Protein Alignment Br140 and mllt10

DIOPT Version :9

• Sequence 1: NP_001286155.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_017209395.2
• Gene: mllt10 / 492342
• ZFINID: ZDB-GENE-041114-176
• Length: 1162
• Species: Danio rerio
• Alignment Length: 1303
• Identity: 273/1303 - (20%)
• Similarity: 424/1303 - (32%)
• Gaps: 492/1303 - (37%)

  Fly   262 EKESHFQAA--ANGTPTGVEVDDDAV---------CCICLDGECQNTNVILFCD--MCNLAVHQD 313
            |::|:|:..  .:......|.|||:.         ||:|.|......|.:::||  .||:||||.
Zfish    16 EEDSYFRECEMVSSELYLAEEDDDSPSNMKEMIGGCCVCSDERGWAENPLVYCDGHGCNVAVHQA 80

  Fly   314 CYGVPYIPEGQWLCRRC-------------------LQSPS---------------------KPV 338
            |||:..:|.|.|.||:|                   .|:|.                     |.:
Zfish    81 CYGIVQVPTGPWFCRKCESQERAARVIKGWRGRKPSWQTPEGGGQSTTCNKEEEDSRLSRSLKTL 145

  Fly   339 N---CVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCK 400
            |   |.|||...||.|:||:|.||||||||:||||.|||...:||| .::::|..|:..|||:|:
Zfish   146 NIVRCELCPQKDGALKRTDNGGWAHVVCALYIPEVEFANVSTMEPI-VLQSVPHERYNKTCYICE 209

  Fly   401 EKG------LGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTPA 459
            |:|      .|||:.|:::.|..||||||||.||| :..:...|..|     |:...||..|.
Zfish   210 EQGRESKAATGACMTCNKHGCRQAFHVTCAQLAGL-LCEEQGSDADN-----VKYCGYCKYHY-- 266

  Fly   460 DAKLKMNV--------------------PDFEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRV 504
             .||:.:.                    .|.|..:||.::..|...||    |:.|.|::.|
Zfish   267 -NKLRRSKGRGSRAQSLSDSSTHSLDKHHDKEKKKHKERDRHKPKHKK----PLELSPSLVP--- 323

  Fly   505 QEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYR 569
               |.|||.::.                |.|        .|.|.:...|
Zfish   324 ---ALMVTPEKS----------------YNN--------SSSGGSVSSI---------------- 345

  Fly   570 QLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQ 634
                                                            ::..|.||...||.:..
Zfish   346 ------------------------------------------------SSTQKRLDDSGARFTNA 362

  Fly   635 IFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYR 699
            .|:      |||.::.  ....|.|:...|..:.:                   :..:..:....
Zfish   363 NFQ------EVPPHSS--SSSKDGGSSDGKSSDSK-------------------SKKSSHSTSSS 400

  Fly   700 AGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPASEGIVQKLLILA 764
            :|.|.|...|                   .:.|...|......      .||:|....|:..:|.
Zfish   401 SGSRGRKSVA-------------------GKPHGPVVTTATSS------TAPSSTSPFQQGHLLG 440

  Fly   765 DKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSD-----DEDTLGGSPSK 824
            ..|. .|:.|                             |....|..||     |.....|....
Zfish   441 SNSS-SKSAT-----------------------------SGSVVQPTSDFLSFSDPSLRAGDSYT 475

  Fly   825 KRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGI 889
            ..:..|.:..|               ..|....|..|:   ||:....|.|  :|.::|||....
Zfish   476 PPSFGRCHMKG---------------GAESGASESMVA---LNTFSMIPLS--QSSSSSSSKHYE 520

  Fly   890 NRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVT--------------- 939
            |..|...|...|.|:.|||          :..:|.||.|.|:|.....|.
Zfish   521 NCHTTGELGSLASASYKRP----------QPSSSSSSATSSSSTGEDGVKKKKRGNWRNRYGPCF 575

  Fly   940 TAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTAL 1004
            |...:.::.||  .|: |:.|.:.|....:.:|....|:..|.|...|:..|||::.....|.:|
Zfish   576 TTQDSKTTDAG--EHI-STMPSSTSPSPSSMSNMVCRGSTVSSTASVGAVGAGTSSLGIQKSPSL 637

  Fly  1005 AMNSKLSANLPVKSPKRPGRYRR-----------VPEVRHSSSMSPKKSPNPA--VTVSQALP-- 1054
            ..|..|........|..||..:|           :|......|||...|..||  ..|..::|
Zfish   638 LRNGSLQGMTVSSPPAVPGEQKRSYPSSSDVACPLPSAVLGGSMSASNSELPAHQSVVVTSMPTL 702

  Fly  1055 --MPETLPF--------ERIPDSFRV---YRANNQRD--------VSDSDDAPS----------- 1087
              :|...||        ..:|.||.:   :...|:.:        ::.|:.:|:
Zfish   703 TSLPSAAPFTSTPSTHANSLPGSFNLAPSHMFGNRLNPNSAMAALIAQSEGSPADQELGDGALGF 767

  Fly  1088 --QSSSPCSSCSDFS-MSGSCSDFDSDEASEGDADGDP---------DRDGGRSRSEERDSTSQE 1140
              :.:||.::.|..| :||....:|:.....|...|..         |:...|..:|.:....|:
Zfish   768 SRRGNSPKTNLSPRSPLSGLHIRYDAGPMVPGLGSGSDTLPPAATSIDQLLERQWNEGQQFLLQQ 832

  Fly  1141 GTTDAMDMQHASLNNVQGNN------------------------------GNMAISSSSGGSGGS 1175
            |:...:.....||:.:|..|                              .:...:::|.....|
Zfish   833 GSQGDVLAMLKSLHQLQVENRRLEEQIRTLTMKKERLQLLSAQLSVPFTPASTTATTASSPMYPS 897

  Fly  1176 SSEDDELEERPLSARQNKPMKVGT----RGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTAT 1236
            ::..|.|        .:|.:::|:    ...|.||...:    |.|...|...|:||...|:..:
Zfish   898 NTHTDML--------HSKSIQLGSVLTESSQPLPTQDPQ----SGGHSSGSSTSSLSTPPSAAHS 950

  Fly  1237 PP------------PLRRA----------------GKLR----------------------SATP 1251
            ||            |::..                |.|:                      |.|.
Zfish   951 PPQQQVNGVGMAGVPVQPGNANSSLPAIAGVTGLMGALQGNHLAMSGIVGALNGVIQTSQSSLTQ 1015

  Fly  1252 NASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNN---HSH-------GQKPALEPL 1306
            |:|||..:..| .:.:.:.|:.|||::.|. ::....:|:|..   |.|       .|:|..|..
Zfish  1016 NSSPLPQSATA-SSASLSMSSSLTNSSMST-TKTRLFTEQHRQILLHQHQLQQLFGSQQPTPEQQ 1078

  Fly  1307 QLV 1309
            |::
Zfish  1079 QVL 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	1/1 (100%)
		PHD_BRPF	283..336	CDD:277047	25/103 (24%)
		ePHD_BRPF	340..456	CDD:277140	57/121 (47%)
		Bromo_brd1_like	615..712	CDD:99944	16/96 (17%)
		BR140_related	1303..1414	CDD:99900	2/7 (29%)
mllt10	XP_017209395.2	PHD_AF10_AF17	50..97	CDD:277049	21/46 (46%)
		ePHD_AF10	148..273	CDD:277178	60/134 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840