Protein Alignment Br140 and brd1a

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_698063.6
• Gene: brd1a / 569574
• ZFINID: ZDB-GENE-041008-168
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1385
• Identity: 453/1385 - (32%)
• Similarity: 661/1385 - (47%)
• Gaps: 356/1385 - (25%)

  Fly   122 VSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPP-------------- 172
            ::|.:.:..|...:||:..|:.|.|.|.::.||:..|.....||.:.:...
Zfish    18 LTYAQAQRMVDLEVDGQLHRISIFDKLEIITDEDPLAQEIIKCISSKENAEKHLQISEYSAQIKN 82

  Fly   173 --LEENAPWARVQ---VPVARVAEIPDYRVSDAPPRPLAYYRFIEKSLEELDGEVEYDVDEEDSA 232
              .::|...:.:|   :|..:...: ||.:...|.||..||::.:|::||||.|||||:||||.|
Zfish    83 NNQKKNTSDSSIQGSILPEPKFHTV-DYNLPVIPSRPSTYYKYEQKTVEELDQEVEYDMDEEDFA 146

  Fly   233 WLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLDGECQNT 297
            ||:.:||:|:..|||.|..|..|.|:||.||||..::....|...:: |:|||||||:||:|.::
Zfish   147 WLDLVNEKRKDEGLNLVSFDDFEFLLDRFEKESFLESQGQHTLQSID-DEDAVCCICMDGDCMDS 210

  Fly   298 NVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVV 362
            |||||||||||||||||||||||||||||||.||.||::|.||:||||.|||.|||:..:|.|||
Zfish   211 NVILFCDMCNLAVHQDCYGVPYIPEGQWLCRHCLHSPTQPANCILCPNKGGAVKQTEDDRWGHVV 275

  Fly   363 CALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQA 427
            ||||:|||.|:||||:||||.:..||||||:||||:|||||:|||||||:.:||.||||:|||::
Zfish   276 CALWVPEVGFSNTVFIEPIDGVSNIPPARWKLTCYLCKEKGVGACIQCHKANCYTAFHVSCAQKS 340

  Fly   428 GLYMTMDTVKDGHNDS---SMHVQKFAYCHAHTPADAKLKMNVPDFEDTR--------------- 474
            ||:|.|:.:| ...||   :..|:|.|||.|||| :..:|..:..::|..
Zfish   341 GLFMKMEPIK-VLTDSGIPTFSVKKTAYCGAHTP-NGSVKRPLAIYKDNETNYGLCQLVDRKSSR 403

  Fly   475 ---HKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNG 536
               :|.|..:|......:|.|.:.:|:...:|:..|...|::|:|..|.:.:::||||||..|||
Zfish   404 IGFNKQKRLKKNEEAIVTTIPPLSVPSFSSERLSPILNQVSLQKKTAFGELVLSYWTLKRQSRNG 468

  Fly   537 VPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAF 601
            |||.||||::.:.....||...|  .:|..|..|||.|..||.||||||:|.||:|||||||...
Zfish   469 VPLNRRLQTRLHPPKNSQRKQTE--EETQALKEQLKEWHQLRHDLERARILLELIRKREKLKREE 531

  Fly   602 VRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLK 666
            |.:.:.::..||.|....|..:||.|:.:|...||.|||:..|||||.|.|..|||..||..:::
Zfish   532 VLLQQTLMEFQLTPFTVILRAVLDQLQEKDQAHIFAEPVNIKEVPDYMDHVLHPMDFSTMSKRIE 596

  Fly   667 ECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRY 731
            ...|..|::.||||:|:..||:.||.|||.||||.:::|||...:..:.|:::||.||
Zfish   597 AQGYKYLDEFEADFNLITDNCMKYNGKDTFFYRAAVKLRDQGGAILRKTRRDVQRIGL------- 654

  Fly   732 HVDHVEAEVEQELRLL------------------LAAPAS------EGIVQKLLILADKSQVLKN 772
                   ::|..|.||                  |..||:      |..:::||...|.:..:|:
Zfish   655 -------DLETGLHLLEPPKIEPSVPFSWEDVDRLLVPANREHMSFEEQLRELLEKLDMTTAMKS 712

  Fly   773 PTYRTKKIKQIRLEIS--RMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPSKKRTRKRFNSSG 835
            ...|::::|.::..||  |:..||:||..|.:..:.|.:
Zfish   713 SPSRSRRLKLLKKNISDVRLELSLRKALTAVKLKNAAEE-------------------------- 751

  Fly   836 VDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRK 900
               |:||          ....|:.:|...|..|....|.  |.:.::|..|.
Zfish   752 ---EVGH----------IHQKGDKSVPPKLEPSVSVLPL--INAESHSEPPT------------- 788

  Fly   901 AQAALKRPSEPLTTPVKEEQHNSQSSN-TQSTSGSS------SSVTTAATAA----SSGAGTLNH 954
                 .:|.||     ..::|:.|... :||.:|.|      |.:...||:.    ||.......
Zfish   789 -----LKPIEP-----NPDKHSHQKDGISQSLNGDSHLLLEDSDINVVATSTLAEPSSPVNRRTS 843

  Fly   955 VLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSP 1019
            ||         |..:::::|....|.....:.|||..||             .:.||..:|
Zfish   844 VL---------FRKSKSSTSPLRTLKDDETLKGSSQIGT-------------KTFLSVVIP---- 882

  Fly  1020 KRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALPMPETLPFER----IPDSFRVYRANNQRDVS 1080
                   |:..:.|:     :|.|..|...|    ..:.||.:|    :.:||.:   :::|::
Zfish   883 -------RLETLLHT-----RKRPRSASGDS----CKDELPIKRLDTELSNSFGL---SSEREL- 927

  Fly  1081 DSDDAPSQSSSPCSSC-SDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSRSEERDSTSQEGTTD 1144
                  |.||.|...| |:.|||.|
Zfish   928 ------SSSSQPRQRCTSESSMSSS---------------------------------------- 946

  Fly  1145 AMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKVGTRGTPTPTTMA 1209
                           |.::|::....|.|           :|...|:|           |....:
Zfish   947 ---------------NSSIALNLMKCGKG-----------KPALIRRN-----------TVEDKS 974

  Fly  1210 RAVALSAGRGRGKRRSNLSESTSSTATPPPLRRAGKLRSATPNASPLVNNIKARRNTTAAGSAPL 1274
            ..:|....|...|.....:|..||:...|            .||:.::
Zfish   975 EIIACIESRNFAKAARIAAEVNSSSIWMP------------SNAATVL----------------- 1010

  Fly  1275 TNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGYPWYPALILDPKTPK-GFVYNGVP 1338
                                        ||||::|||||.|||.|||||:||:.|: |..:|||.
Zfish  1011 ----------------------------LEPLKVVWAKCSGYPSYPALIIDPQMPRVGCQHNGVS 1047

  Fly  1339 LPAPPTDVLALRKNC---LDEIVFLVLFFDVKRTWQWLPANKLDILGIDKQLDQQKLVESRKPAE 1400
            :|.||.:||.:.:..   .:|.::||||||.|||||||..:|:..||:||.:|:.|::|.|..|.
Zfish  1048 IPMPPLNVLQIGEQMQYKSEEKLYLVLFFDNKRTWQWLHKSKMVPLGVDKTIDKIKMMEGRTSAI 1112

  Fly  1401 RKAVKKAYQDALHYQSQVSD 1420
            ||||:.|:..|:::.:.|.|
Zfish  1113 RKAVRTAFNRAMNHLNHVQD 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	226/442 (51%)
		Bromo_brd1_like	615..712	CDD:99944	44/96 (46%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	11/83 (13%)
		PWWP_BRPF	1303..1414	CDD:438964	59/114 (52%)
brd1a	XP_698063.6	None