DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Br140 and kdm4b

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001076274.1	Gene:	kdm4b / 556504	ZFINID:	ZDB-GENE-060503-664	Length:	1134	Species:	Danio rerio

Alignment Length:	422	Identity:	112/422 - (26%)
Similarity:	169/422 - (40%)	Gaps:	87/422 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SSASAGGGSASGVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVAR 162
            :.|:..||....:.| .:.:|.  |...|::..       |..:|.:.|.:..  .|.|......
Zfish   521 AEAALRGGGVEEIKA-DFQDPP--VENGEKKKK-------KKKKLQLTDEMSF--QEVFEQFTTA 573

  Fly   163 GCILNAD--APPLEENAPWARVQVPVARVAEIPDYRVSDAPPR-PLAYYRFIEKSLEEL------ 218
            ..:.|..  |.||:.| |:.:::..| .|.:...:.:|..|.| |.:..:....|.|||
Zfish   574 SEMQNQSNGAAPLQTN-PFTKLKKKV-EVKKSRRHPISKPPMRSPHSIVKQEASSDEELYSGLPV 636

  Fly   219 DGEVEYD--VDEEDSAWLEH----MNEERQRLGLNAV---------------------GIDTMEL 256
            .|.|.::  ..|:...|...    :.|::....::.:                     .|..|..
Zfish   637 GGGVTHESKKPEDSDLWQNRSPNFLAEKQFNAAMSTIEPYCAICTLFCPYTQSVKDPFHISDMSG 701

  Fly   257 LMDR-------LEKESHFQAAA-NGTP--TGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVH 311
            |:.|       |..|..|.|.| |..|  :...:.||            .|:|:|.|..|||.||
Zfish   702 LVSRVGCRTRPLVPEMCFSAGAENMEPLSSNSHIADD------------GTSVLLSCSGCNLQVH 754

  Fly   312 QDCYGV-PYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANT 375
            ..|||| |...:..|:|.|| .:.:....|.||...|||.|:|...:|.||:||:.:.||||.|.
Zfish   755 ASCYGVNPQTKQEGWMCSRC-TTVAWTAACCLCSLRGGALKKTTDERWVHVICAIAVAEVRFVNA 818

  Fly   376 VFLEPIDSIETIPPARWRLTCYVC---KEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVK 437
            :..||:| :..:|..|..|.|..|   .::..||||||.:::|..:||||||..||:.|
Zfish   819 IEREPVD-VTAVPETRKSLKCVYCHKTTKQIFGACIQCSQDNCSTSFHVTCALLAGVVM------ 876

  Fly   438 DGHNDSSMHVQKFAYCHAHTPADAKLKMNVPD 469
               ..:.........||.|...:.|.|....|
Zfish   877 ---KPADWPYVVSVTCHKHKLTNQKAKSGSRD 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	18/112 (16%)
		PHD_BRPF	283..336	CDD:277047	19/53 (36%)
		ePHD_BRPF	340..456	CDD:277140	44/118 (37%)
		Bromo_brd1_like	615..712	CDD:99944
		BR140_related	1303..1414	CDD:99900
kdm4b	NP_001076274.1	JmjN	95..136	CDD:128818
		JmjC	256..372	CDD:202224
		YscO	<408..512	CDD:284686
		PHD_JMJD2B	676..774	CDD:277051	29/109 (27%)
		PHD_SF	783..892	CDD:304600	44/118 (37%)
		TUDOR	905..953	CDD:197660	1/1 (100%)
		tatB	<978..1099	CDD:166942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910