DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Br140 and jade2

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_697831.5	Gene:	jade2 / 569359	ZFINID:	ZDB-GENE-120215-66	Length:	795	Species:	Danio rerio

Alignment Length:	874	Identity:	232/874 - (26%)
Similarity:	371/874 - (42%)	Gaps:	204/874 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPPLEE 175
            |::......:.|.:.::..:..|..|..:. :.:.|:..|..||.:..     |
Zfish    30 SSKNTGTSSTWVRHEQKRPSEVFRTDFITA-MKLPDSAQLSADEFYIL-----C----------- 77

  Fly   176 NAPWAR-----VQVPVARVAEIPDYRVSDAPP-RPLAYYRFIE-KSLEELDGEV-EYDVDEEDSA 232
             .||.:     |||| |.|..||:..|...|. ..:.::..:: :|..|:...: .||:|:.|.|
Zfish    78 -DPWRQEWEKGVQVP-ANVETIPEPVVRMLPEVSRIPFFSAVQTRSQSEISEPLSRYDLDDLDVA 140

  Fly   233 WLEHMNEERQRLGLNAVGIDTMELLMDRLEK---ESHFQAAANGTPTGVEVDDDAVCCICLDGEC 294
            |||.:|.|.::|.|..:...|||.|:..||:   ::..|...|....|:|.|:|.||.:|...|.
Zfish   141 WLELVNAEFRQLALPELDELTMEQLLVELERRCQQNMQQQIENQEGLGIEYDEDVVCDVCRSPEG 205

  Fly   295 QNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRC---LQSPSKPVNCVLCPNAGGAFKQTDHG 356
            ::.|.::|||.||:.|||.|||:..:|:|.||||.|   :||     .|:|||..|||.|.|..|
Zfish   206 EDGNEMVFCDNCNVCVHQACYGILKVPQGNWLCRTCALGVQS-----KCLLCPRRGGALKPTRSG 265

  Fly   357 -QWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFH 420
             :|.||.||||||||.......:|||..:..||.:||.|:|.:|.|.. |.||||...||..|||
Zfish   266 TKWVHVSCALWIPEVSIGCPEKMEPITKVSHIPASRWALSCSLCCEHS-GTCIQCSMPSCTVAFH 329

  Fly   421 VTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTP-----ADAKLKMNVPDFEDTRH----- 475
            ||||...||.| ..|:.|  ||   .|:..:||..|:.     :...::.:.|   |.||
Zfish   330 VTCAFDHGLEM-RTTLAD--ND---EVRFKSYCLEHSSVWRSNSSGGVQSDRP---DPRHAVPDP 385

  Fly   476 ----KMKEARKALAKKRSTAPVVLIPTIPPDRVQEIA----TMVTMQRKKEFL-------DRIIA 525
                |.::|.:..|.:|.            .::||:.    |:|..:...|.|       |.:..
Zfish   386 AAAQKQEQAEREKASQRK------------QKLQELEDEFYTLVDPKDIAESLSLPDAHVDFLFQ 438

  Fly   526 YWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCEL 590
            ||.|:|......||:...:.:.:|  :.|:       :...|||:||.:..|||||||.|.||.:
Zfish   439 YWKLRRKTNGNKPLVSMKRDEVDN--LAQQ-------EQDVLYRRLKLFTHLRQDLERVRNLCCM 494

  Fly   591 VRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQP 655
            :.:|||:|.:...:.|::..||:..:|                               .::|.:.
Zfish   495 ITRREKIKHSLCNLQEKIFSLQIQLME-------------------------------QNLVGEK 528

  Fly   656 MDLG------TMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQ 714
            ...|      .::.::||.:.||.|:                 ||        :.|.....||.|
Zfish   529 SQRGERKHRNRVQERVKERRKNSPEK-----------------KD--------KWRSDDNSLFSQ 568

  Fly   715 V--RKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRT 777
            :  .:....||.|..|.:....|:.|| ....|..|:|...|   ....:|:|  |:|:.    .
Zfish   569 LGFSRSFPIDGSLFDSWQAQSIHISAE-SMLSRWSLSAGTPE---TSASLLSD--QLLRG----E 623

  Fly   778 KKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPSKKR---TRKRFNSSGVDME 839
            :.:..:.:: |.|:.:.:..|...:|...|.:|:   ..||...|:|.:   |.:|       ..
Zfish   624 ESLLSLMMD-SSMQNTWKTPRLGRKHPKSAPRSR---RKTLCSPPAKGKVCVTERR-------CR 677

  Fly   840 LGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAA 904
            .|...:|.:..||                .::.|..|..:..:|..   |:.....:|.:::|.:
Zfish   678 RGEKTEDFQRSSD----------------GRSDPLQPAIAKMDSCH---ISEERDSVLEKRSQKS 723

  Fly   905 LKR--PSEPLTTPVKEEQHNSQSSNTQST 931
            ::.  |.:..|....:...:|..|||..|
Zfish   724 VRMHLPRQSKTRCKSQTVESSVQSNTPDT 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	24/77 (31%)
		PHD_BRPF	283..336	CDD:277047	26/55 (47%)
		ePHD_BRPF	340..456	CDD:277140	56/116 (48%)
		Bromo_brd1_like	615..712	CDD:99944	11/102 (11%)
		BR140_related	1303..1414	CDD:99900
jade2	XP_697831.5	COG5141	107..>515	CDD:227470	151/443 (34%)
		PHD_JADE2	196..241	CDD:277150	22/44 (50%)
		ePHD_JADE2	249..359	CDD:277175	56/116 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810