Protein Alignment Br140 and Br140

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_061502065.1
• Gene: Br140 / 4576217
• VectorBaseID: AGAMI1_006557
• Length: 1168
• Species: Anopheles gambiae
• Alignment Length: 1473
• Identity: 669/1473 - (45%)
• Similarity: 828/1473 - (56%)
• Gaps: 360/1473 - (24%)

  Fly     1 MGLDFDAVEYCKGVKTQQSQPPFACPVRGCDRSYKTIMGLQYHLMKYDHDNPQPLTP--VLTPSR 63
            ||:||:..:|.|.:|  :...||.||:  ||::||:::||||||..||||||.|..|  |.||.:
Mosquito     1 MGIDFEVNDYIKTLK--KDGGPFKCPM--CDKTYKSVIGLQYHLNNYDHDNPSPAVPASVSTPIK 61

  Fly    64 KKARSRSGGHHSTPRPHKDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYNEEE 128
            :|.|....|  .||:              .:..||.                  |:..::|.|.|
Mosquito    62 QKGRKLKVG--VTPK--------------NQIACSP------------------PKEGITYLESE 92

  Fly   129 ATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNAD------APPLEENAPWARVQVPVA 187
            ..|..:.:||:|::.:.||||::..||:.:    .|...:|      |||.|     ..||:|..
Mosquito    93 HLVRLDCNGKTVKIPVLDALPVMSLEEYES----KCKTVSDFEAFAVAPPEE-----PEVQLPEG 148

  Fly   188 RVAEIPDYRVSDAPPRPLAYYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGID 252
            :..||.||.:.|||.||.||.||||||.|||||||||||||||:.||..:||.|....:..|.:|
Mosquito   149 KFKEIEDYTICDAPARPNAYIRFIEKSSEELDGEVEYDVDEEDTTWLSIINERRAAQNVGPVSVD 213

  Fly   253 TMELLMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGV 317
            ::|||||||||||.||||||| ..|..||||||||||:|||||||||||||||||||||||||||
Mosquito   214 SLELLMDRLEKESFFQAAANG-QNGAVVDDDAVCCICMDGECQNTNVILFCDMCNLAVHQDCYGV 277

  Fly   318 PYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPID 382
            ||||||||||||||||||:||:||||||.|||||||||.||||||||||||||||||||||||||
Mosquito   278 PYIPEGQWLCRRCLQSPSRPVDCVLCPNTGGAFKQTDHNQWAHVVCALWIPEVRFANTVFLEPID 342

  Fly   383 SIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHV 447
            ||||||.||||||||:||:||:||||||::..|||||||||||||||.|.||||| |.:.:.:.|
Mosquito   343 SIETIPAARWRLTCYICKQKGIGACIQCNKTYCYAAFHVTCAQQAGLCMRMDTVK-GTDSNPVVV 406

  Fly   448 QKFAYCHAHTPADA--KLKMNVPD-------FEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDR 503
            ||.|||.||||.:|  ....|.||       .|.||.|||:|||.||.||::|||:||||||.:|
Mosquito   407 QKTAYCDAHTPLNALQTTPGNSPDGGPPTDAREVTREKMKKARKLLALKRTSAPVILIPTIPQNR 471

  Fly   504 VQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQ---RNGIEGSPDTG 565
            ::||:::|.:.:|::|:.|:||||||||.|||||||||||||||...|...   |:..:||||..
Mosquito   472 IEEISSLVNIPKKQQFIQRLIAYWTLKRQYRNGVPLLRRLQSQGQAQGTGMPGCRDRTDGSPDAQ 536

  Fly   566 ELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEAR 630
            |||:||||||||||||||:||||||||||||:|:..::.:|::||.||||:|:.|:::||.||.:
Mosquito   537 ELYQQLKYWQCLRQDLERSRLLCELVRKREKIKLILIKTTEQLVMAQLNPIESVLHRILDQLEVK 601

  Fly   631 DSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDT 695
            |..:||||||||.||||||||||.||||||||.|||...|..:|.||.||.|||:||||||||||
Mosquito   602 DDKEIFREPVDTEEVPDYTDIVKHPMDLGTMRQKLKRGAYIRIEDLEQDFQLMIRNCLAYNNKDT 666

  Fly   696 VFYRAGIRMRDQAAPLFVQVRKELQRDGLL------------ARSQR----YHVDHVEAEVEQEL 744
            :|||||:||||..|.:|..|||||:|.|..            |.|.|    ...|::..::|.||
Mosquito   667 MFYRAGVRMRDAGAIVFRTVRKELERSGQFQEPAPVEPIASSALSGRAIGSSSEDNIAMDIENEL 731

  Fly   745 RLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQ 809
            ..:....|:...:.||..|..|:..:::...|:|:|||||.||:|:::::.|.  ..|...:..:
Mosquito   732 TKITGQSANAEHIGKLQTLLSKANGIRHALTRSKRIKQIRNEIARVKRAISKD--PERGLLNDRR 794

  Fly   810 SQSD----DEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQ 870
            ..||    ...:|||:.|...:.|:         |.|....|...|....:...:::....:...
Mosquito   795 ISSDLVGASSSSLGGTASSSFSPKK---------LSHSMHAEPTSSGLGGLAGSSLALAQKHHQI 850

  Fly   871 TPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSS 935
            ||..||:|.|.||.||.|:|||||:|.|||||||||:|...|    |:|
Mosquito   851 TPEASPLKVLQNSPSPSGVNRRTAVLFTRKAQAALKKPEASL----KQE---------------- 895

  Fly   936 SSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLT 1000
                .|:..||.|.|                                 |.||.|.   :....:|
Mosquito   896 ----GASVGASGGTG---------------------------------GAGGPSG---STVTPMT 920

  Fly  1001 STALAMNSKLSANLPVKSPKRPGRYRRVP----------EVRHSSSMSPKKSPNPAVTVSQALPM 1055
            :|.|..          |:.|:..|.:|:.          |...:|::..|             |:
Mosquito   921 TTELLQ----------KTAKKINRGKRIGKSGKGIESFLEATSASALDGK-------------PI 962

  Fly  1056 PETLPFERIPDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADG 1120
             |....|.|||||||||....|::|||:...|.:.|.|||||.||.||:.|:|
Mosquito   963 -ERKSLEAIPDSFRVYRGQQDREISDSESNLSLTGSTCSSCSGFSGSGTESEF------------ 1014

  Fly  1121 DPDRDGGRSRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEER 1185
                                                                 |||::|
Mosquito  1015 -----------------------------------------------------GSSNDD------ 1020

  Fly  1186 PLSARQNKPMKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATPPPLRRAGKLRSAT 1250
                                                    :..:|..||
Mosquito  1021 ----------------------------------------SYCDSEMST---------------- 1029

  Fly  1251 PNASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRG 1315
             |:.|.|                                     .|..:|||||||:||||||||
Mosquito  1030 -NSEPEV-------------------------------------ESFPEKPALEPLKLVWAKCRG 1056

  Fly  1316 YPWYPALILDPKTPKGFVYNGVPLPAPPTDVLALRKNCLDEIVFLVLFFDVKRTWQWLPANKLDI 1380
            ||||||||:||..|||||:|||||||||.||||||.| .||.|||||||||||||||||..||::
Mosquito  1057 YPWYPALIIDPNIPKGFVHNGVPLPAPPADVLALRSN-YDEPVFLVLFFDVKRTWQWLPVGKLEL 1120

  Fly  1381 LGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQVSDLEG 1423
            ||:||:|||.||:|||||.|||||.||||:||||.||||..:|
Mosquito  1121 LGVDKELDQSKLIESRKPTERKAVNKAYQEALHYHSQVSSADG 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516	23/40 (58%)
		COG5141	203..>625	CDD:227470	306/433 (71%)
		Bromo_brd1_like	615..712	CDD:99944	66/96 (69%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	16/82 (20%)
		PWWP_BRPF	1303..1414	CDD:438964	89/110 (81%)
Br140	XP_061502065.1	None