Protein Alignment Br140 and Jade2

DIOPT Version :9

• Sequence 1: NP_001286155.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001344517.1
• Gene: Jade2 / 76901
• MGIID: 1924151
• Length: 901
• Species: Mus musculus
• Alignment Length: 1133
• Identity: 284/1133 - (25%)
• Similarity: 408/1133 - (36%)
• Gaps: 344/1133 - (30%)

  Fly    52 PQPLTP----------VLTPSRKKARSR----SGGHHS--TPRPHKDHPTP------GGGG---- 90
            |:|..|          :..|:...||||    ||||..  .|..|...|.|      ||.|
Mouse     4 PRPPAPAPGAPGFGSILPAPAPAAARSRGQRPSGGHRGARAPGEHTSPPGPPVPSSLGGLGLAEQ 68

  Fly    91 -----AEARNGCSSASAGG----GSASGVSARQYAN-PESLVS----YNEEEATVTFNLDGKSVR 141
                 .|.|...|.:|...    |..:..||.:.:. |.|..|    .||::.:..|..| ....
Mouse    69 STKQMEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTD-LITA 132

  Fly   142 LGIDDALPLVEDEEFAALVARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDAP 201
            :.|.|:..|..|:.:         :.||        ||.:     ||||....| ||:..|...|
Mouse   133 MKIPDSYQLSPDDYY---------ILAD--------PWRQEWEKGVQVPAGAEA-IPEPVVRLLP 179

  Fly   202 P-----------RPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTME 255
            |           .|    ...|.:..:..|...||:||.|:.|||.:|.|.:.:....:...|:|
Mouse   180 PLKGPPTQMSPDSP----TLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKPELDELTLE 240

  Fly   256 LLMDRLEKESH---FQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGV 317
            .:::.||...|   .||.......|:|.|:|.||.:|...|.::.|.::|||.||:.|||.|||:
Mouse   241 RVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGI 305

  Fly   318 PYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPI 381
            ..:|.|.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||.......:|||
Mouse   306 LKVPTGSWLCRTCALGVQP--KCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPI 368

  Fly   382 DSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMH 446
            ..|..||.:||.|:|.:||| ..|.||||...||..|||||||...||  .|.|:. ..||   .
Mouse   369 TKISHIPASRWALSCSLCKE-CTGTCIQCSMPSCITAFHVTCAFDRGL--EMRTIL-ADND---E 426

  Fly   447 VQKFAYCHAHTPADAKLKMNVPDFEDTRHKMKEARKALAKKRSTAPVV--LIPTIPPDRVQEIAT 509
            |:..:.|..|:....:.:......|.:: .:::..|...:|:....:.  ....:.|..|.|
Mouse   427 VKFKSLCQEHSDGGPRSEPTSEPVEPSQ-AVEDLEKVTLRKQRLQQLEENFYELVEPAEVAE--- 487

  Fly   510 MVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE-------- 566
              .:...:..:|.|..||.|||......|||                    :|.|.|
Mouse   488 --RLDLAEALVDFIYQYWKLKRRANANQPLL--------------------TPKTDEVDNLAQQE 530

  Fly   567 ---LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALE 628
               |||:||.:..|||||||.|.||.:|.:||:.|....::.|::..||:..:|..|.:......
Mouse   531 QDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQDLCREPSGRR 595

  Fly   629 AR----DSMQIFRE-PVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCL 688
            ::    ||.:..|| |..:|  |:             .:.|:|....:.|.||.......|
Mouse   596 SKGKKNDSKRKGREGPKGSS--PE-------------KKEKVKAGPESVLGQLGLSTSFPI---- 641

  Fly   689 AYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPAS 753
                 |..|:.:.:...       ||:..|.......:.:..:..|.....:.:||
Mouse   642 -----DGTFFNSWLAQS-------VQITAEDMAMSEWSLNSGHREDPAPGLLSEEL--------- 685

  Fly   754 EGIVQKLLILADKSQVL---KNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDE 815
                     |.|:..:|   ::|:.|..         ...||:..:.|..|:..          .
Mouse   686 ---------LQDEETLLSFMRDPSLRPG---------DPARKARGRTRLPAKKK----------P 722

  Fly   816 DTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSL 880
            ..|...||.:.|               .|...::...:|..|           ||.||.
Mouse   723 SPLQDGPSARTT---------------PDKQPKKAWAQDGKG-----------TQGPPM------ 755

  Fly   881 NNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAA 945
              ...|    |||:..|          ||.|
Mouse   756 --RKPP----RRTSSHL----------PSSP---------------------------------- 770

  Fly   946 SSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKL 1010
            ::|...:...|.|.||.||..                                |..|| .|.|.|
Mouse   771 AAGDCPVPATLESPPPLASEI--------------------------------LDKTA-PMASDL 802

  Fly  1011 SANL--PVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALP-----MPE-TLPFERIPDS 1067
            :..:  |..|||..||.|...|::.|     :|||.........||     .|: :|.|:...|.
Mouse   803 NVQVPGPTVSPKPLGRLRPPREMKVS-----RKSPGARSDAGTGLPSAVAERPKVSLHFDTEADG 862

  Fly  1068 FRVYRANNQRDVSDS----DDAPSQSSS 1091
            :     .:..::|||    :|:..|.:|
Mouse   863 Y-----FSDEEMSDSEVEAEDSGVQRAS 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	22/82 (27%)
		PHD_BRPF	283..336	CDD:277047	24/52 (46%)
		ePHD_BRPF	340..456	CDD:277140	56/116 (48%)
		Bromo_brd1_like	615..712	CDD:99944	17/101 (17%)
		BR140_related	1303..1414	CDD:99900
Jade2	NP_001344517.1	EPL1	209..>578	CDD:331339	140/403 (35%)
		ePHD_JADE2	326..436	CDD:277175	56/116 (48%)
		Atrophin-1	<676..852	CDD:331285	58/332 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810