DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Br140 and brpf1

DIOPT Version :9

Sequence 1:	NP_001286155.1	Gene:	Br140 / 35648	FlyBaseID:	FBgn0033155	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_957310.1	Gene:	brpf1 / 393991	ZFINID:	ZDB-GENE-040426-731	Length:	899	Species:	Danio rerio

Alignment Length:	919	Identity:	392/919 - (42%)
Similarity:	523/919 - (56%)	Gaps:	143/919 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLDFDAVEYCKGVKTQQSQPPFACPVRGCDRSYKTIMGLQYHLMKYDHDNPQPLTPVLTPSRKK 65
            ||||||...:|..::.  ::||:.|||..|.:.||:..|::|||..|||:||.| .|..||.:|
Zfish     1 MGLDFDVKTFCHNLRA--TKPPYECPVESCRKVYKSYSGIEYHLYHYDHENPPP-PPQGTPQKK- 61

  Fly    66 ARSRSGGHHSTPRPHKDHP--TPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYNEEE 128
               |.|   ..||...|.|  :.|.|....:|...|:.|..      |.|.::.....::|.|.:
Zfish    62 ---RKG---RPPRGSSDGPDSSTGPGATSGQNTAPSSPAER------SERSHSPVRETMTYAEAQ 114

  Fly   129 ATVTFNLDGKSVRLGIDDALPLVEDEEFAA--------LVARGC--------------------- 164
            ..|...:.|:..|:.|...|.:|.:|:..|        ..|..|
Zfish   115 RMVEMEIRGRVHRVSIFQNLDVVSEEDSGAEEPPGATGSTAAACNGGGESGGGDRMDTANGEKGA 179

  Fly   165 -------------------ILNADAPPLEENAPWARVQVPVARVAEIPDYRVSDAPPRPLAYYRF 210
                               .:|...|         .|::|.....|:...| .||||||::|||:
Zfish   180 QKTGKHKSKEKKKDSGAHHHINTSGP---------AVKLPEVVFRELDQDR-PDAPPRPMSYYRY 234

  Fly   211 IEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTP 275
            |:||.||||.|||||:||||..||:.|||:|:..|:..:..:..|.|||||||||:|::...|.|
Zfish   235 IDKSAEELDEEVEYDIDEEDYIWLDIMNEKRRSDGVAPIPQEVFEYLMDRLEKESYFESHNKGDP 299

  Fly   276 TGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNC 340
            :.: :|:|||||||.||||||:|||||||||||||||:|||||||||||||||||.||||:.|:|
Zfish   300 SAL-IDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCPQSPSRAVDC 363

  Fly   341 VLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLG 405
            .||||.||||||||..:|||||||||||||.||||||||||||||.||||||:||||:||::|.|
Zfish   364 ALCPNKGGAFKQTDDSRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSG 428

  Fly   406 ACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTP----------- 458
            ||||||:.:||.||||||||||||||.|:.|:: |.|.:|..|:|.|||..|||
Zfish   429 ACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARPLGGVG 493

  Fly   459 ---ADAKLKMNVPDFED-----------------------TRHKMKEARKALAKKRSTAPVVLIP 497
               ||:......|:.|:                       :|.|||.|||.||::|:.|||:.:|
Zfish   494 GVSADSSRSEAEPEEEEEPPAAEDDGKGWSSERAKRAKAKSRLKMKRARKILAERRAAAPVLSVP 558

  Fly   498 TIPPDRVQEIATMVTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSP 562
            .|||.::.:|.:.:|:|||.:|:.|:.:||||||..|||||||||||:    |...||| .|..|
Zfish   559 CIPPHKLSKITSNLTVQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQT----HLQSQRN-TEPLP 618

  Fly   563 DT--GE-----LYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAAL 620
            .|  ||     |..|||.||.||.||||||||.||:|||||||...:::.|..:.:||.||...|
Zfish   619 VTRDGEEKHSVLKEQLKAWQRLRHDLERARLLVELIRKREKLKRETIKVQEMAMEMQLTPLLVLL 683

  Fly   621 NKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQ 685
            .:.|:.|:.||:...|.|||..||||||.|.:::|||...|...::..:|.|.|..|.||..::.
Zfish   684 RRTLEQLQERDTNNFFTEPVPLSEVPDYLDHIERPMDFHKMWKCVESHRYLSFEAFEGDFLQIVN 748

  Fly   686 NCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRDGL-------LARS---QRYHVDHVEAEV 740
            |||.||.||||||||.:|:|:....:..|.|::.:|.|.       |.|.   :..|....:.|.
Zfish   749 NCLKYNAKDTVFYRAALRLREAGGVVLRQARRQAERIGFDYETGLHLHREPSPENTHTHQRDRER 813

  Fly   741 EQ---ELRLLLAAPASEGIVQKLLILADKSQVL---KNPTYRTKKIKQIRLEISRMRKSLQKARF 799
            |:   |..||..:.....:.::|.||..:.:..   |:...:.::.|.::.|::.:|:.|...|.
Zfish   814 ERVYIEGELLSESWRRLPVDEQLQILQSRYEEAASGKHSIGQQRRAKALKKEMTALRRKLAHPRD 878

  Fly   800 AARHSSHAN 808
            .....:|::
Zfish   879 TLLLDTHSH 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_001286155.1	EPL1	<192..264	CDD:287484	40/71 (56%)
		PHD_BRPF	283..336	CDD:277047	48/52 (92%)
		ePHD_BRPF	340..456	CDD:277140	86/116 (74%)
		Bromo_brd1_like	615..712	CDD:99944	43/96 (45%)
		BR140_related	1303..1414	CDD:99900
brpf1	NP_957310.1	EPL1	124..288	CDD:287484	53/173 (31%)
		PHD_BRPF1	300..361	CDD:277146	50/61 (82%)
		ePHD_BRPF1	363..483	CDD:277171	88/119 (74%)
		Bromodomain	678..775	CDD:295360	43/96 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3073
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31251
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47059
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0001002
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102102
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.960