:.|:|.||||.||||||||.|
Human   282 GECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDG 346

  Fly   357 QWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHV 421
            :|||||||||||||.||||||||||||||.||||||:||||:||::|.|||||||:.:||.||||
Human   347 RWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHV 411

  Fly   422 TCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTPADAKLKM----------NVPDFED--- 472
            ||||||||||.|:.|:: |.|.:|..|:|.|||..|||..:..::          :..:.||
Human   412 TCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGK 476

  Fly   473 -------------TRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRII 524
                         :|.|||:|||.||:||:.||||.:|.|||.|:.:|...:|:|||.:|:.|:.
Human   477 GWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLH 541

  Fly   525 AYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN----GIEGSPDTGELYRQLKYWQCLRQDLERAR 585
            :||||||..|||||||||||:    |...|||    |.:.......|..|||.||.||.||||||
Human   542 SYWTLKRQSRNGVPLLRRLQT----HLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERAR 602

  Fly   586 LLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTS------E 644
            ||.||:|||||||...:::.:..:.:||.|....|.|.|:.|:.:|:..||.|||..|      |
Human   603 LLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVTELDE 667

  Fly   645 VPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAA 709
            ||||.|.:|:|||..||:..|:..:|.:.:..|.||:|::.|||.||.|||:||||.:|:|:|..
Human   668 VPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGG 732

  Fly   710 PLFVQVRKELQRDGL-----------LARSQRYHVDHVEAEVEQELRLLLA----APASEGIVQK 759
            .:..|.|::.::.|:           ||..:..|  |.|...|:|..:||.    .|..|.:  |
Human   733 AVLRQARRQAEKMGIDFETGMHIPHSLAGDEATH--HTEDAAEEERLVLLENQKHLPVEEQL--K 793

  Fly   760 LLI-LADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPS 823
            ||: ..|:....|....|:::.|.|:.|::.:|:.|          :|..::..|..:..|  ||
Human   794 LLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKL----------AHQRETGRDGPERHG--PS 846

  Fly   824 KKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPV- 887
            .:       .|........|.|.:.:.:.|:|..::| ||.|         .|    |.||:|.
Human   847 SR-------GSLTPHPAACDKDGQTDSAAEESSSQET-SKGL---------GP----NMSSTPAH 890

  Fly   888 GINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAASSGAGTL 952
            .:.|||::|.::|.......|..|...|     .|.:|..|.|..||
Human   891 EVGRRTSVLFSKKNPKTAGPPKRPGRPP-----KNRESQMTPSHGGS------------------ 932

  Fly   953 NHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVK 1017
                ...||                                                   .||:.
Human   933 ----PVGPP---------------------------------------------------QLPIM 942

  Fly  1018 SPKRPGRYRRVPEVRHSS-SMSPKKSPNPAVTVSQALPMPETLPF-------ERIPDSFRVYRAN 1074
            |..|..:..|.|....|| |.|.|.:.:|          |..||.       :.:..||.|||
Human   943 SSLRQRKRGRSPRPSSSSDSDSDKSTEDP----------PMDLPANGFSGGNQPVKKSFLVYR-- 995

  Fly  1075 NQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSRSEERDSTSQ 1139
                                  :|.|:..|.||.:|..:|...|..|            |.||:
Human   996 ----------------------NDCSLPRSSSDSESSSSSSSSAASD------------RTSTT- 1025

  Fly  1140 EGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKVGTRGTPT 1204
                             ....|....|.|.|.....||||       .|..:|:...|||
Human  1026 -----------------PSKQGRGKPSFSRGTFPEDSSED-------TSGTENEAYSVGT----- 1061

  Fly  1205 PTTMARAVALSAGRGRG-------KRRSNLSESTSSTATPPPLRRAGKLRSATPNASPLVNNIKA 1262
                        |||.|       .|...|.......|:||         :|.|  .||.::.:.
Human  1062 ------------GRGVGHSSKFPCPRPGMLGTQCQGLASPP---------AADP--PPLPHSCEV 1103

  Fly  1263 RRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGYPWYPALILDPK 1327
            .|.:...|:..|        |||..|             .|:.|.||||||||||.|||||:|||
Human  1104 VRKSLGRGAGWL--------SEDEDS-------------PLDALDLVWAKCRGYPSYPALIIDPK 1147

  Fly  1328 TPK-GFVYNGVPLPAPPTDVLALRKNCLDEI---VFLVLFFDVKRTWQWLPANKLDILGIDKQLD 1388
            .|: |..::|||:|.||.:||.|.:....|.   ::||||||.||||||||..||..||:::.||
Human  1148 MPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLD 1212

  Fly  1389 QQKLVESRKPAERKAVKKAYQDALHYQSQV 1418
            ::|::|.||...||:|:.||..||.::|:|
Human  1213 KEKMLEGRKSNIRKSVQIAYHRALQHRSKV 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	43/78 (55%)
		PHD_BRPF	283..336	CDD:277047	49/52 (94%)
		ePHD_BRPF	340..456	CDD:277140	87/116 (75%)
		Bromo_brd1_like	615..712	CDD:99944	45/102 (44%)
		BR140_related	1303..1414	CDD:99900	63/114 (55%)
BRPF1	XP_024309509.1	SFP1	<20..52	CDD:227516	17/31 (55%)
		COG5141	174..657	CDD:227470	279/487 (57%)
		ePHD_BRPF1	330..450	CDD:277171	89/119 (75%)
		Bromo_brd1_like	632..735	CDD:99944	45/102 (44%)
		BR140_related	1123..1238	CDD:99900	63/114 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3056
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31251
Inparanoid	1	1.050	728	1.000	Inparanoid score	I615
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47059
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	1	1.000	-	-		otm41684
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870